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Aliases for ZFYVE26 Gene

Aliases for ZFYVE26 Gene

  • Zinc Finger FYVE-Type Containing 26 2 3 5
  • Spastizin 2 3 4
  • FYVE-CENT 2 3 4
  • FYVE Domain-Containing Centrosomal Protein 3 4
  • Zinc Finger, FYVE Domain Containing 26 2 3
  • Spastic Paraplegia 15 (Complicated, Autosomal Recessive) 2
  • Zinc Finger FYVE Domain-Containing Protein 26 3
  • KIAA0321 4
  • SPG15 3

External Ids for ZFYVE26 Gene

Previous HGNC Symbols for ZFYVE26 Gene

  • SPG15

Previous GeneCards Identifiers for ZFYVE26 Gene

  • GC14M062006
  • GC14M066203
  • GC14M067282
  • GC14M068194
  • GC14M048382

Summaries for ZFYVE26 Gene

Entrez Gene Summary for ZFYVE26 Gene

  • This gene encodes a protein which contains a FYVE zinc finger binding domain. The presence of this domain is thought to target these proteins to membrane lipids through interaction with phospholipids in the membrane. Mutations in this gene are associated with autosomal recessive spastic paraplegia-15. [provided by RefSeq, Oct 2008]

GeneCards Summary for ZFYVE26 Gene

ZFYVE26 (Zinc Finger FYVE-Type Containing 26) is a Protein Coding gene. Diseases associated with ZFYVE26 include Spastic Paraplegia 15, Autosomal Recessive and Spastic Paraplegia 15. Among its related pathways are PI3K / Akt Signaling and Cytoskeletal Signaling. Gene Ontology (GO) annotations related to this gene include phosphatidylinositol-3-phosphate binding. An important paralog of this gene is PLEKHF1.

UniProtKB/Swiss-Prot for ZFYVE26 Gene

  • Phosphatidylinositol 3-phosphate-binding protein required for the abcission step in cytokinesis: recruited to the midbody during cytokinesis and acts as a regulator of abcission. May also be required for efficient homologous recombination DNA double-strand break repair.

Additional gene information for ZFYVE26 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZFYVE26 Gene

Genomics for ZFYVE26 Gene

GeneHancer (GH) Regulatory Elements for ZFYVE26 Gene

Promoters and enhancers for ZFYVE26 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14I067815 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 567 -2.3 -2320 7.3 PKNOX1 CLOCK FOXA2 MLX ARNT ZFP64 ARID4B NEUROD1 SIN3A DMAP1 ZFYVE26 RAD51B RPL12P7 TMEM229B
GH14I067814 Enhancer 0.3 FANTOM5 552.2 +1.6 1607 0.2 RFX1 ZFYVE26 PLEK2 LOC100421541
GH14I068778 Promoter/Enhancer 2.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 22.9 -971.6 -971610 20.4 CLOCK MLX ZFP64 FEZF1 DMAP1 YBX1 IRF4 YY1 SLC30A9 ZNF213 ZFP36L1 DCAF5 ZFYVE26 SRSF5 SUSD6 DDX18P1 RNU6-921P GC14M068736 GC14M068442
GH14I067356 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 22.3 +457.4 457392 5.4 HDGF PKNOX1 CLOCK ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B ATP6V1D EIF2S1 ZFYVE26 PLEK2 ENSG00000258561 GPHN ENSG00000199755
GH14I067531 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 17.1 +283.3 283279 2.8 ATF1 ARNT SIN3A ZBTB7B ZNF48 POLR2B GLIS2 ATF7 SP3 REST TMEM229B PLEKHH1 ZFYVE26
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZFYVE26 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZFYVE26 gene promoter:

Genomic Locations for ZFYVE26 Gene

Genomic Locations for ZFYVE26 Gene
89,238 bases
Minus strand

Genomic View for ZFYVE26 Gene

Genes around ZFYVE26 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZFYVE26 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZFYVE26 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFYVE26 Gene

Proteins for ZFYVE26 Gene

  • Protein details for ZFYVE26 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger FYVE domain-containing protein 26
    Protein Accession:
    Secondary Accessions:
    • B1B5Y3
    • B4E2U3
    • O15035
    • Q68DT9
    • Q6AW90
    • Q6ZR50
    • Q7Z3A4
    • Q7Z3I1
    • Q8N4W7
    • Q96H43

    Protein attributes for ZFYVE26 Gene

    2539 amino acids
    Molecular mass:
    284576 Da
    Quaternary structure:
    • Interacts with AP5Z1, AP5B1, AP5S1 and SPG11. Interacts with TTC19 and KIF13A.
    • Sequence=BAG11658.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAD97882.1; Type=Erroneous termination; Positions=1463; Note=Translated as Gln.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZFYVE26 Gene


neXtProt entry for ZFYVE26 Gene

Post-translational modifications for ZFYVE26 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZFYVE26 Gene

