This gene on the X chromosome is structurally similar to a related gene on the Y chromosome. It encodes a member of the krueppel C2H2-type zinc-finger protein family. The full-length protein contains an acidic transcriptional activation domain (AD), a nuclear localization sequence (NLS) and a DNA binding domain (DBD) consisting of 13 C2H2-type zinc fingers. Studies in mouse emb... See more...

Aliases for ZFX Gene

Aliases for ZFX Gene

  • Zinc Finger Protein X-Linked 2 3 5
  • Zinc Finger X-Chromosomal Protein 3 4
  • ZNF926 2 3
  • X-Linked Zinc Finger Protein 3
  • ZFX 5

External Ids for ZFX Gene

Previous GeneCards Identifiers for ZFX Gene

  • GC0XP022985
  • GC0XP022816
  • GC0XP023369
  • GC0XP023531
  • GC0XP023529
  • GC0XP023927
  • GC0XP024077
  • GC0XP024167
  • GC0XP021912

Summaries for ZFX Gene

Entrez Gene Summary for ZFX Gene

  • This gene on the X chromosome is structurally similar to a related gene on the Y chromosome. It encodes a member of the krueppel C2H2-type zinc-finger protein family. The full-length protein contains an acidic transcriptional activation domain (AD), a nuclear localization sequence (NLS) and a DNA binding domain (DBD) consisting of 13 C2H2-type zinc fingers. Studies in mouse embryonic and adult hematopoietic stem cells showed that this gene was required as a transcriptional regulator for self-renewal of both stem cell types, but it was dispensable for growth and differentiation of their progeny. Multiple alternatively spliced transcript variants encoding different isoforms have been identified, but the full-length nature of some variants has not been determined. [provided by RefSeq, May 2010]

GeneCards Summary for ZFX Gene

ZFX (Zinc Finger Protein X-Linked) is a Protein Coding gene. Among its related pathways are Hematopoietic Stem Cell Gene Regulation by GABP alpha/beta Complex. Gene Ontology (GO) annotations related to this gene include transcription coactivator activity. An important paralog of this gene is ZFY.

UniProtKB/Swiss-Prot Summary for ZFX Gene

Gene Wiki entry for ZFX Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZFX Gene

Genomics for ZFX Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZFX Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZFX on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZFX

Top Transcription factor binding sites by QIAGEN in the ZFX gene promoter:
  • AhR
  • Arnt
  • FOXD3
  • Gfi-1
  • Pax-4a
  • POU3F1
  • Spz1
  • YY1

Genomic Locations for ZFX Gene

Genomic Locations for ZFX Gene
chrX:24,148,982-24,216,255
(GRCh38/hg38)
Size:
67,274 bases
Orientation:
Plus strand
chrX:24,167,290-24,234,372
(GRCh37/hg19)
Size:
67,083 bases
Orientation:
Plus strand

Genomic View for ZFX Gene

Genes around ZFX on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZFX Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZFX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFX Gene

Proteins for ZFX Gene

  • Protein details for ZFX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17010-ZFX_HUMAN
    Recommended name:
    Zinc finger X-chromosomal protein
    Protein Accession:
    P17010
    Secondary Accessions:
    • B9EG97
    • O43668
    • Q8WYJ8

    Protein attributes for ZFX Gene

    Size:
    805 amino acids
    Molecular mass:
    90522 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZFX Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZFX Gene

Post-translational modifications for ZFX Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZFX Gene

Domains & Families for ZFX Gene

Gene Families for ZFX Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZFX Gene

InterPro:
Blocks:
  • C2H2-type zinc finger signature
  • Zfx / Zfy transcription activation region
ProtoNet:

Suggested Antigen Peptide Sequences for ZFX Gene

GenScript: Design optimal peptide antigens:
  • ZFX protein (B7ZKJ5_HUMAN)
  • ZFX protein (B9EG97_HUMAN)
  • X-linked zinc finger protein isoform 5 (Q8NHZ1_HUMAN)
  • X-linked zinc finger protein (Q8NHZ2_HUMAN)
  • X-linked zinc finger protein (Q8NHZ3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P17010

