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Aliases for ZFP41 Gene

Aliases for ZFP41 Gene

  • ZFP41 Zinc Finger Protein 2 3 5
  • Zfp-41 3 4
  • Zinc Finger Protein 41 Homolog (Mouse) 2
  • Zinc Finger Protein 41 Homolog 3
  • ZNF753 3

External Ids for ZFP41 Gene

Previous GeneCards Identifiers for ZFP41 Gene

  • GC08P144404
  • GC08P144330
  • GC08P144331
  • GC08P139582

Summaries for ZFP41 Gene

GeneCards Summary for ZFP41 Gene

ZFP41 (ZFP41 Zinc Finger Protein) is a Protein Coding gene. An important paralog of this gene is ENSG00000264668.

UniProtKB/Swiss-Prot for ZFP41 Gene

  • A putative DNA-binding regulatory protein associated with meiosis in spermatogenesis.

Additional gene information for ZFP41 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZFP41 Gene

Genomics for ZFP41 Gene

GeneHancer (GH) Regulatory Elements for ZFP41 Gene

Promoters and enhancers for ZFP41 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08I143245 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +0.0 20 2.8 PKNOX1 ATF1 ARNT ARID4B SIN3A DMAP1 ZNF48 TCF12 POLR2B GLIS2 ZFP41 ENSG00000264668 MINCR SHARPIN ZNF707 LY6K GLI4 FAM83H-AS1 TOP1MT
GH08I143595 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 20.8 +351.1 351111 5.1 HDGF PKNOX1 CLOCK SMAD1 ARNT ZFP64 ARID4B NEUROD1 SIN3A DMAP1 EEF1D TIGD5 PIR45575 NAPRT CPSF1 ZNF623 VPS28 JRK LOC105375803 GPAA1
GH08I143275 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE dbSUPER 13.9 +32.3 32253 6.5 HDGF PKNOX1 CLOCK SMAD1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 MINCR ZNF623 GPAA1 PARP10 ENSG00000255050 ZNF707 ZFP41 EEF1D ZC3H3 RHPN1
GH08I143289 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 12 +43.9 43864 3.4 PKNOX1 CLOCK SMAD1 MLX ARID4B SIN3A DMAP1 ZNF2 SLC30A9 POLR2B ENSG00000272172 ZNF696 SHARPIN MINCR BREA2 TOP1MT ZNF623 ZFP41 PARP10 GPAA1
GH08I143131 Enhancer 0.7 ENCODE 12.1 -115.6 -115612 0.2 GTF2F1 CTCF PKNOX1 RB1 SIN3A ZBTB7B RAD21 RFX5 CC2D1A CTBP1 LY6H ZFP41 LY6L
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZFP41 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZFP41 gene promoter:

Genomic Locations for ZFP41 Gene

Genomic Locations for ZFP41 Gene
chr8:143,246,821-143,262,705
(GRCh38/hg38)
Size:
15,885 bases
Orientation:
Plus strand
chr8:144,328,991-144,344,875
(GRCh37/hg19)

Genomic View for ZFP41 Gene

Genes around ZFP41 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZFP41 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZFP41 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFP41 Gene

Proteins for ZFP41 Gene

  • Protein details for ZFP41 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N8Y5-ZFP41_HUMAN
    Recommended name:
    Zinc finger protein 41 homolog
    Protein Accession:
    Q8N8Y5
    Secondary Accessions:
    • D3DWJ5

    Protein attributes for ZFP41 Gene

    Size:
    198 amino acids
    Molecular mass:
    22806 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZFP41 Gene

Post-translational modifications for ZFP41 Gene

No Post-translational modifications

Other Protein References for ZFP41 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZFP41 Gene

Domains & Families for ZFP41 Gene

Gene Families for ZFP41 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ZFP41 Gene

Suggested Antigen Peptide Sequences for ZFP41 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N8Y5

UniProtKB/Swiss-Prot:

ZFP41_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZFP41: view

Function for ZFP41 Gene

Molecular function for ZFP41 Gene

UniProtKB/Swiss-Prot Function:
A putative DNA-binding regulatory protein associated with meiosis in spermatogenesis.

