This gene encodes a zinc finger-containing protein that may function as a transcription factor. This gene was once a candidate gene for the testis-determining factor (TDF) and was erroneously referred to as TDF. [provided by RefSeq, Jul 2008] See more...

Aliases for ZFY Gene

Aliases for ZFY Gene

  • Zinc Finger Protein Y-Linked 2 3 5
  • Zinc Finger Y-Chromosomal Protein 3 4
  • ZNF911 2 3
  • ZFY 5

External Ids for ZFY Gene

Previous GeneCards Identifiers for ZFY Gene

  • GC0YP002729
  • GC0YP002448
  • GC0YP002846
  • GC0YP000155

Summaries for ZFY Gene

Entrez Gene Summary for ZFY Gene

  • This gene encodes a zinc finger-containing protein that may function as a transcription factor. This gene was once a candidate gene for the testis-determining factor (TDF) and was erroneously referred to as TDF. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZFY Gene

ZFY (Zinc Finger Protein Y-Linked) is a Protein Coding gene. Diseases associated with ZFY include Hermaphroditism and Campomelic Dysplasia. An important paralog of this gene is ZFX.

UniProtKB/Swiss-Prot Summary for ZFY Gene

  • Probable transcriptional activator. Binds to the consensus sequence 5'-AGGCCY-3'.

Gene Wiki entry for ZFY Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZFY Gene

Genomics for ZFY Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZFY Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0YJ002933 Enhancer 0.8 ENCODE 600.7 +0.5 538 4.3 GATAD2A POLR2A RXRB IRF2 CTCF KMT2B SOX13 KAT7 ZBTB25 YY1 ENSG00000278847 ZFY lnc-ZFY-3 RF00017-8824 TGIF2LY
GH0YJ002999 Promoter/Enhancer 0.9 EPDnew FANTOM5 ENCODE 7 +69.6 69612 10.4 CEBPA NFIL3 HLF LINC00278 ZFY-AS1 piR-45616-004 piR-58524-003 ZFY RPS4Y1 piR-58524-002 RF00017-8824 RF00017-8825 TGIF2LY
GH0YJ002952 Enhancer 0.5 ENCODE 0.4 +17.9 17907 1.1 CEBPA SOX13 CEBPB SMAD4 TEAD3 SOX5 CEBPG ZFY lnc-ZFY-3 RF00017-8824 TGIF2LY
GH0YJ002913 Enhancer 0.4 ENCODE 0.4 -22.0 -21986 0.1 CTCF JUND RAD21 ZNF384 piR-33863-194 ZFY HSFY3P RPS4Y1 RF00017-8824
GH0YJ002884 Enhancer 0.4 ENCODE 0.3 -48.6 -48633 4.8 ZNF7 FOXA2 CTCF FOXA3 HSFY3P lnc-SRY-6 RPS4Y1 ZFY RF00017-8824
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZFY on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZFY

Top Transcription factor binding sites by QIAGEN in the ZFY gene promoter:
  • AhR
  • Arnt
  • Egr-1
  • Olf-1
  • Pax-4a
  • Pax-5

Genomic Locations for ZFY Gene

Genomic Locations for ZFY Gene
chrY:2,935,281-2,982,508
(GRCh38/hg38)
Size:
47,228 bases
Orientation:
Plus strand
chrY:2,803,112-2,850,547
(GRCh37/hg19)
Size:
47,436 bases
Orientation:
Plus strand

Genomic View for ZFY Gene

Genes around ZFY on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZFY Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZFY Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFY Gene

Proteins for ZFY Gene

  • Protein details for ZFY Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08048-ZFY_HUMAN
    Recommended name:
    Zinc finger Y-chromosomal protein
    Protein Accession:
    P08048
    Secondary Accessions:
    • B4DVF7
    • Q14021
    • Q15558
    • Q1RME9
    • Q24JR0
    • Q96TF3

    Protein attributes for ZFY Gene

    Size:
    801 amino acids
    Molecular mass:
    90505 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ZFY Gene

    Alternative splice isoforms for ZFY Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZFY Gene

Post-translational modifications for ZFY Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZFY Gene

Domains & Families for ZFY Gene

Gene Families for ZFY Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZFY Gene

InterPro:
Blocks:
  • C2H2-type zinc finger signature
  • Zfx / Zfy transcription activation region
ProtoNet:

Suggested Antigen Peptide Sequences for ZFY Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ50242, highly similar to Zinc finger Y-chromosomal protein (B4DVF7_HUMAN)
  • ZFY protein (Q24JR0_HUMAN)
  • Zinc finger Y-chromosomal protein (ZFY_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P08048

UniProtKB/Swiss-Prot:

