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The protein encoded by this gene is a member of the zinc finger family of proteins. The gene product contains C2H2-type domains, which are the classical zinc finger domains found in numerous nucleic acid-binding proteins. This protein functions as a regulator of the non-canonical NF-kappaB pathway in lymphotoxin-beta receptor signaling. Alternative splicing results in multiple ... See more...
Aliases for ZFP91 Gene
Aliases for ZFP91 Gene
- ZFP91 Zinc Finger Protein, Atypical E3 Ubiquitin Ligase 2 3
- ZNF757 2 3 4
- Zinc Finger Protein Homologous To Zfp91 In Mouse 2 3
- RING-Type E3 Ubiquitin Transferase ZFP91 3 4
- E3 Ubiquitin-Protein Ligase ZFP91 3 4
- Zinc Finger Protein 91 Homolog 3 4
- ZFP91 Zinc Finger Protein 3 5
- Zinc Finger Protein 757 3 4
- PZF 2 3
External Ids for ZFP91 Gene
- HGNC: 14983
- Entrez Gene: 80829
- Ensembl: ENSG00000186660
- UniProtKB: Q96JP5
Previous GeneCards Identifiers for ZFP91 Gene
- GC11P060740
- GC11P059860
- GC11P058597
- GC11P058122
- GC11P058104
- GC11P058347
- GC11P054694
Summaries for ZFP91 Gene
-
The protein encoded by this gene is a member of the zinc finger family of proteins. The gene product contains C2H2-type domains, which are the classical zinc finger domains found in numerous nucleic acid-binding proteins. This protein functions as a regulator of the non-canonical NF-kappaB pathway in lymphotoxin-beta receptor signaling. Alternative splicing results in multiple transcript variants. A read-through transcript variant composed of ZFP91 and the downstream CNTF gene sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse. A ZFP91-related pseudogene has also been identified on chromosome 2. [provided by RefSeq, Oct 2010]
GeneCards Summary for ZFP91 Gene
ZFP91 (ZFP91 Zinc Finger Protein, Atypical E3 Ubiquitin Ligase) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and ubiquitin-protein transferase activity. An important paralog of this gene is ZFP91-CNTF.
UniProtKB/Swiss-Prot Summary for ZFP91 Gene
-
Atypical E3 ubiquitin-protein ligase that mediates 'Lys-63'-linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK. It thereby acts as an activator of the non-canonical NF-kappa-B2/NFKB2 pathway. May also play an important role in cell proliferation and/or anti-apoptosis.
Additional gene information for ZFP91 Gene
- HGNC(14983)
- Entrez Gene(80829)
- Ensembl(ENSG00000186660)
- UniProtKB(Q96JP5)
- Open Targets Platform(ENSG00000186660)
- Monarch Initiative
- Search for ZFP91 at DataMed
- Search for ZFP91 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZFP91 Gene
Genomics for ZFP91 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for ZFP91 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH11J058571 | Promoter/Enhancer | 2.7 | EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER | 608.8 | -1.6 | -1562 | 11 | BRCA1 ARHGAP35 SP1 HNRNPL CREB1 GATAD2A CTCF PRDM10 REST ZNF629 | LPXN ZFP91 ZFP91-CNTF ENSG00000269570 ENSG00000255139 OR5B21 ENSG00000197254 CTNND1 CNTF FAM111A | |
| GH11J058618 | Promoter | 0.6 | EPDnew | 600.3 | +39.3 | 39341 | 0.1 | CTCF RAD21 HNF4A | piR-45473 ZFP91 CNTF ZFP91-CNTF | |
| GH11J058610 | Promoter | 0.4 | EPDnew | 600.3 | +31.9 | 31945 | 0.1 | ZNF513 | ENSG00000269570 MN309357 ZFP91 CNTF ZFP91-CNTF | |
