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Aliases for ZFP36L1 Gene

Aliases for ZFP36L1 Gene

  • ZFP36 Ring Finger Protein Like 1 2 3 5
  • Zinc Finger Protein 36, C3H1 Type-Like 1 3 4
  • Zinc Finger Protein, C3H Type, 36-Like 1 2 3
  • Zinc Finger Protein 36, C3H Type-Like 1 2 3
  • Butyrate Response Factor 1 3 4
  • TPA-Induced Sequence 11b 3 4
  • EGF-Response Factor 1 3 4
  • ZFP36-Like 1 3 4
  • RNF162B 3 4
  • TIS11B 3 4
  • ERF-1 3 4
  • BRF1 3 4
  • ERF1 3 4
  • MRNA Decay Activator Protein ZFP36L1 3
  • Early Response Factor Berg36 3
  • Berg36 3
  • BERG36 4
  • CMG1 3

External Ids for ZFP36L1 Gene

Previous HGNC Symbols for ZFP36L1 Gene

  • BRF1

Previous GeneCards Identifiers for ZFP36L1 Gene

  • GC14M066759
  • GC14M063048
  • GC14M067244
  • GC14M068324
  • GC14M069254
  • GC14M049422

Summaries for ZFP36L1 Gene

Entrez Gene Summary for ZFP36L1 Gene

  • This gene is a member of the TIS11 family of early response genes, which are induced by various agonists such as the phorbol ester TPA and the polypeptide mitogen EGF. This gene is well conserved across species and has a promoter that contains motifs seen in other early-response genes. The encoded protein contains a distinguishing putative zinc finger domain with a repeating cys-his motif. This putative nuclear transcription factor most likely functions in regulating the response to growth factors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

GeneCards Summary for ZFP36L1 Gene

ZFP36L1 (ZFP36 Ring Finger Protein Like 1) is a Protein Coding gene. Diseases associated with ZFP36L1 include Sotos Syndrome 1. Among its related pathways are Translational Control and PI3K / Akt Signaling. Gene Ontology (GO) annotations related to this gene include mRNA binding. An important paralog of this gene is ZFP36L2.

UniProtKB/Swiss-Prot for ZFP36L1 Gene

  • Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:12198173, PubMed:15538381, PubMed:15467755, PubMed:17030608, PubMed:19179481, PubMed:20702587, PubMed:24700863, PubMed:25106868, PubMed:25014217, PubMed:26542173). Acts as a 3-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:15687258). Functions by recruiting the CCR4-NOT deadenylase complex and components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes (PubMed:15687258, PubMed:18326031, PubMed:25106868). Induces also the degradation of ARE-containing mRNAs even in absence of poly(A) tail (By similarity). Binds to 3-UTR ARE of numerous mRNAs (PubMed:12198173, PubMed:15538381, PubMed:15467755, PubMed:17030608, PubMed:19179481, PubMed:20702587, PubMed:24700863, PubMed:25106868, PubMed:25014217, PubMed:26542173). Positively regulates early adipogenesis by promoting ARE-mediated mRNA decay of immediate early genes (IEGs) (By similarity). Promotes ARE-mediated mRNA decay of mineralocorticoid receptor NR3C2 mRNA in response to hypertonic stress (PubMed:24700863). Negatively regulates hematopoietic/erythroid cell differentiation by promoting ARE-mediated mRNA decay of the transcription factor STAT5B mRNA (PubMed:20702587). Positively regulates monocyte/macrophage cell differentiation by promoting ARE-mediated mRNA decay of the cyclin-dependent kinase CDK6 mRNA (PubMed:26542173). Promotes degradation of ARE-containing pluripotency-associated mRNAs in embryonic stem cells (ESCs), such as NANOG, through a fibroblast growth factor (FGF)-induced MAPK-dependent signaling pathway, and hence attenuates ESC self-renewal and positively regulates mesendoderm differentiation (By similarity). May play a role in mediating pro-apoptotic effects in malignant B-cells by promoting ARE-mediated mRNA decay of BCL2 mRNA (PubMed:25014217). In association with ZFP36L2 maintains quiescence on developing B lymphocytes by promoting ARE-mediated decay of several mRNAs encoding cell cycle regulators that help B cells progress through the cell cycle, and hence ensuring accurate variable-diversity-joining (VDJ) recombination and functional immune cell formation (By similarity). Together with ZFP36L2 is also necessary for thymocyte development and prevention of T-cell acute lymphoblastic leukemia (T-ALL) transformation by promoting ARE-mediated mRNA decay of the oncogenic transcription factor NOTCH1 mRNA (By similarity). Participates in the delivery of target ARE-mRNAs to processing bodies (PBs) (PubMed:17369404). In addition to its cytosolic mRNA-decay function, plays a role in the regulation of nuclear mRNA 3-end processing; modulates mRNA 3-end maturation efficiency of the DLL4 mRNA through binding with an ARE embedded in a weak noncanonical polyadenylation (poly(A)) signal in endothelial cells (PubMed:21832157). Also involved in the regulation of stress granule (SG) and P-body (PB) formation and fusion (PubMed:15967811). Plays a role in vasculogenesis and endocardial development (By similarity). Plays a role in the regulation of keratinocyte proliferation, differentiation and apoptosis (PubMed:27182009). Plays a role in myoblast cell differentiation (By similarity).

