Aliases for ZFYVE1 Gene
External Ids for ZFYVE1 Gene
Previous HGNC Symbols for ZFYVE1 Gene
Previous GeneCards Identifiers for ZFYVE1 Gene
The FYVE domain mediates the recruitment of proteins involved in membrane trafficking and cell signaling to phosphatidylinositol 3-phosphate-containing membranes. This protein contains two zinc-binding FYVE domains in tandem and is reported to localize to the Golgi apparatus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
GeneCards Summary for ZFYVE1 Gene
ZFYVE1 (Zinc Finger FYVE-Type Containing 1) is a Protein Coding gene. Among its related pathways are Autophagy - animal. Gene Ontology (GO) annotations related to this gene include phosphatidylinositol-3,4,5-trisphosphate binding and phosphatidylinositol-3,4-bisphosphate binding. An important paralog of this gene is ZFYVE26.
UniProtKB/Swiss-Prot Summary for ZFYVE1 Gene
Plays a role in the formation of lipid droplets (LDs) which are storage organelles at the center of lipid and energy homeostasis (PubMed:30970241). Regulates the morphology, size and distribution of LDs (PubMed:31293035, PubMed:30970241). Mediates the formation of endoplasmic reticulum-lipid droplets (ER-LD) contacts by forming a complex with RAB18 and ZW10 (PubMed:30970241). Binds to phosphatidylinositol 3-phosphate (PtdIns3P) through FYVE-type zinc finger (PubMed:11739631, PubMed:11256955).