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Aliases for ZFP64 Gene

Aliases for ZFP64 Gene

  • ZFP64 Zinc Finger Protein 2 3 5
  • Zinc Finger Protein 338 2 3 4
  • Zinc Finger Protein 64 2 3
  • ZNF338 3 4
  • Zinc Finger Protein 64 Homolog (Mouse) 2
  • Zinc Finger Protein 64 Homolog 3
  • Zfp-64 4

External Ids for ZFP64 Gene

Previous HGNC Symbols for ZFP64 Gene

  • ZNF338

Previous GeneCards Identifiers for ZFP64 Gene

  • GC20U990053
  • GC20M050388
  • GC20M051338
  • GC20M051385
  • GC20M050133
  • GC20M050668
  • GC20M047448

Summaries for ZFP64 Gene

GeneCards Summary for ZFP64 Gene

ZFP64 (ZFP64 Zinc Finger Protein) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF335.

UniProtKB/Swiss-Prot for ZFP64 Gene

  • May be involved in transcriptional regulation.

Gene Wiki entry for ZFP64 Gene

Additional gene information for ZFP64 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZFP64 Gene

Genomics for ZFP64 Gene

GeneHancer (GH) Regulatory Elements for ZFP64 Gene

Promoters and enhancers for ZFP64 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J052190 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 657.9 +12.5 12523 2.9 HDGF ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF766 ZNF143 FOS KLF13 ZFP64 GC20P052171
GH20J052971 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 36.4 -771.8 -771764 8.6 PKNOX1 FOXA2 ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF213 ZNF416 ZNF548 TSHZ2 GC20M052871 ZFP64 ENSG00000232465 ENSG00000225785 LOC105372672 ENSG00000225563 LINC01524 ENSG00000232294
GH20J051539 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 29.2 +662.9 662937 3.7 HDGF PKNOX1 SMAD1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZBTB7B NFATC2 ADNP ZFP64 PSMD10P1 DPM1 MOCS3 ENSG00000232043 GC20M051470
GH20J051797 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 12.9 +404.0 404036 6 HDGF PKNOX1 ARID4B NEUROD1 SIN3A FEZF1 ZBTB7B YY1 ZNF213 E2F8 SALL4 DPM1 ADNP MOCS3 ZFP64 PSMD10P1 RNU7-6P ATP9A PIR39254 GC20M051835
GH20J051560 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 13.1 +641.7 641693 4.2 FOXA2 NEUROD1 SIN3A ZNF2 ZBTB7B FOS SP3 MXD4 REST ZNF592 NFATC2 ZFP64 ADNP DPM1 GC20M051470
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZFP64 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZFP64 gene promoter:

Genomic Locations for ZFP64 Gene

Genomic Locations for ZFP64 Gene
chr20:52,051,663-52,204,308
(GRCh38/hg38)
Size:
152,646 bases
Orientation:
Minus strand
chr20:50,668,202-50,820,847
(GRCh37/hg19)

Genomic View for ZFP64 Gene

Genes around ZFP64 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZFP64 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZFP64 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFP64 Gene

Proteins for ZFP64 Gene

  • Protein details for ZFP64 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NPA5-ZF64A_HUMAN
    Recommended name:
    Zinc finger protein 64 homolog, isoforms 1 and 2
    Protein Accession:
    Q9NPA5
    Secondary Accessions:
    • Q9NTS7
    • Q9NVH4

    Protein attributes for ZFP64 Gene

    Size:
    681 amino acids
    Molecular mass:
    74644 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ZFP64 Gene

    Alternative splice isoforms for ZFP64 Gene

  • Protein details for ZFP64 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NTW7-ZF64B_HUMAN
    Recommended name:
    Zinc finger protein 64 homolog, isoforms 3 and 4
    Protein Accession:
    Q9NTW7
    Secondary Accessions:
    • A2A2N4
    • Q53H69
    • Q53XQ1
    • Q5JWM0
    • Q5JWM1
    • Q8WU98
    • Q9H9P1

    Protein attributes for ZFP64 Gene

    Size:
    645 amino acids
    Molecular mass:
    72217 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZFP64 Gene

neXtProt entry for ZFP64 Gene

Post-translational modifications for ZFP64 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZFP64 Gene

Domains & Families for ZFP64 Gene

Gene Families for ZFP64 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZFP64 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9NPA5

UniProtKB/Swiss-Prot:

ZF64B_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZFP64: view

Function for ZFP64 Gene

Molecular function for ZFP64 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZFP64 Gene

Gene Ontology (GO) - Molecular Function for ZFP64 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding IBA --
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISA --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZFP64: view
genes like me logo Genes that share phenotypes with ZFP64: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZFP64

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZFP64 Gene

Localization for ZFP64 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZFP64 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZFP64 gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZFP64 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0035097 COLOCALIZES_WITH histone methyltransferase complex IBA --
genes like me logo Genes that share ontologies with ZFP64: view

Pathways & Interactions for ZFP64 Gene

SuperPathways for ZFP64 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZFP64 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
GO:0010468 regulation of gene expression IBA --
GO:0016569 covalent chromatin modification IBA --
genes like me logo Genes that share ontologies with ZFP64: view

No data available for Pathways by source and SIGNOR curated interactions for ZFP64 Gene

Drugs & Compounds for ZFP64 Gene

(1) Drugs for ZFP64 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zinc Approved, Investigational Pharma 2430
genes like me logo Genes that share compounds with ZFP64: view

