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Aliases for ZFP69 Gene

Aliases for ZFP69 Gene

  • ZFP69 Zinc Finger Protein 2 3 5
  • Zinc Finger Protein 642 2 3 4
  • ZFP69 Zinc Finger Protein A 2 3
  • ZNF642 3 4
  • Zinc Finger Protein ZFP69 3
  • ZKSCAN23A 3
  • ZSCAN54A 3
  • ZFP69A 3

External Ids for ZFP69 Gene

Previous HGNC Symbols for ZFP69 Gene

  • ZNF642

Previous GeneCards Identifiers for ZFP69 Gene

  • GC01P040943

Summaries for ZFP69 Gene

GeneCards Summary for ZFP69 Gene

ZFP69 (ZFP69 Zinc Finger Protein) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZFP69B.

UniProtKB/Swiss-Prot for ZFP69 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZFP69 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZFP69 Gene

Genomics for ZFP69 Gene

GeneHancer (GH) Regulatory Elements for ZFP69 Gene

Promoters and enhancers for ZFP69 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I040476 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 564.2 +0.3 303 1.4 PKNOX1 ARID4B SIN3A ZNF2 POLR2B E2F8 ZNF207 ZNF143 SP3 SP5 ZFP69 EXO5 PPIE PPIEL TRIT1 LOC105378672 ENSG00000227278 ENSG00000238186 ZNF684 RLF
GH01I040690 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 16.4 +215.5 215486 4.4 ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 SP3 NFYC MEF2D RIMS3 NFYC-AS1 NFYC ENSG00000259943 EXO5 TRIT1 LOC105378674 ZFP69 SLFNL1 MIR30C1
GH01I040372 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 13.1 -101.4 -101362 5.9 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A FEZF1 ZNF2 YY1 SLC30A9 SMAP2 PPIEL EXO5 PPIE TRIT1 ENSG00000259943 ENSG00000182109 NFYC-AS1 RLF NFYC
GH01I040421 Enhancer 1.3 Ensembl ENCODE dbSUPER 23.8 -54.6 -54624 2.5 FOXA2 MLX ARID4B FEZF1 DMAP1 ZNF48 ETS1 YY1 RXRA NFYC ZFP69 EXO5 PPIE ZFP69B SMAP2 ENSG00000227278 ENSG00000238186 LOC105378672 GC01P040432 GC01M040364
GH01I040449 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 13.7 -26.6 -26625 2.5 HDGF PKNOX1 ARID4B SIN3A ZNF2 IRF4 YY1 POLR2B CBX5 ZNF207 ENSG00000284677 ZFP69B LOC105378672 ZFP69 EXO5 ENSG00000227278 ENSG00000238186 ZNF684 OXCT2 ENSG00000260920
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZFP69 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ZFP69 Gene

Genomic Locations for ZFP69 Gene
chr1:40,477,215-40,496,343
(GRCh38/hg38)
Size:
19,129 bases
Orientation:
Plus strand
chr1:40,942,887-40,962,015
(GRCh37/hg19)

Genomic View for ZFP69 Gene

Genes around ZFP69 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZFP69 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZFP69 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFP69 Gene

Proteins for ZFP69 Gene

  • Protein details for ZFP69 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q49AA0-ZFP69_HUMAN
    Recommended name:
    Zinc finger protein ZFP69
    Protein Accession:
    Q49AA0
    Secondary Accessions:
    • Q5SWM5
    • Q6ZWK8

    Protein attributes for ZFP69 Gene

    Size:
    526 amino acids
    Molecular mass:
    61181 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC85492.1; Type=Erroneous termination; Positions=506; Note=Translated as Tyr.; Evidence={ECO:0000305};

neXtProt entry for ZFP69 Gene

Post-translational modifications for ZFP69 Gene

No Post-translational modifications

Other Protein References for ZFP69 Gene

No data available for DME Specific Peptides for ZFP69 Gene

Domains & Families for ZFP69 Gene

Gene Families for ZFP69 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZFP69 Gene

Suggested Antigen Peptide Sequences for ZFP69 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q49AA0

UniProtKB/Swiss-Prot:

