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Aliases for ZFY Gene

Aliases for ZFY Gene

  • Zinc Finger Protein, Y-Linked 2 3 5
  • Zinc Finger Y-Chromosomal Protein 3
  • ZNF911 3

External Ids for ZFY Gene

Previous GeneCards Identifiers for ZFY Gene

  • GC0YP002729
  • GC0YP002448
  • GC0YP000155

Summaries for ZFY Gene

Entrez Gene Summary for ZFY Gene

  • This gene encodes a zinc finger-containing protein that may function as a transcription factor. This gene was once a candidate gene for the testis-determining factor (TDF) and was erroneously referred to as TDF. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZFY Gene

ZFY (Zinc Finger Protein, Y-Linked) is a Protein Coding gene. Diseases associated with ZFY include Cystadenofibroma and Frasier Syndrome. An important paralog of this gene is ZFX.

UniProtKB/Swiss-Prot for ZFY Gene

  • Probable transcriptional activator. Binds to the consensus sequence 5-AGGCCY-3.

Gene Wiki entry for ZFY Gene

Additional gene information for ZFY Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZFY Gene

Genomics for ZFY Gene

GeneHancer (GH) Regulatory Elements for ZFY Gene

Promoters and enhancers for ZFY Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0YI002933 Promoter/Enhancer 1 EPDnew ENCODE 550.8 +1.4 1403 4.3 CTCF ZNF3 POLR2A CEBPB ZFX ENSG00000278847 GC0YM002935 ZFY GC0YP002981
GH0YI002938 Promoter 0.5 EPDnew 550.8 +3.8 3757 0.1 ZFY GC0YM002935 GC0YP002981
GH0YI002999 Enhancer 0.6 FANTOM5 ENCODE 7 +70.5 70477 10.4 HLF LINC00278 ZFY RPS4Y1 ZFY-AS1 PIR33109
GH0YI002952 Enhancer 0.4 ENCODE 0.4 +18.8 18772 1.1 SKI CEBPB GC0YM002935 ZFY GC0YP002981
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZFY on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZFY gene promoter:

Genomic Locations for ZFY Gene

Genomic Locations for ZFY Gene
48,093 bases
Plus strand

Genomic View for ZFY Gene

Genes around ZFY on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZFY Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZFY Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFY Gene

Proteins for ZFY Gene

  • Protein details for ZFY Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger Y-chromosomal protein
    Protein Accession:
    Secondary Accessions:
    • B4DVF7
    • Q14021
    • Q15558
    • Q1RME9
    • Q24JR0
    • Q96TF3

    Protein attributes for ZFY Gene

    801 amino acids
    Molecular mass:
    90505 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ZFY Gene

    Alternative splice isoforms for ZFY Gene


neXtProt entry for ZFY Gene

Post-translational modifications for ZFY Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZFY Gene

Domains & Families for ZFY Gene

Gene Families for ZFY Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Graphical View of Domain Structure for InterPro Entry



  • The binding of ZFY to DNA is mediated by the interaction of the GGCC core base pairs with zinc fingers 12 and 13.
  • Belongs to the krueppel C2H2-type zinc-finger protein family. ZFX/ZFY subfamily.
  • The binding of ZFY to DNA is mediated by the interaction of the GGCC core base pairs with zinc fingers 12 and 13.
  • Belongs to the krueppel C2H2-type zinc-finger protein family. ZFX/ZFY subfamily.
genes like me logo Genes that share domains with ZFY: view

Function for ZFY Gene

Molecular function for ZFY Gene

GENATLAS Biochemistry:
zinc finger protein,Y-linked
UniProtKB/Swiss-Prot Function:
Probable transcriptional activator. Binds to the consensus sequence 5-AGGCCY-3.

