Aliases for ZFX Gene
External Ids for ZFX Gene
Previous GeneCards Identifiers for ZFX Gene
This gene on the X chromosome is structurally similar to a related gene on the Y chromosome. It encodes a member of the krueppel C2H2-type zinc-finger protein family. The full-length protein contains an acidic transcriptional activation domain (AD), a nuclear localization sequence (NLS) and a DNA binding domain (DBD) consisting of 13 C2H2-type zinc fingers. Studies in mouse embryonic and adult hematopoietic stem cells showed that this gene was required as a transcriptional regulator for self-renewal of both stem cell types, but it was dispensable for growth and differentiation of their progeny. Multiple alternatively spliced transcript variants encoding different isoforms have been identified, but the full-length nature of some variants has not been determined. [provided by RefSeq, May 2010]
GeneCards Summary for ZFX Gene
ZFX (Zinc Finger Protein X-Linked) is a Protein Coding gene. Diseases associated with ZFX include Retinitis Pigmentosa 24. Among its related pathways are Hematopoietic Stem Cell Gene Regulation by GABP alpha/beta Complex. Gene Ontology (GO) annotations related to this gene include transcription coactivator activity. An important paralog of this gene is ZFY.
UniProtKB/Swiss-Prot Summary for ZFX Gene
Probable transcriptional activator.