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Aliases for ZFP36L2 Gene

Aliases for ZFP36L2 Gene

  • ZFP36 Ring Finger Protein Like 2 2 3 5
  • Zinc Finger Protein 36, C3H1 Type-Like 2 3 4
  • Zinc Finger Protein 36, C3H Type-Like 1 2 3
  • Zinc Finger Protein 36, C3H Type-Like 2 2 3
  • Butyrate Response Factor 2 3 4
  • TPA-Induced Sequence 11d 3 4
  • EGF-Response Factor 2 3 4
  • ZFP36-Like 2 3 4
  • RNF162C 3 4
  • TIS11D 3 4
  • ERF-2 3 4
  • BRF2 3 4
  • ERF2 3 4
  • Zinc Finger Protein, C3H Type, 36-Like 2 3
  • MRNA Decay Activator Protein ZFP36L2 3

External Ids for ZFP36L2 Gene

Previous HGNC Symbols for ZFP36L2 Gene

  • BRF2

Previous GeneCards Identifiers for ZFP36L2 Gene

  • GC02M043449
  • GC02M043619
  • GC02M043425
  • GC02M043362
  • GC02M043304

Summaries for ZFP36L2 Gene

Entrez Gene Summary for ZFP36L2 Gene

  • This gene is a member of the TIS11 family of early response genes. Family members are induced by various agonists such as the phorbol ester TPA and the polypeptide mitogen EGF. The encoded protein contains a distinguishing putative zinc finger domain with a repeating cys-his motif. This putative nuclear transcription factor most likely functions in regulating the response to growth factors. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZFP36L2 Gene

ZFP36L2 (ZFP36 Ring Finger Protein Like 2) is a Protein Coding gene. Diseases associated with ZFP36L2 include Acute T Cell Leukemia. Among its related pathways are Preimplantation Embryo and Cellular senescence (KEGG). Gene Ontology (GO) annotations related to this gene include AU-rich element binding. An important paralog of this gene is ZFP36L1.

UniProtKB/Swiss-Prot for ZFP36L2 Gene

  • Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:25106868, PubMed:14981510). Acts as a 3-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:25106868). Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes (PubMed:25106868). Binds to 3-UTR ARE of numerous mRNAs (PubMed:20506496, PubMed:25106868, PubMed:14981510). Promotes ARE-containing mRNA decay of the low-density lipoprotein (LDL) receptor (LDLR) mRNA in response to phorbol 12-myristate 13-acetate (PMA) treatment in a p38 MAPK-dependent manner (PubMed:25106868). Positively regulates early adipogenesis by promoting ARE-mediated mRNA decay of immediate early genes (IEGs). Plays a role in mature peripheral neuron integrity by promoting ARE-containing mRNA decay of the transcriptional repressor REST mRNA. Plays a role in ovulation and oocyte meiotic maturation by promoting ARE-mediated mRNA decay of the luteinizing hormone receptor LHCGR mRNA. Acts as a negative regulator of erythroid cell differentiation: promotes glucocorticoid-induced self-renewal of erythroid cells by binding mRNAs that are induced or highly expressed during terminal erythroid differentiation and promotes their degradation, preventing erythroid cell differentiation. In association with ZFP36L1 maintains quiescence on developing B lymphocytes by promoting ARE-mediated decay of several mRNAs encoding cell cycle regulators that help B cells progress through the cell cycle, and hence ensuring accurate variable-diversity-joining (VDJ) recombination process and functional immune cell formation. Together with ZFP36L1 is also necessary for thymocyte development and prevention of T-cell acute lymphoblastic leukemia (T-ALL) transformation by promoting ARE-mediated mRNA decay of the oncogenic transcription factor NOTCH1 mRNA.

Additional gene information for ZFP36L2 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZFP36L2 Gene

