Aliases for ZFP69B Gene

Aliases for ZFP69B Gene

  • ZFP69 Zinc Finger Protein B 2 3 5
  • Zinc Finger Protein 643 2 3 4
  • Zinc Finger Protein 69 Homolog B 3 4
  • ZNF643 3 4
  • Zinc Finger Protein ZFP69B 3
  • Novel Zinc Finger Protein 3
  • ZKSCAN23B 3
  • ZSCAN54B 3

External Ids for ZFP69B Gene

Previous HGNC Symbols for ZFP69B Gene

  • ZNF643

Previous GeneCards Identifiers for ZFP69B Gene

  • GC01P040916

Summaries for ZFP69B Gene

GeneCards Summary for ZFP69B Gene

ZFP69B (ZFP69 Zinc Finger Protein B) is a Protein Coding gene. Diseases associated with ZFP69B include Vitreous Syneresis. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity. An important paralog of this gene is ZFP69.

UniProtKB/Swiss-Prot Summary for ZFP69B Gene

  • May be involved in transcriptional regulation. Essential for Golgi structural integrity (PubMed:29851555).

Additional gene information for ZFP69B Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZFP69B Gene

Genomics for ZFP69B Gene

GeneHancer (GH) Regulatory Elements for ZFP69B Gene

Promoters and enhancers for ZFP69B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZFP69B on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZFP69B

Genomic Locations for ZFP69B Gene

Genomic Locations for ZFP69B Gene
chr1:40,450,086-40,463,718
(GRCh38/hg38)
Size:
13,633 bases
Orientation:
Plus strand
chr1:40,915,774-40,929,390
(GRCh37/hg19)
Size:
13,617 bases
Orientation:
Plus strand

Genomic View for ZFP69B Gene

Genes around ZFP69B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZFP69B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZFP69B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFP69B Gene

Proteins for ZFP69B Gene

  • Protein details for ZFP69B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UJL9-ZF69B_HUMAN
    Recommended name:
    Zinc finger protein 69 homolog B
    Protein Accession:
    Q9UJL9
    Secondary Accessions:
    • Q5QPL4

    Protein attributes for ZFP69B Gene

    Size:
    534 amino acids
    Molecular mass:
    61481 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH17498.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZFP69B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZFP69B Gene

Post-translational modifications for ZFP69B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZFP69B Gene

No data available for DME Specific Peptides for ZFP69B Gene

Domains & Families for ZFP69B Gene

Gene Families for ZFP69B Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZFP69B Gene

Blocks:
  • KRAB box
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZFP69B Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 643, isoform CRA_b (D3DPV3_HUMAN)
  • Zinc finger protein 643 (Q5QPL3_HUMAN)
  • Zinc finger protein 643 (ZN643_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9UJL9

UniProtKB/Swiss-Prot:

ZF69B_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZFP69B: view

Function for ZFP69B Gene

Molecular function for ZFP69B Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation. Essential for Golgi structural integrity (PubMed:29851555).
UniProtKB/Swiss-Prot Induction:
Up-regulated by Golgi stress-inducing agent nigericin.

Phenotypes From GWAS Catalog for ZFP69B Gene

Gene Ontology (GO) - Molecular Function for ZFP69B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IBA 21873635
GO:0005515 protein binding IPI 25416956
GO:0043565 sequence-specific DNA binding IBA 21873635
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZFP69B: view
genes like me logo Genes that share phenotypes with ZFP69B: view

Animal Model Products

CRISPR Products

miRNA for ZFP69B Gene

miRTarBase miRNAs that target ZFP69B

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZFP69B

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZFP69B Gene

Localization for ZFP69B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZFP69B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZFP69B gene
Compartment Confidence
nucleus 4
cytosol 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZFP69B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with ZFP69B: view

Pathways & Interactions for ZFP69B Gene

genes like me logo Genes that share pathways with ZFP69B: view

Pathways by source for ZFP69B Gene

2 Reactome pathways for ZFP69B Gene
1 KEGG pathway for ZFP69B Gene

Interacting Proteins for ZFP69B Gene

;

Gene Ontology (GO) - Biological Process for ZFP69B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZFP69B: view

No data available for SIGNOR curated interactions for ZFP69B Gene

Drugs & Compounds for ZFP69B Gene

No Compound Related Data Available

Transcripts for ZFP69B Gene

mRNA/cDNA for ZFP69B Gene

2 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZFP69B

Alternative Splicing Database (ASD) splice patterns (SP) for ZFP69B Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c
SP1:
SP2: - -
SP3:
SP4: -

Relevant External Links for ZFP69B Gene

GeneLoc Exon Structure for
ZFP69B

Expression for ZFP69B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZFP69B Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZFP69B

SOURCE GeneReport for Unigene cluster for ZFP69B Gene:

Hs.133034
genes like me logo Genes that share expression patterns with ZFP69B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZFP69B Gene

Orthologs for ZFP69B Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZFP69B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZFP69B 31
  • 99 (a)
OneToOne
ZNF643 30
  • 99 (n)
dog
(Canis familiaris)
Mammalia ZNF643 30
  • 89.58 (n)
ZFP69B 31
  • 87 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZFP69B 30
  • 87.85 (n)
-- 31
  • 16 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 42 (a)
OneToMany
Species where no ortholog for ZFP69B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZFP69B Gene

ENSEMBL:
Gene Tree for ZFP69B (if available)
TreeFam:
Gene Tree for ZFP69B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZFP69B: view image

Paralogs for ZFP69B Gene

(457) SIMAP similar genes for ZFP69B Gene using alignment to 2 proteins:

  • ZF69B_HUMAN
  • E9PS66_HUMAN
genes like me logo Genes that share paralogs with ZFP69B: view

Variants for ZFP69B Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZFP69B Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
773395 Likely Benign: not provided 40,462,880(+) G/A MISSENSE_VARIANT
rs12407929 - p.Gly359Arg
rs2272994 - p.Cys115Tyr

Additional dbSNP identifiers (rs#s) for ZFP69B Gene

Structural Variations from Database of Genomic Variants (DGV) for ZFP69B Gene

Variant ID Type Subtype PubMed ID
esv2763289 CNV loss 21179565
nsv546064 CNV gain 21841781

Variation tolerance for ZFP69B Gene

Residual Variation Intolerance Score: 89.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.16; 80.78% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZFP69B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZFP69B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZFP69B Gene

Disorders for ZFP69B Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZFP69B Gene - From: DISEASES

Disorder Aliases PubMed IDs
vitreous syneresis
  • vitreous degeneration
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZFP69B

genes like me logo Genes that share disorders with ZFP69B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZFP69B Gene

Publications for ZFP69B Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  2. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R … Stanton LW (Nature biotechnology 2004) 3 4 54
  3. Targeted protein unfolding uncovers a Golgi-specific transcriptional stress response. (PMID: 29851555) Serebrenik YV … Crews CM (Molecular biology of the cell 2018) 4 54
  4. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 54
  5. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R … Boisvert FM (Molecular & cellular proteomics : MCP 2015) 3 54

Products for ZFP69B Gene

Sources for ZFP69B Gene