The protein encoded by this gene is a member of the zinc finger family of proteins. The gene product contains C2H2-type domains, which are the classical zinc finger domains found in numerous nucleic acid-binding proteins. This protein functions as a regulator of the non-canonical NF-kappaB pathway in lymphotoxin-beta receptor signaling. Alternative splicing results in multiple ... See more...
Aliases for ZFP91 Gene
Aliases for ZFP91 Gene
External Ids for ZFP91 Gene
- HGNC: 14983
- Entrez Gene: 80829
- Ensembl: ENSG00000186660
- UniProtKB: Q96JP5
Previous GeneCards Identifiers for ZFP91 Gene
- GC11P060740
- GC11P059860
- GC11P058597
- GC11P058122
- GC11P058104
- GC11P058347
- GC11P054694
Summaries for ZFP91 Gene
-
The protein encoded by this gene is a member of the zinc finger family of proteins. The gene product contains C2H2-type domains, which are the classical zinc finger domains found in numerous nucleic acid-binding proteins. This protein functions as a regulator of the non-canonical NF-kappaB pathway in lymphotoxin-beta receptor signaling. Alternative splicing results in multiple transcript variants. A read-through transcript variant composed of ZFP91 and the downstream CNTF gene sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse. A ZFP91-related pseudogene has also been identified on chromosome 2. [provided by RefSeq, Oct 2010]
GeneCards Summary for ZFP91 Gene
ZFP91 (ZFP91 Zinc Finger Protein) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and ubiquitin-protein transferase activity. An important paralog of this gene is ZFP91-CNTF.
UniProtKB/Swiss-Prot Summary for ZFP91 Gene
-
Atypical E3 ubiquitin-protein ligase that mediates 'Lys-63'-linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK. It thereby acts as an activator of the non-canonical NF-kappa-B2/NFKB2 pathway. May also play an important role in cell proliferation and/or anti-apoptosis.
Additional gene information for ZFP91 Gene
- Monarch Initiative
- Search for ZFP91 at DataMed
- Search for ZFP91 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZFP91 Gene
Genomics for ZFP91 Gene
GeneHancer (GH) Regulatory Elements for ZFP91 Gene
Promoters and enhancers for ZFP91 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH11J058571 | Promoter/Enhancer | 2.7 | EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER | 793.1 | -1.6 | -1562 | 11 | SIN3A ZNF24 SP1 ZBTB40 CTCF SIX5 LCORL ZBTB6 FOXA1 RBPJ | ZFP91 LPXN ZFP91-CNTF ENSG00000269570 ENSG00000255139 ENSG00000255008 FAM111A CLP1 CTNND1 ZDHHC5 | |
| GH11J058618 | Promoter | 0.6 | EPDnew | 750.3 | +39.3 | 39341 | 0.1 | RAD21 CTCF HNF4A | piR-45473 ZFP91 CNTF ZFP91-CNTF | |
| GH11J058610 | Promoter | 0.4 | EPDnew | 750.3 | +31.9 | 31945 | 0.1 | ZNF513 | ENSG00000269570 ZFP91 ZFP91-CNTF | |
| GH11J058611 | Promoter | 0.3 | EPDnew | 750.3 | +32.5 | 32523 | 0.1 | ENSG00000269570 ZFP91 ZFP91-CNTF | ||
| GH11J058617 | Promoter | 0.3 | EPDnew | 750.3 | +38.4 | 38377 | 0.1 | piR-45473 ZFP91 ENSG00000269570 ZFP91-CNTF |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around ZFP91 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the ZFP91 gene promoter:
-
- AREB6
- ATF6
- c-Ets-1
- C/EBPalpha
- C/EBPbeta
- FOXC1
- HOXA3
- Sp1
Genomic Locations for ZFP91 Gene
Genomic Locations for ZFP91 Gene
- chr11:58,579,063-58,621,550
- (GRCh38/hg38)
- Size:
- 42,488 bases
- Orientation:
- Plus strand
- chr11:58,346,584-58,389,023
- (GRCh37/hg19)
- Size:
- 42,440 bases
- Orientation:
- Plus strand
Genomic View for ZFP91 Gene
Genes around ZFP91 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q12.1 by HGNC
- 11q12.1 by Entrez Gene
- 11q12.1 by Ensembl
ZFP91 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ZFP91 Gene
Proteins for ZFP91 Gene
-
Protein details for ZFP91 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96JP5-ZFP91_HUMAN
- Recommended name:
- E3 ubiquitin-protein ligase ZFP91
- Protein Accession:
- Q96JP5
- A6NHC4
- A8MSG7
- Q86V47
- Q96JP4
- Q96QA3
Protein attributes for ZFP91 Gene
- Size:
- 570 amino acids
- Molecular mass:
- 63445 Da
- Quaternary structure:
-
- Interacts with MAP3K14/NIK.