Genomics for ZFP36L2 Gene

GeneHancer (GH) Regulatory Elements for ZFP36L2 Gene

Promoters and enhancers for ZFP36L2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I043216 Promoter/Enhancer 3.2 VISTA UCNEbase EPDnew Ensembl ENCODE dbSUPER 550.8 +3.3 3324 13 CLOCK MLX ZFP64 DMAP1 YY1 SLC30A9 E2F8 ZNF143 SP3 NFYC ZFP36L2 THADA RNU6-1048P PLEKHH2 ENSG00000234936 LINC01126 LINC02580 GC02P042660
GH02I043126 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 24.1 +92.5 92482 14.6 HDGF PKNOX1 ARID4B NEUROD1 SIN3A DMAP1 IRF4 SLC30A9 CBX5 ZNF207 ZFP36L2 OXER1 ENSG00000234936 RNU6-242P THADA LOC105374570 LINC02580 GC02P042660
GH02I043190 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 14.9 +32.7 32663 7.6 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B DMAP1 YY1 CBX5 ZNF143 THADA RNU6-1048P ZFP36L2 HAAO LINC02580 GC02P042660
GH02I043264 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 16 -41.1 -41108 6.2 JUN PYGO2 ZNF644 RAD21 TCF12 FOXK2 POLR2A CBFA2T2 RCOR1 FOS ENSG00000234936 ZFP36L2 RNU6-958P THADA GC02P042660
GH02I043209 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.1 +15.6 15636 2 HDGF PKNOX1 SMAD1 FOXA2 MLX ARID4B DMAP1 ZNF766 MCM3 SP5 RNU6-1048P PLEKHH2 THADA OXER1 DYNC2LI1 ZFP36L2 C1GALT1C1L LINC02580 GC02P042660
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZFP36L2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZFP36L2 gene promoter:

Genomic Locations for ZFP36L2 Gene

Genomic Locations for ZFP36L2 Gene
chr2:43,222,402-43,226,609
(GRCh38/hg38)
Size:
4,208 bases
Orientation:
Minus strand
chr2:43,449,541-43,453,748
(GRCh37/hg19)

Genomic View for ZFP36L2 Gene

Genes around ZFP36L2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZFP36L2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZFP36L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFP36L2 Gene

Proteins for ZFP36L2 Gene

  • Protein details for ZFP36L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P47974-TISD_HUMAN
    Recommended name:
    mRNA decay activator protein ZFP36L2
    Protein Accession:
    P47974
    Secondary Accessions:
    • Q53TB4
    • Q9BSJ3

    Protein attributes for ZFP36L2 Gene

    Size:
    494 amino acids
    Molecular mass:
    51063 Da
    Quaternary structure:
    • Associates with the cytoplasmic CCR4-NOT deadenylase to trigger ARE-containing mRNA deadenylation and decay processes (PubMed:25106868). Interacts with CNOT7; this interaction is inhibited in response to phorbol 12-myristate 13-acetate (PMA) treatment in a p38 MAPK-dependent manner (PubMed:25106868).

    Three dimensional structures from OCA and Proteopedia for ZFP36L2 Gene

neXtProt entry for ZFP36L2 Gene

Post-translational modifications for ZFP36L2 Gene

  • Phosphorylated by RPS6KA1 at Ser-490 and Ser-492 upon phorbol 12-myristate 13-acetate (PMA) treatment; this phosphorylation results in dissociation of the CCR4-NOT-deadenylase complex and induces p38 MAPK-mediated stabilization of the low-density lipoprotein (LDL) receptor (LDLR) mRNA (PubMed:25106868). Phosphorylation occurs during early preadipocyte differentiation (By similarity).

Other Protein References for ZFP36L2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZFP36L2 Gene

Domains & Families for ZFP36L2 Gene

Gene Families for ZFP36L2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for ZFP36L2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZFP36L2: view

No data available for UniProtKB/Swiss-Prot for ZFP36L2 Gene

Function for ZFP36L2 Gene

Molecular function for ZFP36L2 Gene

UniProtKB/Swiss-Prot Function:
Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:25106868, PubMed:14981510). Acts as a 3-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:25106868). Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes (PubMed:25106868). Binds to 3-UTR ARE of numerous mRNAs (PubMed:20506496, PubMed:25106868, PubMed:14981510). Promotes ARE-containing mRNA decay of the low-density lipoprotein (LDL) receptor (LDLR) mRNA in response to phorbol 12-myristate 13-acetate (PMA) treatment in a p38 MAPK-dependent manner (PubMed:25106868). Positively regulates early adipogenesis by promoting ARE-mediated mRNA decay of immediate early genes (IEGs). Plays a role in mature peripheral neuron integrity by promoting ARE-containing mRNA decay of the transcriptional repressor REST mRNA. Plays a role in ovulation and oocyte meiotic maturation by promoting ARE-mediated mRNA decay of the luteinizing hormone receptor LHCGR mRNA. Acts as a negative regulator of erythroid cell differentiation: promotes glucocorticoid-induced self-renewal of erythroid cells by binding mRNAs that are induced or highly expressed during terminal erythroid differentiation and promotes their degradation, preventing erythroid cell differentiation. In association with ZFP36L1 maintains quiescence on developing B lymphocytes by promoting ARE-mediated decay of several mRNAs encoding cell cycle regulators that help B cells progress through the cell cycle, and hence ensuring accurate variable-diversity-joining (VDJ) recombination process and functional immune cell formation. Together with ZFP36L1 is also necessary for thymocyte development and prevention of T-cell acute lymphoblastic leukemia (T-ALL) transformation by promoting ARE-mediated mRNA decay of the oncogenic transcription factor NOTCH1 mRNA.
UniProtKB/Swiss-Prot Induction:
Up-regulated by butyrate in colorectal cancer cells (PubMed:10367403). Up-regulated in keratinocytes after wounding (PubMed:20166898, PubMed:27182009). Up-regulated strongly by granulocyte macrophage colony-stimulating factor (GM-CSF) in keratinocytes (PubMed:20166898). Up-regulated moderately by transforming growth factor (TGF-beta), epidermal growth factor (EGF), tumor necrosis factor (TNF-alpha) and fibroblast growth factor (FGF1) in keratinocytes (PubMed:20166898). Up-regulated also by glucocorticoid dexamethasone in keratinocytes (PubMed:20166898).

