Aliases for ZFPM1 Gene
External Ids for ZFPM1 Gene
Previous GeneCards Identifiers for ZFPM1 Gene
GeneCards Summary for ZFPM1 Gene
ZFPM1 (Zinc Finger Protein, FOG Family Member 1) is a Protein Coding gene. Diseases associated with ZFPM1 include Dyserythropoietic Anemia And Thrombocytopenia and Thrombocytopenia With Beta-Thalassemia, X-Linked. Among its related pathways are Signaling events mediated by HDAC Class I and Response to elevated platelet cytosolic Ca2+. Gene Ontology (GO) annotations related to this gene include transcription factor binding and RNA polymerase II transcription factor binding. An important paralog of this gene is ZFPM2.
UniProtKB/Swiss-Prot Summary for ZFPM1 Gene
Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be involved in regulation of some genes in gonads. May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2 (By similarity).