Aliases for ZFPM1 Gene

Aliases for ZFPM1 Gene

  • Zinc Finger Protein, FOG Family Member 1 2 3 5
  • Zinc Finger Protein, Multitype 1 2 3
  • Zinc Finger Protein ZFPM1 3 4
  • Friend Of GATA Protein 1 3 4
  • Zinc Finger Protein 89A 3 4
  • Friend Of GATA 1 3 4
  • FOG-1 3 4
  • FOG1 3 4
  • Zinc Finger Protein Multitype 1 4
  • ZC2HC11A 3
  • ZNF408 3
  • ZNF89A 3
  • ZFN89A 4
  • FOG 3

External Ids for ZFPM1 Gene

Previous GeneCards Identifiers for ZFPM1 Gene

  • GC16P089491
  • GC16P088225
  • GC16P088266
  • GC16P087047
  • GC16P074246

Summaries for ZFPM1 Gene

GeneCards Summary for ZFPM1 Gene

ZFPM1 (Zinc Finger Protein, FOG Family Member 1) is a Protein Coding gene. Diseases associated with ZFPM1 include Thrombocytopenia 1 and Dyserythropoietic Anemia And Thrombocytopenia. Among its related pathways are C-MYB transcription factor network and Factors involved in megakaryocyte development and platelet production. Gene Ontology (GO) annotations related to this gene include transcription factor binding and RNA polymerase II transcription factor binding. An important paralog of this gene is ZFPM2.

UniProtKB/Swiss-Prot Summary for ZFPM1 Gene

  • Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be involved in regulation of some genes in gonads. May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2 (By similarity).

Gene Wiki entry for ZFPM1 Gene

Additional gene information for ZFPM1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZFPM1 Gene

Genomics for ZFPM1 Gene

GeneHancer (GH) Regulatory Elements for ZFPM1 Gene

Promoters and enhancers for ZFPM1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J088452 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 760.8 +3.5 3505 6 ZNF785 ZBTB40 MLX RBPJ SMARCE1 POLR2A TCF7L2 USF2 MIXL1 RUNX1 ZFPM1 ZC3H18 ZNF778 ZCCHC14 ENSG00000259877 CTU2 RNF166 ACSF3 KLHDC4 BANP
GH16J088451 Promoter/Enhancer 0.7 EPDnew ENCODE dbSUPER 750.6 +0.3 319 0.1 ZFPM1 MIR5189
GH16J088449 Enhancer 0.2 dbSUPER 755.2 -1.8 -1757 0.6 ZFPM1 HSALNG0113502
GH16J088523 Enhancer 1.3 Ensembl ENCODE dbSUPER 12.7 +74.5 74484 5 CTCF MLX RBPJ MIXL1 CC2D1A L3MBTL2 DACH1 RAD21 ZNF121 TEAD4 ZC3H18 APRT ENSG00000261744 ANKRD11 ENSG00000260121 ZFPM1 ENSG00000268218 LINC00304 ZNF469 PIEZO1
GH16J088468 Enhancer 1.5 FANTOM5 ENCODE CraniofacialAtlas dbSUPER 8.5 +20.0 19957 6.4 ZBTB40 ZBTB6 SMARCE1 NFYC L3MBTL2 MAX DACH1 MNT TEAD4 ZNF652 ZC3H18 ENSG00000268218 LINC00304 ENSG00000259877 BANP RNF166 ZFPM1 ENSG00000261744 APRT CTU2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZFPM1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZFPM1 gene promoter:
  • GATA-6
  • Sp1

Genomic Locations for ZFPM1 Gene

Genomic Locations for ZFPM1 Gene
chr16:88,451,431-88,537,031
(GRCh38/hg38)
Size:
85,601 bases
Orientation:
Plus strand
chr16:88,519,725-88,603,424
(GRCh37/hg19)
Size:
83,700 bases
Orientation:
Plus strand

Genomic View for ZFPM1 Gene

Genes around ZFPM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZFPM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZFPM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFPM1 Gene

Proteins for ZFPM1 Gene

  • Protein details for ZFPM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IX07-FOG1_HUMAN
    Recommended name:
    Zinc finger protein ZFPM1
    Protein Accession:
    Q8IX07

    Protein attributes for ZFPM1 Gene

    Size:
    1006 amino acids
    Molecular mass:
    104888 Da
    Quaternary structure:
    • Interacts with corepressor CTBP2; this interaction is however not essential for corepressor activity (By similarity). Interacts with the N-terminal zinc-finger of GATA1, GATA2 and probably GATA3.

