Free for academic non-profit institutions. Other users need a Commercial license
The FYVE domain mediates the recruitment of proteins involved in membrane trafficking and cell signaling to phosphatidylinositol 3-phosphate-containing membranes. This protein contains two zinc-binding FYVE domains in tandem and is reported to localize to the Golgi apparatus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
ZFYVE1 (Zinc Finger FYVE-Type Containing 1) is a Protein Coding gene. Among its related pathways are Autophagy - animal. Gene Ontology (GO) annotations related to this gene include phosphatidylinositol-3,4,5-trisphosphate binding and phosphatidylinositol-3,4-bisphosphate binding. An important paralog of this gene is ZFYVE26.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 19389623 |
GO:0005545 | 1-phosphatidylinositol binding | IDA | 11256955 |
GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding | IDA | 11804589 |
GO:0008270 | zinc ion binding | NAS | 11739631 |
GO:0032266 | phosphatidylinositol-3-phosphate binding | IDA | 31293035 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000407 | phagophore assembly site | IDA | 23455425 |
GO:0005739 | mitochondrion | IDA | 25876663 |
GO:0005776 | autophagosome | IDA | 22456507 |
GO:0005783 | endoplasmic reticulum | IEA,IDA | 11739631 |
GO:0005789 | endoplasmic reticulum membrane | IDA | 30970241 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Autophagy - animal |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0009267 | cellular response to starvation | IDA | 25578879 |
GO:0010923 | negative regulation of phosphatase activity | IDA | 19389623 |
GO:0016236 | macroautophagy | IDA | 25578879 |
GO:0140042 | lipid droplet formation | IMP | 30970241 |
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | · | 9c | ^ | 10a | · | 10b | ^ | 11a | · | 11b | ^ | 12 | ^ | 13a | · | 13b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||
SP3: | - | - | - | ||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | ||||||||||||||||||||||||||||||||||||||
SP5: | |||||||||||||||||||||||||||||||||||||||||
SP6: | - | ||||||||||||||||||||||||||||||||||||||||
SP7: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ZFYVE1 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | ZFYVE1 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | ZFYVE1 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | ZFYVE1 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Zfyve1 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Zfyve1 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | ZFYVE1 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | ZFYVE1 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | ZFYVE1 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | zfyve1 30 |
|
||
Str.6293 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.16326 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | ZFYVE1 31 |
|
OneToOne | |
zfyve1 30 |
|
||||
Dr.18806 30 |
|
||||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP002036 30 |
|
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3634896 | CNV | loss | 21293372 |
esv3634897 | CNV | loss | 21293372 |
esv3634898 | CNV | loss | 21293372 |
nsv1035460 | CNV | gain | 25217958 |
nsv1048734 | CNV | gain | 25217958 |
nsv1049819 | CNV | gain | 25217958 |
nsv1116032 | CNV | deletion | 24896259 |
nsv1122912 | CNV | deletion | 24896259 |
nsv1348 | CNV | deletion | 18451855 |
nsv565050 | CNV | gain | 21841781 |
nsv983842 | CNV | duplication | 23825009 |
No disorders were found for ZFYVE1 Gene.