| GH11J058611 | Promoter | 0.3 | EPDnew | 600.3 | +32.5 | 32523 | 0.1 | ENSG00000269570 MN309357 ZFP91 CNTF ZFP91-CNTF | ||
| GH11J058619 | Promoter | 0.3 | EPDnew | 600.3 | +39.9 | 39914 | 0.1 | piR-45473 ZFP91 CNTF ZFP91-CNTF |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around ZFP91 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZFP91
- Top Transcription factor binding sites by QIAGEN in the ZFP91 gene promoter:
-
- AREB6
- ATF6
- c-Ets-1
- C/EBPalpha
- C/EBPbeta
- FOXC1
- HOXA3
- Sp1
Genomic Locations for ZFP91 Gene
Genomic Locations for ZFP91 Gene
- chr11:58,579,063-58,621,550
- (GRCh38/hg38)
- Size:
- 42,488 bases
- Orientation:
- Plus strand
- chr11:58,346,584-58,389,023
- (GRCh37/hg19)
- Size:
- 42,440 bases
- Orientation:
- Plus strand
Genomic View for ZFP91 Gene
Genes around ZFP91 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q12.1 by HGNC
- 11q12.1 by Entrez Gene
- 11q12.1 by Ensembl
ZFP91 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ZFP91 Gene
Proteins for ZFP91 Gene
-
Protein details for ZFP91 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96JP5-ZFP91_HUMAN
- Recommended name:
- E3 ubiquitin-protein ligase ZFP91
- Protein Accession:
- Q96JP5
- A6NHC4
- A8MSG7
- Q86V47
- Q96JP4
- Q96QA3
Protein attributes for ZFP91 Gene
- Size:
- 570 amino acids
- Molecular mass:
- 63445 Da
- Quaternary structure:
-
- Interacts with MAP3K14/NIK.
- SequenceCaution:
-
- Sequence=AAL09963.1; Type=Frameshift; Evidence={ECO:0000305};
- Miscellaneous:
-
- In contrast to other E3 ubiquitin-protein ligase, does not contain any domain (RING-type zinc finger or HECT domain) known to mediate E3 ligase activity.
Protein Expression for ZFP91 Gene
Post-translational modifications for ZFP91 Gene
Other Protein References for ZFP91 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences ZFP91 Antibody (LS-B10151) and ZFP91 Antibody (LS-B14788)
- HUABIO Anti-ZFP91 Antibody
-
Custom Antibody ServicesOriGene Antibodies for ZFP91
- Novus Biologicals Antibodies for ZFP91
-
Abcam antibodies for ZFP91
- Invitrogen Antibodies for ZFP91 (AFLGC-ZFP91)
-
Boster Bio Antibodies for ZFP91
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for ZFP91
- Origene Custom Protein Services for ZFP91
- antibodies-online: Show 3 available ZFP91 Proteins ranked by validation data
- Compare Top ZFP91 Proteins
-
Quality Products:
-
Signalway Proteins for ZFP91
No data available for DME Specific Peptides for ZFP91 Gene
Domains & Families for ZFP91 Gene
Gene Families for ZFP91 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
- Transcription factors
Protein Domains for ZFP91 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for ZFP91 Gene
- GenScript: Design optimal peptide antigens:
-
- PRO2869 (Q96JQ9_HUMAN)
- Zinc finger protein 91 homolog (ZFP91_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q96JP5- Family:
-
- Belongs to the krueppel C2H2-type zinc-finger protein family.
Function for ZFP91 Gene
Molecular function for ZFP91 Gene
- UniProtKB/Swiss-Prot Function:
- Atypical E3 ubiquitin-protein ligase that mediates 'Lys-63'-linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK. It thereby acts as an activator of the non-canonical NF-kappa-B2/NFKB2 pathway. May also play an important role in cell proliferation and/or anti-apoptosis.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27;.