Gene Wiki entry for ZFP36L1 Gene

Additional gene information for ZFP36L1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZFP36L1 Gene

Genomics for ZFP36L1 Gene

GeneHancer (GH) Regulatory Elements for ZFP36L1 Gene

Promoters and enhancers for ZFP36L1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J068778 Promoter/Enhancer 2.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 652.4 +8.0 8032 20.4 CLOCK MLX ZFP64 FEZF1 DMAP1 YBX1 IRF4 YY1 SLC30A9 ZNF213 ZFP36L1 SRSF5 ZFYVE26 DCAF5 SUSD6 DDX18P1 RNU6-921P GC14M068736 GC14M068442
GH14J068818 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 12.8 -24.6 -24553 5 HDGF PKNOX1 SMAD1 NEUROD1 IRF4 YY1 GLIS2 ZNF143 ATF7 FOS ZFP36L1 DCAF5 GC14P068845 GC14M068442
GH14J068237 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 12.2 +550.7 550690 15.3 FEZF1 TCF12 ZNF766 ARID2 ZNF143 ZFP91 FOS RUNX3 RXRA JUNB ZFP36L1 RN7SL108P GC14P068302 RAD51B
GH14J068931 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 8 -146.1 -146148 22.8 PKNOX1 FOXA2 ZFP64 ARID4B SIN3A YY1 ZNF143 FOS SP5 MXD4 ACTN1 ZFP36L1 DCAF5 GALNT16 BANF1P1 GC14P068937
GH14J068732 Enhancer 1.3 FANTOM5 Ensembl ENCODE 10.8 +60.9 60877 4.8 HDGF MAX TSC22D4 EBF1 BATF IRF4 ZNF48 RELA ZFHX2 GATA3 GC14M068736 RNU6-921P ZFYVE26 DCAF5 SRSF5 DDX18P1 SUSD6 ZFP36L1 ENSG00000258623 GC14P068694
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZFP36L1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZFP36L1 gene promoter:
  • ATF-2
  • c-Jun
  • AP-1
  • c-Fos
  • AREB6
  • COMP1
  • Egr-3
  • Gfi-1

Genomic Locations for ZFP36L1 Gene

Genomic Locations for ZFP36L1 Gene
chr14:68,787,655-68,796,253
(GRCh38/hg38)
Size:
8,599 bases
Orientation:
Minus strand
chr14:69,254,375-69,263,190
(GRCh37/hg19)
Size:
8,816 bases
Orientation:
Minus strand

Genomic View for ZFP36L1 Gene

Genes around ZFP36L1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZFP36L1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZFP36L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFP36L1 Gene

Proteins for ZFP36L1 Gene

  • Protein details for ZFP36L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q07352-TISB_HUMAN
    Recommended name:
    mRNA decay activator protein ZFP36L1
    Protein Accession:
    Q07352
    Secondary Accessions:
    • Q13851

