Aliases for ZFYVE27 Gene
External Ids for ZFYVE27 Gene
Previous GeneCards Identifiers for ZFYVE27 Gene
This gene encodes a protein with several transmembrane domains, a Rab11-binding domain and a lipid-binding FYVE finger domain. The encoded protein appears to promote neurite formation. A mutation in this gene has been reported to be associated with hereditary spastic paraplegia, however the pathogenicity of the mutation, which may simply represent a polymorphism, is unclear. [provided by RefSeq, Mar 2010]
GeneCards Summary for ZFYVE27 Gene
ZFYVE27 (Zinc Finger FYVE-Type Containing 27) is a Protein Coding gene. Diseases associated with ZFYVE27 include Spastic Paraplegia 33, Autosomal Dominant and Paraplegia. Among its related pathways are Endocytosis.
UniProtKB/Swiss-Prot Summary for ZFYVE27 Gene
Key regulator of RAB11-dependent vesicular trafficking during neurite extension through polarized membrane transport (PubMed:17082457). Promotes axonal elongation and contributes to the establishment of neuronal cell polarity (By similarity). Involved in nerve growth factor-induced neurite formation in VAPA-dependent manner (PubMed:19289470). Contributes to both the formation and stabilization of the tubular ER network (PubMed:24668814). Involved in ER morphogenesis by regulating the sheet-to-tubule balance and possibly the density of tubule interconnections (PubMed:23969831). Acts as an adapter protein and facilitates the interaction of KIF5A with VAPA, VAPB, SURF4, RAB11A, RAB11B and RTN3 and the ZFYVE27-KIF5A complex contributes to the transport of these proteins in neurons. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a KIF5A/B-dependent manner (PubMed:21976701).