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Aliases for ZFP62 Gene

Aliases for ZFP62 Gene

  • ZFP62 Zinc Finger Protein 2 3 5
  • Zfp-62 3 4
  • Zinc Finger Protein 62 Homolog (Mouse) 2
  • Zinc Finger Protein 62 Homolog 3
  • Zinc Finger Protein 62 2
  • ZNF755 3
  • ZET 3

External Ids for ZFP62 Gene

Previous GeneCards Identifiers for ZFP62 Gene

  • GC05M180338
  • GC05M180385
  • GC05M9A0012
  • GC05M9B0012
  • GC05M180209
  • GC05M180274
  • GC05M174999

Summaries for ZFP62 Gene

GeneCards Summary for ZFP62 Gene

ZFP62 (ZFP62 Zinc Finger Protein) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF91.

UniProtKB/Swiss-Prot for ZFP62 Gene

  • May play a role in differentiating skeletal muscle.

Additional gene information for ZFP62 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZFP62 Gene

Genomics for ZFP62 Gene

GeneHancer (GH) Regulatory Elements for ZFP62 Gene

Promoters and enhancers for ZFP62 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I180859 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 580.5 +0.3 261 2.4 FOXA2 PKNOX1 CLOCK ARID4B NEUROD1 SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZFP62 ENSG00000233937 TRIM52 SNORD96A CNOT6 MRNIP GFPT2 LINC00847 GC05P181054
GH05I180862 Enhancer 0.5 ENCODE 560.4 -1.8 -1778 0.7 CTCF MEIS2 NFIC SMAD5 L3MBTL2 ZFP62 BTNL8
GH05I180069 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 45.4 +790.3 790307 3.6 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 POLR2B RNF130 ZFP62 MRNIP HNRNPH1 MAML1 LOC100996419 RN7SKP150 CNOT6 RUFY1 TBC1D9B
GH05I181202 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 25.1 -344.4 -344424 5.6 CLOCK ZFP64 IRF4 YY1 ZNF213 E2F8 SP3 NFYC ZNF610 GLIS1 TRIM7 ENSG00000248514 GC05P181245 PIR42038 TRA-TGC3-1 TRIM52 ENSG00000233937 ZFP62 CNOT6 RACK1
GH05I181187 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE dbSUPER 25.9 -328.9 -328944 6.5 MLX FEZF1 DMAP1 YY1 ZNF213 ZNF143 SP3 SSRP1 GLIS1 RCOR2 LINC01962 LOC105377769 TRP-TGG3-1 TRT-TGT6-1 TRV-AAC2-1 PIR54518 GC05M181234 GC05M181233 TRIM52 ENSG00000233937
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZFP62 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZFP62 gene promoter:

Genomic Locations for ZFP62 Gene

Genomic Locations for ZFP62 Gene
chr5:180,845,338-180,861,286
(GRCh38/hg38)
Size:
15,949 bases
Orientation:
Minus strand
chr5:180,274,611-180,288,286
(GRCh37/hg19)

Genomic View for ZFP62 Gene

Genes around ZFP62 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZFP62 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZFP62 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFP62 Gene

Proteins for ZFP62 Gene

  • Protein details for ZFP62 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NB50-ZFP62_HUMAN
    Recommended name:
    Zinc finger protein 62 homolog
    Protein Accession:
    Q8NB50
    Secondary Accessions:
    • B4DIP6
    • B4E0N3
    • B5MDX6
    • B7ZVZ2
    • B9EIP6
    • E9PFT8
    • J3QTA9

    Protein attributes for ZFP62 Gene

    Size:
    900 amino acids
    Molecular mass:
    102511 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI40762.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC03691.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG58558.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical GTG valine codon.; Evidence={ECO:0000305}; Sequence=CAI46133.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZFP62 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZFP62 Gene

Post-translational modifications for ZFP62 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZFP62 Gene

Domains & Families for ZFP62 Gene

Gene Families for ZFP62 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZFP62 Gene

Suggested Antigen Peptide Sequences for ZFP62 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NB50

UniProtKB/Swiss-Prot:

ZFP62_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZFP62: view

Function for ZFP62 Gene

Molecular function for ZFP62 Gene

UniProtKB/Swiss-Prot Function:
May play a role in differentiating skeletal muscle.

