This gene encodes a transcription factor that belongs to a large family of zinc finger proteins. A similar protein in mouse is thought to play a role in regulating the structures of the nucleolus and centromere in neurons. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013] See more...

Aliases for ZFP37 Gene

Aliases for ZFP37 Gene

  • ZFP37 Zinc Finger Protein 2 3 5
  • Zinc Finger Protein Homologous To Zfp37 In Mouse 2 3
  • Zinc Finger Protein 37 Homolog 3 4
  • ZNF906 2 3
  • Zfp-37 3 4
  • Zinc Finger Protein 37 Homolog (Mouse) 2
  • ZFP37 5

External Ids for ZFP37 Gene

Previous GeneCards Identifiers for ZFP37 Gene

  • GC09M106602
  • GC09M107536
  • GC09M109217
  • GC09M111140
  • GC09M111141
  • GC09M112883
  • GC09M114840
  • GC09M115800
  • GC09M085402

Summaries for ZFP37 Gene

Entrez Gene Summary for ZFP37 Gene

  • This gene encodes a transcription factor that belongs to a large family of zinc finger proteins. A similar protein in mouse is thought to play a role in regulating the structures of the nucleolus and centromere in neurons. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

GeneCards Summary for ZFP37 Gene

ZFP37 (ZFP37 Zinc Finger Protein) is a Protein Coding gene. Diseases associated with ZFP37 include Acrofacial Dysostosis 1, Nager Type. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity. An important paralog of this gene is ZNF180.

UniProtKB/Swiss-Prot Summary for ZFP37 Gene

Additional gene information for ZFP37 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZFP37 Gene

Genomics for ZFP37 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZFP37 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J113055 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 608.3 +0.3 258 2.6 ARHGAP35 HNRNPL GATAD2A PRDM10 ZNF629 SIX5 GABPA ZNF143 RBFOX2 POLR2A ZFP37 PRPF4 ENSG00000285447 lnc-ZFP37-1 RF00017-7837
GH09J113011 Promoter/Enhancer 1.6 Ensembl ENCODE CraniofacialAtlas 12.5 +44.7 44658 1.8 PRDM10 SIX5 NFKBIZ ZNF692 FOXA1 RBFOX2 RXRB MTA1 IRF2 GABPA ZNF883 PRPF4 ZFP37 CDC26 ZNF618 NONHSAG053226.2 ENSG00000285447 lnc-ZFP37-1 SLC46A2 RF00017-7837
GH09J113613 Promoter/Enhancer 1.4 Ensembl ENCODE CraniofacialAtlas dbSUPER 13.1 -559.1 -559088 4 REST IKZF2 SP1 RELA EED ZBTB20 DPF2 RELB EGR1 CEBPB ENSG00000227482 ENSG00000282897 C9orf43 ZFP37 ZNF618 POLE3 ALAD RGS3
GH09J113952 Enhancer 0.9 ENCODE CraniofacialAtlas dbSUPER 15 -898.9 -898888 6.8 ATF7 SP1 CEBPB ZNF23 USF1 YY1 ZBTB17 PRDM6 JUN TOE1 ZFP37 ZNF618 HSALNG0073869 lnc-COL27A1-1 AMBP
GH09J113059 Promoter 0.8 Ensembl 7.7 -3.0 -3042 0.4 ZNF629 ZIC2 PATZ1 NR2C1 HDAC1 SP2 ZXDB ZBTB17 ZBTB11 ZNF335 ENSG00000285115 ZFP37 SLC31A2 RF00017-7837
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZFP37 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZFP37

Top Transcription factor binding sites by QIAGEN in the ZFP37 gene promoter:
  • HNF-1
  • HNF-1A
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3
  • Nkx3-1 v4
  • RFX1
  • RP58
  • YY1

Genomic Locations for ZFP37 Gene

Genomic Locations for ZFP37 Gene
chr9:113,038,377-113,056,759
(GRCh38/hg38)
Size:
18,383 bases
Orientation:
Minus strand
chr9:115,800,660-115,819,039
(GRCh37/hg19)
Size:
18,380 bases
Orientation:
Minus strand

Genomic View for ZFP37 Gene

Genes around ZFP37 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZFP37 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZFP37 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFP37 Gene

Proteins for ZFP37 Gene

  • Protein details for ZFP37 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6Q3-ZFP37_HUMAN
    Recommended name:
    Zinc finger protein 37 homolog
    Protein Accession:
    Q9Y6Q3
    Secondary Accessions:
    • A0AVJ9
    • B4DVX4
    • G3V3L7
    • Q5T7Q4

    Protein attributes for ZFP37 Gene

    Size:
    630 amino acids
    Molecular mass:
    71209 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZFP37 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZFP37 Gene

Post-translational modifications for ZFP37 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZFP37 Gene

No data available for DME Specific Peptides for ZFP37 Gene

Domains & Families for ZFP37 Gene

Gene Families for ZFP37 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZFP37 Gene

InterPro:
Blocks:
  • KRAB box
ProtoNet:

Suggested Antigen Peptide Sequences for ZFP37 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 37 homolog (ZFP37_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9Y6Q3

UniProtKB/Swiss-Prot:

ZFP37_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZFP37: view

Function for ZFP37 Gene

Molecular function for ZFP37 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
GENATLAS Biochemistry:
zinc finger protein 37,with a Kruppel-associated box domain (KRAB domain),expressed in fetal cartilage

Gene Ontology (GO) - Molecular Function for ZFP37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IBA,NAS 9585434
GO:0008270 zinc ion binding NAS 9585434
GO:0043565 sequence-specific DNA binding IBA 21873635
genes like me logo Genes that share ontologies with ZFP37: view
genes like me logo Genes that share phenotypes with ZFP37: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZFP37