    Three dimensional structures from OCA and Proteopedia for ZFPM1 Gene

neXtProt entry for ZFPM1 Gene

Post-translational modifications for ZFPM1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZFPM1 Gene

No data available for DME Specific Peptides for ZFPM1 Gene

Domains & Families for ZFPM1 Gene

Gene Families for ZFPM1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZFPM1 Gene

Suggested Antigen Peptide Sequences for ZFPM1 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein multitype 1 (FOG1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8IX07

UniProtKB/Swiss-Prot:

FOG1_HUMAN :
  • The CCHC FOG-type zinc fingers 1, 2, 3 and 5 directly bind to GATA-type zinc fingers. The Tyr residue adjacent to the last Cys of the CCHC FOG-type zinc finger is essential for the interaction with GATA-type zinc fingers (By similarity).
  • Belongs to the FOG (Friend of GATA) family.
Domain:
  • The CCHC FOG-type zinc fingers 1, 2, 3 and 5 directly bind to GATA-type zinc fingers. The Tyr residue adjacent to the last Cys of the CCHC FOG-type zinc finger is essential for the interaction with GATA-type zinc fingers (By similarity).
Family:
  • Belongs to the FOG (Friend of GATA) family.
genes like me logo Genes that share domains with ZFPM1: view

Function for ZFPM1 Gene

Molecular function for ZFPM1 Gene

UniProtKB/Swiss-Prot Function:
Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be involved in regulation of some genes in gonads. May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2 (By similarity).

Phenotypes From GWAS Catalog for ZFPM1 Gene

Gene Ontology (GO) - Molecular Function for ZFPM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA,IDA 15920471
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific NAS 19274049
GO:0001085 RNA polymerase II transcription factor binding IPI,IEA 11675338
GO:0001102 RNA polymerase II activating transcription factor binding IEA --
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific IGI 15920471
genes like me logo Genes that share ontologies with ZFPM1: view
genes like me logo Genes that share phenotypes with ZFPM1: view

Animal Models for ZFPM1 Gene

MGI Knock Outs for ZFPM1:

Animal Model Products

CRISPR Products

Clone Products

  • Addgene plasmids for ZFPM1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZFPM1 Gene

Localization for ZFPM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZFPM1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZFPM1 gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 1
cytoskeleton 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZFPM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005654 nucleoplasm TAS --
GO:0005667 transcription factor complex IDA 15920471
GO:0017053 transcriptional repressor complex IDA 15920471
genes like me logo Genes that share ontologies with ZFPM1: view

Pathways & Interactions for ZFPM1 Gene

genes like me logo Genes that share pathways with ZFPM1: view

Pathways by source for ZFPM1 Gene

SIGNOR curated interactions for ZFPM1 Gene

Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for ZFPM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IGI 15920471
GO:0002295 T-helper cell lineage commitment IC 21646796
GO:0003151 outflow tract morphogenesis IEA,ISS --
GO:0003181 atrioventricular valve morphogenesis IEA,ISS --
GO:0003192 mitral valve formation ISS,IEA --
genes like me logo Genes that share ontologies with ZFPM1: view

Drugs & Compounds for ZFPM1 Gene

(1) Drugs for ZFPM1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with ZFPM1: view

Transcripts for ZFPM1 Gene

mRNA/cDNA for ZFPM1 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(33) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for ZFPM1

Alternative Splicing Database (ASD) splice patterns (SP) for ZFPM1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1: - -
SP2: - -
SP3:

Relevant External Links for ZFPM1 Gene

GeneLoc Exon Structure for
ZFPM1
ECgene alternative splicing isoforms for
ZFPM1

Expression for ZFPM1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZFPM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZFPM1 Gene

This gene is overexpressed in Pancreas (x4.2).

Protein differential expression in normal tissues from HIPED for ZFPM1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (22.7), NK cells (19.6), and CD8 Tcells (16.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZFPM1 Gene



Protein tissue co-expression partners for ZFPM1 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZFPM1 Gene:

ZFPM1

SOURCE GeneReport for Unigene cluster for ZFPM1 Gene:

Hs.632218

mRNA Expression by UniProt/SwissProt for ZFPM1 Gene:

Q8IX07-FOG1_HUMAN
Tissue specificity: Mainly expressed in hematopoietic tissues. Also expressed in adult cerebellum, stomach, lymph node, liver and pancreas. Expressed in fetal heart, liver and spleen.

Evidence on tissue expression from TISSUES for ZFPM1 Gene

  • Blood(4.4)
  • Liver(4.1)
  • Muscle(2.4)
  • Nervous system(2)
genes like me logo Genes that share expression patterns with ZFPM1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ZFPM1 Gene

Orthologs for ZFPM1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZFPM1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZFPM1 33
  • 92 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZFPM1 33 32
  • 82.83 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Zfpm1 17 33 32
  • 77.06 (n)
rat
(Rattus norvegicus)
Mammalia Zfpm1 32
  • 76.17 (n)
dog
(Canis familiaris)
Mammalia ZFPM1 33
  • 71 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZFPM1 33
  • 53 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZFPM1 33
  • 50 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZFPM1 33 32
  • 69.36 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZFPM1 33
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zfpm1 32
  • 58.54 (n)
African clawed frog
(Xenopus laevis)
Amphibia LOC398166 32
zebrafish
(Danio rerio)
Actinopterygii zfpm1 33 32
  • 55.89 (n)
OneToOne
Species where no ortholog for ZFPM1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZFPM1 Gene