    Protein attributes for ZFP36L1 Gene

    Size:
    338 amino acids
    Molecular mass:
    36314 Da
    Quaternary structure:
    • Associates with the cytoplasmic CCR4-NOT deadenylase and RNA exosome complexes to trigger ARE-containing mRNA deadenylation and decay processes (PubMed:15687258, PubMed:18326031, PubMed:25106868). Interacts with CNOT1 (PubMed:25106868). Interacts (via N-terminus) with CNOT6 (PubMed:15687258, PubMed:18326031). Interacts with CNOT7; this interaction is inhibited in response to phorbol 12-myristate 13-acetate (PMA) treatment in a p38 MAPK-dependent manner (PubMed:25106868). Interacts with DCP1A (PubMed:15687258). Interacts (via N-terminus) with DCP2 (PubMed:15687258, PubMed:18326031). Interacts (via N-terminus) with EXOSC2 (PubMed:15687258, PubMed:18326031). Interacts with XRN1 (PubMed:15687258). Interacts (via phosphorylated form) with YWHAB; this interaction occurs in a protein kinase AKT1-dependent manner (PubMed:15538381, PubMed:17030608, PubMed:18326031). Interacts (via phosphorylated form) with YWHAZ; this interaction occurs in a p38 MAPK- and AKT-signaling pathways (By similarity).

    Three dimensional structures from OCA and Proteopedia for ZFP36L1 Gene

neXtProt entry for ZFP36L1 Gene

Post-translational modifications for ZFP36L1 Gene

  • Phosphorylated (PubMed:19179481). Phosphorylated by RPS6KA1 at Ser-334 upon phorbol 12-myristate 13-acetate (PMA) treatment; this phosphorylation results in dissociation of the CCR4-NOT deadenylase complex and induces p38 MAPK-mediated stabilization of the low-density lipoprotein receptor LDLR mRNA (PubMed:25106868). Phosphorylated by protein kinase AKT1 at Ser-92 and Ser-203 in response to insulin; these phosphorylations stabilize ZFP36L1, increase the association with 14-3-3 proteins and mediate ARE-containing mRNA stabilization (PubMed:15538381, PubMed:17030608). AKT1-mediated phosphorylation at Ser-92 does not impair ARE-containing RNA-binding (PubMed:15538381). Phosphorylated at Ser-54, Ser-92 and Ser-203 by MAPKAPK2; these phosphorylations increase the association with 14-3-3 proteins and mediate ARE-containing mRNA stabilization in a protein kinase AKT1-independent manner (PubMed:18326031). MAPKAPK2-mediated phosphorylations at Ser-54, Ser-92 and Ser-203 do not impair ARE-containing RNA-binding (PubMed:18326031). Phosphorylations increase the association with 14-3-3 proteins and mediate ARE-containing mRNA stabilization during early adipogenesis in a p38 MAPK- and AKT-dependent manner (By similarity).
  • Ubiquitinated. Ubiquitination leads to proteasomal degradation, a process inhibited by phosphorylations at Ser-90, Ser-92 and Ser-203 (PubMed:17030608).
  • Ubiquitination at isoforms=103
  • Modification sites at PhosphoSitePlus

Other Protein References for ZFP36L1 Gene

No data available for DME Specific Peptides for ZFP36L1 Gene

Domains & Families for ZFP36L1 Gene

Gene Families for ZFP36L1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for ZFP36L1 Gene

Suggested Antigen Peptide Sequences for ZFP36L1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZFP36L1: view

