Aliases for ZFYVE21 Gene

Aliases for ZFYVE21 Gene

  • Zinc Finger FYVE-Type Containing 21 2 3 5
  • ZF21 2 3 4
  • Zinc Finger FYVE Domain-Containing Protein 21 3 4
  • Zinc Finger, FYVE Domain Containing 21 2 3
  • HCV P7-Transactivated Protein 1 3
  • FYVE Domain Containing 21 3
  • HCVP7TP1 3
  • ZFYVE21 5
  • MGC2550 2

External Ids for ZFYVE21 Gene

Previous GeneCards Identifiers for ZFYVE21 Gene

  • GC14P097997
  • GC14P102172
  • GC14P103251
  • GC14P104182
  • GC14P084360

Summaries for ZFYVE21 Gene

GeneCards Summary for ZFYVE21 Gene

ZFYVE21 (Zinc Finger FYVE-Type Containing 21) is a Protein Coding gene. Diseases associated with ZFYVE21 include Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, And Stroke-Like Episodes.

UniProtKB/Swiss-Prot Summary for ZFYVE21 Gene

  • Plays a role in cell adhesion, and thereby in cell motility which requires repeated formation and disassembly of focal adhesions. Regulates microtubule-induced PTK2/FAK1 dephosphorylation, an event important for focal adhesion disassembly, as well as integrin beta-1/ITGB1 cell surface expression.

Additional gene information for ZFYVE21 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZFYVE21 Gene

Genomics for ZFYVE21 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZFYVE21 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZFYVE21 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZFYVE21

Top Transcription factor binding sites by QIAGEN in the ZFYVE21 gene promoter:
  • C/EBPalpha
  • CHOP-10
  • GR
  • GR-alpha
  • GR-beta
  • p53
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for ZFYVE21 Gene

Genomic Locations for ZFYVE21 Gene
chr14:103,715,730-103,733,668
(GRCh38/hg38)
Size:
17,939 bases
Orientation:
Plus strand
chr14:104,182,067-104,200,005
(GRCh37/hg19)
Size:
17,939 bases
Orientation:
Plus strand

Genomic View for ZFYVE21 Gene

Genes around ZFYVE21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZFYVE21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZFYVE21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFYVE21 Gene

Proteins for ZFYVE21 Gene

  • Protein details for ZFYVE21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BQ24-ZFY21_HUMAN
    Recommended name:
    Zinc finger FYVE domain-containing protein 21
    Protein Accession:
    Q9BQ24
    Secondary Accessions:
    • A8K3A4
    • Q86T05
    • Q96LT1

    Protein attributes for ZFYVE21 Gene

    Size:
    234 amino acids
    Molecular mass:
    26506 Da
    Quaternary structure:
    • Interacts with PTK2/FAK1.
    SequenceCaution:
    • Sequence=CAD62589.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ZFYVE21 Gene

    Alternative splice isoforms for ZFYVE21 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZFYVE21 Gene

Post-translational modifications for ZFYVE21 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZFYVE21 Gene

No data available for DME Specific Peptides for ZFYVE21 Gene

Domains & Families for ZFYVE21 Gene

Gene Families for ZFYVE21 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ZFYVE21 Gene

InterPro:
Blocks:
  • Zn-finger, FYVE type
ProtoNet:

Suggested Antigen Peptide Sequences for ZFYVE21 Gene

GenScript: Design optimal peptide antigens:
  • HCV p7-transactivated protein 1 (Q6PLM3_HUMAN)
  • Zinc finger FYVE domain-containing protein 21 (ZFY21_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9BQ24

UniProtKB/Swiss-Prot:

ZFY21_HUMAN :
  • The FYVE-type zinc finger mediates interaction with PTK2/FAK1, and also interaction with PI(3)P and association with endosomes.
Domain:
  • The FYVE-type zinc finger mediates interaction with PTK2/FAK1, and also interaction with PI(3)P and association with endosomes.
  • The C-terminal region exhibits a structure similar to canonical PH domains, but lacks a positively charged interface to bind phosphatidylinositol phosphate.
genes like me logo Genes that share domains with ZFYVE21: view

Function for ZFYVE21 Gene

Molecular function for ZFYVE21 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in cell adhesion, and thereby in cell motility which requires repeated formation and disassembly of focal adhesions. Regulates microtubule-induced PTK2/FAK1 dephosphorylation, an event important for focal adhesion disassembly, as well as integrin beta-1/ITGB1 cell surface expression.

