Aliases for ZFP41 Gene

Aliases for ZFP41 Gene

  • ZFP41 Zinc Finger Protein 2 3 5
  • Zinc Finger Protein 41 Homolog 3 4
  • ZNF753 2 3
  • Zfp-41 3 4
  • Zinc Finger Protein 41 Homolog (Mouse) 2
  • FLJ38705 2
  • FLJ00028 2
  • ZFP41 5

External Ids for ZFP41 Gene

Previous GeneCards Identifiers for ZFP41 Gene

  • GC08P144404
  • GC08P144330
  • GC08P144331
  • GC08P139582

Summaries for ZFP41 Gene

GeneCards Summary for ZFP41 Gene

ZFP41 (ZFP41 Zinc Finger Protein) is a Protein Coding gene. An important paralog of this gene is ENSG00000264668.

UniProtKB/Swiss-Prot Summary for ZFP41 Gene

  • A putative DNA-binding regulatory protein associated with meiosis in spermatogenesis.

Additional gene information for ZFP41 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZFP41 Gene

Genomics for ZFP41 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZFP41 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZFP41 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZFP41

Top Transcription factor binding sites by QIAGEN in the ZFP41 gene promoter:
  • Bach1
  • E47
  • Olf-1
  • STAT5A

Genomic Locations for ZFP41 Gene

Genomic Locations for ZFP41 Gene
chr8:143,246,821-143,262,705
(GRCh38/hg38)
Size:
15,885 bases
Orientation:
Plus strand
chr8:144,328,991-144,344,875
(GRCh37/hg19)
Size:
15,885 bases
Orientation:
Plus strand

Genomic View for ZFP41 Gene

Genes around ZFP41 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZFP41 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZFP41 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFP41 Gene

Proteins for ZFP41 Gene

  • Protein details for ZFP41 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N8Y5-ZFP41_HUMAN
    Recommended name:
    Zinc finger protein 41 homolog
    Protein Accession:
    Q8N8Y5
    Secondary Accessions:
    • D3DWJ5

    Protein attributes for ZFP41 Gene

    Size:
    198 amino acids
    Molecular mass:
    22806 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZFP41 Gene

Post-translational modifications for ZFP41 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZFP41 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZFP41 Gene

Domains & Families for ZFP41 Gene

Gene Families for ZFP41 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ZFP41 Gene

InterPro:
Blocks:
  • C2H2-type zinc finger signature
ProtoNet:

Suggested Antigen Peptide Sequences for ZFP41 Gene

GenScript: Design optimal peptide antigens:
  • FLJ00028 protein (Q9H7P0_HUMAN)
  • Zinc finger protein 41 homolog (ZFP41_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8N8Y5

UniProtKB/Swiss-Prot:

ZFP41_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZFP41: view

Function for ZFP41 Gene

Molecular function for ZFP41 Gene

UniProtKB/Swiss-Prot Function:
A putative DNA-binding regulatory protein associated with meiosis in spermatogenesis.

Phenotypes From GWAS Catalog for ZFP41 Gene

Gene Ontology (GO) - Molecular Function for ZFP41 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IBA 21873635
GO:0043565 sequence-specific DNA binding IBA 21873635
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZFP41: view
genes like me logo Genes that share phenotypes with ZFP41: view

Animal Model Products

CRISPR Products

miRNA for ZFP41 Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZFP41

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZFP41 Gene

Localization for ZFP41 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZFP41 Gene

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZFP41 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with ZFP41: view

No data available for Subcellular locations from COMPARTMENTS for ZFP41 Gene

Pathways & Interactions for ZFP41 Gene

PathCards logo

SuperPathways for ZFP41 Gene

No Data Available

Interacting Proteins for ZFP41 Gene

Gene Ontology (GO) - Biological Process for ZFP41 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007275 multicellular organism development IEA --
GO:0007283 spermatogenesis IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with ZFP41: view

No data available for Pathways by source and SIGNOR curated interactions for ZFP41 Gene

Drugs & Compounds for ZFP41 Gene

No Compound Related Data Available

Transcripts for ZFP41 Gene

mRNA/cDNA for ZFP41 Gene

2 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZFP41

Alternative Splicing Database (ASD) splice patterns (SP) for ZFP41 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14
SP1:
SP2: - -
SP3: - - - - - -
SP4: - - -
SP5: - - - -
SP6: - -
SP7: - - - -
SP8: - -
SP9: -
SP10:

Relevant External Links for ZFP41 Gene

GeneLoc Exon Structure for
ZFP41

Expression for ZFP41 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZFP41 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZFP41

SOURCE GeneReport for Unigene cluster for ZFP41 Gene:

Hs.668016
genes like me logo Genes that share expression patterns with ZFP41: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZFP41 Gene

Orthologs for ZFP41 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZFP41 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZFP41 30
  • 99.33 (n)
-- 31
  • 99 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia -- 31
  • 82 (a)
OneToMany
ZFP41 30
  • 81.37 (n)
Mouse
(Mus musculus)
Mammalia Zfp41 30 17 31
  • 78.17 (n)
OneToMany
Cow
(Bos Taurus)
Mammalia ZFP41 30
  • 77.66 (n)
Zebrafish
(Danio rerio)
Actinopterygii BX649341.4 31
  • 34 (a)
ManyToMany
si:dkey-247i3.7 31
  • 18 (a)
ManyToMany
Worm
(Caenorhabditis elegans)
Secernentea mnm-2 31
  • 15 (a)
OneToMany
Species where no ortholog for ZFP41 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for ZFP41 Gene

ENSEMBL:
Gene Tree for ZFP41 (if available)
TreeFam:
Gene Tree for ZFP41 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZFP41: view image

Paralogs for ZFP41 Gene

(489) SIMAP similar genes for ZFP41 Gene using alignment to 1 proteins:

  • ZFP41_HUMAN

Pseudogenes.org Pseudogenes for ZFP41 Gene

genes like me logo Genes that share paralogs with ZFP41: view

Variants for ZFP41 Gene

Additional dbSNP identifiers (rs#s) for ZFP41 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZFP41 Gene

Variant ID Type Subtype PubMed ID
esv2737981 CNV deletion 23290073
nsv1016726 CNV loss 25217958
nsv465992 CNV loss 19166990
nsv473814 CNV novel sequence insertion 20440878
nsv612726 CNV loss 21841781
nsv612728 CNV loss 21841781
nsv950010 CNV deletion 24416366

Variation tolerance for ZFP41 Gene

Residual Variation Intolerance Score: 72.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.09; 22.14% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZFP41 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZFP41

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZFP41 Gene

Disorders for ZFP41 Gene

No disorders were found for ZFP41 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZFP41 Gene

Publications for ZFP41 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. Characterization of long cDNA clones from human adult spleen. (PMID: 11214971) Hattori A … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3
  3. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  4. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3
  5. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. (PMID: 29117863) Choudhury NR … Michlewski G (BMC biology 2017) 3

Products for ZFP41 Gene

Sources for ZFP41 Gene