No data available for UniProtKB/Swiss-Prot for ZFP36L1 Gene

Function for ZFP36L1 Gene

Molecular function for ZFP36L1 Gene

UniProtKB/Swiss-Prot Function:
Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:12198173, PubMed:15538381, PubMed:15467755, PubMed:17030608, PubMed:19179481, PubMed:20702587, PubMed:24700863, PubMed:25106868, PubMed:25014217, PubMed:26542173). Acts as a 3-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:15687258). Functions by recruiting the CCR4-NOT deadenylase complex and components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes (PubMed:15687258, PubMed:18326031, PubMed:25106868). Induces also the degradation of ARE-containing mRNAs even in absence of poly(A) tail (By similarity). Binds to 3-UTR ARE of numerous mRNAs (PubMed:12198173, PubMed:15538381, PubMed:15467755, PubMed:17030608, PubMed:19179481, PubMed:20702587, PubMed:24700863, PubMed:25106868, PubMed:25014217, PubMed:26542173). Positively regulates early adipogenesis by promoting ARE-mediated mRNA decay of immediate early genes (IEGs) (By similarity). Promotes ARE-mediated mRNA decay of mineralocorticoid receptor NR3C2 mRNA in response to hypertonic stress (PubMed:24700863). Negatively regulates hematopoietic/erythroid cell differentiation by promoting ARE-mediated mRNA decay of the transcription factor STAT5B mRNA (PubMed:20702587). Positively regulates monocyte/macrophage cell differentiation by promoting ARE-mediated mRNA decay of the cyclin-dependent kinase CDK6 mRNA (PubMed:26542173). Promotes degradation of ARE-containing pluripotency-associated mRNAs in embryonic stem cells (ESCs), such as NANOG, through a fibroblast growth factor (FGF)-induced MAPK-dependent signaling pathway, and hence attenuates ESC self-renewal and positively regulates mesendoderm differentiation (By similarity). May play a role in mediating pro-apoptotic effects in malignant B-cells by promoting ARE-mediated mRNA decay of BCL2 mRNA (PubMed:25014217). In association with ZFP36L2 maintains quiescence on developing B lymphocytes by promoting ARE-mediated decay of several mRNAs encoding cell cycle regulators that help B cells progress through the cell cycle, and hence ensuring accurate variable-diversity-joining (VDJ) recombination and functional immune cell formation (By similarity). Together with ZFP36L2 is also necessary for thymocyte development and prevention of T-cell acute lymphoblastic leukemia (T-ALL) transformation by promoting ARE-mediated mRNA decay of the oncogenic transcription factor NOTCH1 mRNA (By similarity). Participates in the delivery of target ARE-mRNAs to processing bodies (PBs) (PubMed:17369404). In addition to its cytosolic mRNA-decay function, plays a role in the regulation of nuclear mRNA 3-end processing; modulates mRNA 3-end maturation efficiency of the DLL4 mRNA through binding with an ARE embedded in a weak noncanonical polyadenylation (poly(A)) signal in endothelial cells (PubMed:21832157). Also involved in the regulation of stress granule (SG) and P-body (PB) formation and fusion (PubMed:15967811). Plays a role in vasculogenesis and endocardial development (By similarity). Plays a role in the regulation of keratinocyte proliferation, differentiation and apoptosis (PubMed:27182009). Plays a role in myoblast cell differentiation (By similarity).
UniProtKB/Swiss-Prot Induction:
Down-regulated under hypoxic conditions in endothelial cells (at protein level) (PubMed:21832157). Up-regulated by growth factor (TGF-beta), cytokines, tumor necrosis factor (TNF-alpha) and epidermal growth factor (EGF) in keratinocytes (PubMed:20166898). Up-regulated also by glucocorticoid dexamethasone in keratinocytes (PubMed:20166898). Up-regulated in keratinocytes in response to wounding in a p38 MAPK-dependent manner (PubMed:20166898, PubMed:27182009). Up-regulated by the parathyroid hormone (PTH) in osteoblast-like cells in a cAMP/PKA-dependent manner (PubMed:15465005, PubMed:19179481). Up-regulated in response to adrenocorticotropic hormone (ACTH) (PubMed:19179481). Up-regulated during monocyte/macrophage differentiation in response to phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) (PubMed:26542173). Down-regulated by butyrate in colorectal cancer cells (PubMed:10367403).

Phenotypes From GWAS Catalog for ZFP36L1 Gene

Gene Ontology (GO) - Molecular Function for ZFP36L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISM 19274049
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity NAS 8595910
GO:0003723 RNA binding HDA,IEA 22658674
GO:0003729 mRNA binding IDA 15467755
genes like me logo Genes that share ontologies with ZFP36L1: view
genes like me logo Genes that share phenotypes with ZFP36L1: view

Animal Models for ZFP36L1 Gene

MGI Knock Outs for ZFP36L1:

Animal Model Products

CRISPR Products

miRNA for ZFP36L1 Gene

miRTarBase miRNAs that target ZFP36L1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZFP36L1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZFP36L1 Gene

