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Aliases for ZFP37 Gene

Aliases for ZFP37 Gene

  • ZFP37 Zinc Finger Protein 2 3 5
  • Zinc Finger Protein Homologous To Zfp37 In Mouse 2 3
  • Zfp-37 3 4
  • Zinc Finger Protein 37 Homolog (Mouse) 2
  • Zinc Finger Protein 37 Homolog 3
  • ZNF906 3

External Ids for ZFP37 Gene

Previous GeneCards Identifiers for ZFP37 Gene

  • GC09M106602
  • GC09M107536
  • GC09M109217
  • GC09M111140
  • GC09M111141
  • GC09M112883
  • GC09M114840
  • GC09M115800
  • GC09M085402

Summaries for ZFP37 Gene

Entrez Gene Summary for ZFP37 Gene

  • This gene encodes a transcription factor that belongs to a large family of zinc finger proteins. A similar protein in mouse is thought to play a role in regulating the structures of the nucleolus and centromere in neurons. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

GeneCards Summary for ZFP37 Gene

ZFP37 (ZFP37 Zinc Finger Protein) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA binding transcription factor activity. An important paralog of this gene is ZNF544.

UniProtKB/Swiss-Prot for ZFP37 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZFP37 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZFP37 Gene

Genomics for ZFP37 Gene

GeneHancer (GH) Regulatory Elements for ZFP37 Gene

Promoters and enhancers for ZFP37 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J113055 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 658.4 +0.2 185 1.6 ATF1 FOXA2 ARID4B SIN3A ZNF2 ZNF48 YY1 ETS1 ZNF766 ZNF143 ZFP37 ENSG00000285447
GH09J113613 Enhancer 1.2 Ensembl ENCODE dbSUPER 13.1 -559.1 -559056 4 HDGF ZNF133 YBX1 RAD21 YY1 EGR1 RCOR1 IKZF2 RXRA ZNF114 ENSG00000282897 LOC105376222 C9orf43 ZFP37 ZNF618 POLE3 ALAD
GH09J113952 Enhancer 1 Ensembl ENCODE dbSUPER 15 -898.9 -898856 6.8 USF1 JUN USF2 ATF2 YY1 MITF SP1 PRDM6 ZNF23 IKZF1 ZFP37 ZNF618 GC09P114791
GH09J113011 Enhancer 1.1 Ensembl ENCODE 12.5 +44.6 44575 1.2 ATF1 FOXA2 DMAP1 ZNF2 ZNF48 YY1 ETS1 ZNF416 ZNF143 ZNF548 ZNF883 PRPF4 ZFP37 CDC26 ZNF618 PIR31639 ENSG00000285447
GH09J112747 Enhancer 1.1 FANTOM5 ENCODE dbSUPER 1.5 +309.5 309545 0.4 SOX5 SOX13 GATAD2A HMG20B SAP130 CEBPB CEBPG ZNF644 NFIL3 XRCC5 INIP SNX30 KIAA1958 ZFP37 ZNF883
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZFP37 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZFP37 gene promoter:
  • Nkx3-1 v4
  • Nkx3-1 v3
  • Nkx3-1 v2
  • Nkx3-1 v1
  • Nkx3-1
  • YY1
  • RFX1
  • HNF-1A
  • HNF-1
  • RP58

Genomic Locations for ZFP37 Gene

Genomic Locations for ZFP37 Gene
18,412 bases
Minus strand
18,380 bases
Minus strand

Genomic View for ZFP37 Gene

Genes around ZFP37 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZFP37 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZFP37 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFP37 Gene

Proteins for ZFP37 Gene

  • Protein details for ZFP37 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 37 homolog
    Protein Accession:
    Secondary Accessions:
    • A0AVJ9
    • B4DVX4
    • G3V3L7
    • Q5T7Q4

    Protein attributes for ZFP37 Gene

    630 amino acids
    Molecular mass:
    71209 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZFP37 Gene


neXtProt entry for ZFP37 Gene

Post-translational modifications for ZFP37 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZFP37 Gene

No data available for DME Specific Peptides for ZFP37 Gene

Domains & Families for ZFP37 Gene

Gene Families for ZFP37 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZFP37 Gene

Suggested Antigen Peptide Sequences for ZFP37 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZFP37: view

Function for ZFP37 Gene

Molecular function for ZFP37 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
GENATLAS Biochemistry:
zinc finger protein 37,with a Kruppel-associated box domain (KRAB domain),expressed in fetal cartilage

Gene Ontology (GO) - Molecular Function for ZFP37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity NAS 9585434
GO:0008270 zinc ion binding NAS 9585434
GO:0043565 sequence-specific DNA binding IBA --
genes like me logo Genes that share ontologies with ZFP37: view
genes like me logo Genes that share phenotypes with ZFP37: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZFP37

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZFP37 Gene

Localization for ZFP37 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZFP37 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZFP37 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleus (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZFP37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZFP37: view

