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Aliases for ZFP91 Gene

Aliases for ZFP91 Gene

  • ZFP91 Zinc Finger Protein 2 3 5
  • Zinc Finger Protein Homologous To Zfp91 In Mouse 2 3
  • RING-Type E3 Ubiquitin Transferase ZFP91 3 4
  • Zinc Finger Protein 91 Homolog 3 4
  • Zinc Finger Protein 757 3 4
  • ZFP-91 3 4
  • ZNF757 3 4
  • Drug Resistance-Associated Sequence In Melanoma 8 3
  • Zinc Finger Protein 91 Homolog (Mouse) 2
  • E3 Ubiquitin-Protein Ligase ZFP91 3
  • Penta Zinc Finger Protein 3
  • EC 4
  • FKSG11 3
  • DMS-8 3
  • DSM-8 3
  • PZF 3

External Ids for ZFP91 Gene

Previous GeneCards Identifiers for ZFP91 Gene

  • GC11P060740
  • GC11P059860
  • GC11P058597
  • GC11P058122
  • GC11P058104
  • GC11P058347
  • GC11P054694

Summaries for ZFP91 Gene

Entrez Gene Summary for ZFP91 Gene

  • The protein encoded by this gene is a member of the zinc finger family of proteins. The gene product contains C2H2-type domains, which are the classical zinc finger domains found in numerous nucleic acid-binding proteins. This protein functions as a regulator of the non-canonical NF-kappaB pathway in lymphotoxin-beta receptor signaling. Alternative splicing results in multiple transcript variants. A read-through transcript variant composed of ZFP91 and the downstream CNTF gene sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse. A ZFP91-related pseudogene has also been identified on chromosome 2. [provided by RefSeq, Oct 2010]

GeneCards Summary for ZFP91 Gene

ZFP91 (ZFP91 Zinc Finger Protein) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and ubiquitin-protein transferase activity. An important paralog of this gene is ZFP91-CNTF.

UniProtKB/Swiss-Prot for ZFP91 Gene

  • Atypical E3 ubiquitin-protein ligase that mediates Lys-63-linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK. It thereby acts as an activator of the non-canonical NF-kappa-B2/NFKB2 pathway. May also play an important role in cell proliferation and/or anti-apoptosis.

Gene Wiki entry for ZFP91 Gene

Additional gene information for ZFP91 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZFP91 Gene

Genomics for ZFP91 Gene

GeneHancer (GH) Regulatory Elements for ZFP91 Gene

Promoters and enhancers for ZFP91 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I058572 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 558.9 -1.6 -1625 9.5 CLOCK DMAP1 IRF4 YY1 E2F8 ZNF143 ZNF263 SP3 NFYC PPARGC1A LPXN ZFP91 ZFP91-CNTF ENSG00000269570 ENSG00000255008 OR5B21 CLP1 ENSG00000197254 CTNND1 ZDHHC5
GH11I057666 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 20.5 -910.7 -910651 4.6 HDGF PKNOX1 CLOCK SMAD1 FOXA2 ARNT ARID4B SIN3A YY1 POLR2B ZDHHC5 SSRP1 ENSG00000269570 ZFP91 MED19 YPEL4 ENSG00000254732 SELENOH BTBD18 CTNND1
GH11I059106 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 20.5 +528.8 528752 3.4 PKNOX1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 E2F8 ATF7 KLF7 ZNF548 FAM111B ENSG00000269570 ENSG00000255008 LOC101927226 ZFP91 PATL1 STX3 ENSG00000255299 FAM111A FABP5P7
GH11I057710 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 20.5 -866.6 -866552 3.3 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B MED19 PIR45741 TMX2 TMX2-CTNND1 SSRP1 ZFP91 ENSG00000269570 YPEL4 ENSG00000254732 SELENOH
GH11I058605 Enhancer 1.1 ENCODE dbSUPER 19.9 +26.6 26639 1.2 HDAC1 PKNOX1 RB1 ARNT FEZF1 ZBTB40 TCF12 ZNF366 IKZF2 RUNX3 ZFP91 LPXN ZFP91-CNTF CLP1 ENSG00000269570 ZDHHC5 FAM111A GC11P058595
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZFP91 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZFP91 gene promoter:

Genomic Locations for ZFP91 Gene

Genomic Locations for ZFP91 Gene
42,440 bases
Plus strand

Genomic View for ZFP91 Gene

Genes around ZFP91 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZFP91 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZFP91 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFP91 Gene

Proteins for ZFP91 Gene

  • Protein details for ZFP91 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    E3 ubiquitin-protein ligase ZFP91
    Protein Accession:
    Secondary Accessions:
    • A6NHC4
    • A8MSG7
    • Q86V47
    • Q96JP4
    • Q96QA3

    Protein attributes for ZFP91 Gene

    570 amino acids
    Molecular mass:
    63445 Da
    Quaternary structure:
    • Interacts with MAP3K14/NIK.
    • In contrast to other E3 ubiquitin-protein ligase, does not contain any domain (RING-type zinc finger or HECT domain) known to mediate E3 ligase activity.
    • Sequence=AAL09963.1; Type=Frameshift; Positions=72, 80; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ZFP91 Gene

    Alternative splice isoforms for ZFP91 Gene


neXtProt entry for ZFP91 Gene

Post-translational modifications for ZFP91 Gene

No Post-translational modifications

Other Protein References for ZFP91 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZFP91 Gene

Domains & Families for ZFP91 Gene

Gene Families for ZFP91 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZFP91 Gene

Suggested Antigen Peptide Sequences for ZFP91 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZFP91: view

Function for ZFP91 Gene

Molecular function for ZFP91 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
UniProtKB/Swiss-Prot Function:
Atypical E3 ubiquitin-protein ligase that mediates Lys-63-linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK. It thereby acts as an activator of the non-canonical NF-kappa-B2/NFKB2 pathway. May also play an important role in cell proliferation and/or anti-apoptosis.