ENSEMBL:
Gene Tree for ZFPM1 (if available)
TreeFam:
Gene Tree for ZFPM1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZFPM1: view image

Paralogs for ZFPM1 Gene

Paralogs for ZFPM1 Gene

genes like me logo Genes that share paralogs with ZFPM1: view

Variants for ZFPM1 Gene

Sequence variations from dbSNP and Humsavar for ZFPM1 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000014011 -- 88,518,097(+) C/T intron_variant
rs1000022964 -- 88,452,479(+) C/CC genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000029778 -- 88,490,616(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000030630 -- 88,486,234(+) G/A/C/T genic_upstream_transcript_variant, intron_variant
rs1000059386 -- 88,463,549(+) C/G/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZFPM1 Gene

Variant ID Type Subtype PubMed ID
dgv171n21 CNV loss 19592680
dgv516e199 CNV deletion 23128226
dgv5293n54 CNV loss 21841781
dgv5294n54 CNV loss 21841781
dgv5295n54 CNV gain 21841781
dgv5296n54 CNV gain 21841781
dgv5297n54 CNV loss 21841781
dgv5298n54 CNV loss 21841781
esv1139853 CNV deletion 17803354
esv1407878 CNV insertion 17803354
esv2335139 CNV deletion 18987734
esv26368 CNV gain 19812545
esv2671819 CNV deletion 23128226
esv2678641 CNV deletion 23128226
esv26997 CNV loss 19812545
esv2715008 CNV deletion 23290073
esv2715009 CNV deletion 23290073
esv2715010 CNV deletion 23290073
esv2715011 CNV deletion 23290073
esv2715012 CNV deletion 23290073
esv2715013 CNV deletion 23290073
esv2715014 CNV deletion 23290073
esv2715015 CNV deletion 23290073
esv2715016 CNV deletion 23290073
esv2715018 CNV deletion 23290073
esv2715019 CNV deletion 23290073
esv2715020 CNV deletion 23290073
esv2715021 CNV deletion 23290073
esv2758669 CNV gain 17122850
esv29069 CNV loss 19812545
esv3307839 CNV mobile element insertion 20981092
esv33406 CNV gain 17666407
esv3639549 CNV loss 21293372
esv3639550 CNV loss 21293372
esv3639551 CNV gain 21293372
nsv103216 CNV insertion 16902084
nsv1061590 CNV gain 25217958
nsv1070366 CNV deletion 25765185
nsv1112695 CNV deletion 24896259
nsv1116172 CNV deletion 24896259
nsv1127526 CNV deletion 24896259
nsv1131285 CNV deletion 24896259
nsv1135822 CNV deletion 24896259
nsv1143832 CNV deletion 24896259
nsv1148344 CNV deletion 26484159
nsv1924 CNV insertion 18451855
nsv1925 CNV deletion 18451855
nsv471111 CNV loss 18288195
nsv471112 CNV gain 18288195
nsv526557 CNV loss 19592680
nsv528456 CNV loss 19592680
nsv573589 CNV loss 21841781
nsv573590 CNV loss 21841781
nsv573593 CNV loss 21841781
nsv573607 CNV gain 21841781
nsv817747 CNV loss 17921354
nsv827830 CNV loss 20364138
nsv827832 CNV gain 20364138
nsv952070 CNV deletion 24416366

Variation tolerance for ZFPM1 Gene

Gene Damage Index Score: 7.53; 82.33% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZFPM1 Gene

Human Gene Mutation Database (HGMD)
ZFPM1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZFPM1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZFPM1 Gene

Disorders for ZFPM1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for ZFPM1 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
thrombocytopenia 1
  • thc1
dyserythropoietic anemia and thrombocytopenia
  • gata1-related x-linked cytopenia
exudative vitreoretinopathy
  • exudative vitreoretinopathy 1
- elite association - COSMIC cancer census association via MalaCards
Search ZFPM1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ZFPM1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ZFPM1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZFPM1 Gene

Publications for ZFPM1 Gene

  1. Molecular cloning and characterization of the GATA1 cofactor human FOG1 and assessment of its binding to GATA1 proteins carrying D218 substitutions. (PMID: 12483298) Freson K … Van Geet C (Human genetics 2003) 3 4 23 56
  2. Genetic susceptibility to distinct bladder cancer subphenotypes. (PMID: 19692168) Guey LT … EPICURO/Spanish Bladder Cancer Study investigators (European urology 2010) 3 43 56
  3. PTEN identified as important risk factor of chronic obstructive pulmonary disease. (PMID: 19625176) Hosgood HD … Lan Q (Respiratory medicine 2009) 3 43 56
  4. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PMID: 19170196) Shen M … Lan Q (Environmental and molecular mutagenesis 2009) 3 43 56
  5. Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. (PMID: 18676680) Hosgood HD … Lan Q (Carcinogenesis 2008) 3 43 56

Products for ZFPM1 Gene

Sources for ZFPM1 Gene