Localization for ZFP36L1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZFP36L1 Gene

Nucleus. Cytoplasm. Cytoplasmic granule. Cytoplasm, P-body. Note=Shuttles between the nucleus and the cytoplasm in a XPO1/CRM1-dependent manner (By similarity). Component of cytoplasmic stress granules (PubMed:15967811). Localizes in processing bodies (PBs) (PubMed:17369404). {ECO:0000250 UniProtKB:P23950, ECO:0000269 PubMed:15967811, ECO:0000269 PubMed:17369404}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZFP36L1 gene
Compartment Confidence
nucleus 5
cytosol 4
extracellular 1

Gene Ontology (GO) - Cellular Components for ZFP36L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000932 P-body IDA,IEA 17369404
GO:0005634 nucleus IDA,IEA 12198173
GO:0005737 cytoplasm IEA,IDA 12198173
GO:0005829 cytosol TAS,IBA --
GO:1990904 ribonucleoprotein complex IDA 15687258
genes like me logo Genes that share ontologies with ZFP36L1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZFP36L1 Gene

Pathways & Interactions for ZFP36L1 Gene

genes like me logo Genes that share pathways with ZFP36L1: view

Pathways by source for ZFP36L1 Gene

SIGNOR curated interactions for ZFP36L1 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for ZFP36L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade IDA 18326031
GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IEA --
GO:0001570 vasculogenesis IEA --
GO:0003342 proepicardium development IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZFP36L1: view

Drugs & Compounds for ZFP36L1 Gene

(1) Drugs for ZFP36L1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for ZFP36L1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ZFP36L1: view

Transcripts for ZFP36L1 Gene

mRNA/cDNA for ZFP36L1 Gene

Unigene Clusters for ZFP36L1 Gene

ZFP36 ring finger protein-like 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZFP36L1

Alternative Splicing Database (ASD) splice patterns (SP) for ZFP36L1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5
SP1: - - -
SP2: -
SP3: -
SP4:

Relevant External Links for ZFP36L1 Gene

GeneLoc Exon Structure for
ZFP36L1
ECgene alternative splicing isoforms for
ZFP36L1

Expression for ZFP36L1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZFP36L1 Gene

Protein differential expression in normal tissues from HIPED for ZFP36L1 Gene

This gene is overexpressed in Cervix (24.1), Lung (17.2), and Serum (16.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZFP36L1 Gene



NURSA nuclear receptor signaling pathways regulating expression of ZFP36L1 Gene:

ZFP36L1

SOURCE GeneReport for Unigene cluster for ZFP36L1 Gene:

Hs.85155

mRNA Expression by UniProt/SwissProt for ZFP36L1 Gene:

Q07352-TISB_HUMAN
Tissue specificity: Expressed mainly in the basal epidermal layer, weakly in the suprabasal epidermal layers (PubMed:27182009). Expressed in epidermal keratinocytes (at protein level) (PubMed:27182009). Expressed in osteoblasts (PubMed:15465005).

Evidence on tissue expression from TISSUES for ZFP36L1 Gene

  • Liver(4.4)
  • Nervous system(4.4)
  • Lung(3.1)
  • Blood(2.9)
  • Intestine(2.7)
  • Kidney(2.7)
  • Adrenal gland(2.5)
  • Gall bladder(2)
  • Lymph node(2)
  • Muscle(2)
  • Spleen(2)
genes like me logo Genes that share expression patterns with ZFP36L1: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZFP36L1 Gene