Phenotypes From GWAS Catalog for ZFP36L2 Gene

Gene Ontology (GO) - Molecular Function for ZFP36L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity TAS 7835719
GO:0003723 RNA binding HDA,IEA 22658674
GO:0005515 protein binding IPI 25106868
GO:0017091 AU-rich element binding IDA 20506496
genes like me logo Genes that share ontologies with ZFP36L2: view
genes like me logo Genes that share phenotypes with ZFP36L2: view

Animal Models for ZFP36L2 Gene

MGI Knock Outs for ZFP36L2:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZFP36L2 Gene

Localization for ZFP36L2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZFP36L2 Gene

Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm in a XPO1/CRM1-dependent manner. {ECO:0000250 UniProtKB:P23949}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZFP36L2 gene
Compartment Confidence
nucleus 5
cytosol 4

Gene Ontology (GO) - Cellular Components for ZFP36L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm ISS --
GO:0005829 cytosol IBA --
GO:0030529 intracellular ribonucleoprotein complex IEA --
genes like me logo Genes that share ontologies with ZFP36L2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZFP36L2 Gene

Pathways & Interactions for ZFP36L2 Gene

genes like me logo Genes that share pathways with ZFP36L2: view

Pathways by source for ZFP36L2 Gene

1 BioSystems pathway for ZFP36L2 Gene
1 KEGG pathway for ZFP36L2 Gene

Gene Ontology (GO) - Biological Process for ZFP36L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006402 mRNA catabolic process IEA,ISS --
GO:0007275 multicellular organism development IEA --
GO:0008283 cell proliferation TAS 7835719
genes like me logo Genes that share ontologies with ZFP36L2: view

No data available for SIGNOR curated interactions for ZFP36L2 Gene

Drugs & Compounds for ZFP36L2 Gene

(1) Drugs for ZFP36L2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for ZFP36L2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ZFP36L2: view

Transcripts for ZFP36L2 Gene

mRNA/cDNA for ZFP36L2 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(223) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZFP36L2 Gene

ZFP36 ring finger protein-like 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZFP36L2 Gene

No ASD Table

Relevant External Links for ZFP36L2 Gene

GeneLoc Exon Structure for
ZFP36L2
ECgene alternative splicing isoforms for
ZFP36L2

Expression for ZFP36L2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZFP36L2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZFP36L2 Gene

This gene is overexpressed in Testis (27.4), CD8 Tcells (13.0), and Adipocyte (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZFP36L2 Gene



Protein tissue co-expression partners for ZFP36L2 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZFP36L2 Gene:

ZFP36L2

SOURCE GeneReport for Unigene cluster for ZFP36L2 Gene:

Hs.503093

mRNA Expression by UniProt/SwissProt for ZFP36L2 Gene:

P47974-TISD_HUMAN
Tissue specificity: Expressed mainly in the basal epidermal layer, weakly in the suprabasal epidermal layers (PubMed:27182009). Expressed in epidermal keratinocytes (at protein level) (PubMed:27182009).

Evidence on tissue expression from TISSUES for ZFP36L2 Gene

  • Liver(4.4)
  • Pancreas(4.4)
  • Lung(3.9)
  • Nervous system(3.6)
  • Kidney(3.4)
  • Intestine(3.2)
  • Stomach(2.3)
  • Heart(2)
  • Lymph node(2)
  • Spleen(2)
  • Thyroid gland(2)
genes like me logo Genes that share expression patterns with ZFP36L2: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZFP36L2 Gene