- Miscellaneous:
-
- In contrast to other E3 ubiquitin-protein ligase, does not contain any domain (RING-type zinc finger or HECT domain) known to mediate E3 ligase activity.
- SequenceCaution:
-
- Sequence=AAL09963.1; Type=Frameshift; Positions=72, 80; Evidence={ECO:0000305};
Protein Expression for ZFP91 Gene
Post-translational modifications for ZFP91 Gene
Other Protein References for ZFP91 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Atlas Antibodies Anti-ZFP91 Antibody (HPA024037) and Anti-ZFP91 Antibody (HPA065325)
-
Custom Antibody ServicesOriGene Antibodies for ZFP91
- Novus Biologicals Antibodies for ZFP91
-
Abcam antibodies for ZFP91
- Invitrogen Antibodies for ZFP91 (AFLGC-ZFP91)
Protein Products
- Atlas Antibodies PrEST Antigen ZFP91 (APrEST73788) and PrEST Antigen ZFP91 (APrEST92557)
-
OriGene Purified Proteins for ZFP91
- Search Origene for MassSpec and Protein Over-expression Lysates for ZFP91
- Origene Custom Protein Services for ZFP91
- antibodies-online: Show 3 available ZFP91 Proteins ranked by validation data
- Compare Top ZFP91 Proteins
-
Quality Products:
No data available for DME Specific Peptides for ZFP91 Gene
Domains & Families for ZFP91 Gene
Gene Families for ZFP91 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
- Transcription factors
Protein Domains for ZFP91 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for ZFP91 Gene
- GenScript: Design optimal peptide antigens:
-
- PRO2869 (Q96JQ9_HUMAN)
- Zinc finger protein 91 homolog (ZFP91_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q96JP5- Family:
-
- Belongs to the krueppel C2H2-type zinc-finger protein family.
Function for ZFP91 Gene
Molecular function for ZFP91 Gene
- UniProtKB/Swiss-Prot Function:
- Atypical E3 ubiquitin-protein ligase that mediates 'Lys-63'-linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK. It thereby acts as an activator of the non-canonical NF-kappa-B2/NFKB2 pathway. May also play an important role in cell proliferation and/or anti-apoptosis.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27;.
Enzyme Numbers (IUBMB) for ZFP91 Gene
Phenotypes From GWAS Catalog for ZFP91 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | ISA | -- |
| GO:0003676 | nucleic acid binding | IEA | -- |
| GO:0004842 | ubiquitin-protein transferase activity | IDA | 20682767 |
| GO:0016740 | transferase activity | IEA | -- |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for ZFP91 Gene
- GenomeRNAi human phenotypes for ZFP91:
-
- Increased HPV18 LCR reporter activity
- Decreased viability ratio
- Negative genetic interaction between PTEN-/- and PTEN+/+
- Decreased viability in esophageal squamous lineage
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Decreased viability with paclitaxel
- Increased cell number in S
- shRNA abundance <= 50%
- Increased viability
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ZFP91 - Select products 50% OFF >
- * ZFP91 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * ZFP91 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
OriGene CRISPR knockouts for ZFP91
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ZFP91
- genomics-online: gRNA clones - Search for available ZFP91 gRNA products
- Overview of 104 available ZFP91 gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for ZFP91
miRNA for ZFP91 Gene
- miRTarBase miRNAs that target ZFP91
-
- hsa-mir-375 (MIRT019693)
- hsa-mir-93-5p (MIRT027985)
- hsa-mir-29a-3p (MIRT049964)
- hsa-mir-595 (MIRT181494)
- hsa-mir-548p (MIRT181514)
- hsa-mir-887-5p (MIRT231124)
