ZFTA Gene (Protein Coding)

Zinc Finger Translocation Associated

GC11M066191
GIFtS:
24
See more...

Aliases for ZFTA Gene

Aliases for ZFTA Gene

  • Zinc Finger Translocation Associated 2 3
  • Chromosome 11 Open Reading Frame 95 2 5
  • Uncharacterized Protein C11orf95 3 4
  • C11orf95 3 5
  • MGC3032 2

External Ids for ZFTA Gene

Previous HGNC Symbols for ZFTA Gene

  • C11orf95

Summaries for ZFTA Gene

GeneCards Summary for ZFTA Gene

ZFTA (Zinc Finger Translocation Associated) is a Protein Coding gene. Diseases associated with ZFTA include Cellular Ependymoma and Rela Fusion-Positive Ependymoma.

Additional gene information for ZFTA Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZFTA Gene

Genomics for ZFTA Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for ZFTA Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH11J064183 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 11.4 -416.9 -416926 5 CHD2 TBP SP1 MXD4 CEBPA MNT DEK IKZF1 SMAD5 ETS1 STIP1 lnc-MACROD1-1 lnc-STIP1-1 TRPT1 KCNK4 IMMP1LP1 RTN3 FERMT3 NRXN2 ZFTA
GH11J064267 Promoter/Enhancer 2.1 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.1 -501.9 -501925 7.2 ZSCAN16 CHD2 TBP ZBTB10 BCL11A SP1 MXD4 CEBPA SIX5 NR2C1 GPR137 HSALNG0084769 SF1 POLA2 ZFPL1 ENSG00000257086 ENSG00000236935 KCNK4 PLCB3 TRPT1
GH11J064145 Enhancer 1.2 Ensembl ENCODE dbSUPER 10.7 -377.3 -377326 1.4 FOXA1 IKZF1 ZNF217 CTCF ZBTB7B NONO SIN3B SP1 VEZF1 SMAD4 ZFTA RTN3 piR-33354 L13712-002 MACROD1 FLRT1
GH11J064643 Promoter/Enhancer 1.2 Ensembl ENCODE dbSUPER 10.7 -874.0 -874035 2.4 SPI1 BHLHE40 REST ZNF148 GLIS1 ZNF398 GATA2 ZBTB7A CREB1 ZNF366 NRXN2-AS1 ZFTA NRXN2 lnc-RASGRP2-2 SLC22A12
GH11J063693 Enhancer 0.4 Ensembl 10.3 +73.9 73874 2.6 ZNF585B EGR2 ZNF10 HSALNG0084710 SPINDOC ATL3 ENSG00000256789 ZFTA RTN3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZFTA on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZFTA

Genomic Locations for ZFTA Gene

Latest Assembly
chr11:63,759,892-63,768,775
(GRCh38/hg38)
Size:
8,884 bases
Orientation:
Minus strand

Previous Assembly
chr11:63,527,364-63,536,247
(GRCh37/hg19 by Entrez Gene)
Size:
8,884 bases
Orientation:
Minus strand

chr11:63,527,364-63,536,113
(GRCh37/hg19 by Ensembl)
Size:
8,750 bases
Orientation:
Minus strand

Genomic View for ZFTA Gene

Genes around ZFTA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZFTA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZFTA Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for ZFTA Gene

Proteins for ZFTA Gene

Products:

  1. Antibodies for research
  2. Protein products for research
  3. Assay products for research

  • Protein details for ZFTA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    C9JLR9-CK095_HUMAN
    Recommended name:
    Uncharacterized protein C11orf95
    Protein Accession:
    C9JLR9
    Secondary Accessions:
    • A6NLS7
    • Q3C1V4

    Protein attributes for ZFTA Gene

    Size:
    678 amino acids
    Molecular mass:
    73197 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAE46893.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};

neXtProt entry for ZFTA Gene

Post-translational modifications for ZFTA Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZFTA Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZFTA Gene

Domains & Families for ZFTA Gene

Gene Families for ZFTA Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins

Protein Domains for ZFTA Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with ZFTA: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ZFTA Gene

Function for ZFTA Gene

Products:

  1. Animal Models for research
  2. CRISPR products for research
  3. miRNA products for research
  4. Inhibitory RNAs for research
  5. Clone products for research
  6. Cell Lines for research

Phenotypes for ZFTA Gene

GenomeRNAi human phenotypes for ZFTA:
genes like me logo Genes that share phenotypes with ZFTA: view

Human Phenotype Ontology for ZFTA Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

miRNA for ZFTA Gene

miRTarBase miRNAs that target ZFTA

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZFTA

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for ZFTA Gene

Localization for ZFTA Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZFTA gene
Compartment Confidence
nucleus 2
plasma membrane 1
extracellular 1
cytoskeleton 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Intermediate filaments (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ZFTA Gene

