This gene encodes a member of the zinc finger protein family that modulates gene expression. The encoded protein derepresses the transcription of certain fetal cardiac genes and may contribute to the genetic reprogramming that occurs during the development of heart failure. Genome wide association studies have identified this gene among ulcerative colitis risk loci. Alternative... See more...

Aliases for ZFP90 Gene

Aliases for ZFP90 Gene

  • ZFP90 Zinc Finger Protein 2 3 5
  • ZNF756 2 3 4
  • Zinc Finger Protein 90 Homolog 3 4
  • Zinc Finger Protein 756 3 4
  • KIAA1954 2 4
  • Zfp-90 3 4
  • NK10 2 3
  • FOXP3-Interacting KRAB Domain-Containing Protein 3
  • Zinc Finger Protein 90 Homolog (Mouse) 2
  • Zinc Finger Protein 476 3
  • ZFP90 5
  • FIK 3

External Ids for ZFP90 Gene

Previous GeneCards Identifiers for ZFP90 Gene

  • GC16P068308
  • GC16P068297
  • GC16P068316
  • GC16P067130
  • GC16U900523
  • GC16P068573
  • GC16P054446
  • GC16P068563

Summaries for ZFP90 Gene

Entrez Gene Summary for ZFP90 Gene

  • This gene encodes a member of the zinc finger protein family that modulates gene expression. The encoded protein derepresses the transcription of certain fetal cardiac genes and may contribute to the genetic reprogramming that occurs during the development of heart failure. Genome wide association studies have identified this gene among ulcerative colitis risk loci. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Mar 2015]

GeneCards Summary for ZFP90 Gene

ZFP90 (ZFP90 Zinc Finger Protein) is a Protein Coding gene. Diseases associated with ZFP90 include Spastic Paraplegia, Optic Atrophy, And Neuropathy and Ulcerative Colitis. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific. An important paralog of this gene is ZFP37.

UniProtKB/Swiss-Prot Summary for ZFP90 Gene

  • Inhibits the transcriptional repressor activity of REST by inhibiting its binding to DNA, thereby derepressing transcription of REST target genes.
  • [Isoform 2]: Acts as a bridge between FOXP3 and the corepressor TRIM28, and is required for the transcriptional repressor activity of FOXP3 in regulatory T-cells (Treg).

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZFP90 Gene

Genomics for ZFP90 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZFP90 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZFP90 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZFP90

Top Transcription factor binding sites by QIAGEN in the ZFP90 gene promoter:
  • AhR
  • Arnt
  • c-Rel
  • E47
  • Egr-4
  • Evi-1
  • MyoD
  • NCX
  • Tal-1
  • YY1

Genomic Locations for ZFP90 Gene

Genomic Locations for ZFP90 Gene
chr16:68,530,090-68,576,072
(GRCh38/hg38)
Size:
45,983 bases
Orientation:
Plus strand
chr16:68,563,993-68,609,975
(GRCh37/hg19)
Size:
45,983 bases
Orientation:
Plus strand

Genomic View for ZFP90 Gene

Genes around ZFP90 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZFP90 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZFP90 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFP90 Gene

Proteins for ZFP90 Gene

  • Protein details for ZFP90 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TF47-ZFP90_HUMAN
    Recommended name:
    Zinc finger protein 90 homolog
    Protein Accession:
    Q8TF47
    Secondary Accessions:
    • B2RU00
    • B3KVE7
    • L7S2P3
    • Q49AD1
    • Q96MQ6

    Protein attributes for ZFP90 Gene

    Size:
    636 amino acids
    Molecular mass:
    73031 Da
    Quaternary structure:
    • Interacts (via N- and C-termini) with REST (via zinc-finger DNA-binding domain); the interaction inhibits REST repressor activity (PubMed:21284946).
    • [Isoform 2]: Interacts with FOXP3 and TRIM28 (PubMed:23543754).
    SequenceCaution:
    • Sequence=AX721106; Type=Frameshift; Evidence={ECO:0000305}; Sequence=BAB71228.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAG53759.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};
    Miscellaneous:
    • [Isoform 2]: Interacts (via 75-113 AA) with FOXP3. Interacts (via KRAB domain) with TRIM28.

    Alternative splice isoforms for ZFP90 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZFP90 Gene

Post-translational modifications for ZFP90 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZFP90 Gene

Domains & Families for ZFP90 Gene

Gene Families for ZFP90 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZFP90 Gene

InterPro:
Blocks:
  • C2H2-type zinc finger signature
  • KRAB box
ProtoNet:

Suggested Antigen Peptide Sequences for ZFP90 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ44179 fis, clone THYMU2038189 (Q6ZTW2_HUMAN)
  • Zinc finger protein 756 (ZFP90_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8TF47

UniProtKB/Swiss-Prot:

ZFP90_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZFP90: view

Function for ZFP90 Gene

Molecular function for ZFP90 Gene

UniProtKB/Swiss-Prot Function:
Inhibits the transcriptional repressor activity of REST by inhibiting its binding to DNA, thereby derepressing transcription of REST target genes.
UniProtKB/Swiss-Prot Function:
[Isoform 2]: Acts as a bridge between FOXP3 and the corepressor TRIM28, and is required for the transcriptional repressor activity of FOXP3 in regulatory T-cells (Treg).