Gene Ontology (GO) - Molecular Function for ZFY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 26871637
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZFY: view
genes like me logo Genes that share phenotypes with ZFY: view

miRNA for ZFY Gene

miRTarBase miRNAs that target ZFY

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZFY Gene

Localization for ZFY Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZFY Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZFY gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZFY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with ZFY: view

Pathways & Interactions for ZFY Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZFY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001541 ovarian follicle development IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007275 multicellular organism development IBA --
GO:0007281 germ cell development IEA --
genes like me logo Genes that share ontologies with ZFY: view

No data available for Pathways by source and SIGNOR curated interactions for ZFY Gene

Drugs & Compounds for ZFY Gene

(3) Drugs for ZFY Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zinc Approved, Investigational Pharma 2430
Beta-Cyclohexyl-Alanine Experimental Pharma Target 0
PCL-016 Investigational Pharma Target 0

(1) Additional Compounds for ZFY Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ZFY: view

Transcripts for ZFY Gene

Unigene Clusters for ZFY Gene

Zinc finger protein, Y-linked:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZFY Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8
SP1: - - - - -
SP3: -

Relevant External Links for ZFY Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZFY Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZFY Gene

Protein differential expression in normal tissues from HIPED for ZFY Gene

This gene is overexpressed in Nasal epithelium (67.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZFY Gene

Protein tissue co-expression partners for ZFY Gene

NURSA nuclear receptor signaling pathways regulating expression of ZFY Gene:


SOURCE GeneReport for Unigene cluster for ZFY Gene:


Evidence on tissue expression from TISSUES for ZFY Gene

  • Spleen(4.2)
genes like me logo Genes that share expression patterns with ZFY: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZFY Gene

Orthologs for ZFY Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZFY Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZFY 33 34
  • 99.5 (n)
(Bos Taurus)
Mammalia ZFX 34
  • 94 (a)
(Canis familiaris)
Mammalia ZFX 34
  • 94 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 92 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 82 (a)
(Mus musculus)
Mammalia Zfy2 34
  • 71 (a)
Zfy1 34
  • 70 (a)
(Gallus gallus)
Aves -- 34
  • 87 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 79 (a)
(Danio rerio)
Actinopterygii CABZ01079241.1 34
  • 64 (a)
zfx 34
  • 58 (a)
Species where no ortholog for ZFY was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZFY Gene

Gene Tree for ZFY (if available)
Gene Tree for ZFY (if available)

Paralogs for ZFY Gene

Paralogs for ZFY Gene

(10) SIMAP similar genes for ZFY Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZFY: view

Variants for ZFY Gene

Sequence variations from dbSNP and Humsavar for ZFY Gene

SNP ID Clin Chr 0Y pos Variation AA Info Type
rs1000144147 -- 2,935,615(+) T/C 5_prime_UTR_variant, intron_variant
rs1000260605 -- 2,936,577(+) C/G intron_variant
rs1000333799 -- 2,939,571(+) G/T intron_variant
rs1000613335 -- 2,980,551(+) G/A 3_prime_UTR_variant
rs1000767075 -- 2,978,717(+) G/A intron_variant

Variation tolerance for ZFY Gene

Gene Damage Index Score: 0.06; 1.37% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZFY Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZFY Gene

Disorders for ZFY Gene

MalaCards: The human disease database

(2) MalaCards diseases for ZFY Gene - From: DISEASES

Disorder Aliases PubMed IDs
  • cystadenofibroma, nos
frasier syndrome
  • fs
- elite association - COSMIC cancer census association via MalaCards
Search ZFY in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with ZFY: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZFY Gene

Publications for ZFY Gene

  1. Sex chromosomal transposable element accumulation and male-driven substitutional evolution in humans. (PMID: 10779541) Erlandsson R … Pääbo S (Molecular biology and evolution 2000) 3 4 22 58
  2. Comparison of ZFY and ZFX gene structure and analysis of alternative 3' untranslated regions of ZFY. (PMID: 2041734) North M … Ferguson-Smith MA (Nucleic acids research 1991) 3 4 22 58
  3. Comparison of human ZFY and ZFX transcripts. (PMID: 2308929) Palmer MS … Goodfellow PN (Proceedings of the National Academy of Sciences of the United States of America 1990) 3 4 22 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. (PMID: 12815422) Skaletsky H … Page DC (Nature 2003) 3 4 58

Products for ZFY Gene

Sources for ZFY Gene

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