Aliases for ZG16B Gene

Aliases for ZG16B Gene

  • Zymogen Granule Protein 16B 2 3 5
  • Jacalin-Like Lectin Domain Containing 2 2 3
  • Zymogen Granule Protein 16 Homolog B 3 4
  • HRPE773 2 3
  • PRO1567 2 3
  • JCLN2 2 3
  • Pancreatic Adenocarcinoma Upregulated Factor 3
  • Zymogen Granule Protein 16 Homolog B (Rat) 2
  • Endocrine And Exocrine Protein 3
  • ZG16B 5
  • EECP 3
  • PAUF 3

External Ids for ZG16B Gene

Previous GeneCards Identifiers for ZG16B Gene

  • GC16P002821
  • GC16P002881
  • GC16P002832
  • GC16P003741
  • GC16P003826
  • GC16P003878
  • GC16P004053
  • GC16P002836
  • GC16P002895
  • GC16P002941
  • GC16P002975
  • GC16P003512
  • GC16P003593

Summaries for ZG16B Gene

GeneCards Summary for ZG16B Gene

ZG16B (Zymogen Granule Protein 16B) is a Protein Coding gene. Diseases associated with ZG16B include Pancreatic Adenocarcinoma. Gene Ontology (GO) annotations related to this gene include carbohydrate binding.

Gene Wiki entry for ZG16B Gene

Additional gene information for ZG16B Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZG16B Gene

Genomics for ZG16B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZG16B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J002829 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 635.4 +0.0 32 1.4 HNRNPL GATAD2A FOXA1 RXRB GABPA GTF2F1 SOX13 ZFX CTBP1 KLF4 ZG16B HSALNG0109069 PRSS22
GH16J002867 Promoter/Enhancer 1.9 Ensembl ENCODE CraniofacialAtlas dbSUPER 12.5 +38.3 38307 2 CREB1 GATAD2A CTCF ZNF629 TFE3 IKZF1 NFKBIZ KDM1A ZNF692 POLR2A ENSG00000263280 LOC101929566 FLYWCH2 ZG16B FLYWCH1 PRSS41 SNORA3C PRSS33 ELOB SRRM2-AS1
GH16J002835 Enhancer 1.1 ENCODE dbSUPER 19.6 +6.3 6291 2.4 GATAD2A ZBTB33 PRDM10 ZNF629 IKZF1 JUND PRDM1 ZSCAN4 PATZ1 GABPA ZNF263 E4F1 SRRM2 SNORA64 ENSG00000255513 ENSG00000262482 TSC2 ERVK13-1 ENSG00000261938 TRAF7
GH16J002816 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 8.2 -12.6 -12628 1.7 CTCF HNRNPL MTA2 HDAC1 NRF1 NONO MGA NKRF SMARCC1 POLR2A HSALNG0109066 PRSS21 ZG16B PRSS41 lnc-PRSS22-3
GH16J002822 Enhancer 0.5 ENCODE 23.2 -7.0 -6953 0.8 CTCF REST ZNF600 RAD21 SMC3 ZNF654 ZBTB33 ZNF652 EIF1P4 lnc-PRSS22-3 ZG16B PRSS21
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZG16B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZG16B

Top Transcription factor binding sites by QIAGEN in the ZG16B gene promoter:
  • AP-1
  • Arnt
  • En-1
  • NF-1
  • NRSF form 1
  • NRSF form 2
  • Roaz
  • RORalpha1

Genomic Locations for ZG16B Gene

Genomic Locations for ZG16B Gene
9,417 bases
Plus strand
8,798 bases
Plus strand

Genomic View for ZG16B Gene

Genes around ZG16B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZG16B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZG16B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZG16B Gene

Proteins for ZG16B Gene

  • Protein details for ZG16B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zymogen granule protein 16 homolog B
    Protein Accession:
    Secondary Accessions:
    • A6NIY1
    • B2R4F6
    • Q6UW28

    Protein attributes for ZG16B Gene

    208 amino acids
    Molecular mass:
    22739 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAQ89380.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAG34753.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ZG16B Gene

neXtProt entry for ZG16B Gene

Post-translational modifications for ZG16B Gene

  • Glycosylation at Asn197
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • ZG16B_HUMAN (1909)

Other Protein References for ZG16B Gene

No data available for DME Specific Peptides for ZG16B Gene

Domains & Families for ZG16B Gene

Gene Families for ZG16B Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for ZG16B Gene