ZFY_HUMAN :
  • The binding of ZFY to DNA is mediated by the interaction of the GGCC core base pairs with zinc fingers 12 and 13.
  • Belongs to the krueppel C2H2-type zinc-finger protein family. ZFX/ZFY subfamily.
Domain:
  • The binding of ZFY to DNA is mediated by the interaction of the GGCC core base pairs with zinc fingers 12 and 13.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family. ZFX/ZFY subfamily.
genes like me logo Genes that share domains with ZFY: view

Function for ZFY Gene

Molecular function for ZFY Gene

UniProtKB/Swiss-Prot Function:
Probable transcriptional activator. Binds to the consensus sequence 5'-AGGCCY-3'.
GENATLAS Biochemistry:
zinc finger protein,Y-linked

Gene Ontology (GO) - Molecular Function for ZFY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISM 19274049
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 26871637
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZFY: view
genes like me logo Genes that share phenotypes with ZFY: view

Animal Model Products

CRISPR Products

miRNA for ZFY Gene

miRTarBase miRNAs that target ZFY

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZFY

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZFY Gene

Localization for ZFY Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZFY Gene

Nucleus.

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZFY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with ZFY: view

No data available for Subcellular locations from COMPARTMENTS for ZFY Gene

Pathways & Interactions for ZFY Gene

PathCards logo

SuperPathways for ZFY Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZFY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZFY: view

No data available for Pathways by source and SIGNOR curated interactions for ZFY Gene

Drugs & Compounds for ZFY Gene

(3) Drugs for ZFY Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zinc Approved, Investigational Pharma 1594
3-Cyclohexyl-L-alanine Experimental Pharma Target 0
PCL-016 Investigational Pharma Target 0

(1) Additional Compounds for ZFY Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ZFY: view

Transcripts for ZFY Gene

mRNA/cDNA for ZFY Gene

12 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZFY

Alternative Splicing Database (ASD) splice patterns (SP) for ZFY Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8
SP1: - - - - -
SP2:
SP3: -
SP4:
SP5:

Relevant External Links for ZFY Gene

GeneLoc Exon Structure for
ZFY

Expression for ZFY Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZFY Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZFY Gene

This gene is overexpressed in Nasal epithelium (67.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZFY Gene



Protein tissue co-expression partners for ZFY Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZFY

SOURCE GeneReport for Unigene cluster for ZFY Gene:

Hs.522845
genes like me logo Genes that share expression patterns with ZFY: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZFY Gene

Orthologs for ZFY Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZFY Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZFY 30 31
  • 99.5 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ZFX 31
  • 94 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia ZFX 31
  • 94 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 92 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 82 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Zfy2 31
  • 71 (a)
ManyToMany
Zfy1 31
  • 70 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves -- 31
  • 87 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 79 (a)
OneToMany
Zebrafish
(Danio rerio)
Actinopterygii CABZ01079241.1 31
  • 64 (a)
ManyToMany
zfx 31
  • 58 (a)
ManyToMany
Species where no ortholog for ZFY was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ZFY Gene

ENSEMBL:
Gene Tree for ZFY (if available)
TreeFam:
Gene Tree for ZFY (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZFY: view image

Paralogs for ZFY Gene

(10) SIMAP similar genes for ZFY Gene using alignment to 2 proteins:

  • ZFY_HUMAN
  • C9JQM1_HUMAN
genes like me logo Genes that share paralogs with ZFY: view

Variants for ZFY Gene

Additional dbSNP identifiers (rs#s) for ZFY Gene

Variation tolerance for ZFY Gene

Gene Damage Index Score: 0.06; 1.37% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZFY Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZFY

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Structural Variations from Database of Genomic Variants (DGV) for ZFY Gene

Disorders for ZFY Gene

MalaCards: The human disease database

(2) MalaCards diseases for ZFY Gene - From: GeneCards

Disorder Aliases PubMed IDs
hermaphroditism
campomelic dysplasia
  • cmpd
- elite association - COSMIC cancer census association via MalaCards
Search ZFY in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with ZFY: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZFY Gene

Publications for ZFY Gene

  1. Sex chromosomal transposable element accumulation and male-driven substitutional evolution in humans. (PMID: 10779541) Erlandsson R … Pääbo S (Molecular biology and evolution 2000) 3 4 23
  2. Comparison of ZFY and ZFX gene structure and analysis of alternative 3' untranslated regions of ZFY. (PMID: 2041734) North M … Ferguson-Smith MA (Nucleic acids research 1991) 3 4 23
  3. Comparison of human ZFY and ZFX transcripts. (PMID: 2308929) Palmer MS … Goodfellow PN (Proceedings of the National Academy of Sciences of the United States of America 1990) 3 4 23
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. (PMID: 12815422) Skaletsky H … Page DC (Nature 2003) 3 4

Products for ZFY Gene

  • Signalway Proteins for ZFY

Sources for ZFY Gene