Aliases for ZFPL1 Gene

Aliases for ZFPL1 Gene

  • Zinc Finger Protein Like 1 2 3 5
  • Zinc-Finger Protein In MEN1 Region 2 3
  • Zinc Finger Protein-Like 1 3 4
  • Zinc Finger Protein MCG4 3 4
  • D11S750 2 3
  • MCG4 2 3
  • ZFPL1 5

External Ids for ZFPL1 Gene

Previous GeneCards Identifiers for ZFPL1 Gene

  • GC11P067367
  • GC11P066533
  • GC11P065101
  • GC11P064627
  • GC11P064608
  • GC11P064851
  • GC11P061179

Summaries for ZFPL1 Gene

GeneCards Summary for ZFPL1 Gene

ZFPL1 (Zinc Finger Protein Like 1) is a Protein Coding gene. Diseases associated with ZFPL1 include Achondrogenesis and Cohen Syndrome.

UniProtKB/Swiss-Prot Summary for ZFPL1 Gene

  • Required for cis-Golgi integrity and efficient ER to Golgi transport. Involved in the maintenance of the integrity of the cis-Golgi, possibly via its interaction with GOLGA2/GM130.

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZFPL1 Gene

Genomics for ZFPL1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZFPL1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZFPL1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZFPL1

Top Transcription factor binding sites by QIAGEN in the ZFPL1 gene promoter:
  • C/EBPalpha
  • FOXO1
  • FOXO1a
  • ISGF-3
  • p53
  • Pax-4a
  • SRF
  • SRF (504 AA)

Genomic Locations for ZFPL1 Gene

Latest Assembly
chr11:65,084,210-65,088,398
(GRCh38/hg38)
Size:
4,189 bases
Orientation:
Plus strand

Previous Assembly
chr11:64,851,694-64,855,870
(GRCh37/hg19 by Entrez Gene)
Size:
4,177 bases
Orientation:
Plus strand

chr11:64,851,695-64,855,870
(GRCh37/hg19 by Ensembl)
Size:
4,176 bases
Orientation:
Plus strand

Genomic View for ZFPL1 Gene

Genes around ZFPL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZFPL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZFPL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFPL1 Gene

Proteins for ZFPL1 Gene

  • Protein details for ZFPL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95159-ZFPL1_HUMAN
    Recommended name:
    Zinc finger protein-like 1
    Protein Accession:
    O95159
    Secondary Accessions:
    • A8K7E9
    • O14616
    • Q9UID0

    Protein attributes for ZFPL1 Gene

    Size:
    310 amino acids
    Molecular mass:
    34114 Da
    Quaternary structure:
    • Interacts with GOLGA2/GM130.
    SequenceCaution:
    • Sequence=AAB86533.1; Type=Frameshift; Evidence={ECO:0000305};

neXtProt entry for ZFPL1 Gene

Post-translational modifications for ZFPL1 Gene

No data available for DME Specific Peptides for ZFPL1 Gene

Domains & Families for ZFPL1 Gene

Gene Families for ZFPL1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for ZFPL1 Gene

InterPro:
Blocks:
  • Zn-finger, RING
ProtoNet:

Suggested Antigen Peptide Sequences for ZFPL1 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein MCG4 (ZFPL1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O95159

UniProtKB/Swiss-Prot:

ZFPL1_HUMAN :
  • The B box-type and RING-type zinc fingers although degenerate play a central role in function of the protein.
  • Belongs to the ZFPL1 family.
Domain:
  • The B box-type and RING-type zinc fingers although degenerate play a central role in function of the protein.
Family:
  • Belongs to the ZFPL1 family.
genes like me logo Genes that share domains with ZFPL1: view

Function for ZFPL1 Gene

Molecular function for ZFPL1 Gene

UniProtKB/Swiss-Prot Function:
Required for cis-Golgi integrity and efficient ER to Golgi transport. Involved in the maintenance of the integrity of the cis-Golgi, possibly via its interaction with GOLGA2/GM130.
GENATLAS Biochemistry:
zinc finger protein-like 1,34kDa,expressed in exocrine pancreas

Phenotypes From GWAS Catalog for ZFPL1 Gene

Gene Ontology (GO) - Molecular Function for ZFPL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding NAS 9653652
GO:0005515 protein binding IPI 32296183
GO:0008270 zinc ion binding NAS 9653652
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZFPL1: view
genes like me logo Genes that share phenotypes with ZFPL1: view

Animal Models for ZFPL1 Gene

MGI Knock Outs for ZFPL1:
  • Zfpl1 Zfpl1<tm2b(EUCOMM)Wtsi>

miRNA for ZFPL1 Gene

miRTarBase miRNAs that target ZFPL1

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZFPL1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZFPL1 Gene

Localization for ZFPL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZFPL1 Gene