Transcripts for ZFP64 Gene

mRNA/cDNA for ZFP64 Gene

Unigene Clusters for ZFP64 Gene

ZFP64 zinc finger protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZFP64

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZFP64 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^
SP1: - - - - - - - -
SP2: - - - - - - -
SP3: - - - -
SP4: - - - - -
SP5: - - - -
SP6: - - - - - - -
SP7: - -
SP8: - - -
SP9: - - -
SP10: - - - - - - -
SP11: - - -
SP12: - - - - - - - - - - -
SP13:
SP14:
SP15: - - - -
SP16: -
SP17:

ExUns: 13a · 13b ^ 14 ^ 15a · 15b ^ 16a · 16b
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7: -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13: -
SP14:
SP15:
SP16:
SP17:

Relevant External Links for ZFP64 Gene

GeneLoc Exon Structure for
ZFP64
ECgene alternative splicing isoforms for
ZFP64

Expression for ZFP64 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZFP64 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZFP64 Gene

This gene is overexpressed in Lung (41.9), Liver (18.2), and Liver, secretome (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZFP64 Gene



Protein tissue co-expression partners for ZFP64 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZFP64 Gene:

ZFP64

SOURCE GeneReport for Unigene cluster for ZFP64 Gene:

Hs.473082

Evidence on tissue expression from TISSUES for ZFP64 Gene

  • Nervous system(4.5)
  • Intestine(4.1)
genes like me logo Genes that share expression patterns with ZFP64: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZFP64 Gene

Orthologs for ZFP64 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZFP64 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZFP64 34 33
  • 99.41 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ZFP64 34 33
  • 91.36 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ZFP64 34 33
  • 87.12 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp64 16 34 33
  • 85.11 (n)
rat
(Rattus norvegicus)
Mammalia Zfp64 33
  • 84.76 (n)
oppossum
(Monodelphis domestica)
Mammalia ZFP64 34
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZFP64 34
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZFP64 34 33
  • 73.05 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZFP64 34
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zfp64 33
  • 62.07 (n)
Str.3425 33
zebrafish
(Danio rerio)
Actinopterygii zfp64 34 33
  • 57.27 (n)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7584 33
Species where no ortholog for ZFP64 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZFP64 Gene

ENSEMBL:
Gene Tree for ZFP64 (if available)
TreeFam:
Gene Tree for ZFP64 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZFP64: view image

Paralogs for ZFP64 Gene

Paralogs for ZFP64 Gene

(359) SIMAP similar genes for ZFP64 Gene using alignment to 5 proteins:

  • ZF64A_HUMAN
  • ZF64B_HUMAN
  • A2A2N5_HUMAN
  • A2A2N6_HUMAN
  • H0Y669_HUMAN

Pseudogenes.org Pseudogenes for ZFP64 Gene

genes like me logo Genes that share paralogs with ZFP64: view

Variants for ZFP64 Gene

Sequence variations from dbSNP and Humsavar for ZFP64 Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
VAR_035564 A breast cancer sample p.Asp593Glu
VAR_035565 A breast cancer sample p.Lys609Asn
rs1000010681 -- 52,101,852(-) C/T genic_downstream_transcript_variant, intron_variant
rs1000062976 -- 52,101,717(-) T/G genic_downstream_transcript_variant, intron_variant
rs1000125947 -- 52,189,438(-) AGATCATAG/AG genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZFP64 Gene

Variant ID Type Subtype PubMed ID
dgv2262n106 CNV deletion 24896259
dgv7600n54 CNV gain+loss 21841781
dgv7601n54 CNV loss 21841781
dgv7602n54 CNV loss 21841781
esv1009237 CNV loss 20482838
esv2065897 CNV deletion 18987734
esv24606 CNV loss 19812545
esv2532221 CNV deletion 19546169
esv2670525 CNV deletion 23128226
esv2676181 CNV deletion 23128226
esv2722522 CNV deletion 23290073
esv32674 CNV gain 17666407
esv3557184 CNV deletion 23714750
esv3557185 CNV deletion 23714750
esv3557186 CNV deletion 23714750
esv3568015 CNV loss 25503493
esv3568016 CNV loss 25503493
esv3646084 CNV loss 21293372
esv3942 CNV loss 18987735
esv995025 CNV deletion 20482838
esv999399 CNV insertion 20482838
nsv1058100 CNV gain 25217958
nsv1072120 CNV deletion 25765185
nsv179098 CNV deletion 16902084
nsv179831 CNV deletion 16902084
nsv473344 CNV novel sequence insertion 20440878
nsv514942 CNV loss 21397061
nsv586194 CNV loss 21841781
nsv586201 CNV gain 21841781

Variation tolerance for ZFP64 Gene

Residual Variation Intolerance Score: 41.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.36; 53.90% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZFP64 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZFP64

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZFP64 Gene

Disorders for ZFP64 Gene

Additional Disease Information for ZFP64

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ZFP64 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZFP64 Gene

Publications for ZFP64 Gene

  1. Genome-wide genotyping in amyotrophic lateral sclerosis and neurologically normal controls: first stage analysis and public release of data. (PMID: 17362836) Schymick JC … Traynor BJ (The Lancet. Neurology 2007) 3 44 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4 58
  5. A search for a mammalian homologue of the Drosophila photoreceptor development gene glass yields Zfp64, a zinc finger encoding gene which maps to the distal end of mouse chromosome 2. (PMID: 9034307) Mack HG … Bowtell DD (Gene 1997) 2 3 58

Products for ZFP64 Gene

Sources for ZFP64 Gene

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