Orthologs for ZFP36L2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZFP36L2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZFP36L2 33 34
  • 99.19 (n)
dog
(Canis familiaris)
Mammalia ZFP36L2 33 34
  • 91.08 (n)
rat
(Rattus norvegicus)
Mammalia LOC100911319 33
  • 88.38 (n)
mouse
(Mus musculus)
Mammalia Zfp36l2 33 16 34
  • 87.71 (n)
cow
(Bos Taurus)
Mammalia ZFP36L2 33 34
  • 87.01 (n)
oppossum
(Monodelphis domestica)
Mammalia ZFP36L2 34
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZFP36L2 34
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZFP36L2 34
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zfp36l2 33
  • 72.66 (n)
Str.4111 33
African clawed frog
(Xenopus laevis)
Amphibia zfp36l2-prov 33
zebrafish
(Danio rerio)
Actinopterygii zfp36l2 33 34
  • 64.86 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8295 33
fruit fly
(Drosophila melanogaster)
Insecta Tis11 35 34
  • 81 (a)
worm
(Caenorhabditis elegans)
Secernentea ccch-2 34
  • 27 (a)
ManyToMany
C35D6.4 34
  • 26 (a)
ManyToMany
Y60A9.3 34
  • 26 (a)
ManyToMany
F38C2.7 34
  • 25 (a)
ManyToMany
Y116A8C.19 34
  • 25 (a)
ManyToMany
ccch-5 34
  • 24 (a)
ManyToMany
dct-13 34
  • 24 (a)
ManyToMany
Y116A8C.20 34
  • 23 (a)
ManyToMany
ccch-1 34
  • 21 (a)
ManyToMany
pos-1 34
  • 20 (a)
ManyToMany
mex-1 34
  • 16 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CTH1 34 36
  • 18 (a)
ManyToMany
TIS11 34
  • 17 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6084 34
  • 32 (a)
OneToMany
Species where no ortholog for ZFP36L2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZFP36L2 Gene

ENSEMBL:
Gene Tree for ZFP36L2 (if available)
TreeFam:
Gene Tree for ZFP36L2 (if available)

Paralogs for ZFP36L2 Gene

Paralogs for ZFP36L2 Gene

genes like me logo Genes that share paralogs with ZFP36L2: view

Variants for ZFP36L2 Gene

Sequence variations from dbSNP and Humsavar for ZFP36L2 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000348230 -- 43,224,205(-) A/G 3_prime_UTR_variant
rs1000653563 -- 43,224,249(-) G/A/T 3_prime_UTR_variant
rs1000937047 -- 43,227,530(-) G/C upstream_transcript_variant
rs1001127236 -- 43,226,646(-) T/C upstream_transcript_variant
rs1001282627 -- 43,227,385(-) C/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ZFP36L2 Gene

Variant ID Type Subtype PubMed ID
nsv829097 CNV gain 20364138
nsv581649 CNV loss 21841781
nsv581648 CNV gain 21841781
nsv581647 CNV loss 21841781
nsv1007740 CNV gain 25217958
esv25646 CNV loss 19812545
dgv6828n54 CNV loss 21841781
dgv6827n54 CNV loss 21841781

Variation tolerance for ZFP36L2 Gene

Residual Variation Intolerance Score: 23% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.35; 70.81% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZFP36L2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZFP36L2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZFP36L2 Gene

Disorders for ZFP36L2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZFP36L2 Gene - From: GeneCards

Disorder Aliases PubMed IDs
acute t cell leukemia
  • precursor t lymphoblastic leukemia
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

TISD_HUMAN
  • Note=Defects in ZFP36L2 may be a cause of leukemias. Frameshfits mutations disrupting ZFP36L2 have been found in a patient with acute myeloid leukemia (PubMed:21109922). {ECO:0000269 PubMed:21109922}.

Additional Disease Information for ZFP36L2

genes like me logo Genes that share disorders with ZFP36L2: view

No data available for Genatlas for ZFP36L2 Gene

Publications for ZFP36L2 Gene

  1. Recognition of the mRNA AU-rich element by the zinc finger domain of TIS11d. (PMID: 14981510) Hudson BP … Wright PE (Nature structural & molecular biology 2004) 2 3 4 22 58
  2. Identification of a member of the TIS11 early response gene family at the insertion point of a DNA fragment containing a gene for the T-cell receptor beta chain in an acute T-cell leukemia. (PMID: 8545129) Ino T … Kurosawa Y (Oncogene 1995) 2 3 4 22 58
  3. ZFP36L1 is regulated by growth factors and cytokines in keratinocytes and influences their VEGF production. (PMID: 20166898) Hacker C … Munz B (Growth factors (Chur, Switzerland) 2010) 3 4 22 58
  4. ERF-2, the human homologue of the murine Tis11d early response gene. (PMID: 7835719) Nie XF … Bustin SA (Gene 1995) 2 3 4 58
  5. Functional analysis of ZFP36 proteins in keratinocytes. (PMID: 27182009) Prenzler F … Munz B (European journal of cell biology 2016) 3 4 58

Products for ZFP36L2 Gene

Sources for ZFP36L2 Gene

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