Enzyme Numbers (IUBMB) for ZFP91 Gene

Phenotypes From GWAS Catalog for ZFP91 Gene

Gene Ontology (GO) - Molecular Function for ZFP91 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0004842 ubiquitin-protein transferase activity IDA 20682767
GO:0016740 transferase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZFP91: view
genes like me logo Genes that share phenotypes with ZFP91: view

miRNA for ZFP91 Gene

miRTarBase miRNAs that target ZFP91

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZFP91 Gene

Localization for ZFP91 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZFP91 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZFP91 gene
Compartment Confidence
nucleus 4

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleus (3)
  • Nucleoli (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZFP91 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with ZFP91: view

Pathways & Interactions for ZFP91 Gene

SuperPathways for ZFP91 Gene

No Data Available

UniProtKB/Swiss-Prot Q96JP5-ZFP91_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

SIGNOR curated interactions for ZFP91 Gene


Gene Ontology (GO) - Biological Process for ZFP91 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007250 activation of NF-kappaB-inducing kinase activity IDA 20682767
GO:0016567 protein ubiquitination IEA --
GO:0070534 protein K63-linked ubiquitination IDA 20682767
genes like me logo Genes that share ontologies with ZFP91: view

No data available for Pathways by source for ZFP91 Gene

Drugs & Compounds for ZFP91 Gene

No Compound Related Data Available

Transcripts for ZFP91 Gene

mRNA/cDNA for ZFP91 Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZFP91 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b
SP1: - - - -
SP2: -
SP3: -

Relevant External Links for ZFP91 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZFP91 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZFP91 Gene

Protein differential expression in normal tissues from HIPED for ZFP91 Gene

This gene is overexpressed in Adrenal (20.4), Lung (11.8), and Testis (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZFP91 Gene

Protein tissue co-expression partners for ZFP91 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZFP91 Gene:


mRNA Expression by UniProt/SwissProt for ZFP91 Gene:

Tissue specificity: Expressed ubiquitously, particularly at high level in testis. Isoform 2 is testis specific.

Evidence on tissue expression from TISSUES for ZFP91 Gene

  • Blood(4.3)
  • Heart(2.5)
  • Muscle(2.5)
genes like me logo Genes that share expression patterns with ZFP91: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZFP91 Gene

Orthologs for ZFP91 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZFP91 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZFP91 33 34
  • 98.35 (n)
(Canis familiaris)
Mammalia -- 34
  • 92 (a)
ZFP91 33
  • 91.74 (n)
(Mus musculus)
Mammalia Zfp91 33 16 34
  • 90.02 (n)
(Rattus norvegicus)
Mammalia Zfp91 33
  • 89.54 (n)
(Bos Taurus)
Mammalia -- 34
  • 89 (a)
ZFP91 33
  • 84.63 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 87 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 83 (a)
(Gallus gallus)
Aves ZFP91 33 34
  • 74.35 (n)
(Anolis carolinensis)
Reptilia -- 34
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia zfp91 33
  • 68.15 (n)
Str.4542 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.24472 33
(Danio rerio)
Actinopterygii ZFP91 34
  • 36 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 13 (a)
Species where no ortholog for ZFP91 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZFP91 Gene

Gene Tree for ZFP91 (if available)
Gene Tree for ZFP91 (if available)

Paralogs for ZFP91 Gene

Paralogs for ZFP91 Gene

(4) SIMAP similar genes for ZFP91 Gene using alignment to 2 proteins: Pseudogenes for ZFP91 Gene

genes like me logo Genes that share paralogs with ZFP91: view

Variants for ZFP91 Gene

Sequence variations from dbSNP and Humsavar for ZFP91 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000069415 -- 58,622,037(+) G/A downstream_transcript_variant
rs1000128669 -- 58,599,161(+) T/C intron_variant
rs1000148222 -- 58,582,084(+) G/C intron_variant
rs1000230816 -- 58,605,444(+) G/A intron_variant
rs1000281474 -- 58,605,172(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZFP91 Gene

Variant ID Type Subtype PubMed ID
nsv528190 CNV loss 19592680
nsv1118212 CNV deletion 24896259
esv3355754 CNV insertion 20981092
esv3304488 CNV mobile element insertion 20981092

Variation tolerance for ZFP91 Gene

Residual Variation Intolerance Score: 55.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.37; 85.45% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZFP91 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZFP91 Gene

Disorders for ZFP91 Gene

Additional Disease Information for ZFP91

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ZFP91 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZFP91 Gene

Publications for ZFP91 Gene

  1. An atypical E3 ligase zinc finger protein 91 stabilizes and activates NF-kappaB-inducing kinase via Lys63-linked ubiquitination. (PMID: 20682767) Jin X … Lee JJ (The Journal of biological chemistry 2010) 2 3 4 58
  2. Identification of a novel human gene, ZFP91, involved in acute myelogenous leukemia. (PMID: 12738986) Unoki M … Nakamura Y (International journal of oncology 2003) 2 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. ZFP91: A Noncanonical NF-κB Signaling Pathway Regulator with Oncogenic Properties Is Overexpressed in Prostate Cancer. (PMID: 27975057) Paschke L … Malendowicz LK (BioMed research international 2016) 3 58

Products for ZFP91 Gene

Sources for ZFP91 Gene

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