Aliases for ZFP69 Gene

Aliases for ZFP69 Gene

  • ZFP69 Zinc Finger Protein 2 3 5
  • Zinc Finger Protein 642 2 3 4
  • Zinc Finger Protein 69 Homolog 3 4
  • ZFP69 Zinc Finger Protein A 2 3
  • ZKSCAN23A 2 3
  • ZSCAN54A 2 3
  • ZFP69A 2 3
  • ZNF642 3 4
  • Zinc Finger Protein ZFP69 3
  • FLJ16030 2
  • ZFP69 5

External Ids for ZFP69 Gene

Previous HGNC Symbols for ZFP69 Gene

  • ZNF642

Previous GeneCards Identifiers for ZFP69 Gene

  • GC01P040943

Summaries for ZFP69 Gene

GeneCards Summary for ZFP69 Gene

ZFP69 (ZFP69 Zinc Finger Protein) is a Protein Coding gene. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZFP69B.

UniProtKB/Swiss-Prot Summary for ZFP69 Gene

  • Putative transcription factor that appears to regulate lipid metabolism.

Additional gene information for ZFP69 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZFP69 Gene

Genomics for ZFP69 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZFP69 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZFP69 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZFP69

Genomic Locations for ZFP69 Gene

Genomic Locations for ZFP69 Gene
chr1:40,477,220-40,496,343
(GRCh38/hg38)
Size:
19,124 bases
Orientation:
Plus strand
chr1:40,942,887-40,962,015
(GRCh37/hg19)
Size:
19,129 bases
Orientation:
Plus strand

Genomic View for ZFP69 Gene

Genes around ZFP69 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZFP69 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZFP69 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFP69 Gene

Proteins for ZFP69 Gene

  • Protein details for ZFP69 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q49AA0-ZFP69_HUMAN
    Recommended name:
    Zinc finger protein 69 homolog
    Protein Accession:
    Q49AA0
    Secondary Accessions:
    • Q5SWM5
    • Q6ZWK8

    Protein attributes for ZFP69 Gene

    Size:
    526 amino acids
    Molecular mass:
    61181 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC85492.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};

neXtProt entry for ZFP69 Gene

Post-translational modifications for ZFP69 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZFP69 Gene

No data available for DME Specific Peptides for ZFP69 Gene

Domains & Families for ZFP69 Gene

Gene Families for ZFP69 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZFP69 Gene

InterPro:
Blocks:
  • KRAB box
ProtoNet:

Suggested Antigen Peptide Sequences for ZFP69 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 642 (ZN642_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q49AA0

UniProtKB/Swiss-Prot:

ZFP69_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZFP69: view

Function for ZFP69 Gene

Molecular function for ZFP69 Gene

UniProtKB/Swiss-Prot Function:
Putative transcription factor that appears to regulate lipid metabolism.
UniProtKB/Swiss-Prot Induction:
Up-regulated in both visceral and subcutaneous adipose tissue of diabetic individuals.

Phenotypes From GWAS Catalog for ZFP69 Gene

Gene Ontology (GO) - Molecular Function for ZFP69 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IBA 21873635
GO:0043565 sequence-specific DNA binding IBA 21873635
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZFP69: view
genes like me logo Genes that share phenotypes with ZFP69: view

Animal Model Products

CRISPR Products

miRNA for ZFP69 Gene

miRTarBase miRNAs that target ZFP69

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZFP69

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZFP69 Gene

Localization for ZFP69 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZFP69 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZFP69 gene
Compartment Confidence
nucleus 5
cytoskeleton 2
cytosol 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZFP69 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,ISS --
genes like me logo Genes that share ontologies with ZFP69: view

Pathways & Interactions for ZFP69 Gene

genes like me logo Genes that share pathways with ZFP69: view

Pathways by source for ZFP69 Gene

2 Reactome pathways for ZFP69 Gene
1 KEGG pathway for ZFP69 Gene

Interacting Proteins for ZFP69 Gene

Gene Ontology (GO) - Biological Process for ZFP69 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006629 lipid metabolic process IEA --
GO:0019216 regulation of lipid metabolic process ISS --
genes like me logo Genes that share ontologies with ZFP69: view

No data available for SIGNOR curated interactions for ZFP69 Gene

Drugs & Compounds for ZFP69 Gene

No Compound Related Data Available

Transcripts for ZFP69 Gene

mRNA/cDNA for ZFP69 Gene

3 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZFP69

Alternative Splicing Database (ASD) splice patterns (SP) for ZFP69 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b
SP1: - -
SP2: - - -
SP3:
SP4:

Relevant External Links for ZFP69 Gene

GeneLoc Exon Structure for
ZFP69

Expression for ZFP69 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZFP69 Gene

Protein differential expression in normal tissues from HIPED for ZFP69 Gene

This gene is overexpressed in Rectum (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZFP69 Gene



Protein tissue co-expression partners for ZFP69 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZFP69

SOURCE GeneReport for Unigene cluster for ZFP69 Gene:

Hs.434385

mRNA Expression by UniProt/SwissProt for ZFP69 Gene:

Q49AA0-ZFP69_HUMAN
Tissue specificity: Expressed in visceral and subcutaneous adipose tissue.
genes like me logo Genes that share expression patterns with ZFP69: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZFP69 Gene

Orthologs for ZFP69 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZFP69 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF642 30 31
  • 99.75 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ZFP69 30 31
  • 89.93 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ZNF642 30
  • 89.25 (n)
-- 31
  • 11 (a)
ManyToMany
Rat
(Rattus norvegicus)
Mammalia Zfp69 30
  • 79.46 (n)
Mouse
(Mus musculus)
Mammalia Zfp69 30 17 31
  • 78.21 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 40 (a)
OneToMany
Species where no ortholog for ZFP69 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZFP69 Gene

ENSEMBL:
Gene Tree for ZFP69 (if available)
TreeFam:
Gene Tree for ZFP69 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZFP69: view image

Paralogs for ZFP69 Gene

(461) SIMAP similar genes for ZFP69 Gene using alignment to 1 proteins:

  • ZFP69_HUMAN
genes like me logo Genes that share paralogs with ZFP69: view

Variants for ZFP69 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZFP69 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
767668 Benign: not provided 40,489,205(+) G/C MISSENSE_VARIANT
rs34752670 - p.Val113Leu

Additional dbSNP identifiers (rs#s) for ZFP69 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZFP69 Gene

Variant ID Type Subtype PubMed ID
esv2597296 CNV deletion 19546169
nsv1160834 CNV deletion 26073780
nsv546064 CNV gain 21841781

Variation tolerance for ZFP69 Gene

Residual Variation Intolerance Score: 86.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.32; 41.32% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZFP69 Gene

Human Gene Mutation Database (HGMD)
ZFP69
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZFP69

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZFP69 Gene

Disorders for ZFP69 Gene

No disorders were found for ZFP69 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZFP69 Gene

Publications for ZFP69 Gene

  1. Positional cloning of zinc finger domain transcription factor Zfp69, a candidate gene for obesity-associated diabetes contributed by mouse locus Nidd/SJL. (PMID: 19578398) Scherneck S … Joost HG (PLoS genetics 2009) 3 4
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for ZFP69 Gene

Sources for ZFP69 Gene