Aliases for ZFR2 Gene

Aliases for ZFR2 Gene

  • Zinc Finger RNA Binding Protein 2 2 3 5
  • KIAA1086 2 3 4
  • Zinc Finger RNA-Binding Protein 2 3 4
  • ZFR2 5

External Ids for ZFR2 Gene

Previous HGNC Symbols for ZFR2 Gene

  • KIAA1086

Previous GeneCards Identifiers for ZFR2 Gene

  • GC19M003756
  • GC19M003568

Summaries for ZFR2 Gene

GeneCards Summary for ZFR2 Gene

ZFR2 (Zinc Finger RNA Binding Protein 2) is a Protein Coding gene. Diseases associated with ZFR2 include Malignant Essential Hypertension. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZFR.

Additional gene information for ZFR2 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZFR2 Gene

Genomics for ZFR2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZFR2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J003867 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE CraniofacialAtlas 609.8 +0.4 402 1.3 TEAD4 POLR2A MGA SP2 USF1 YY1 ZBTB33 TAF1 L3MBTL2 SP1 ZFR2 RF00017-2751 MATK
GH19J003869 Enhancer 0.3 ENCODE 600.7 -0.3 -325 0.1 SP2 L3MBTL2 FTLP5 ZFR2 ATCAY
GH19J003811 Enhancer 1.1 FANTOM5 ENCODE 17.9 +55.7 55710 3.3 LEF1 ETV6 JUND PKNOX1 SP1 ZNF24 DPF2 HDAC1 SOX6 GATAD2B RF00017-2748 ZFR2 ATCAY ANKRD24 MATK MAP2K2 FZR1 ZBTB7A YJU2 APBA3
GH19J003828 Enhancer 0.9 Ensembl ENCODE 19.3 +40.4 40437 2 JUND NRF1 MGA UBTF SMARCC1 EGR1 CEBPB RCOR1 SMARCB1 FOSL1 ZFR2 ATCAY RAX2 MRPL54 APBA3 RF00017-2749 MATK RF00017-2750
GH19J003881 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE 12.9 -12.3 -12263 2.2 POLR2A RAD21 ZBTB17 ZNF335 SPI1 ZNF384 KLF17 ADNP ZFP64 ATF2 ATCAY piR-55985-085 ZFR2 piR-32214-330 NMRK2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZFR2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZFR2

Top Transcription factor binding sites by QIAGEN in the ZFR2 gene promoter:
  • c-Myb
  • CBF(2)
  • CBF-B
  • E47
  • STAT1
  • STAT1alpha
  • STAT1beta
  • Tal-1beta
  • USF-1
  • USF1

Genomic Locations for ZFR2 Gene

Genomic Locations for ZFR2 Gene
chr19:3,804,024-3,869,038
(GRCh38/hg38)
Size:
65,015 bases
Orientation:
Minus strand
chr19:3,804,022-3,869,030
(GRCh37/hg19)
Size:
65,009 bases
Orientation:
Minus strand

Genomic View for ZFR2 Gene

Genes around ZFR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZFR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZFR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFR2 Gene

Proteins for ZFR2 Gene

  • Protein details for ZFR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UPR6-ZFR2_HUMAN
    Recommended name:
    Zinc finger RNA-binding protein 2
    Protein Accession:
    Q9UPR6
    Secondary Accessions:
    • B4DHD0

    Protein attributes for ZFR2 Gene

    Size:
    939 amino acids
    Molecular mass:
    101330 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZFR2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZFR2 Gene

Post-translational modifications for ZFR2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZFR2 Gene

Domains & Families for ZFR2 Gene

Gene Families for ZFR2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ZFR2 Gene

Suggested Antigen Peptide Sequences for ZFR2 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ60529, weakly similar to Mus musculus zinc finger RNA binding protein (Zfr), mRNA (B4DHD0_HUMAN)
  • Zinc finger RNA-binding protein 2 (ZFR2_HUMAN)
genes like me logo Genes that share domains with ZFR2: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ZFR2 Gene

Function for ZFR2 Gene

Phenotypes From GWAS Catalog for ZFR2 Gene

Gene Ontology (GO) - Molecular Function for ZFR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003725 double-stranded RNA binding IBA 21873635
GO:0003727 single-stranded RNA binding IBA 21873635
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with ZFR2: view
genes like me logo Genes that share phenotypes with ZFR2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZFR2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZFR2 Gene

Localization for ZFR2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZFR2 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZFR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with ZFR2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ZFR2 Gene

Pathways & Interactions for ZFR2 Gene

PathCards logo

SuperPathways for ZFR2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZFR2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ZFR2 Gene

Drugs & Compounds for ZFR2 Gene

No Compound Related Data Available

Transcripts for ZFR2 Gene

mRNA/cDNA for ZFR2 Gene

2 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZFR2

Alternative Splicing Database (ASD) splice patterns (SP) for ZFR2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
SP1:
SP2: - -
SP3: -
SP4:

Relevant External Links for ZFR2 Gene

GeneLoc Exon Structure for
ZFR2

Expression for ZFR2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZFR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZFR2 Gene

This gene is overexpressed in Pituitary (x9.2), Brain - Cortex (x5.6), Brain - Hypothalamus (x4.6), Brain - Frontal Cortex (BA9) (x4.5), Testis (x4.1), Brain - Anterior cingulate cortex (BA24) (x4.1), and Brain - Nucleus accumbens (basal ganglia) (x4.0).