Pathways & Interactions for ZFTA Gene

PathCards logo

SuperPathways for ZFTA Gene

No Data Available

Interacting Proteins for ZFTA Gene

Gene Ontology (GO) - Biological Process for ZFTA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045892 negative regulation of transcription, DNA-templated IBA 21873635
genes like me logo Genes that share ontologies with ZFTA: view

No data available for Pathways by source and SIGNOR curated interactions for ZFTA Gene

Drugs & Compounds for ZFTA Gene

Products:

  1. Drug products for research
No Compound Related Data Available

Transcripts for ZFTA Gene

Products:

  1. CRISPR products for research
  2. miRNA products for research
  3. Inhibitory RNAs for research
  4. Clone products for research

mRNA/cDNA for ZFTA Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZFTA

Alternative Splicing Database (ASD) splice patterns (SP) for ZFTA Gene

No ASD Table

Relevant External Links for ZFTA Gene

GeneLoc Exon Structure for
ZFTA

Expression for ZFTA Gene

Products:

  1. Primer products for research

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZFTA

SOURCE GeneReport for Unigene cluster for ZFTA Gene:

Hs.191073
genes like me logo Genes that share expression patterns with ZFTA: view

Primer products for research

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZFTA Gene

Orthologs for ZFTA Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZFTA Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia C11H11orf95 30
  • 97.92 (n)
Cow
(Bos Taurus)
 Mammalia C29H11orf95 30
  • 91.36 (n)
Dog
(Canis familiaris)
 Mammalia C18H11orf95 30
  • 88.51 (n)
Mouse
(Mus musculus)
 Mammalia 2700081O15Rik 30
  • 88.18 (n)
Zfta 17
Rat
(Rattus norvegicus)
 Mammalia RGD1560108 30
  • 87.98 (n)
Species where no ortholog for ZFTA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZFTA Gene

ENSEMBL:
Gene Tree for ZFTA (if available)
TreeFam:
Gene Tree for ZFTA (if available)

Paralogs for ZFTA Gene

No data available for Paralogs for ZFTA Gene

Variants for ZFTA Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for ZFTA Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for ZFTA Gene

Variant ID Type Subtype PubMed ID
esv24244 CNV loss 19812545
esv33170 CNV gain 17666407
nsv1070464 CNV deletion 25765185
nsv1136128 CNV deletion 24896259
nsv1143684 CNV deletion 24896259
nsv555180 CNV loss 21841781
nsv832183 CNV loss 17160897
nsv975941 CNV duplication 23825009

Additional Variant Information for ZFTA Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZFTA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for ZFTA Gene

Disorders for ZFTA Gene

MalaCards: The human disease database

(24) MalaCards diseases for ZFTA Gene - From: ORP, COP, and GCD

Disorder Aliases PubMed IDs
cellular ependymoma
  • ependymoma
rela fusion-positive ependymoma
  • supratentorial c11orf95-rela fused ependymoma
chondroid lipoma
pediatric supratentorial ependymoma
  • childhood supratentorial ependymoma
supratentorial cancer
  • brain neoplasm, supratentorial
- elite association - COSMIC cancer census association via MalaCards
Search ZFTA in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

CK095_HUMAN
  • Note=A chromosomal aberration involving MRTFB is found in 3 chondroid lipomas. Translocation t(11;16)(q13;p13) with MRTFB produces a C11orf95-MRTFB fusion protein (PubMed:20607705). {ECO:0000269 PubMed:20607705}.
  • Note=A chromosomal aberration involving RELA is found in more than two-thirds of supratentorial ependymomas. Translocation with RELA produces a C11orf95-RELA fusion protein. C11orf95-RELA translocations are potent oncogenes that probably transform neural stem cells by driving an aberrant NF-kappa-B transcription program (PubMed:24553141). {ECO:0000269 PubMed:24553141}.

Additional Disease Information for ZFTA

Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with ZFTA: view

No data available for Genatlas for ZFTA Gene

Publications for ZFTA Gene

  1. C11orf95-RELA fusions drive oncogenic NF-κB signalling in ependymoma. (PMID: 24553141) Parker M … Gilbertson RJ (Nature 2014) 2 3 4
  2. C11orf95-MKL2 is the resulting fusion oncogene of t(11;16)(q13;p13) in chondroid lipoma. (PMID: 20607705) Huang D … Bridge JA (Genes, chromosomes & cancer 2010) 2 3 4
  3. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4
  4. Biology and management of ependymomas. (PMID: 27022130) Wu J … Gilbert MR (Neuro-oncology 2016) 3
  5. C11orf95-RELA fusion present in a primary intracranial extra-axial ependymoma: Report of a case with literature review. (PMID: 27121356) Nambirajan A … Garg A (Neuropathology : official journal of the Japanese Society of Neuropathology 2016) 3

No data available for Mastermind for ZFTA Gene

Products for ZFTA Gene

Sources for ZFTA Gene