- hsa-mir-3148 (MIRT241451)
- hsa-mir-4668-5p (MIRT241452)
- hsa-mir-29b-3p (MIRT267090)
- hsa-mir-29c-3p (MIRT267093)
- hsa-mir-767-5p (MIRT267095)
- hsa-mir-1249-5p (MIRT267096)
- hsa-mir-3663-3p (MIRT267097)
- hsa-mir-4461 (MIRT267100)
- hsa-mir-4802-5p (MIRT267103)
- hsa-mir-6515-5p (MIRT267104)
- hsa-mir-6797-5p (MIRT267108)
- hsa-mir-8076 (MIRT267112)
- hsa-mir-5197-3p (MIRT333632)
- hsa-mir-648 (MIRT373531)
- hsa-mir-1909-3p (MIRT373532)
- hsa-mir-6722-3p (MIRT373533)
- hsa-mir-6732-5p (MIRT373534)
- hsa-mir-6798-5p (MIRT373535)
- hsa-mir-6835-5p (MIRT373537)
- hsa-mir-6886-5p (MIRT373538)
- hsa-mir-218-5p (MIRT439237)
- hsa-mir-6807-5p (MIRT442133)
- hsa-mir-4699-5p (MIRT442134)
- hsa-mir-877-5p (MIRT463287)
- hsa-mir-765 (MIRT463288)
- hsa-mir-5703 (MIRT463289)
- hsa-mir-4516 (MIRT463290)
- hsa-mir-4434 (MIRT463291)
- hsa-mir-4784 (MIRT463292)
- hsa-mir-3150b-3p (MIRT463293)
- hsa-mir-6770-5p (MIRT463294)
- hsa-mir-4645-3p (MIRT463295)
- hsa-mir-7515 (MIRT463296)
- hsa-mir-936 (MIRT463297)
- hsa-mir-6859-5p (MIRT463298)
- hsa-mir-3916 (MIRT463299)
- hsa-mir-3125 (MIRT463300)
- hsa-mir-3154 (MIRT463301)
- hsa-mir-6513-5p (MIRT545904)
- hsa-mir-3913-5p (MIRT545905)
- hsa-mir-3122 (MIRT545906)
- hsa-mir-450a-1-3p (MIRT545907)
- hsa-mir-510-3p (MIRT545908)
- hsa-mir-6844 (MIRT545909)
- hsa-mir-6739-5p (MIRT545910)
- hsa-mir-6733-5p (MIRT545911)
- hsa-mir-3153 (MIRT545912)
- hsa-mir-186-5p (MIRT545913)
- hsa-mir-3124-3p (MIRT611361)
- hsa-mir-338-3p (MIRT611362)
- hsa-mir-4530 (MIRT611363)
- hsa-mir-545-3p (MIRT611364)
- hsa-mir-598-3p (MIRT611365)
- hsa-mir-424-3p (MIRT611366)
- hsa-mir-3180-5p (MIRT641774)
- hsa-mir-6720-5p (MIRT641775)
- hsa-mir-6512-3p (MIRT641776)
- hsa-mir-7162-5p (MIRT697414)
- hsa-mir-516b-3p (MIRT697415)
- hsa-mir-516a-3p (MIRT697416)
- hsa-mir-6514-5p (MIRT697417)
- hsa-mir-505-5p (MIRT697418)
- hsa-mir-708-5p (MIRT697419)
- hsa-mir-3139 (MIRT697420)
- hsa-mir-28-5p (MIRT697421)
- hsa-mir-1255a (MIRT736583)
- hsa-mir-1255b-5p (MIRT736606)
- hsa-mir-4712-3p (MIRT747455)
- hsa-mir-5187-5p (MIRT749867)
- hsa-mir-576-3p (MIRT751446)
- hsa-mir-6077 (MIRT751730)
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for ZFP91
- Browse OriGene Inhibitory RNA Products For ZFP91
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZFP91
- genomics-online: shRNA clones - Search for available ZFP91 shRNA products
- Overview of 104 available ZFP91 gene related products
Clone Products
- Applied Biological Materials (abm): Clones for ZFP91 - Select products 50% OFF >
- * ZFP91 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * ZFP91 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
- Sino Biological Human cDNA Clone for ZFP91
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ZFP91
- genomics-online: cdna clones - Search for available ZFP91 CDNA products
- Overview of 104 available ZFP91 gene related products
- orf clones - Search for available ZFP91 ORF products
- Overview of 104 available ZFP91 gene related products
Cell Line Products
-
Horizon Cell Lines for ZFP91
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZFP91 Gene
Localization for ZFP91 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ZFP91 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 4 |
| cytoskeleton | 1 |
- Nucleus (3)
- Nucleoli (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA | -- |
| GO:0005730 | nucleolus | IDA | -- |
Pathways & Interactions for ZFP91 Gene
UniProtKB/Swiss-Prot Q96JP5-ZFP91_HUMAN
- Pathway: Protein modification; protein ubiquitination.