Phenotypes From GWAS Catalog for ZFYVE21 Gene

Gene Ontology (GO) - Molecular Function for ZFYVE21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZFYVE21: view
genes like me logo Genes that share phenotypes with ZFYVE21: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZFYVE21

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZFYVE21 Gene

Localization for ZFYVE21 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZFYVE21 Gene

Cell junction, focal adhesion. Cytoplasmic vesicle. Endosome. Note=Within cytoplasmic vesicles, partially colocalizes with EEA1, an endosomal marker.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZFYVE21 gene
Compartment Confidence
endosome 5
extracellular 3
cytosol 3
plasma membrane 1
cytoskeleton 1
nucleus 1
lysosome 1
mitochondrion 0

Gene Ontology (GO) - Cellular Components for ZFYVE21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IEA --
GO:0005925 focal adhesion IEA --
GO:0030054 cell junction IEA --
GO:0031410 cytoplasmic vesicle IEA --
genes like me logo Genes that share ontologies with ZFYVE21: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZFYVE21 Gene

Pathways & Interactions for ZFYVE21 Gene

PathCards logo

SuperPathways for ZFYVE21 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZFYVE21 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ZFYVE21 Gene

Drugs & Compounds for ZFYVE21 Gene

No Compound Related Data Available

Transcripts for ZFYVE21 Gene

mRNA/cDNA for ZFYVE21 Gene

2 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZFYVE21

Alternative Splicing Database (ASD) splice patterns (SP) for ZFYVE21 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c
SP1: - - - - -
SP2: - - - - -
SP3: - - - - - -
SP4: - - -
SP5: - -
SP6: - -
SP7: - -
SP8:

Relevant External Links for ZFYVE21 Gene

GeneLoc Exon Structure for
ZFYVE21

Expression for ZFYVE21 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZFYVE21 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZFYVE21 Gene

This gene is overexpressed in Heart (45.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZFYVE21 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZFYVE21

SOURCE GeneReport for Unigene cluster for ZFYVE21 Gene:

Hs.592322

Evidence on tissue expression from TISSUES for ZFYVE21 Gene

  • Nervous system(4.7)
  • Skin(4.4)
  • Bone marrow(4.2)
genes like me logo Genes that share expression patterns with ZFYVE21: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZFYVE21 Gene

Orthologs for ZFYVE21 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZFYVE21 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZFYVE21 30 31
  • 97.62 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ZFYVE21 30 31
  • 88.36 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Zfyve21 30 17 31
  • 83.9 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Zfyve21 30
  • 83.71 (n)
Cow
(Bos Taurus)
Mammalia ZFYVE21 30 31
  • 81.87 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia ZFYVE21 31
  • 78 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia ZFYVE21 31
  • 64 (a)
OneToOne
Chicken
(Gallus gallus)
Aves ZFYVE21 30 31
  • 76.5 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia ZFYVE21 31
  • 76 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia zfyve21 30
  • 70.29 (n)
Str.904 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.24182 30
Zebrafish
(Danio rerio)
Actinopterygii zfyve21 30 31
  • 69.76 (n)
OneToOne
wufb66b01 30
Fruit Fly
(Drosophila melanogaster)
Insecta Sara 31
  • 4 (a)
ManyToMany
Worm
(Caenorhabditis elegans)
Secernentea aka-1 31
  • 5 (a)
OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FAB1 31
  • 2 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.4065 31
  • 4 (a)
OneToMany
Species where no ortholog for ZFYVE21 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for ZFYVE21 Gene

ENSEMBL:
Gene Tree for ZFYVE21 (if available)
TreeFam:
Gene Tree for ZFYVE21 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZFYVE21: view image

Paralogs for ZFYVE21 Gene

No data available for Paralogs for ZFYVE21 Gene

Variants for ZFYVE21 Gene

Additional dbSNP identifiers (rs#s) for ZFYVE21 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZFYVE21 Gene

Variant ID Type Subtype PubMed ID
esv2760013 CNV loss 17122850
nsv1054574 CNV loss 25217958
nsv1131077 CNV deletion 24896259
nsv470673 CNV loss 18288195
nsv527425 CNV loss 19592680
nsv566023 CNV loss 21841781
nsv827071 CNV gain 20364138
nsv9171 CNV gain 18304495
nsv952260 CNV deletion 24416366

Variation tolerance for ZFYVE21 Gene

Residual Variation Intolerance Score: 27.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.38; 27.19% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZFYVE21 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZFYVE21

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZFYVE21 Gene

Disorders for ZFYVE21 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZFYVE21 Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZFYVE21

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with ZFYVE21: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZFYVE21 Gene

Publications for ZFYVE21 Gene

  1. ZF21 protein, a regulator of the disassembly of focal adhesions and cancer metastasis, contains a novel noncanonical pleckstrin homology domain. (PMID: 21768110) Nagano M … Seiki M (The Journal of biological chemistry 2011) 2 3 4
  2. ZF21 protein regulates cell adhesion and motility. (PMID: 20439989) Nagano M … Seiki M (The Journal of biological chemistry 2010) 3 4
  3. Single-nucleotide polymorphisms in DNA-repair genes and cutaneous melanoma. (PMID: 20601096) Figl A … Kumar R (Mutation research 2010) 3 41
  4. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PMID: 19773279) Hosgood HD … Lan Q (Occupational and environmental medicine 2009) 3 41
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4

Products for ZFYVE21 Gene

Sources for ZFYVE21 Gene