Aliases for ZFP90 Gene
External Ids for ZFP90 Gene
Previous GeneCards Identifiers for ZFP90 Gene
This gene encodes a member of the zinc finger protein family that modulates gene expression. The encoded protein derepresses the transcription of certain fetal cardiac genes and may contribute to the genetic reprogramming that occurs during the development of heart failure. Genome wide association studies have identified this gene among ulcerative colitis risk loci. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Mar 2015]
GeneCards Summary for ZFP90 Gene
ZFP90 (ZFP90 Zinc Finger Protein) is a Protein Coding gene. Diseases associated with ZFP90 include Spastic Paraplegia, Optic Atrophy, And Neuropathy and Ulcerative Colitis. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific. An important paralog of this gene is ZFP37.
UniProtKB/Swiss-Prot Summary for ZFP90 Gene
Inhibits the transcriptional repressor activity of REST by inhibiting its binding to DNA, thereby derepressing transcription of REST target genes.
[Isoform 2]: Acts as a bridge between FOXP3 and the corepressor TRIM28, and is required for the transcriptional repressor activity of FOXP3 in regulatory T-cells (Treg).