Interacting Proteins for ZFP91 Gene
GPS-Prot Interaction Network for ZFP91
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006357 | regulation of transcription by RNA polymerase II | IEA | -- |
| GO:0007250 | activation of NF-kappaB-inducing kinase activity | IDA | 20682767 |
| GO:0016567 | protein ubiquitination | IEA | -- |
| GO:0070534 | protein K63-linked ubiquitination | IDA | 20682767 |
No data available for Pathways by source for ZFP91 Gene
Drugs & Compounds for ZFP91 Gene
No Compound Related Data Available
Drug Products
- Atlas Antibodies PrEST Antigen ZFP91 (APrEST73788) and PrEST Antigen ZFP91 (APrEST92557)
Transcripts for ZFP91 Gene
mRNA/cDNA for ZFP91 Gene
- (2) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (493) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000316059 5776 bps (ENST00000316059.6)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ZFP91 - Select products 50% OFF >
- * ZFP91 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * ZFP91 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
OriGene CRISPR knockouts for ZFP91
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ZFP91
- genomics-online: gRNA clones - Search for available ZFP91 gRNA products
- Overview of 104 available ZFP91 gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for ZFP91
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for ZFP91
- Browse OriGene Inhibitory RNA Products For ZFP91
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZFP91
- genomics-online: shRNA clones - Search for available ZFP91 shRNA products
- Overview of 104 available ZFP91 gene related products
Clone Products
- Applied Biological Materials (abm): Clones for ZFP91 - Select products 50% OFF >
- * ZFP91 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * ZFP91 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
- Sino Biological Human cDNA Clone for ZFP91
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ZFP91
- genomics-online: cdna clones - Search for available ZFP91 CDNA products
- Overview of 104 available ZFP91 gene related products
- orf clones - Search for available ZFP91 ORF products
- Overview of 104 available ZFP91 gene related products
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b | ^ | 10a | · | 10b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | |||||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||
| SP5: |
Expression for ZFP91 Gene
This gene is overexpressed in Adrenal (20.4), Lung (11.8), and Testis (6.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZFP91 Gene
NURSA nuclear receptor signaling pathways regulating expression of ZFP91 Gene:
ZFP91mRNA Expression by UniProt/SwissProt for ZFP91 Gene:
Q96JP5-ZFP91_HUMAN
Tissue specificity:
Expressed ubiquitously, particularly at high level in testis. Isoform 2 is testis specific.
Evidence on tissue expression from TISSUES for ZFP91 Gene
- Blood(4.3)
- Heart(2.5)
- Muscle(2.5)
Primer Products
-
OriGene qPCR primer pairs for ZFP91
- genomics-online: primer clones - Search for available ZFP91 Primer products
- Overview of 104 available ZFP91 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZFP91 Gene
Orthologs for ZFP91 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ZFP91 33 32 |
|
OneToMany | |
| dog (Canis familiaris) |
Mammalia | -- 33 |
|
OneToMany | |
| ZFP91 32 |
|
||||
| mouse (Mus musculus) |
Mammalia | Zfp91 17 33 32 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Zfp91 32 |
|
||
| cow (Bos Taurus) |
Mammalia | -- 33 |
|
OneToMany | |
| ZFP91 32 |
|
||||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 33 |
|
OneToMany | |
| oppossum (Monodelphis domestica) |
Mammalia | -- 33 |
|
OneToMany | |
| chicken (Gallus gallus) |
Aves | ZFP91 33 32 |
|
OneToMany | |
| lizard (Anolis carolinensis) |
Reptilia | -- 33 |
|
OneToMany | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | zfp91 32 |
|
||
| Str.4542 32 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.24472 32 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | ZFP91 33 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 33 |
|
OneToMany |
- Species where no ortholog for ZFP91 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for ZFP91 Gene
- ENSEMBL:
- Gene Tree for ZFP91 (if available)
- TreeFam:
- Gene Tree for ZFP91 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ZFP91: view image
Paralogs for ZFP91 Gene
Paralogs for ZFP91 Gene
- ZFP91-CNTF 5
- ZNF692 5
- ZNF653 5
- ZNF276 5
- ZBTB20 5
- ZNF76 5
- ZNF148 5
- ZNF296 5
- ZNF143 5
- ZNF451 5
- PRDM1 5
- MTF1 5
- PATZ1 5
- HIC1 5
- ZNF384 5
- ZBTB7C 5
- PRDM10 5
- ZBTB45 5
- PRDM14 5
- MAZ 5
- ZNF281 5
- ZNF410 5
