Aliases for ZFYVE19 Gene
External Ids for ZFYVE19 Gene
Previous GeneCards Identifiers for ZFYVE19 Gene
GeneCards Summary for ZFYVE19 Gene
ZFYVE19 (Zinc Finger FYVE-Type Containing 19) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include phosphatidylinositol-3-phosphate binding. An important paralog of this gene is RUFY2.
UniProtKB/Swiss-Prot Summary for ZFYVE19 Gene
Key regulator of abscission step in cytokinesis: part of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage. Together with CHMP4C, required to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. Deactivation of AURKB results in dephosphorylation of CHMP4C followed by its dissociation from ZFYVE19/ANCHR and VPS4 and subsequent abscission.