Golgi apparatus, cis-Golgi network membrane. Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZFPL1 gene
Compartment Confidence
nucleus 5
golgi apparatus 5
plasma membrane 2
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZFPL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 9653652
GO:0005794 Golgi apparatus IEA,IDA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ZFPL1: view

Pathways & Interactions for ZFPL1 Gene

PathCards logo

SuperPathways for ZFPL1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZFPL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated NAS 9653652
GO:0016192 vesicle-mediated transport IEA --
genes like me logo Genes that share ontologies with ZFPL1: view

No data available for Pathways by source and SIGNOR curated interactions for ZFPL1 Gene

Drugs & Compounds for ZFPL1 Gene

No Compound Related Data Available

Transcripts for ZFPL1 Gene

mRNA/cDNA for ZFPL1 Gene

1 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
15 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZFPL1

Alternative Splicing Database (ASD) splice patterns (SP) for ZFPL1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9
SP1: - - - - -
SP2: - - - - - -
SP3: - - -
SP4: - - -
SP5:
SP6: - -
SP7: -

Relevant External Links for ZFPL1 Gene

GeneLoc Exon Structure for
ZFPL1

Expression for ZFPL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZFPL1 Gene

Protein differential expression in normal tissues from HIPED for ZFPL1 Gene

This gene is overexpressed in Nasal epithelium (35.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZFPL1 Gene



Protein tissue co-expression partners for ZFPL1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZFPL1

SOURCE GeneReport for Unigene cluster for ZFPL1 Gene:

Hs.98170

mRNA Expression by UniProt/SwissProt for ZFPL1 Gene:

O95159-ZFPL1_HUMAN
Tissue specificity: Expressed strongly in the exocrine pancreas.

Evidence on tissue expression from TISSUES for ZFPL1 Gene

  • Muscle(4.3)
  • Nervous system(4)
  • Lung(2.2)
genes like me logo Genes that share expression patterns with ZFPL1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZFPL1 Gene

Orthologs for ZFPL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZFPL1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZFPL1 30 31
  • 99.25 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ZFPL1 30 31
  • 90.54 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ZFPL1 30 31
  • 90 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Zfpl1 30 17 31
  • 87.2 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Zfpl1 30
  • 86.45 (n)
Oppossum
(Monodelphis domestica)
Mammalia ZFPL1 31
  • 73 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia zfpl1 30
  • 60.37 (n)
Zebrafish
(Danio rerio)
Actinopterygii zfpl1 30 31
  • 61.2 (n)
OneToOne
zgc63760 30
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4298 30
Fruit Fly
(Drosophila melanogaster)
Insecta CG5382 30 31 32
  • 56.21 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000127 30
  • 54.89 (n)
Worm
(Caenorhabditis elegans)
Secernentea Y45G12B.2a 32
  • 66 (a)
Y45G12B.2 30 31
  • 51.92 (n)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.8053 31
  • 37 (a)
OneToOne
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.9728 30
Species where no ortholog for ZFPL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for ZFPL1 Gene

ENSEMBL:
Gene Tree for ZFPL1 (if available)
TreeFam:
Gene Tree for ZFPL1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZFPL1: view image

Paralogs for ZFPL1 Gene

No data available for Paralogs for ZFPL1 Gene

Variants for ZFPL1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZFPL1 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs35251366 - p.Arg218Gln

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for ZFPL1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for ZFPL1 Gene

Variant ID Type Subtype PubMed ID
nsv526181 CNV gain 19592680

Variation tolerance for ZFPL1 Gene

Residual Variation Intolerance Score: 83.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.33; 63.08% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZFPL1 Gene

Human Gene Mutation Database (HGMD)
ZFPL1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZFPL1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZFPL1 Gene

Disorders for ZFPL1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ZFPL1 Gene - From: COP

Disorder Aliases PubMed IDs
achondrogenesis
  • achondrogenesis syndrome
cohen syndrome
  • coh1
- elite association - COSMIC cancer census association via MalaCards
Search ZFPL1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ZFPL1

genes like me logo Genes that share disorders with ZFPL1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZFPL1 Gene

Publications for ZFPL1 Gene

  1. A putative human zinc-finger gene (ZFPL1) on 11q13, highly conserved in the mouse and expressed in exocrine pancreas. The European Consortium on MEN 1. (PMID: 9653652) Höppener JW … Kas K (Genomics 1998) 2 3 4 23
  2. ZFPL1, a novel ring finger protein required for cis-Golgi integrity and efficient ER-to-Golgi transport. (PMID: 18323775) Chiu CF … Lowe M (The EMBO journal 2008) 3 4 23
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. A transcript map for the 2.8-Mb region containing the multiple endocrine neoplasia type 1 locus. (PMID: 9253601) Guru SC … Chandrasekharappa SC (Genome research 1997) 3 4
  5. Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms. (PMID: 33060197) Gordon DE … Krogan NJ (Science (New York, N.Y.) 2020) 3

Products for ZFPL1 Gene

Sources for ZFPL1 Gene