UniProtKB/Swiss-Prot:

ZFX_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family. ZFX/ZFY subfamily.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family. ZFX/ZFY subfamily.
genes like me logo Genes that share domains with ZFX: view

Function for ZFX Gene

Molecular function for ZFX Gene

UniProtKB/Swiss-Prot Function:
Probable transcriptional activator.
GENATLAS Biochemistry:
zinc finger protein,X-linked,putative transcription activator with alternative isoforms,575 and 804 AA,escaping inactivation

Phenotypes From GWAS Catalog for ZFX Gene

Gene Ontology (GO) - Molecular Function for ZFX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISM 19274049
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding TAS,IEA --
GO:0003713 transcription coactivator activity TAS 2105457
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZFX: view
genes like me logo Genes that share phenotypes with ZFX: view

Animal Models for ZFX Gene

MGI Knock Outs for ZFX:
  • Zfx Zfx<tm1.2Reiz>
  • Zfx Zfx<tm1Dcp>

Animal Model Products

CRISPR Products

miRNA for ZFX Gene

miRTarBase miRNAs that target ZFX
Targeted motifs for ZFX Gene
HOMER Transcription Factor Regulatory Elements motif ZFX
  • Consensus sequence: AGGCCTGG Submotif: canonical Cell Type: mES GEO ID: GSE11431

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZFX

Clone Products

  • Addgene plasmids for ZFX

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Transcription Factor Targets for ZFX Gene

Localization for ZFX Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZFX Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZFX gene
Compartment Confidence
nucleus 5
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endosome 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZFX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with ZFX: view

Pathways & Interactions for ZFX Gene

genes like me logo Genes that share pathways with ZFX: view

Pathways by source for ZFX Gene

Gene Ontology (GO) - Biological Process for ZFX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
GO:0007275 multicellular organism development IBA --
GO:1903508 positive regulation of nucleic acid-templated transcription IEA --
genes like me logo Genes that share ontologies with ZFX: view

No data available for SIGNOR curated interactions for ZFX Gene

Drugs & Compounds for ZFX Gene

(2) Drugs for ZFX Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with ZFX: view

Transcripts for ZFX Gene

mRNA/cDNA for ZFX Gene

6 REFSEQ mRNAs :
22 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZFX

Clone Products

  • Addgene plasmids for ZFX

Alternative Splicing Database (ASD) splice patterns (SP) for ZFX Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d · 8e ^ 9
SP1: - - - -
SP2: - - - - -
SP3: - - - - - -
SP4: - - -
SP5: -
SP6: -
SP7: - - - - - -

Relevant External Links for ZFX Gene

GeneLoc Exon Structure for
ZFX

Expression for ZFX Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZFX Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZFX Gene

This gene is overexpressed in Peripheral blood mononuclear cells (34.8), Rectum (16.7), and Ovary (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZFX Gene



Protein tissue co-expression partners for ZFX Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZFX

SOURCE GeneReport for Unigene cluster for ZFX Gene:

Hs.336681

Evidence on tissue expression from TISSUES for ZFX Gene

  • Nervous system(3)
  • Kidney(2.8)
  • Muscle(2.5)
  • Skin(2.2)
  • Liver(2.2)
  • Blood(2.2)
  • Lung(2.2)
  • Pancreas(2.1)
  • Intestine(2.1)
  • Heart(2)
  • Bone marrow(2)
genes like me logo Genes that share expression patterns with ZFX: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZFX Gene