Domains & Families for ZFYVE26 Gene

Gene Families for ZFYVE26 Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for ZFYVE26 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The FYVE-type zinc finger mediates binding to phosphatidylinositol 3-phosphate and recruitment to the midbody during cytokinesis.
  • The FYVE-type zinc finger mediates binding to phosphatidylinositol 3-phosphate and recruitment to the midbody during cytokinesis.
genes like me logo Genes that share domains with ZFYVE26: view

Function for ZFYVE26 Gene

Molecular function for ZFYVE26 Gene

UniProtKB/Swiss-Prot Function:
Phosphatidylinositol 3-phosphate-binding protein required for the abcission step in cytokinesis: recruited to the midbody during cytokinesis and acts as a regulator of abcission. May also be required for efficient homologous recombination DNA double-strand break repair.

Phenotypes From GWAS Catalog for ZFYVE26 Gene

Gene Ontology (GO) - Molecular Function for ZFYVE26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20208530
GO:0008289 lipid binding IEA --
GO:0032266 phosphatidylinositol-3-phosphate binding IEA,IDA 20208530
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZFYVE26: view
genes like me logo Genes that share phenotypes with ZFYVE26: view

Human Phenotype Ontology for ZFYVE26 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for ZFYVE26 Gene

MGI Knock Outs for ZFYVE26:

Animal Model Products

CRISPR Products

miRNA for ZFYVE26 Gene

miRTarBase miRNAs that target ZFYVE26

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for ZFYVE26 Gene

Localization for ZFYVE26 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZFYVE26 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Midbody. Note=Localizes to the centrosome during all stages of the cell cycle. Recruited to the midbody during cytokinesis by KIF13A.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZFYVE26 gene
Compartment Confidence
cytoskeleton 5
lysosome 5
nucleus 3
cytosol 3
endosome 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for ZFYVE26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005765 lysosomal membrane HDA,IDA 17897319
GO:0005813 centrosome IDA 20208530
GO:0005815 microtubule organizing center IEA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with ZFYVE26: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZFYVE26 Gene

Pathways & Interactions for ZFYVE26 Gene

genes like me logo Genes that share pathways with ZFYVE26: view

Pathways by source for ZFYVE26 Gene

2 Cell Signaling Technology pathways for ZFYVE26 Gene

Gene Ontology (GO) - Biological Process for ZFYVE26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000724 double-strand break repair via homologous recombination IMP 20613862
GO:0000910 cytokinesis IMP,IEA 20208530
GO:0006281 DNA repair IEA --
GO:0006974 cellular response to DNA damage stimulus IEA --
GO:0007049 cell cycle IEA --
genes like me logo Genes that share ontologies with ZFYVE26: view

No data available for SIGNOR curated interactions for ZFYVE26 Gene

Drugs & Compounds for ZFYVE26 Gene

No Compound Related Data Available

Transcripts for ZFYVE26 Gene

Unigene Clusters for ZFYVE26 Gene

Zinc finger, FYVE domain containing 26:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZFYVE26 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^
SP1: -
SP2: - -

ExUns: 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32a · 32b ^ 33 ^ 34a · 34b ^ 35a · 35b ^ 36a · 36b ^ 37 ^ 38 ^ 39 ^ 40 ^ 41a · 41b ^ 42
SP1: - - -
SP3: -

Relevant External Links for ZFYVE26 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZFYVE26 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZFYVE26 Gene

Protein differential expression in normal tissues from HIPED for ZFYVE26 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (21.4), Blymphocyte (15.2), Pancreas (12.2), and Placenta (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZFYVE26 Gene

Protein tissue co-expression partners for ZFYVE26 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZFYVE26 Gene:


SOURCE GeneReport for Unigene cluster for ZFYVE26 Gene:


mRNA Expression by UniProt/SwissProt for ZFYVE26 Gene:

Tissue specificity: Strongest expression in the adrenal gland, bone marrow, adult brain, fetal brain, lung, placenta, prostate, skeletal muscle, testis, thymus, and retina. Intermediate levels are detected in other structures, including the spinal cord.

Evidence on tissue expression from TISSUES for ZFYVE26 Gene

  • Nervous system(4.5)
  • Liver(4.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for ZFYVE26 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
  • digestive
  • nervous
  • skeletal muscle
  • skeleton
  • urinary
Head and neck:
  • brain
  • cranial nerve
  • eye
  • head
  • intestine
  • large intestine
  • small intestine
  • prostate
  • urethra
  • urinary bladder
  • foot
  • hand
  • lower limb
  • upper limb
  • peripheral nerve
  • peripheral nervous system
  • spinal cord
genes like me logo Genes that share expression patterns with ZFYVE26: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ZFYVE26 Gene

