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Aliases for ZFP69B Gene

Aliases for ZFP69B Gene

  • ZFP69 Zinc Finger Protein B 2 3 5
  • Zinc Finger Protein 643 2 3 4
  • ZNF643 3 4
  • Zinc Finger Protein ZFP69B 3
  • Novel Zinc Finger Protein 3
  • ZKSCAN23B 3
  • ZSCAN54B 3

External Ids for ZFP69B Gene

Previous HGNC Symbols for ZFP69B Gene

  • ZNF643

Previous GeneCards Identifiers for ZFP69B Gene

  • GC01P040916

Summaries for ZFP69B Gene

GeneCards Summary for ZFP69B Gene

ZFP69B (ZFP69 Zinc Finger Protein B) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA binding transcription factor activity. An important paralog of this gene is ZFP69.

UniProtKB/Swiss-Prot for ZFP69B Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZFP69B Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZFP69B Gene

Genomics for ZFP69B Gene

GeneHancer (GH) Regulatory Elements for ZFP69B Gene

Promoters and enhancers for ZFP69B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J040449 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.7 +0.5 504 2.5 HDGF PKNOX1 ARID4B SIN3A ZNF2 IRF4 YY1 POLR2B CBX5 ZNF207 ENSG00000284677 ZFP69B EXO5 LOC105378672 PPIEL ZFP69 PPIE ENSG00000227278 ENSG00000238186 RLF
GH01J040406 Promoter/Enhancer 0.7 EPDnew dbSUPER 650.3 -43.3 -43295 0.1 ZFP69B GC01P040432 GC01M040364 SMAP2
GH01J040421 Enhancer 1.3 Ensembl ENCODE dbSUPER 12.9 -27.5 -27495 2.5 FOXA2 MLX ARID4B FEZF1 DMAP1 ZNF48 ETS1 YY1 NFKBIZ RXRA ZFP69 PPIE EXO5 ZFP69B NFYC SMAP2 ENSG00000227278 ENSG00000238186 LOC105378672 LOC101929516
GH01J040413 Enhancer 0.9 ENCODE dbSUPER 12 -35.8 -35815 1.7 SOX13 IRF2 FOXA2 ZNF644 RARA ZNF205 RERE NR2F6 CREM SOX5 SMAP2 ZFP69B COL9A2 EXO5 LOC105378672 ENSG00000231296 ZMPSTE24 ZFP69 RLF HEYL
GH01J040140 Enhancer 0.9 Ensembl ENCODE 11.3 -309.7 -309726 0.3 CTBP1 GATA3 ZNF350 ZNF444 RCOR1 HLF CEBPB ELF1 DPF2 GATAD2B RLF ZFP69B COL9A2 PPT1 EXO5 ZMPSTE24 ENSG00000231296 TMCO2 PPIE PPIEL
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZFP69B on UCSC Golden Path with GeneCards custom track

Genomic Locations for ZFP69B Gene

Genomic Locations for ZFP69B Gene
13,633 bases
Plus strand
13,617 bases
Plus strand

Genomic View for ZFP69B Gene

Genes around ZFP69B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZFP69B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZFP69B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFP69B Gene

Proteins for ZFP69B Gene

  • Protein details for ZFP69B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein ZFP69B
    Protein Accession:
    Secondary Accessions:
    • Q5QPL4

    Protein attributes for ZFP69B Gene

    534 amino acids
    Molecular mass:
    61481 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH17498.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAI19856.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ZFP69B Gene


neXtProt entry for ZFP69B Gene

Post-translational modifications for ZFP69B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZFP69B Gene

No data available for DME Specific Peptides for ZFP69B Gene

Domains & Families for ZFP69B Gene

Gene Families for ZFP69B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZFP69B Gene

Suggested Antigen Peptide Sequences for ZFP69B Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZFP69B: view

Function for ZFP69B Gene

Molecular function for ZFP69B Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZFP69B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IEA,IBA --
GO:0005515 protein binding IPI 25416956
GO:0043565 sequence-specific DNA binding IBA --
genes like me logo Genes that share ontologies with ZFP69B: view
genes like me logo Genes that share phenotypes with ZFP69B: view

Animal Model Products

CRISPR Products

miRNA for ZFP69B Gene

miRTarBase miRNAs that target ZFP69B

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZFP69B

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZFP69B Gene

Localization for ZFP69B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZFP69B Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZFP69B gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZFP69B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZFP69B: view

Pathways & Interactions for ZFP69B Gene

SuperPathways for ZFP69B Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZFP69B: view

Pathways by source for ZFP69B Gene

2 Reactome pathways for ZFP69B Gene

Gene Ontology (GO) - Biological Process for ZFP69B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZFP69B: view

No data available for SIGNOR curated interactions for ZFP69B Gene

Drugs & Compounds for ZFP69B Gene

No Compound Related Data Available

Transcripts for ZFP69B Gene

mRNA/cDNA for ZFP69B Gene

(6) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(18) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZFP69B Gene

ZFP69 zinc finger protein B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZFP69B

Alternative Splicing Database (ASD) splice patterns (SP) for ZFP69B Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c
SP2: - -
SP4: -

Relevant External Links for ZFP69B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZFP69B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZFP69B Gene

NURSA nuclear receptor signaling pathways regulating expression of ZFP69B Gene:


SOURCE GeneReport for Unigene cluster for ZFP69B Gene:

genes like me logo Genes that share expression patterns with ZFP69B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZFP69B Gene

Orthologs for ZFP69B Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZFP69B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZFP69B 34
  • 99 (a)
ZNF643 33
  • 99 (n)
(Canis familiaris)
Mammalia ZNF643 33
  • 89.58 (n)
ZFP69B 34
  • 87 (a)
(Bos Taurus)
Mammalia ZFP69B 33
  • 87.85 (n)
-- 34
  • 16 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 42 (a)
Species where no ortholog for ZFP69B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZFP69B Gene

Gene Tree for ZFP69B (if available)
Gene Tree for ZFP69B (if available)
Evolutionary constrained regions (ECRs) for ZFP69B: view image

Paralogs for ZFP69B Gene

Paralogs for ZFP69B Gene

(457) SIMAP similar genes for ZFP69B Gene using alignment to 2 proteins:

  • E9PS66_HUMAN
genes like me logo Genes that share paralogs with ZFP69B: view

Variants for ZFP69B Gene

Sequence variations from dbSNP and Humsavar for ZFP69B Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000057720 -- 40,452,814(+) C/T intron_variant
rs1000088450 -- 40,452,495(+) C/T intron_variant
rs1000354739 -- 40,459,277(+) T/G intron_variant
rs1000360370 -- 40,465,263(+) A/G 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000694220 -- 40,464,072(+) C/G/T 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ZFP69B Gene

Variant ID Type Subtype PubMed ID
esv2763289 CNV loss 21179565
nsv546064 CNV gain 21841781

Variation tolerance for ZFP69B Gene

Residual Variation Intolerance Score: 89.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.16; 80.78% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZFP69B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZFP69B Gene

Disorders for ZFP69B Gene

Additional Disease Information for ZFP69B

No disorders were found for ZFP69B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZFP69B Gene

Publications for ZFP69B Gene

  1. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R … Stanton LW (Nature biotechnology 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 58
  4. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R … Boisvert FM (Molecular & cellular proteomics : MCP 2015) 3 58
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58

Products for ZFP69B Gene

Sources for ZFP69B Gene

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