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZFP37 Gene

Localization for ZFP37 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZFP37 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZFP37 gene
Compartment Confidence
nucleus 4
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZFP37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with ZFP37: view

Pathways & Interactions for ZFP37 Gene

genes like me logo Genes that share pathways with ZFP37: view

Pathways by source for ZFP37 Gene

2 Reactome pathways for ZFP37 Gene
1 KEGG pathway for ZFP37 Gene

Interacting Proteins for ZFP37 Gene

Gene Ontology (GO) - Biological Process for ZFP37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated NAS 9585434
genes like me logo Genes that share ontologies with ZFP37: view

No data available for SIGNOR curated interactions for ZFP37 Gene

Drugs & Compounds for ZFP37 Gene

No Compound Related Data Available

Transcripts for ZFP37 Gene

mRNA/cDNA for ZFP37 Gene

3 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZFP37

Alternative Splicing Database (ASD) splice patterns (SP) for ZFP37 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b
SP1:
SP2:

Relevant External Links for ZFP37 Gene

GeneLoc Exon Structure for
ZFP37

Expression for ZFP37 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZFP37 Gene

Protein differential expression in normal tissues from HIPED for ZFP37 Gene

This gene is overexpressed in Ovary (50.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZFP37 Gene



Protein tissue co-expression partners for ZFP37 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZFP37

SOURCE GeneReport for Unigene cluster for ZFP37 Gene:

Hs.150406

mRNA Expression by UniProt/SwissProt for ZFP37 Gene:

Q9Y6Q3-ZFP37_HUMAN
Tissue specificity: Expressed at low level in several tissues including fetal cartilage.

Evidence on tissue expression from TISSUES for ZFP37 Gene

  • Nervous system(4.3)
  • Spleen(4.1)
genes like me logo Genes that share expression patterns with ZFP37: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZFP37 Gene

Orthologs for ZFP37 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZFP37 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZFP37 30 31
  • 99.11 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ZFP37 30 31
  • 88.04 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ZFP37 30
  • 87.59 (n)
-- 31
  • 53 (a)
ManyToMany
Mouse
(Mus musculus)
Mammalia Zfp37 30 17 31
  • 80.73 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Zfp37 30
  • 77.78 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 56 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 55 (a)
OneToMany
Chicken
(Gallus gallus)
Aves -- 31
  • 43 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta Kr-h1 32
  • 50 (a)
CG9650 32
  • 45 (a)
dwg 32
  • 44 (a)
CG12299 32
  • 42 (a)
CG3407 32
  • 38 (a)
CG7963 32
  • 36 (a)
Neu2 32
  • 32 (a)
Species where no ortholog for ZFP37 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZFP37 Gene

ENSEMBL:
Gene Tree for ZFP37 (if available)
TreeFam:
Gene Tree for ZFP37 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZFP37: view image

Paralogs for ZFP37 Gene

(535) SIMAP similar genes for ZFP37 Gene using alignment to 2 proteins:

  • ZFP37_HUMAN
  • G3V3L7_HUMAN

Pseudogenes.org Pseudogenes for ZFP37 Gene

genes like me logo Genes that share paralogs with ZFP37: view

Variants for ZFP37 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZFP37 Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
rs202181932 Uncertain Significance: not provided 113,056,670(-) C/G MISSENSE_VARIANT
rs2282076 - p.Val7Asp

Additional dbSNP identifiers (rs#s) for ZFP37 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZFP37 Gene

Variant ID Type Subtype PubMed ID
dgv1232n67 CNV gain 20364138
dgv12853n54 CNV loss 21841781
dgv943n27 CNV loss 19166990
esv2759710 CNV gain 17122850
esv2764155 CNV loss 21179565
esv3573363 CNV loss 25503493
esv3621526 CNV gain 21293372
esv3621527 CNV loss 21293372
esv3621528 CNV gain 21293372
esv3891712 CNV loss 25118596
esv3891713 CNV loss 25118596
nsv1037784 CNV loss 25217958
nsv1128515 CNV deletion 24896259
nsv1161899 CNV deletion 26073780
nsv466491 CNV loss 19166990
nsv508563 CNV deletion 20534489
nsv509318 CNV insertion 20534489
nsv510987 OTHER complex 20534489
nsv517282 CNV loss 19592680
nsv525545 CNV gain 19592680
nsv615204 CNV loss 21841781
nsv6672 CNV deletion 18451855
nsv831691 CNV loss 17160897
nsv8562 CNV gain+loss 18304495

Variation tolerance for ZFP37 Gene

Residual Variation Intolerance Score: 45% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.53; 77.77% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZFP37 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZFP37

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZFP37 Gene

Disorders for ZFP37 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZFP37 Gene - From: DISEASES

Disorder Aliases PubMed IDs
acrofacial dysostosis 1, nager type
  • afd1
- elite association - COSMIC cancer census association via MalaCards
Search ZFP37 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with ZFP37: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZFP37 Gene

Publications for ZFP37 Gene

  1. Cloning, characterization, and chromosomal assignment of the human ortholog of murine Zfp-37, a candidate gene for Nager syndrome. (PMID: 9585434) Dreyer SD … Lee B (Mammalian genome : official journal of the International Mammalian Genome Society 1998) 3 4
  2. The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery. (PMID: 29180619) Kumar R … Vertegaal ACO (Nature communications 2017) 3
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3

Products for ZFP37 Gene

Sources for ZFP37 Gene