Orthologs for ZFYVE26 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZFYVE26 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZFYVE26 33 34
  • 99.62 (n)
(Canis familiaris)
Mammalia ZFYVE26 33 34
  • 88.15 (n)
(Bos Taurus)
Mammalia ZFYVE26 33 34
  • 87.32 (n)
(Mus musculus)
Mammalia Zfyve26 33 16 34
  • 83.87 (n)
(Rattus norvegicus)
Mammalia Zfyve26 33
  • 83.39 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 82 (a)
-- 34
  • 73 (a)
-- 34
  • 62 (a)
-- 34
  • 57 (a)
-- 34
  • 55 (a)
(Monodelphis domestica)
Mammalia ZFYVE26 34
  • 74 (a)
(Gallus gallus)
Aves -- 34
  • 76 (a)
ZFYVE26 33
  • 64.67 (n)
-- 34
  • 63 (a)
-- 34
  • 61 (a)
-- 34
  • 51 (a)
(Anolis carolinensis)
Reptilia ZFYVE26 34
  • 58 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia zfyve26 33
  • 57.42 (n)
(Danio rerio)
Actinopterygii zfyve26 33 34
  • 54.48 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG5270 34
  • 21 (a)
Species where no ortholog for ZFYVE26 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZFYVE26 Gene

Gene Tree for ZFYVE26 (if available)
Gene Tree for ZFYVE26 (if available)

Paralogs for ZFYVE26 Gene

Paralogs for ZFYVE26 Gene

genes like me logo Genes that share paralogs with ZFYVE26: view

Variants for ZFYVE26 Gene

Sequence variations from dbSNP and Humsavar for ZFYVE26 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1002595925 uncertain-significance, Retinitis Pigmentosa, Recessive 67,734,282(-) A/T genic_downstream_transcript_variant, intron_variant
rs1008121121 uncertain-significance, Spastic Paraplegia, Recessive 67,816,570(-) C/A/T 5_prime_UTR_variant, genic_upstream_transcript_variant
rs10288 benign, Spastic Paraplegia, Recessive 67,747,027(-) G/A 3_prime_UTR_variant, genic_downstream_transcript_variant, intron_variant
rs1044126 benign, Spastic Paraplegia, Recessive 67,747,075(-) A/G 3_prime_UTR_variant, genic_downstream_transcript_variant, intron_variant
rs104894476 pathogenic, Leber congenital amaurosis 13 67,729,220(-) C/G 3_prime_UTR_variant, genic_downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ZFYVE26 Gene

Variant ID Type Subtype PubMed ID
dgv648e212 CNV loss 25503493
esv3360565 CNV insertion 20981092
nsv1054697 CNV gain 25217958
nsv1323 CNV insertion 18451855
nsv983838 CNV duplication 23825009

Variation tolerance for ZFYVE26 Gene

Residual Variation Intolerance Score: 9.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.10; 90.22% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZFYVE26 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZFYVE26 Gene

Disorders for ZFYVE26 Gene

MalaCards: The human disease database

(13) MalaCards diseases for ZFYVE26 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
spastic paraplegia 15, autosomal recessive
  • spg15
spastic paraplegia 15
  • kjellin syndrome
neuropathy, hereditary sensory, with spastic paraplegia, autosomal recessive
  • neuropathy, hereditary sensory, with spastic paraplegia
hereditary spastic paraplegia
  • spastic paraplegia 3, autosomal dominant
spastic paraplegia 7, autosomal recessive
  • spg7
- elite association - COSMIC cancer census association via MalaCards


  • Spastic paraplegia 15, autosomal recessive (SPG15) [MIM:270700]: A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. SPG15 is a complex form associated with additional neurological symptoms such as cognitive deterioration or mental retardation, axonal neuropathy, mild cerebellar signs, and, less frequently, a central hearing deficit, decreased visual acuity, or retinal degeneration. {ECO:0000269 PubMed:18394578, ECO:0000269 PubMed:19084844, ECO:0000269 PubMed:19805727}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for ZFYVE26

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ZFYVE26: view

No data available for Genatlas for ZFYVE26 Gene

Publications for ZFYVE26 Gene

  1. Identification of the SPG15 gene, encoding spastizin, as a frequent cause of complicated autosomal-recessive spastic paraplegia, including Kjellin syndrome. (PMID: 18394578) Hanein S … Stevanin G (American journal of human genetics 2008) 2 3 4 58
  2. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9205841) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1997) 2 3 4 58
  3. PtdIns(3)P controls cytokinesis through KIF13A-mediated recruitment of FYVE-CENT to the midbody. (PMID: 20208530) Sagona AP … Stenmark H (Nature cell biology 2010) 3 4 58
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  5. A genome-scale DNA repair RNAi screen identifies SPG48 as a novel gene associated with hereditary spastic paraplegia. (PMID: 20613862) Słabicki M … Buchholz F (PLoS biology 2010) 3 4 58

Products for ZFYVE26 Gene

Sources for ZFYVE26 Gene

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