Enzyme Numbers (IUBMB) for ZFP91 Gene
Phenotypes From GWAS Catalog for ZFP91 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003676 | nucleic acid binding | IEA | -- |
| GO:0004842 | ubiquitin-protein transferase activity | IDA | 20682767 |
| GO:0016740 | transferase activity | IEA | -- |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for ZFP91 Gene
- MGI mutant phenotypes for ZFP91:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for ZFP91:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Decreased viability
- Decreased viability ratio
- Decreased viability in non-small-cell lung cancer (NSCLC) lineage
- shRNA abundance <= 25%
- Increased HPV18 LCR reporter activity
- Negative genetic interaction between PTEN-/- and PTEN+/+
- Increased cell number in G1, average or increased nuclei size in G1
- Decreased viability with paclitaxel
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ZFP91 - Select products 50% OFF >
- * ZFP91 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for ZFP91
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ZFP91
-
Santa Cruz Biotechnology (SCBT) CRISPR for ZFP91
miRNA for ZFP91 Gene
- miRTarBase miRNAs that target ZFP91
-
- mmu-miR-7b-5p (MIRT009104)
- mmu-miR-223-3p (MIRT009539)
- mmu-miR-34b-5p (MIRT012650)
- hsa-miR-375 (MIRT019693)
- hsa-miR-93-5p (MIRT027985)
- hsa-miR-29a-3p (MIRT049964)
- hsa-miR-595 (MIRT181494)
- hsa-miR-548p (MIRT181514)
- hsa-miR-887-5p (MIRT231124)
- hsa-miR-3148 (MIRT241451)
- hsa-miR-4668-5p (MIRT241452)
- hsa-miR-29b-3p (MIRT267090)
- hsa-miR-29c-3p (MIRT267093)
- hsa-miR-767-5p (MIRT267095)
- hsa-miR-1249-5p (MIRT267096)
- hsa-miR-3663-3p (MIRT267097)
- hsa-miR-4461 (MIRT267100)
- hsa-miR-4802-5p (MIRT267103)
- hsa-miR-6515-5p (MIRT267104)
- hsa-miR-6797-5p (MIRT267108)
- hsa-miR-8076 (MIRT267112)
- hsa-miR-5197-3p (MIRT333632)
- hsa-miR-648 (MIRT373531)
- hsa-miR-1909-3p (MIRT373532)
- hsa-miR-6722-3p (MIRT373533)
- hsa-miR-6732-5p (MIRT373534)
- hsa-miR-6798-5p (MIRT373535)
- hsa-miR-6835-5p (MIRT373537)
- hsa-miR-6886-5p (MIRT373538)
- hsa-miR-218-5p (MIRT439237)
- hsa-miR-6807-5p (MIRT442133)
- hsa-miR-4699-5p (MIRT442134)
- hsa-miR-877-5p (MIRT463287)
- hsa-miR-765 (MIRT463288)
- hsa-miR-5703 (MIRT463289)
- hsa-miR-4516 (MIRT463290)
- hsa-miR-4434 (MIRT463291)
- hsa-miR-4784 (MIRT463292)
- hsa-miR-3150b-3p (MIRT463293)
- hsa-miR-6770-5p (MIRT463294)
- hsa-miR-4645-3p (MIRT463295)
- hsa-miR-7515 (MIRT463296)
- hsa-miR-936 (MIRT463297)
- hsa-miR-6859-5p (MIRT463298)
- hsa-miR-3916 (MIRT463299)
- hsa-miR-3125 (MIRT463300)
- hsa-miR-3154 (MIRT463301)
- hsa-miR-6513-5p (MIRT545904)
- hsa-miR-3913-5p (MIRT545905)
- hsa-miR-3122 (MIRT545906)
- hsa-miR-450a-1-3p (MIRT545907)
- hsa-miR-510-3p (MIRT545908)
- hsa-miR-6844 (MIRT545909)
- hsa-miR-6739-5p (MIRT545910)
- hsa-miR-6733-5p (MIRT545911)
- hsa-miR-3153 (MIRT545912)
- hsa-miR-186-5p (MIRT545913)
- hsa-miR-3124-3p (MIRT611361)
- hsa-miR-338-3p (MIRT611362)
- hsa-miR-4530 (MIRT611363)
- hsa-miR-545-3p (MIRT611364)
- hsa-miR-598-3p (MIRT611365)
- hsa-miR-424-3p (MIRT611366)
- hsa-miR-3180-5p (MIRT641774)
- hsa-miR-6720-5p (MIRT641775)
- hsa-miR-6512-3p (MIRT641776)
- hsa-miR-7162-5p (MIRT697414)
- hsa-miR-516b-3p (MIRT697415)
- hsa-miR-516a-3p (MIRT697416)
- hsa-miR-6514-5p (MIRT697417)