Pathways & Interactions for ZFP37 Gene

SuperPathways for ZFP37 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZFP37: view

Pathways by source for ZFP37 Gene

2 Reactome pathways for ZFP37 Gene

Gene Ontology (GO) - Biological Process for ZFP37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated NAS 9585434
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZFP37: view

No data available for SIGNOR curated interactions for ZFP37 Gene

Drugs & Compounds for ZFP37 Gene

No Compound Related Data Available

Transcripts for ZFP37 Gene

mRNA/cDNA for ZFP37 Gene

(3) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZFP37 Gene

ZFP37 zinc finger protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZFP37

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZFP37 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b

Relevant External Links for ZFP37 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZFP37 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZFP37 Gene

Protein differential expression in normal tissues from HIPED for ZFP37 Gene

This gene is overexpressed in Ovary (50.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZFP37 Gene

Protein tissue co-expression partners for ZFP37 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZFP37 Gene:


SOURCE GeneReport for Unigene cluster for ZFP37 Gene:


mRNA Expression by UniProt/SwissProt for ZFP37 Gene:

Tissue specificity: Expressed at low level in several tissues including fetal cartilage.

Evidence on tissue expression from TISSUES for ZFP37 Gene

  • Spleen(4.1)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with ZFP37: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZFP37 Gene

Orthologs for ZFP37 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZFP37 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZFP37 34 33
  • 99.11 (n)
(Canis familiaris)
Mammalia ZFP37 34 33
  • 88.04 (n)
(Bos Taurus)
Mammalia ZFP37 33
  • 87.59 (n)
-- 34
  • 53 (a)
(Mus musculus)
Mammalia Zfp37 16 34 33
  • 80.73 (n)
(Rattus norvegicus)
Mammalia Zfp37 33
  • 77.78 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 56 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 55 (a)
(Gallus gallus)
Aves -- 34
  • 43 (a)
fruit fly
(Drosophila melanogaster)
Insecta Kr-h1 35
  • 50 (a)
CG9650 35
  • 45 (a)
dwg 35
  • 44 (a)
CG12299 35
  • 42 (a)
CG3407 35
  • 38 (a)
CG7963 35
  • 36 (a)
Neu2 35
  • 32 (a)
Species where no ortholog for ZFP37 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZFP37 Gene

Gene Tree for ZFP37 (if available)
Gene Tree for ZFP37 (if available)
Evolutionary constrained regions (ECRs) for ZFP37: view image

Paralogs for ZFP37 Gene

(535) SIMAP similar genes for ZFP37 Gene using alignment to 2 proteins:

  • G3V3L7_HUMAN Pseudogenes for ZFP37 Gene

genes like me logo Genes that share paralogs with ZFP37: view

Variants for ZFP37 Gene

Sequence variations from dbSNP and Humsavar for ZFP37 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs202181932 uncertain-significance, not provided 113,056,670(-) C/G/T coding_sequence_variant, missense_variant
rs1000046363 -- 113,045,320(-) A/T intron_variant
rs1000109458 -- 113,055,097(-) G/A intron_variant
rs1000313089 -- 113,045,382(-) T/C intron_variant
rs1000326493 -- 113,052,505(-) A/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZFP37 Gene

Variant ID Type Subtype PubMed ID
dgv1232n67 CNV gain 20364138
dgv12853n54 CNV loss 21841781
dgv943n27 CNV loss 19166990
esv2759710 CNV gain 17122850
esv2764155 CNV loss 21179565
esv3573363 CNV loss 25503493
esv3621526 CNV gain 21293372
esv3621527 CNV loss 21293372
esv3621528 CNV gain 21293372
esv3891712 CNV loss 25118596
esv3891713 CNV loss 25118596
nsv1037784 CNV loss 25217958
nsv1128515 CNV deletion 24896259
nsv1161899 CNV deletion 26073780
nsv466491 CNV loss 19166990
nsv508563 CNV deletion 20534489
nsv509318 CNV insertion 20534489
nsv510987 OTHER complex 20534489
nsv517282 CNV loss 19592680
nsv525545 CNV gain 19592680
nsv615204 CNV loss 21841781
nsv6672 CNV deletion 18451855
nsv831691 CNV loss 17160897
nsv8562 CNV gain+loss 18304495

Variation tolerance for ZFP37 Gene

Residual Variation Intolerance Score: 45% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.53; 77.77% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZFP37 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZFP37 Gene

Disorders for ZFP37 Gene

Additional Disease Information for ZFP37

No disorders were found for ZFP37 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZFP37 Gene

Publications for ZFP37 Gene

  1. Cloning, characterization, and chromosomal assignment of the human ortholog of murine Zfp-37, a candidate gene for Nager syndrome. (PMID: 9585434) Dreyer SD … Lee B (Mammalian genome : official journal of the International Mammalian Genome Society 1998) 3 4 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 58
  5. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 4 58

Products for ZFP37 Gene

Sources for ZFP37 Gene

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