Suggested Antigen Peptide Sequences for ZG16B Gene

GenScript: Design optimal peptide antigens:
  • Pancreatic adenocarcinoma upregulated factor (C3PTT6_HUMAN)
  • Zymogen granule protein 16 homolog B (ZG16B_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the jacalin lectin family.
  • Belongs to the jacalin lectin family.
genes like me logo Genes that share domains with ZG16B: view

Function for ZG16B Gene

Phenotypes From GWAS Catalog for ZG16B Gene

Gene Ontology (GO) - Molecular Function for ZG16B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with ZG16B: view
genes like me logo Genes that share phenotypes with ZG16B: view

Animal Model Products

CRISPR Products

miRNA for ZG16B Gene

miRTarBase miRNAs that target ZG16B

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZG16B

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZG16B Gene

Localization for ZG16B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZG16B Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZG16B gene
Compartment Confidence
extracellular 4
nucleus 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZG16B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IBA 21873635
GO:0070062 extracellular exosome HDA 19056867
genes like me logo Genes that share ontologies with ZG16B: view

Pathways & Interactions for ZG16B Gene

PathCards logo

SuperPathways for ZG16B Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZG16B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001895 retina homeostasis HEP 23580065
genes like me logo Genes that share ontologies with ZG16B: view

No data available for Pathways by source and SIGNOR curated interactions for ZG16B Gene

Drugs & Compounds for ZG16B Gene

No Compound Related Data Available

Transcripts for ZG16B Gene

mRNA/cDNA for ZG16B Gene

8 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZG16B

Alternative Splicing Database (ASD) splice patterns (SP) for ZG16B Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c
SP1: - -
SP2: -
SP4: -

Relevant External Links for ZG16B Gene

GeneLoc Exon Structure for

Expression for ZG16B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZG16B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZG16B Gene

This gene is overexpressed in Minor Salivary Gland (x52.0).

Protein differential expression in normal tissues from HIPED for ZG16B Gene

This gene is overexpressed in Skin (26.6), Salivary gland (23.0), and Saliva (10.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZG16B Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZG16B

SOURCE GeneReport for Unigene cluster for ZG16B Gene:


Evidence on tissue expression from TISSUES for ZG16B Gene

  • Pancreas(2)
genes like me logo Genes that share expression patterns with ZG16B: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZG16B Gene

Orthologs for ZG16B Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZG16B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZG16B 30 31
  • 99.2 (n)
(Bos Taurus)
Mammalia ZG16B 30
  • 68.1 (n)
-- 31
  • 52 (a)
-- 31
  • 45 (a)
-- 31
  • 41 (a)
(Canis familiaris)
Mammalia ZG16B 30 31
  • 64.52 (n)
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 29 (a)
-- 31
  • 29 (a)
(Mus musculus)
Mammalia Sbp 31
  • 24 (a)
Sbpl 31
  • 20 (a)
Species where no ortholog for ZG16B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZG16B Gene

Gene Tree for ZG16B (if available)
Gene Tree for ZG16B (if available)
Evolutionary constrained regions (ECRs) for ZG16B: view image

Paralogs for ZG16B Gene

(3) SIMAP similar genes for ZG16B Gene using alignment to 3 proteins:

  • I3L1H9_HUMAN
  • I3L3X0_HUMAN
genes like me logo Genes that share paralogs with ZG16B: view

No data available for Paralogs for ZG16B Gene

Variants for ZG16B Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZG16B Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
rs35533993 - p.Met133Val

Additional dbSNP identifiers (rs#s) for ZG16B Gene

Structural Variations from Database of Genomic Variants (DGV) for ZG16B Gene

Variant ID Type Subtype PubMed ID
esv2663371 CNV deletion 23128226
nsv952905 CNV deletion 24416366

Variation tolerance for ZG16B Gene

Residual Variation Intolerance Score: 66% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.46; 43.23% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZG16B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZG16B Gene

Disorders for ZG16B Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZG16B Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
pancreatic adenocarcinoma
  • adenocarcinoma of the pancreas
- elite association - COSMIC cancer census association via MalaCards
Search ZG16B in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with ZG16B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZG16B Gene

Publications for ZG16B Gene

  1. Crystal structures of human secretory proteins ZG16p and ZG16b reveal a Jacalin-related β-prism fold. (PMID: 21110947) Kanagawa M … Yamaguchi Y (Biochemical and biophysical research communications 2011) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4
  4. Mass spectrometry allows direct identification of proteins in large genomes. (PMID: 11678034) Küster B … Mann M (Proteomics 2001) 3 4
  5. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3

Products for ZG16B Gene

Sources for ZG16B Gene