Phenotypes From GWAS Catalog for ZFP90 Gene

Gene Ontology (GO) - Molecular Function for ZFP90 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific IEA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IBA 21873635
GO:0043565 sequence-specific DNA binding IBA 21873635
genes like me logo Genes that share ontologies with ZFP90: view
genes like me logo Genes that share phenotypes with ZFP90: view

Animal Model Products

CRISPR Products

miRNA for ZFP90 Gene

miRTarBase miRNAs that target ZFP90

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZFP90

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZFP90 Gene

Localization for ZFP90 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZFP90 Gene

Nucleus. Note=Colocalizes with REST in the nucleus. {ECO:0000250 UniProtKB:Q61967}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZFP90 gene
Compartment Confidence
nucleus 4
plasma membrane 2
cytoskeleton 2
cytosol 2
extracellular 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (2)
  • Plasma membrane (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZFP90 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with ZFP90: view

Pathways & Interactions for ZFP90 Gene

genes like me logo Genes that share pathways with ZFP90: view

Pathways by source for ZFP90 Gene

2 Reactome pathways for ZFP90 Gene
1 KEGG pathway for ZFP90 Gene

Gene Ontology (GO) - Biological Process for ZFP90 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IBA 21873635
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0043392 negative regulation of DNA binding IEA --
GO:0045892 negative regulation of transcription, DNA-templated IBA 21873635
GO:0045893 positive regulation of transcription, DNA-templated IBA,IMP 21284946
genes like me logo Genes that share ontologies with ZFP90: view

No data available for SIGNOR curated interactions for ZFP90 Gene

Drugs & Compounds for ZFP90 Gene

No Compound Related Data Available

Transcripts for ZFP90 Gene

mRNA/cDNA for ZFP90 Gene

6 REFSEQ mRNAs :
17 NCBI additional mRNA sequence :
19 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZFP90

Alternative Splicing Database (ASD) splice patterns (SP) for ZFP90 Gene

No ASD Table

Relevant External Links for ZFP90 Gene

GeneLoc Exon Structure for
ZFP90

Expression for ZFP90 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZFP90 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZFP90 Gene

This gene is overexpressed in CD8 Tcells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZFP90 Gene



Protein tissue co-expression partners for ZFP90 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZFP90

SOURCE GeneReport for Unigene cluster for ZFP90 Gene:

Hs.461074

mRNA Expression by UniProt/SwissProt for ZFP90 Gene:

Q8TF47-ZFP90_HUMAN
Tissue specificity: Expressed in heart (PubMed:21284946). Isoform 2: Highly expressed in regulatory T-cells (Treg) (PubMed:23543754).

Evidence on tissue expression from TISSUES for ZFP90 Gene

  • Nervous system(4.8)
  • Intestine(3.4)
  • Lung(2.7)
  • Skin(2.1)
  • Heart(2)
genes like me logo Genes that share expression patterns with ZFP90: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZFP90 Gene

Orthologs for ZFP90 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZFP90 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZFP90 30 31
  • 99.69 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ZFP90 30 31
  • 91.49 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ZFP90 30 31
  • 90.01 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Zfp90 30
  • 84.99 (n)
Mouse
(Mus musculus)
Mammalia Zfp90 30 17 31
  • 83.12 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 52 (a)
OneToMany
Species where no ortholog for ZFP90 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZFP90 Gene

ENSEMBL:
Gene Tree for ZFP90 (if available)
TreeFam:
Gene Tree for ZFP90 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZFP90: view image

Paralogs for ZFP90 Gene

(470) SIMAP similar genes for ZFP90 Gene using alignment to 9 proteins:

  • ZFP90_HUMAN
  • H3BMI1_HUMAN
  • H3BVC6_HUMAN
  • I3L0T2_HUMAN
  • I3L0X7_HUMAN
  • I3L1L4_HUMAN
  • I3L2Q3_HUMAN
  • I3L3M0_HUMAN
  • J3QKQ8_HUMAN
genes like me logo Genes that share paralogs with ZFP90: view

Variants for ZFP90 Gene

Additional dbSNP identifiers (rs#s) for ZFP90 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZFP90 Gene

Variant ID Type Subtype PubMed ID
nsv457515 CNV gain 19166990
nsv476841 CNV novel sequence insertion 20440878
nsv572908 CNV gain 21841781

Variation tolerance for ZFP90 Gene

Residual Variation Intolerance Score: 25.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.21; 24.39% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZFP90 Gene

Human Gene Mutation Database (HGMD)
ZFP90
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZFP90

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZFP90 Gene

Disorders for ZFP90 Gene

MalaCards: The human disease database

(4) MalaCards diseases for ZFP90 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
spastic paraplegia, optic atrophy, and neuropathy
  • spoan
ulcerative colitis
  • left-sided ulcerative colitis
colitis
desmoid disease, hereditary
  • desmd
- elite association - COSMIC cancer census association via MalaCards
Search ZFP90 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ZFP90

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with ZFP90: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZFP90 Gene

Publications for ZFP90 Gene

  1. Developmentally regulated mouse gene NK10 encodes a zinc finger repressor protein with differential DNA-binding domains. (PMID: 7576184) Lange R … Heinlein UA (DNA and cell biology 1995) 2 3 23
  2. Zinc-finger protein 90 negatively regulates neuron-restrictive silencer factor-mediated transcriptional repression of fetal cardiac genes. (PMID: 21284946) Hata L … Nakao K (Journal of molecular and cellular cardiology 2011) 3 4
  3. Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. (PMID: 21297633) Anderson CA … Rioux JD (Nature genetics 2011) 3 41
  4. Genomewide association study for determinants of HIV-1 acquisition and viral set point in HIV-1 serodiscordant couples with quantified virus exposure. (PMID: 22174851) Lingappa JR … Partners in Prevention HSV/HIV Transmission Study Team (PloS one 2011) 3 41
  5. Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia. (PMID: 21107309) McClay JL … van den Oord EJ (Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2011) 3 41

Products for ZFP90 Gene

Sources for ZFP90 Gene