- hsa-miR-505-5p (MIRT697418)
- hsa-miR-708-5p (MIRT697419)
- hsa-miR-3139 (MIRT697420)
- hsa-miR-28-5p (MIRT697421)
- hsa-miR-1255a (MIRT736583)
- hsa-miR-1255b-5p (MIRT736606)
- hsa-miR-4712-3p (MIRT747455)
- hsa-miR-5187-5p (MIRT749867)
- hsa-miR-576-3p (MIRT751446)
- hsa-miR-6077 (MIRT751730)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ZFP91
- Browse OriGene Inhibitory RNA Products For ZFP91
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZFP91
Clone Products
- Applied Biological Materials (abm): Clones for ZFP91 - Select products 50% OFF >
- * ZFP91 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for ZFP91
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ZFP91
Cell Line Products
-
Horizon Cell Lines for ZFP91
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZFP91 Gene
Localization for ZFP91 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ZFP91 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 4 |
| cytosol | 4 |
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
- Nucleoplasm (3)
- Cytosol (1)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005829 | cytosol | IDA | -- |
Pathways & Interactions for ZFP91 Gene
UniProtKB/Swiss-Prot Q96JP5-ZFP91_HUMAN
- Pathway: Protein modification; protein ubiquitination.
Interacting Proteins for ZFP91 Gene
GPS-Prot Interaction Network for ZFP91
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007250 | activation of NF-kappaB-inducing kinase activity | IDA | 20682767 |
| GO:0016567 | protein ubiquitination | IEA | -- |
| GO:0070534 | protein K63-linked ubiquitination | IDA | 20682767 |
No data available for Pathways by source for ZFP91 Gene
Transcripts for ZFP91 Gene
mRNA/cDNA for ZFP91 Gene
- 2 REFSEQ mRNAs :
- 9 NCBI additional mRNA sequence :
- 1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000316059 5776 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ZFP91 - Select products 50% OFF >
- * ZFP91 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for ZFP91
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ZFP91
-
Santa Cruz Biotechnology (SCBT) CRISPR for ZFP91
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ZFP91
- Browse OriGene Inhibitory RNA Products For ZFP91
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZFP91
Clone Products
- Applied Biological Materials (abm): Clones for ZFP91 - Select products 50% OFF >
- * ZFP91 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for ZFP91
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ZFP91
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b | ^ | 10a | · | 10b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | |||||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||
| SP5: |
Relevant External Links for ZFP91 Gene
- GeneLoc Exon Structure for
- ZFP91
Expression for ZFP91 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Testis (Reproductive System)
This gene is overexpressed in Adrenal (20.4), Lung (11.8), and Testis (6.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZFP91 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZFP91
mRNA Expression by UniProt/SwissProt for ZFP91 Gene:
Q96JP5-ZFP91_HUMAN
Tissue specificity:
Expressed ubiquitously, particularly at high level in testis. Isoform 2 is testis specific.