Orthologs for ZFX Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZFX Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZFX 30 31
  • 99.58 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 96 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia ZFX 30 31
  • 95.41 (n)
OneToMany
Cow
(Bos Taurus)
Mammalia ZFX 30 31
  • 94.12 (n)
OneToMany
Mouse
(Mus musculus)
Mammalia Zfx 30 17 31
  • 91.81 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Zfx 30
  • 90.59 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 87 (a)
OneToMany
Chicken
(Gallus gallus)
Aves -- 31
  • 91 (a)
OneToMany
ZFX 30
  • 84.39 (n)
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 82 (a)
OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia zfx 30
  • 73.52 (n)
Str.4675 30
African clawed frog
(Xenopus laevis)
Amphibia XZFY-1 30
Zebrafish
(Danio rerio)
Actinopterygii zfx 30 31
  • 64.03 (n)
ManyToMany
CABZ01079241.1 31
  • 64 (a)
ManyToMany
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1741 30
Species where no ortholog for ZFX was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ZFX Gene

ENSEMBL:
Gene Tree for ZFX (if available)
TreeFam:
Gene Tree for ZFX (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZFX: view image

Paralogs for ZFX Gene

(237) SIMAP similar genes for ZFX Gene using alignment to 17 proteins:

  • ZFX_HUMAN
  • B7ZKJ5_HUMAN
  • B9EG97_HUMAN
  • C9J682_HUMAN
  • C9JGU9_HUMAN
  • E9PEP7_HUMAN
  • L8E7U7_HUMAN
  • Q8NHZ1_HUMAN
  • Q8NHZ2_HUMAN
  • Q8NHZ3_HUMAN
  • Q8NHZ4_HUMAN
  • Q8NHZ5_HUMAN
  • Q8WWU0_HUMAN
  • Q8WXB7_HUMAN
  • Q8WXB8_HUMAN
  • Q8WXB9_HUMAN
  • Q9BYX9_HUMAN
genes like me logo Genes that share paralogs with ZFX: view

Variants for ZFX Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZFX Gene

SNP ID Clinical significance and condition Chr 0X pos Variation AA Info Type
711679 Benign: not provided 24,179,316(+) C/A SYNONYMOUS_VARIANT,INTRON_VARIANT
731146 Benign: not provided 24,210,545(+) T/C SYNONYMOUS_VARIANT,THREE_PRIME_UTR_VARIANT

Additional dbSNP identifiers (rs#s) for ZFX Gene

Structural Variations from Database of Genomic Variants (DGV) for ZFX Gene

Variant ID Type Subtype PubMed ID
dgv504n21 CNV gain 19592680
esv2674864 CNV deletion 23128226
nsv1076250 CNV deletion 25765185
nsv1122261 CNV deletion 24896259
nsv1145288 CNV deletion 24896259
nsv515191 CNV gain 21397061
nsv515192 CNV gain 21397061
nsv524256 CNV gain 19592680
nsv818019 CNV gain 17921354

Variation tolerance for ZFX Gene

Residual Variation Intolerance Score: 24.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.22; 24.40% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZFX Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZFX

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZFX Gene

Disorders for ZFX Gene

No disorders were found for ZFX Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZFX Gene

Publications for ZFX Gene

  1. Comparison of ZFY and ZFX gene structure and analysis of alternative 3' untranslated regions of ZFY. (PMID: 2041734) North M … Ferguson-Smith MA (Nucleic acids research 1991) 3 4 23
  2. Cloning and comparative analysis of the bovine, porcine, and equine sex chromosome genes ZFX and ZFY. (PMID: 15060604) Poloumienko A (Genome 2004) 3 23
  3. Paternal transcripts for glucose-6-phosphate dehydrogenase and adenosine deaminase are first detectable in the human preimplantation embryo at the three- to four-cell stage. (PMID: 9364438) Taylor DM … Handyside AH (Molecular reproduction and development 1997) 3 23
  4. Comparison of human ZFY and ZFX transcripts. (PMID: 2308929) Palmer MS … Goodfellow PN (Proceedings of the National Academy of Sciences of the United States of America 1990) 3 4
  5. Putative transcription activator with alternative isoforms encoded by human ZFX gene. (PMID: 2512506) Schneider-Gädicke A … Page DC (Nature 1989) 3 4

Products for ZFX Gene

Sources for ZFX Gene