Protein differential expression in normal tissues from HIPED for ZFR2 Gene

This gene is overexpressed in Adipocyte (67.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZFR2 Gene



Protein tissue co-expression partners for ZFR2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZFR2

SOURCE GeneReport for Unigene cluster for ZFR2 Gene:

Hs.65750

Evidence on tissue expression from TISSUES for ZFR2 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with ZFR2: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZFR2 Gene

Orthologs for ZFR2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZFR2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZFR2 30 31
  • 97.83 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ZFR2 30 31
  • 74.48 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ZFR2 30 31
  • 73.68 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Zfr2 30
  • 71.55 (n)
Mouse
(Mus musculus)
Mammalia Zfr2 30 17 31
  • 69.25 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia ZFR2 31
  • 53 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 45 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves -- 31
  • 4 (a)
ManyToMany
Zebrafish
(Danio rerio)
Actinopterygii zfr2 31
  • 48 (a)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta Zn72D 31
  • 40 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea Y95B8A.8 31
  • 29 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.9218 31
  • 21 (a)
OneToMany
Species where no ortholog for ZFR2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for ZFR2 Gene

ENSEMBL:
Gene Tree for ZFR2 (if available)
TreeFam:
Gene Tree for ZFR2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZFR2: view image

Paralogs for ZFR2 Gene

(3) SIMAP similar genes for ZFR2 Gene using alignment to 5 proteins:

  • ZFR2_HUMAN
  • B4DHD0_HUMAN
  • K7EKD7_HUMAN
  • K7EPY6_HUMAN
  • K7EQC0_HUMAN
genes like me logo Genes that share paralogs with ZFR2: view

Variants for ZFR2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZFR2 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs2240232 - p.Pro235Leu
rs2240233 - p.Val210Leu
rs2240234 - p.Val183Met
rs2240235 - p.Ser164Leu
rs2301839 - p.Asp589Asn

Additional dbSNP identifiers (rs#s) for ZFR2 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZFR2 Gene

Variant ID Type Subtype PubMed ID
dgv1693n106 CNV deletion 24896259
dgv6227n54 CNV gain 21841781
esv1602911 CNV deletion 17803354
esv1995150 CNV deletion 18987734
esv2071608 CNV deletion 18987734
esv2666653 CNV deletion 23128226
esv2717969 CNV deletion 23290073
esv2717970 CNV deletion 23290073
esv2717971 CNV deletion 23290073
esv2717972 CNV deletion 23290073
esv2717974 CNV deletion 23290073
esv2717975 CNV deletion 23290073
esv2743112 CNV deletion 23290073
esv3325589 CNV duplication 20981092
esv3383353 CNV duplication 20981092
esv3555889 CNV deletion 23714750
esv3643473 CNV gain 21293372
esv3643475 CNV loss 21293372
esv3643476 CNV gain 21293372
esv3643477 CNV loss 21293372
esv3643478 CNV loss 21293372
esv5059 CNV loss 18987735
esv991288 CNV deletion 20482838
nsv1072843 CNV deletion 25765185
nsv1123210 CNV deletion 24896259
nsv1138657 CNV deletion 24896259
nsv1150390 CNV deletion 26484159
nsv138020 CNV deletion 16902084
nsv470114 CNV loss 18288195
nsv509718 CNV insertion 20534489
nsv833715 CNV loss 17160897

Variation tolerance for ZFR2 Gene

Gene Damage Index Score: 11.33; 92.63% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZFR2 Gene

Human Gene Mutation Database (HGMD)
ZFR2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZFR2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZFR2 Gene

Disorders for ZFR2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZFR2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
malignant essential hypertension
  • accelerated essential hypertension
- elite association - COSMIC cancer census association via MalaCards
Search ZFR2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ZFR2

genes like me logo Genes that share disorders with ZFR2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZFR2 Gene

Publications for ZFR2 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10470851) Kikuno R … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 2 3 4
  2. E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins. (PMID: 29676528) Khanna R … Parnaik VK (The FEBS journal 2018) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C … Emili A (Nature 2015) 3
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3

Products for ZFR2 Gene

Sources for ZFR2 Gene