ZFP69_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZFP69: view

Function for ZFP69 Gene

Molecular function for ZFP69 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZFP69 Gene

Gene Ontology (GO) - Molecular Function for ZFP69 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZFP69: view
genes like me logo Genes that share phenotypes with ZFP69: view

miRNA for ZFP69 Gene

miRTarBase miRNAs that target ZFP69

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZFP69 Gene

Localization for ZFP69 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZFP69 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZFP69 gene
Compartment Confidence
nucleus 5
cytoskeleton 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZFP69 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZFP69: view

Pathways & Interactions for ZFP69 Gene

SuperPathways for ZFP69 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZFP69: view

Pathways by source for ZFP69 Gene

2 Reactome pathways for ZFP69 Gene

Interacting Proteins for ZFP69 Gene

Gene Ontology (GO) - Biological Process for ZFP69 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZFP69: view

No data available for SIGNOR curated interactions for ZFP69 Gene

Drugs & Compounds for ZFP69 Gene

No Compound Related Data Available

Transcripts for ZFP69 Gene

mRNA/cDNA for ZFP69 Gene

Unigene Clusters for ZFP69 Gene

ZFP69 zinc finger protein:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZFP69 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b
SP1: - -
SP2: - - -
SP3:
SP4:

Relevant External Links for ZFP69 Gene

GeneLoc Exon Structure for
ZFP69
ECgene alternative splicing isoforms for
ZFP69

Expression for ZFP69 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZFP69 Gene

Protein differential expression in normal tissues from HIPED for ZFP69 Gene

This gene is overexpressed in Rectum (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZFP69 Gene



Protein tissue co-expression partners for ZFP69 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZFP69 Gene:

ZFP69

SOURCE GeneReport for Unigene cluster for ZFP69 Gene:

Hs.434385
genes like me logo Genes that share expression patterns with ZFP69: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZFP69 Gene

Orthologs for ZFP69 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZFP69 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF642 33 34
  • 99.75 (n)
cow
(Bos Taurus)
Mammalia ZFP69 33 34
  • 89.93 (n)
dog
(Canis familiaris)
Mammalia ZNF642 33
  • 89.25 (n)
-- 34
  • 11 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Zfp69 33
  • 79.46 (n)
mouse
(Mus musculus)
Mammalia Zfp69 33 16 34
  • 78.21 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 40 (a)
OneToMany
Species where no ortholog for ZFP69 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZFP69 Gene

ENSEMBL:
Gene Tree for ZFP69 (if available)
TreeFam:
Gene Tree for ZFP69 (if available)

Paralogs for ZFP69 Gene

Paralogs for ZFP69 Gene

(461) SIMAP similar genes for ZFP69 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZFP69: view

Variants for ZFP69 Gene

Sequence variations from dbSNP and Humsavar for ZFP69 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000119744 -- 40,490,971(+) G/A intron_variant
rs1000602900 -- 40,475,797(+) G/A upstream_transcript_variant
rs1000988784 -- 40,475,398(+) C/G upstream_transcript_variant
rs1001054163 -- 40,493,049(+) A/C intron_variant
rs1001513992 -- 40,481,977(+) C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZFP69 Gene

Variant ID Type Subtype PubMed ID
nsv546064 CNV gain 21841781
nsv1160834 CNV deletion 26073780
esv2597296 CNV deletion 19546169

Variation tolerance for ZFP69 Gene

Residual Variation Intolerance Score: 86.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.32; 41.32% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZFP69 Gene

Human Gene Mutation Database (HGMD)
ZFP69
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZFP69

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZFP69 Gene

Disorders for ZFP69 Gene

Additional Disease Information for ZFP69

No disorders were found for ZFP69 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZFP69 Gene

Publications for ZFP69 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 58
  5. Positional cloning of zinc finger domain transcription factor Zfp69, a candidate gene for obesity-associated diabetes contributed by mouse locus Nidd/SJL. (PMID: 19578398) Scherneck S … Joost HG (PLoS genetics 2009) 3 58

Products for ZFP69 Gene

Sources for ZFP69 Gene

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