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ZFPM1 (Zinc Finger Protein, FOG Family Member 1) is a Protein Coding gene. Diseases associated with ZFPM1 include Thrombocytopenia 1 and Dyserythropoietic Anemia And Thrombocytopenia. Among its related pathways are C-MYB transcription factor network and Response to elevated platelet cytosolic Ca2+. Gene Ontology (GO) annotations related to this gene include transcription factor binding and RNA polymerase II transcription factor binding. An important paralog of this gene is ZFPM2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IEA,IDA | 15920471 |
GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | ISA | -- |
GO:0001085 | RNA polymerase II transcription factor binding | IEA,IPI | 11675338 |
GO:0001102 | RNA polymerase II activating transcription factor binding | IEA | -- |
GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific | IGI | 15920471 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000790 | nuclear chromatin | ISA | -- |
GO:0005634 | nucleus | IBA | 21873635 |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005667 | transcription factor complex | IDA | 15920471 |
GO:0017053 | transcriptional repressor complex | IDA | 15920471 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Factors involved in megakaryocyte development and platelet production | ||
2 | Response to elevated platelet cytosolic Ca2+ |
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3 | C-MYB transcription factor network | ||
4 | Signaling events mediated by HDAC Class I |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000122 | negative regulation of transcription by RNA polymerase II | IEA,IGI | 15920471 |
GO:0002295 | T-helper cell lineage commitment | IC | 21646796 |
GO:0003151 | outflow tract morphogenesis | IEA,ISS | -- |
GO:0003181 | atrioventricular valve morphogenesis | IEA,ISS | -- |
GO:0003192 | mitral valve formation | IEA,ISS | -- |
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||||||||||||||
SP2: | - | - | |||||||||||||||||||||||
SP3: |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ZFPM1 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | ZFPM1 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Zfpm1 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Zfpm1 30 |
|
||
Dog (Canis familiaris) |
Mammalia | ZFPM1 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | ZFPM1 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | ZFPM1 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | ZFPM1 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | ZFPM1 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | zfpm1 30 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | LOC398166 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | zfpm1 30 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 16 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
784346 | Benign: not provided | 88,489,094(+) | G/C | MISSENSE_VARIANT | |
786298 | Benign: not provided | 88,526,888(+) | C/T | SYNONYMOUS_VARIANT | |
791649 | Benign: not provided | 88,533,290(+) | G/C | MISSENSE_VARIANT | |
rs34916016 | - | p.Gly70Ala |
Disorder | Aliases | PubMed IDs |
---|---|---|
thrombocytopenia 1 |
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dyserythropoietic anemia and thrombocytopenia |
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thrombocytopenia with beta-thalassemia, x-linked |
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thrombocytopenia |
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retinitis pigmentosa 56 |
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