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The protein encoded by this gene is a member of the zinc finger family of proteins. The gene product contains C2H2-type domains, which are the classical zinc finger domains found in numerous nucleic acid-binding proteins. This protein functions as a regulator of the non-canonical NF-kappaB pathway in lymphotoxin-beta receptor signaling. Alternative splicing results in multiple transcript variants. A read-through transcript variant composed of ZFP91 and the downstream CNTF gene sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse. A ZFP91-related pseudogene has also been identified on chromosome 2. [provided by RefSeq, Oct 2010]
ZFP91 (ZFP91 Zinc Finger Protein, Atypical E3 Ubiquitin Ligase) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and ubiquitin-protein transferase activity. An important paralog of this gene is ZFP91-CNTF.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH11J058571 | Promoter/Enhancer | 2.7 | EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER | 608.8 | -1.6 | -1562 | 11 | BRCA1 ARHGAP35 SP1 HNRNPL CREB1 GATAD2A CTCF PRDM10 REST ZNF629 | LPXN ZFP91 ZFP91-CNTF ENSG00000269570 ENSG00000255139 OR5B21 ENSG00000197254 CTNND1 CNTF FAM111A | |
GH11J058618 | Promoter | 0.6 | EPDnew | 600.3 | +39.3 | 39341 | 0.1 | CTCF RAD21 HNF4A | piR-45473 ZFP91 CNTF ZFP91-CNTF | |
GH11J058610 | Promoter | 0.4 | EPDnew | 600.3 | +31.9 | 31945 | 0.1 | ZNF513 | ENSG00000269570 MN309357 ZFP91 CNTF ZFP91-CNTF | |
GH11J058611 | Promoter | 0.3 | EPDnew | 600.3 | +32.5 | 32523 | 0.1 | ENSG00000269570 MN309357 ZFP91 CNTF ZFP91-CNTF | ||
GH11J058619 | Promoter | 0.3 | EPDnew | 600.3 | +39.9 | 39914 | 0.1 | piR-45473 ZFP91 CNTF ZFP91-CNTF |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003676 | nucleic acid binding | IEA | -- |
GO:0004842 | ubiquitin-protein transferase activity | IDA | 20682767 |
GO:0016740 | transferase activity | IEA | -- |
GO:0046872 | metal ion binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA | -- |
GO:0005654 | nucleoplasm | IDA | -- |
GO:0005829 | cytosol | IDA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007250 | activation of NF-kappaB-inducing kinase activity | IDA | 20682767 |
GO:0016567 | protein ubiquitination | IEA | -- |
GO:0070534 | protein K63-linked ubiquitination | IDA | 20682767 |
ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b | ^ | 10a | · | 10b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | |||||||||||||||||||||||||||
SP2: | - | ||||||||||||||||||||||||||||||
SP3: | - | ||||||||||||||||||||||||||||||
SP4: | |||||||||||||||||||||||||||||||
SP5: |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ZFP91 30 31 |
|
OneToMany | |
Dog (Canis familiaris) |
Mammalia | -- 31 |
|
OneToMany | |
ZFP91 30 |
|
||||
Mouse (Mus musculus) |
Mammalia | Zfp91 30 17 31 |
|
OneToMany | |
Rat (Rattus norvegicus) |
Mammalia | Zfp91 30 |
|
||
Cow (Bos Taurus) |
Mammalia | -- 31 |
|
OneToMany | |
ZFP91 30 |
|
||||
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
Chicken (Gallus gallus) |
Aves | ZFP91 30 31 |
|
OneToMany | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | zfp91 30 |
|
||
Str.4542 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.24472 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | ZFP91 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs17854702 | - | p.Val37Ile | |||
rs8373 | - | p.Ser207Gly |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3304488 | CNV | mobile element insertion | 20981092 |
esv3355754 | CNV | insertion | 20981092 |
nsv1118212 | CNV | deletion | 24896259 |
nsv528190 | CNV | loss | 19592680 |
No disorders were found for ZFP91 Gene.