Gene Ontology (GO) - Molecular Function for ZFP41 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZFP41: view

Phenotypes for ZFP41 Gene

GenomeRNAi human phenotypes for ZFP41:
genes like me logo Genes that share phenotypes with ZFP41: view

Animal Model Products

miRNA for ZFP41 Gene

miRTarBase miRNAs that target ZFP41

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZFP41 Gene

Localization for ZFP41 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZFP41 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZFP41 gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (1)
  • Nucleus (1)
  • Plasma membrane (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZFP41 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZFP41: view

Pathways & Interactions for ZFP41 Gene

SuperPathways for ZFP41 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZFP41 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007275 multicellular organism development IEA --
GO:0007283 spermatogenesis IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with ZFP41: view

No data available for Pathways by source and SIGNOR curated interactions for ZFP41 Gene

Drugs & Compounds for ZFP41 Gene

No Compound Related Data Available

Transcripts for ZFP41 Gene

mRNA/cDNA for ZFP41 Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZFP41 Gene

ZFP41 zinc finger protein:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZFP41 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14
SP1:
SP2: - -
SP3: - - - - - -
SP4: - - -
SP5: - - - -
SP6: - -
SP7: - - - -
SP8: - -
SP9: -
SP10:

Relevant External Links for ZFP41 Gene

GeneLoc Exon Structure for
ZFP41
ECgene alternative splicing isoforms for
ZFP41

Expression for ZFP41 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZFP41 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of ZFP41 Gene:

ZFP41

SOURCE GeneReport for Unigene cluster for ZFP41 Gene:

Hs.668016

Evidence on tissue expression from TISSUES for ZFP41 Gene

  • Kidney(4.3)
  • Nervous system(3.7)
genes like me logo Genes that share expression patterns with ZFP41: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZFP41 Gene

Orthologs for ZFP41 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZFP41 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZFP41 33
  • 99.33 (n)
-- 34
  • 99 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 34
  • 82 (a)
OneToMany
ZFP41 33
  • 81.37 (n)
mouse
(Mus musculus)
Mammalia Zfp41 33 16 34
  • 78.17 (n)
cow
(Bos Taurus)
Mammalia ZFP41 33
  • 77.66 (n)
zebrafish
(Danio rerio)
Actinopterygii BX649341.4 34
  • 34 (a)
ManyToMany
si:dkey-247i3.7 34
  • 18 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea mnm-2 34
  • 15 (a)
OneToMany
Species where no ortholog for ZFP41 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ZFP41 Gene

ENSEMBL:
Gene Tree for ZFP41 (if available)
TreeFam:
Gene Tree for ZFP41 (if available)

Paralogs for ZFP41 Gene

Paralogs for ZFP41 Gene

(489) SIMAP similar genes for ZFP41 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for ZFP41 Gene

genes like me logo Genes that share paralogs with ZFP41: view

Variants for ZFP41 Gene

Sequence variations from dbSNP and Humsavar for ZFP41 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000127547 -- 143,248,826(+) T/A intron_variant
rs1000283836 -- 143,258,012(+) A/G genic_downstream_transcript_variant, intron_variant
rs1000313555 -- 143,252,262(+) G/A intron_variant
rs1000354130 -- 143,248,212(+) G/A intron_variant
rs1000580424 -- 143,252,485(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZFP41 Gene

Variant ID Type Subtype PubMed ID
nsv950010 CNV deletion 24416366
nsv612728 CNV loss 21841781
nsv612726 CNV loss 21841781
nsv473814 CNV novel sequence insertion 20440878
nsv465992 CNV loss 19166990
nsv1016726 CNV loss 25217958
esv2737981 CNV deletion 23290073

Variation tolerance for ZFP41 Gene

Residual Variation Intolerance Score: 72.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.09; 22.14% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZFP41 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZFP41

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZFP41 Gene

Disorders for ZFP41 Gene

Additional Disease Information for ZFP41

No disorders were found for ZFP41 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZFP41 Gene

Publications for ZFP41 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. Characterization of long cDNA clones from human adult spleen. (PMID: 11214971) Hattori A … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58

Products for ZFP41 Gene

Sources for ZFP41 Gene

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