- ZBTB1 5
- ZBTB16 5
- SCRT1 5
- SCRT2 5
- VEZF1 5
- HIC2 5
- PRDM6 5
- ZNF362 5
- ZNF575 5
- SNAI2 5
- SNAI3 5
- ZBTB32 5
- SNAI1 5
- ZBTB42 5
- ZBTB18 5
- ENSG00000267477 5
(4) SIMAP similar genes for ZFP91 Gene using alignment to 2 proteins:
- ZFP91_HUMAN
- Q96JQ9_HUMAN
Pseudogenes.org Pseudogenes for ZFP91 Gene
Variants for ZFP91 Gene
| SNP ID | Clin | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000069415 | -- | 58,622,037(+) | G/A | downstream_transcript_variant | |
| rs1000128669 | -- | 58,599,161(+) | T/C | intron_variant | |
| rs1000148222 | -- | 58,582,084(+) | G/C | intron_variant | |
| rs1000230816 | -- | 58,605,444(+) | G/A | intron_variant | |
| rs1000281474 | -- | 58,605,172(+) | A/G | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3304488 | CNV | mobile element insertion | 20981092 |
| esv3355754 | CNV | insertion | 20981092 |
| nsv1118212 | CNV | deletion | 24896259 |
| nsv528190 | CNV | loss | 19592680 |
Residual Variation Intolerance Score:
55.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
8.37;
85.45% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ZFP91 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ZFP91
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZFP91 Gene
Disorders for ZFP91 Gene
Additional Disease Information for ZFP91
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for ZFP91 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZFP91 Gene
Publications for ZFP91 Gene
- An atypical E3 ligase zinc finger protein 91 stabilizes and activates NF-kappaB-inducing kinase via Lys63-linked ubiquitination. (PMID: 20682767) Jin X … Lee JJ (The Journal of biological chemistry 2010) 2 3 4 56
- Identification of a novel human gene, ZFP91, involved in acute myelogenous leukemia. (PMID: 12738986) Unoki M … Nakamura Y (International journal of oncology 2003) 2 3 4 56
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
- An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations. (PMID: 29568061) Liu X … Varjosalo M (Nature communications 2018) 3 56
- Defining the human C2H2 zinc finger degrome targeted by thalidomide analogs through CRBN. (PMID: 30385546) Sievers QL … Thomä NH (Science (New York, N.Y.) 2018) 3 56
ExternalLinks
Products for ZFP91 Gene
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- Quality Products:
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Sources for ZFP91 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
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- (13) UniProtKB/TrEMBL
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- (15) ProtoNet
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- (25) DrugBank
- (26) HMDB
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) CGAP SAGE
- (31) SOURCE
- (32) HomoloGene
- (33) PanEnsembl
- (34) euGenes
- (35) SGD
- (36) FlyBase
- (37) WormBase
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- (40) dbSNP
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- (45) HuGE
- (46) Atlas
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- (55) OriGene
- (56) PubMed
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- (61) Novus Biologicals
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- (63) Sino Biological
- (64) GenScript
- (65) Qiagen
- (66) OCA
- (67) Proteopedia
- (68) MOPED
- (69) neXtProt
- (70) Reactome
- (71) GeneGo (Thomson Reuters)
- (72) DISEASES
- (73) SIMAP
- (74) GenomeRNAi
- (75) LifeMap
- (76) miRTarBase
- (77) MalaCards
- (78) Invitrogen
- (79) BitterDB
- (80) ESI-BIO
- (81) RefSeq
- (82) BioSystems
- (83) MaxQB
- (84) IUPHAR
- (85) BioGPS
- (86) Illumina
- (87) COMPARTMENTS
- (88) HOMER
- (89) PaxDb
- (90) ApexBio
- (91) Addgene
- (92) antibodies-online
- (93) CYP
- (94) NONCODE
- (95) TreeFam
- (96) PathCards
- (97) GeneReviews
- (98) GeneTex
- (99) Taconic Biosciences
- (100) GTEx
- (101) ProteomicsDB
- (102) SCBT
- (103) DGIdb
- (104) ClinicalTrials
- (105) RVIS
- (106) SIGNOR
- (107) diseasecard
- (108) NIH Rare Diseases
- (109) Orphanet
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- (112) Disease Ontology
- (113) Genetics Home Reference
- (114) MeSH
- (115) MedlinePlus
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- (118) NCBI Bookshelf
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- (144) genomics-online
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- (147) Applied Biosystems
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- (152) RNACentral
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- (154) LOVD
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- (156) DiseaseEnhancer
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