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Aliases for ZFPL1 Gene

Aliases for ZFPL1 Gene

  • Zinc Finger Protein Like 1 2 3 5
  • Zinc-Finger Protein In MEN1 Region 2 3
  • Zinc Finger Protein MCG4 3 4
  • Zinc Finger Protein-Like 1 3
  • D11S750 3
  • MCG4 3

External Ids for ZFPL1 Gene

Previous GeneCards Identifiers for ZFPL1 Gene

  • GC11P067367
  • GC11P066533
  • GC11P065101
  • GC11P064627
  • GC11P064608
  • GC11P064851
  • GC11P061179

Summaries for ZFPL1 Gene

GeneCards Summary for ZFPL1 Gene

ZFPL1 (Zinc Finger Protein Like 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for ZFPL1 Gene

  • Required for cis-Golgi integrity and efficient ER to Golgi transport. Involved in the maintenance of the integrity of the cis-Golgi, possibly via its interaction with GOLGA2/GM130.

Additional gene information for ZFPL1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZFPL1 Gene

Genomics for ZFPL1 Gene

GeneHancer (GH) Regulatory Elements for ZFPL1 Gene

Promoters and enhancers for ZFPL1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I065082 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 562.8 -0.1 -54 2.7 PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 ZFPL1 CDCA5 SF1 PCNX3 SNX15 POLA2 EIF1AD MUS81 SART1 RELA
GH11I065470 Promoter/Enhancer 2.9 VISTA FANTOM5 Ensembl ENCODE dbSUPER 157.1 +405.9 405862 40 CLOCK MLX ZFP64 FEZF1 DMAP1 YBX1 IRF4 YY1 SLC30A9 ZNF213 LOC105369346 SF1 PCNX3 POLA2 ZFPL1 EIF1AD SART1 MUS81 LOC105369352 KAT5
GH11I065414 Promoter/Enhancer 2.4 FANTOM5 Ensembl ENCODE dbSUPER 104.4 +340.0 339959 18.8 CLOCK MLX ZFP64 FEZF1 DMAP1 YBX1 IRF4 YY1 SLC30A9 ZNF213 NEAT1 ENSG00000277599 ENSG00000278144 GC11P065529 ENSG00000278050 SF1 ZFPL1 EIF1AD POLA2 PCNX3
GH11I065851 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 74 +773.3 773262 12.2 CLOCK MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 MUS81 CFL1 EIF1AD POLA2 PCNX3 SART1 ENSG00000258297 ZFPL1 RBM14 RBM4
GH11I066000 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 68.5 +918.1 918061 3 CLOCK ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 EIF1AD BANF1 ENSG00000258297 ZFPL1 PCNX3 POLA2 SART1 RBM14 RBM4 SF3B2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZFPL1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZFPL1 gene promoter:

Genomic Locations for ZFPL1 Gene

Genomic Locations for ZFPL1 Gene
chr11:65,084,222-65,088,402
(GRCh38/hg38)
Size:
4,181 bases
Orientation:
Plus strand
chr11:64,851,694-64,855,874
(GRCh37/hg19)

Genomic View for ZFPL1 Gene

Genes around ZFPL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZFPL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZFPL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFPL1 Gene

Proteins for ZFPL1 Gene

  • Protein details for ZFPL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95159-ZFPL1_HUMAN
    Recommended name:
    Zinc finger protein-like 1
    Protein Accession:
    O95159
    Secondary Accessions:
    • A8K7E9
    • O14616
    • Q9UID0

    Protein attributes for ZFPL1 Gene

    Size:
    310 amino acids
    Molecular mass:
    34114 Da
    Quaternary structure:
    • Interacts with GOLGA2/GM130.
    SequenceCaution:
    • Sequence=AAB86533.1; Type=Frameshift; Positions=110, 114, 127, 156, 157, 255; Evidence={ECO:0000305};

neXtProt entry for ZFPL1 Gene

Post-translational modifications for ZFPL1 Gene

No data available for DME Specific Peptides for ZFPL1 Gene

Domains & Families for ZFPL1 Gene

Gene Families for ZFPL1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for ZFPL1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ZFPL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95159

UniProtKB/Swiss-Prot:

ZFPL1_HUMAN :
  • The B box-type and RING-type zinc fingers although degenerate play a central role in function of the protein.
  • Belongs to the ZFPL1 family.
Domain:
  • The B box-type and RING-type zinc fingers although degenerate play a central role in function of the protein.
Family:
  • Belongs to the ZFPL1 family.
genes like me logo Genes that share domains with ZFPL1: view

Function for ZFPL1 Gene

Molecular function for ZFPL1 Gene

GENATLAS Biochemistry:
zinc finger protein-like 1,34kDa,expressed in exocrine pancreas
UniProtKB/Swiss-Prot Function:
Required for cis-Golgi integrity and efficient ER to Golgi transport. Involved in the maintenance of the integrity of the cis-Golgi, possibly via its interaction with GOLGA2/GM130.