Phenotypes From GWAS Catalog for ZFP62 Gene

Gene Ontology (GO) - Molecular Function for ZFP62 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZFP62: view
genes like me logo Genes that share phenotypes with ZFP62: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZFP62 Gene

Localization for ZFP62 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZFP62 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZFP62 gene
Compartment Confidence
nucleus 5
cytoskeleton 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Actin filaments (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZFP62 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZFP62: view

Pathways & Interactions for ZFP62 Gene

SuperPathways for ZFP62 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZFP62 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZFP62: view

No data available for Pathways by source and SIGNOR curated interactions for ZFP62 Gene

Drugs & Compounds for ZFP62 Gene

No Compound Related Data Available

Transcripts for ZFP62 Gene

mRNA/cDNA for ZFP62 Gene

(14) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZFP62 Gene

ZFP62 zinc finger protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZFP62 Gene

No ASD Table

Relevant External Links for ZFP62 Gene

GeneLoc Exon Structure for
ZFP62
ECgene alternative splicing isoforms for
ZFP62

Expression for ZFP62 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZFP62 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZFP62 Gene



Protein tissue co-expression partners for ZFP62 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZFP62 Gene:

ZFP62

SOURCE GeneReport for Unigene cluster for ZFP62 Gene:

Hs.509227

Evidence on tissue expression from TISSUES for ZFP62 Gene

  • Nervous system(4.3)
  • Lung(4.2)
  • Lymph node(4.2)
genes like me logo Genes that share expression patterns with ZFP62: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZFP62 Gene

Orthologs for ZFP62 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZFP62 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZFP62 33 34
  • 99.63 (n)
dog
(Canis familiaris)
Mammalia ZFP62 33 34
  • 91.48 (n)
cow
(Bos Taurus)
Mammalia ZFP62 33 34
  • 91.3 (n)
rat
(Rattus norvegicus)
Mammalia RGD1560191 33
  • 87.98 (n)
mouse
(Mus musculus)
Mammalia Zfp62 33 16 34
  • 87.47 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 53 (a)
ManyToMany
-- 34
  • 52 (a)
ManyToMany
-- 34
  • 52 (a)
ManyToMany
-- 34
  • 52 (a)
ManyToMany
-- 34
  • 51 (a)
ManyToMany
-- 34
  • 50 (a)
ManyToMany
-- 34
  • 50 (a)
ManyToMany
-- 34
  • 50 (a)
ManyToMany
-- 34
  • 50 (a)
ManyToMany
-- 34
  • 48 (a)
ManyToMany
-- 34
  • 43 (a)
ManyToMany
-- 34
  • 43 (a)
ManyToMany
-- 34
  • 28 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 53 (a)
OneToMany
Species where no ortholog for ZFP62 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZFP62 Gene

ENSEMBL:
Gene Tree for ZFP62 (if available)
TreeFam:
Gene Tree for ZFP62 (if available)

Paralogs for ZFP62 Gene

(527) SIMAP similar genes for ZFP62 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ZFP62: view

Variants for ZFP62 Gene

Sequence variations from dbSNP and Humsavar for ZFP62 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000013042 -- 180,849,058(-) A/G coding_sequence_variant, intron_variant, missense_variant
rs1000015 -- 180,849,788(-) T/C coding_sequence_variant, synonymous_variant
rs1000025661 -- 180,859,094(-) C/T intron_variant
rs1000036831 -- 180,859,316(-) A/G intron_variant
rs1000065098 -- 180,857,786(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZFP62 Gene

Variant ID Type Subtype PubMed ID
dgv9n29 CNV loss 16826518
esv2759399 CNV gain 17122850
nsv1026417 CNV gain 25217958
nsv1161322 CNV duplication 26073780
nsv428133 CNV gain 18775914
nsv820020 CNV loss 19587683
nsv830566 CNV loss 17160897

Variation tolerance for ZFP62 Gene

Gene Damage Index Score: 2.94; 49.16% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZFP62 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZFP62

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZFP62 Gene

Disorders for ZFP62 Gene

Additional Disease Information for ZFP62

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ZFP62 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZFP62 Gene

Publications for ZFP62 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Differentiation dependent expression in muscle cells of ZT3, a novel zinc finger factor differentially expressed in embryonic and adult tissues. (PMID: 8808410) Polimeni M … Bouché M (Mechanisms of development 1996) 2 3 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 58

Products for ZFP62 Gene

Sources for ZFP62 Gene

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