Aliases for ZG16 Gene

Aliases for ZG16 Gene

  • Zymogen Granule Protein 16 2 3 4 5
  • Jacalin-Like Lectin Domain Containing 2 3
  • Zymogen Granule Membrane Protein 16 3 4
  • Secretory Lectin ZG16 3 4
  • JCLN1 2 3
  • ZG16A 2 3
  • HZG16 2 4
  • Zymogen Granule Protein 16 Homolog (Rat) 2
  • Zymogen Granule Protein 16 Homolog 3
  • JCLN 3
  • ZG16 5

External Ids for ZG16 Gene

Previous HGNC Symbols for ZG16 Gene

  • JCLN

Previous GeneCards Identifiers for ZG16 Gene

  • GC16M028630
  • GC16P030113
  • GC16P029788
  • GC16P029828
  • GC16P9F0076
  • GC16P029699
  • GC16P9G0076
  • GC16P029790
  • GC16P027450

Summaries for ZG16 Gene

GeneCards Summary for ZG16 Gene

ZG16 (Zymogen Granule Protein 16) is a Protein Coding gene. Diseases associated with ZG16 include Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip/Palate Syndrome 1 and Atypical Polypoid Adenomyoma. Gene Ontology (GO) annotations related to this gene include carbohydrate binding.

UniProtKB/Swiss-Prot Summary for ZG16 Gene

  • May play a role in protein trafficking. May act as a linker molecule between the submembranous matrix on the luminal side of zymogen granule membrane (ZGM) and aggregated secretory proteins during granule formation in the TGN.

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZG16 Gene

Genomics for ZG16 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZG16 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J029778 Promoter/Enhancer 1.2 EPDnew Ensembl ENCODE 600.4 +19.1 19116 3.8 CREB1 TEAD4 FOXA1 ZNF600 ATF7 ZKSCAN1 CTBP1 ZNF444 ZNF592 KLF4 ZG16 TBX6 SEPHS2 lnc-ZG16-1 lnc-ZG16-4 KIF22 ENSG00000260719
GH16J029760 Promoter/Enhancer 1.1 EPDnew Ensembl ENCODE 600.7 +0.4 372 2.1 RFX1 NR2C1 SP1 ESR1 NR2C2 BCL6 TFAP4 HNF4A RXRA ZBTB33 ZG16 ENSG00000261367 lnc-ZG16-4 KIF22 ENSG00000260719
GH16J029765 Enhancer 1.1 Ensembl ENCODE 0.7 +4.8 4797 1.2 HNRNPL GATAD2A PRDM10 TFE3 SOX13 NFKBIZ RCOR2 ZHX2 FOXA1 ZIC2 ENSG00000258130 MYLPF ZG16 lnc-ZG16-4 KIF22 ENSG00000260719
GH16J029783 Promoter/Enhancer 1.7 FANTOM5 ENCODE CraniofacialAtlas dbSUPER 0.4 +23.5 23515 2.3 HNRNPL GATAD2A CTCF TEAD4 PRDM10 TFE3 IKZF1 RCOR2 TARDBP ZNF143 piR-49034-002 C16orf92 NPIPB13 NPIPB12 SRCAP ENSG00000260853 ZNF747 INO80E SPNS1 SMG1P5
GH16J029757 Enhancer 0.8 ENCODE 0.7 -2.6 -2566 1.3 GATAD2A ATF7 ZNF512 RCOR2 ZIC2 RXRB SP1 ZNF600 CEBPA SOX13 MYLPF KR153241-006 ZG16 C16orf54 ENSG00000260719
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZG16 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZG16

Top Transcription factor binding sites by QIAGEN in the ZG16 gene promoter:
  • Evi-1
  • FOXD1
  • GATA-3
  • Lmo2
  • RFX1
  • Spz1
  • STAT1
  • STAT1alpha
  • STAT1beta

Genomic Locations for ZG16 Gene

Genomic Locations for ZG16 Gene
22,170 bases
Plus strand
3,536 bases
Plus strand

Genomic View for ZG16 Gene

Genes around ZG16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZG16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZG16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZG16 Gene

Proteins for ZG16 Gene

  • Protein details for ZG16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zymogen granule membrane protein 16
    Protein Accession:
    Secondary Accessions:
    • B2R4Z3
    • B9EK72

    Protein attributes for ZG16 Gene

    167 amino acids
    Molecular mass:
    18147 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ZG16 Gene

neXtProt entry for ZG16 Gene

Post-translational modifications for ZG16 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZG16 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZG16 Gene

Domains & Families for ZG16 Gene

Gene Families for ZG16 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for ZG16 Gene

  • Jacalin-related lectin

Suggested Antigen Peptide Sequences for ZG16 Gene

GenScript: Design optimal peptide antigens:
  • Secretory lectin ZG16 (ZG16_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the jacalin lectin family.
  • Belongs to the jacalin lectin family.
genes like me logo Genes that share domains with ZG16: view

Function for ZG16 Gene

Molecular function for ZG16 Gene

UniProtKB/Swiss-Prot Function:
May play a role in protein trafficking. May act as a linker molecule between the submembranous matrix on the luminal side of zymogen granule membrane (ZGM) and aggregated secretory proteins during granule formation in the TGN.