Phenotypes From GWAS Catalog for ZFPL1 Gene

Gene Ontology (GO) - Molecular Function for ZFPL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding NAS 9653652
GO:0008270 zinc ion binding NAS 9653652
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZFPL1: view
genes like me logo Genes that share phenotypes with ZFPL1: view

Animal Model Products

CRISPR Products

miRNA for ZFPL1 Gene

miRTarBase miRNAs that target ZFPL1

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZFPL1 Gene

Localization for ZFPL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZFPL1 Gene

Golgi apparatus, cis-Golgi network membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZFPL1 gene
Compartment Confidence
nucleus 5
golgi apparatus 5
plasma membrane 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZFPL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 9653652
GO:0005794 Golgi apparatus IDA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ZFPL1: view

Pathways & Interactions for ZFPL1 Gene

SuperPathways for ZFPL1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZFPL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated NAS 9653652
GO:0006810 transport IEA --
GO:0016192 vesicle-mediated transport IEA --
genes like me logo Genes that share ontologies with ZFPL1: view

No data available for Pathways by source and SIGNOR curated interactions for ZFPL1 Gene

Drugs & Compounds for ZFPL1 Gene

No Compound Related Data Available

Transcripts for ZFPL1 Gene

Unigene Clusters for ZFPL1 Gene

Zinc finger protein-like 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZFPL1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9
SP1: - - - - -
SP2: - - - - - -
SP3: - - -
SP4: - - -
SP5:
SP6: - -
SP7: -

Relevant External Links for ZFPL1 Gene

GeneLoc Exon Structure for
ZFPL1
ECgene alternative splicing isoforms for
ZFPL1

Expression for ZFPL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZFPL1 Gene

Protein differential expression in normal tissues from HIPED for ZFPL1 Gene

This gene is overexpressed in Nasal epithelium (35.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZFPL1 Gene



Protein tissue co-expression partners for ZFPL1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZFPL1 Gene:

ZFPL1

SOURCE GeneReport for Unigene cluster for ZFPL1 Gene:

Hs.98170

mRNA Expression by UniProt/SwissProt for ZFPL1 Gene:

O95159-ZFPL1_HUMAN
Tissue specificity: Expressed strongly in the exocrine pancreas.

Evidence on tissue expression from TISSUES for ZFPL1 Gene

  • Muscle(4.3)
  • Nervous system(3.8)
  • Lung(2.2)
genes like me logo Genes that share expression patterns with ZFPL1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZFPL1 Gene

Orthologs for ZFPL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZFPL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZFPL1 33 34
  • 99.25 (n)
dog
(Canis familiaris)
Mammalia ZFPL1 33 34
  • 90.54 (n)
cow
(Bos Taurus)
Mammalia ZFPL1 33 34
  • 90 (n)
mouse
(Mus musculus)
Mammalia Zfpl1 33 16 34
  • 87.2 (n)
rat
(Rattus norvegicus)
Mammalia Zfpl1 33
  • 86.45 (n)
oppossum
(Monodelphis domestica)
Mammalia ZFPL1 34
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zfpl1 33
  • 60.37 (n)
zebrafish
(Danio rerio)
Actinopterygii zfpl1 33 34
  • 61.2 (n)
zgc63760 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4298 33
fruit fly
(Drosophila melanogaster)
Insecta CG5382 35 33 34
  • 56.21 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000127 33
  • 54.89 (n)
worm
(Caenorhabditis elegans)
Secernentea Y45G12B.2a 35
  • 66 (a)
Y45G12B.2 33 34
  • 51.92 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8053 34
  • 37 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.9728 33
Species where no ortholog for ZFPL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZFPL1 Gene

ENSEMBL:
Gene Tree for ZFPL1 (if available)
TreeFam:
Gene Tree for ZFPL1 (if available)

Paralogs for ZFPL1 Gene

No data available for Paralogs for ZFPL1 Gene

Variants for ZFPL1 Gene

Sequence variations from dbSNP and Humsavar for ZFPL1 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000057588 -- 65,087,144(+) T/G intron_variant
rs1000728244 -- 65,085,673(+) T/C intron_variant
rs1001856820 -- 65,086,111(+) A/G intron_variant
rs1003098812 -- 65,087,578(+) T/C intron_variant
rs1003606382 -- 65,082,833(+) G/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ZFPL1 Gene

Variant ID Type Subtype PubMed ID
nsv526181 CNV gain 19592680

Variation tolerance for ZFPL1 Gene

Residual Variation Intolerance Score: 83.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.33; 63.08% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZFPL1 Gene

Human Gene Mutation Database (HGMD)
ZFPL1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZFPL1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZFPL1 Gene

Disorders for ZFPL1 Gene

Additional Disease Information for ZFPL1

No disorders were found for ZFPL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZFPL1 Gene

Publications for ZFPL1 Gene

  1. A putative human zinc-finger gene (ZFPL1) on 11q13, highly conserved in the mouse and expressed in exocrine pancreas. The European Consortium on MEN 1. (PMID: 9653652) Höppener JW … Kas K (Genomics 1998) 2 3 4 22 58
  2. ZFPL1, a novel ring finger protein required for cis-Golgi integrity and efficient ER-to-Golgi transport. (PMID: 18323775) Chiu CF … Lowe M (The EMBO journal 2008) 3 4 22 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. A transcript map for the 2.8-Mb region containing the multiple endocrine neoplasia type 1 locus. (PMID: 9253601) Guru SC … Chandrasekharappa SC (Genome research 1997) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for ZFPL1 Gene

Sources for ZFPL1 Gene

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