Aliases for ZFYVE16 Gene
External Ids for ZFYVE16 Gene
Previous GeneCards Identifiers for ZFYVE16 Gene
This gene encodes an endosomal protein that belongs to the FYVE zinc finger family of proteins. The encoded protein is thought to regulate membrane trafficking in the endosome. This protein functions as a scaffold protein in the transforming growth factor-beta signaling pathway and is involved in positive and negative feedback regulation of the bone morphogenetic protein signaling pathway. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
GeneCards Summary for ZFYVE16 Gene
ZFYVE16 (Zinc Finger FYVE-Type Containing 16) is a Protein Coding gene. Among its related pathways are TGF-beta receptor signaling (Pathway Interaction Database) and Endocytosis. Gene Ontology (GO) annotations related to this gene include protein transporter activity and 1-phosphatidylinositol binding. An important paralog of this gene is ZFYVE9.
UniProtKB/Swiss-Prot for ZFYVE16 Gene
May be involved in regulating membrane trafficking in the endosomal pathway. Overexpression induces endosome aggregation. Required to target TOM1 to endosomes.