Evidence on tissue expression from TISSUES for ZFP91 Gene
- Blood(4.4)
- Muscle(2.7)
- Heart(2.7)
- Nervous system(2.5)
- Kidney(2.1)
- Liver(2)
Primer Products
-
OriGene qPCR primer pairs for ZFP91
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZFP91 Gene
Orthologs for ZFP91 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | ZFP91 30 31 |
|
OneToMany | |
| Dog (Canis familiaris) |
Mammalia | -- 31 |
|
OneToMany | |
| ZFP91 30 |
|
||||
| Mouse (Mus musculus) |
Mammalia | Zfp91 30 17 31 |
|
OneToMany | |
| Rat (Rattus norvegicus) |
Mammalia | Zfp91 30 |
|
||
| Cow (Bos Taurus) |
Mammalia | -- 31 |
|
OneToMany | |
| ZFP91 30 |
|
||||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
| Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
| Chicken (Gallus gallus) |
Aves | ZFP91 30 31 |
|
OneToMany | |
| Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | zfp91 30 |
|
||
| Str.4542 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.24472 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | ZFP91 31 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
- Species where no ortholog for ZFP91 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for ZFP91 Gene
- ENSEMBL:
- Gene Tree for ZFP91 (if available)
- TreeFam:
- Gene Tree for ZFP91 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ZFP91: view image
Paralogs for ZFP91 Gene
Paralogs for ZFP91 Gene
- ZFP91-CNTF 5
- ZNF692 5
- ZNF653 5
- ZNF276 5
- HIC1 5
- ZBTB7C 5
- PRDM10 5
- ZBTB20 5
- MTF1 5
- PRDM14 5
- HIC2 5
- ZNF410 5
- ZNF384 5
- ZNF143 5
- PRDM1 5
- ZNF76 5
- ZNF148 5
- ZBTB16 5
- ZNF296 5
- ZBTB1 5
- ZNF362 5
- ZNF281 5
- PRDM6 5
- ZNF451 5
- PATZ1 5
- SCRT1 5
- MAZ 5
- ZBTB32 5
- SCRT2 5
- VEZF1 5
- ZBTB45 5
- ZNF575 5
- SNAI2 5
- ZBTB18 5
- SNAI3 5
- ZBTB42 5
- SNAI1 5
- ENSG00000267477 5
(4) SIMAP similar genes for ZFP91 Gene using alignment to 2 proteins:
- ZFP91_HUMAN
- Q96JQ9_HUMAN
Pseudogenes.org Pseudogenes for ZFP91 Gene
Variants for ZFP91 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZFP91 Gene
| SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs17854702 | - | p.Val37Ile | |||
| rs8373 | - | p.Ser207Gly |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3304488 | CNV | mobile element insertion | 20981092 |
| esv3355754 | CNV | insertion | 20981092 |
| nsv1118212 | CNV | deletion | 24896259 |
| nsv528190 | CNV | loss | 19592680 |
Residual Variation Intolerance Score:
55.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
8.37;
85.45% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ZFP91 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ZFP91
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZFP91 Gene
Disorders for ZFP91 Gene
Additional Disease Information for ZFP91
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No disorders were found for ZFP91 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZFP91 Gene
Publications for ZFP91 Gene
- An atypical E3 ligase zinc finger protein 91 stabilizes and activates NF-kappaB-inducing kinase via Lys63-linked ubiquitination. (PMID: 20682767) Jin X … Lee JJ (The Journal of biological chemistry 2010) 2 3 4
- Identification of a novel human gene, ZFP91, involved in acute myelogenous leukemia. (PMID: 12738986) Unoki M … Nakamura Y (International journal of oncology 2003) 2 3 4
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
- A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
- The ubiquitinase ZFP91 promotes tumor cell survival and confers chemoresistance through FOXA1 destabilization. (PMID: 31046116) Tang DE … Xu SH (Carcinogenesis 2020) 3
ExternalLinks
Products for ZFP91 Gene
- Custom Antibody ServicesOriGene Antibodies for ZFP91
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- antibodies-online: Show 34 available ZFP91 Antibodies ranked by validation data
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- Boster Bio Antibodies for ZFP91
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- Signalway Proteins for ZFP91
Sources for ZFP91 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
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- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
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- (55) TGDB
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- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
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- (109) Disease Ontology
- (110) Genetics Home Reference
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- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
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- (122) ENCODE
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- (124) Horizon
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- (133) TISSUES
- (134) Gene ORGANizer
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- (136) Human Protein Atlas
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- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
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- (143) Applied Biosystems
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- (148) RNACentral
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- (152) DiseaseEnhancer
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- (156) Mastermind
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- (159) GeneImprint
- (160) Synthego
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- (163) LncBase
- (164) LncBook
- (165) LNCipedia
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- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
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- (175) Open Targets Platform
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- (177) snoDB
- (178) MirGeneDB