Orthologs for ZFP36L1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ZFP36L1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZFP36L1 34 33
  • 95.76 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ZFP36L1 34 33
  • 94.77 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp36l1 33
  • 94.38 (n)
mouse
(Mus musculus)
Mammalia Zfp36l1 16 34 33
  • 93.59 (n)
oppossum
(Monodelphis domestica)
Mammalia ZFP36L1 34
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZFP36L1 34 33
  • 89.66 (n)
OneToOne
chicken
(Gallus gallus)
Aves ZFP36L1 33
  • 86.51 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia zfp36l1 33
  • 73.46 (n)
Str.16375 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.475 33
zebrafish
(Danio rerio)
Actinopterygii zfp36l1a 34 33
  • 69.55 (n)
OneToMany
zfp36l1b 34
  • 56 (a)
OneToMany
wufc06f10 33
fruit fly
(Drosophila melanogaster)
Insecta Tis11 34 35
  • 23 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C35D6.4 34
  • 27 (a)
ManyToMany
ccch-2 34
  • 26 (a)
ManyToMany
ccch-5 34
  • 24 (a)
ManyToMany
F38C2.7 34
  • 24 (a)
ManyToMany
Y116A8C.19 34
  • 24 (a)
ManyToMany
Y116A8C.20 34
  • 23 (a)
ManyToMany
Y60A9.3 34
  • 23 (a)
ManyToMany
dct-13 34
  • 22 (a)
ManyToMany
pos-1 34
  • 22 (a)
ManyToMany
ccch-1 34
  • 20 (a)
ManyToMany
mex-1 34
  • 15 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CTH1 34
  • 18 (a)
ManyToMany
TIS11 34
  • 15 (a)
ManyToMany
rice
(Oryza sativa)
Liliopsida Os.30567 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6084 34
  • 33 (a)
OneToMany
Cin.12113 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.12113 33
Species where no ortholog for ZFP36L1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZFP36L1 Gene

ENSEMBL:
Gene Tree for ZFP36L1 (if available)
TreeFam:
Gene Tree for ZFP36L1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZFP36L1: view image

Paralogs for ZFP36L1 Gene

Paralogs for ZFP36L1 Gene

(2) SIMAP similar genes for ZFP36L1 Gene using alignment to 6 proteins:

  • TISB_HUMAN
  • G3V2D5_HUMAN
  • G3V2P5_HUMAN
  • G3V382_HUMAN
  • G3V515_HUMAN
  • J3QTN8_HUMAN
genes like me logo Genes that share paralogs with ZFP36L1: view

Variants for ZFP36L1 Gene

Sequence variations from dbSNP and Humsavar for ZFP36L1 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000267514 -- 68,794,603(-) A/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000399122 -- 68,788,530(-) C/G/T 3_prime_UTR_variant
rs1000478834 -- 68,787,684(-) T/C 3_prime_UTR_variant
rs1000577039 -- 68,794,756(-) T/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000850905 -- 68,787,924(-) G/A 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for ZFP36L1 Gene

Variant ID Type Subtype PubMed ID
dgv1097n106 CNV deletion 24896259
nsv1070226 CNV deletion 25765185
nsv1116460 OTHER inversion 24896259
nsv952859 CNV deletion 24416366

Variation tolerance for ZFP36L1 Gene

Residual Variation Intolerance Score: 19.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.62; 13.36% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZFP36L1 Gene

Human Gene Mutation Database (HGMD)
ZFP36L1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZFP36L1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZFP36L1 Gene

Disorders for ZFP36L1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZFP36L1 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
sotos syndrome 1
  • sotos1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZFP36L1

genes like me logo Genes that share disorders with ZFP36L1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZFP36L1 Gene

Publications for ZFP36L1 Gene

  1. Cloning and characterization of ERF-1, a human member of the Tis11 family of early-response genes. (PMID: 8024689) Bustin SA … McKay IA (DNA and cell biology 1994) 2 3 4 22 58
  2. ZFP36L1 is regulated by growth factors and cytokines in keratinocytes and influences their VEGF production. (PMID: 20166898) Hacker C … Munz B (Growth factors (Chur, Switzerland) 2010) 3 4 22 58
  3. Butyrate response factor 1 is regulated by parathyroid hormone and bone morphogenetic protein-2 in osteoblastic cells. (PMID: 15465005) Reppe S … Jemtland R (Biochemical and biophysical research communications 2004) 3 4 22 58
  4. Destabilization of vascular endothelial growth factor mRNA by the zinc-finger protein TIS11b. (PMID: 15467755) Ciais D … Feige JJ (Oncogene 2004) 3 4 22 58
  5. Functional cloning of BRF1, a regulator of ARE-dependent mRNA turnover. (PMID: 12198173) Stoecklin G … Moroni C (The EMBO journal 2002) 3 4 22 58

Products for ZFP36L1 Gene

Sources for ZFP36L1 Gene

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