Gene Ontology (GO) - Molecular Function for ZG16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0030246 carbohydrate binding IEA --
GO:0042834 peptidoglycan binding IEA --
genes like me logo Genes that share ontologies with ZG16: view
genes like me logo Genes that share phenotypes with ZG16: view

Animal Models for ZG16 Gene

MGI Knock Outs for ZG16:

Animal Model Products

  • Taconic Biosciences Mouse Models for ZG16

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZG16 Gene

Localization for ZG16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZG16 Gene

Secreted, extracellular space, extracellular matrix. Cytoplasmic vesicle lumen. Golgi apparatus lumen. Note=Stored in zymogen granules. {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZG16 gene
Compartment Confidence
extracellular 5
golgi apparatus 5
plasma membrane 1
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for ZG16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IBA 21873635
GO:0005794 Golgi apparatus IEA --
GO:0005796 Golgi lumen IEA,IDA 17307141
GO:0031410 cytoplasmic vesicle IEA --
genes like me logo Genes that share ontologies with ZG16: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZG16 Gene

Pathways & Interactions for ZG16 Gene

PathCards logo

SuperPathways for ZG16 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZG16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001816 cytokine production IEA --
GO:0015031 protein transport TAS 17307141
GO:0032609 interferon-gamma production IEA --
GO:0032633 interleukin-4 production IEA --
GO:0032635 interleukin-6 production IEA --
genes like me logo Genes that share ontologies with ZG16: view

No data available for Pathways by source and SIGNOR curated interactions for ZG16 Gene

Drugs & Compounds for ZG16 Gene

No Compound Related Data Available

Transcripts for ZG16 Gene

mRNA/cDNA for ZG16 Gene

6 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for ZG16 Gene

No ASD Table

Relevant External Links for ZG16 Gene

GeneLoc Exon Structure for

Expression for ZG16 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZG16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZG16 Gene

This gene is overexpressed in Colon - Transverse (x41.0) and Small Intestine - Terminal Ileum (x8.7).

Protein differential expression in normal tissues from HIPED for ZG16 Gene

This gene is overexpressed in Rectum (31.2), Colon (25.2), and Pancreatic juice (12.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZG16 Gene

Protein tissue co-expression partners for ZG16 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZG16

SOURCE GeneReport for Unigene cluster for ZG16 Gene:


mRNA Expression by UniProt/SwissProt for ZG16 Gene:

Tissue specificity: Highly expressed in liver. Detected at lower levels in colon, ileum and jejunum.

Evidence on tissue expression from TISSUES for ZG16 Gene

  • Intestine(4.7)
  • Liver(2.2)
genes like me logo Genes that share expression patterns with ZG16: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ZG16 Gene

Orthologs for ZG16 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZG16 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZG16 30 31
  • 99 (n)
(Canis familiaris)
Mammalia ZG16 30 31
  • 86.03 (n)
(Mus musculus)
Mammalia Zg16 30 17 31
  • 82.83 (n)
(Rattus norvegicus)
Mammalia Zg16 30
  • 82.63 (n)
(Monodelphis domestica)
Mammalia -- 31
  • 82 (a)
-- 31
  • 73 (a)
-- 31
  • 73 (a)
(Bos Taurus)
Mammalia ZG16 30 31
  • 80.35 (n)
(Ornithorhynchus anatinus)
Mammalia ZG16 31
  • 72 (a)
(Anolis carolinensis)
Reptilia -- 31
  • 75 (a)
-- 31
  • 48 (a)
-- 31
  • 44 (a)
-- 31
  • 42 (a)
-- 31
  • 42 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia zg16 30
  • 58.81 (n)
Species where no ortholog for ZG16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZG16 Gene

Gene Tree for ZG16 (if available)
Gene Tree for ZG16 (if available)
Evolutionary constrained regions (ECRs) for ZG16: view image

Paralogs for ZG16 Gene

(3) SIMAP similar genes for ZG16 Gene using alignment to 1 proteins:

  • ZG16_HUMAN
genes like me logo Genes that share paralogs with ZG16: view

No data available for Paralogs for ZG16 Gene

Variants for ZG16 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZG16 Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
771485 Benign: not provided 29,779,608(+) GGTCCGA/G INFRAME_DELETION
777003 Benign: not provided 29,780,400(+) G/. NO_SEQUENCE_ALTERATION
784331 Benign: not provided 29,780,104(+) T/A SYNONYMOUS_VARIANT
rs235636 - p.Gly32Ser
rs235638 - p.Ser162Thr

Additional dbSNP identifiers (rs#s) for ZG16 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZG16 Gene

Variant ID Type Subtype PubMed ID
dgv34n68 CNV loss 17160897
nsv833186 CNV loss 17160897

Variation tolerance for ZG16 Gene

Gene Damage Index Score: 2.50; 43.71% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZG16 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZG16 Gene

Disorders for ZG16 Gene

MalaCards: The human disease database

(3) MalaCards diseases for ZG16 Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards
Search ZG16 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with ZG16: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZG16 Gene

Publications for ZG16 Gene

  1. Crystal structures of human secretory proteins ZG16p and ZG16b reveal a Jacalin-related β-prism fold. (PMID: 21110947) Kanagawa M … Yamaguchi Y (Biochemical and biophysical research communications 2011) 2 3 4
  2. hZG16, a novel human secreted protein expressed in liver, was down-regulated in hepatocellular carcinoma. (PMID: 17307141) Zhou YB … Han ZG (Biochemical and biophysical research communications 2007) 3 4
  3. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z … Henzel WJ (Protein science : a publication of the Protein Society 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PMID: 10493829) Loftus BJ … Adams MD (Genomics 1999) 3 4

Products for ZG16 Gene

Sources for ZG16 Gene