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Aliases for ZFP30 Gene

Aliases for ZFP30 Gene

  • ZFP30 Zinc Finger Protein 2 3 5
  • Zinc Finger Protein 745 3 4
  • ZNF745 3 4
  • Zinc Finger Protein 30 Homolog (Mouse) 2
  • Zinc Finger Protein 30 Homolog 3
  • KIAA0961 4
  • Zfp-30 4

External Ids for ZFP30 Gene

Previous GeneCards Identifiers for ZFP30 Gene

  • GC19M042799
  • GC19M042815
  • GC19U900417
  • GC19M038123
  • GC19M034573

Summaries for ZFP30 Gene

GeneCards Summary for ZFP30 Gene

ZFP30 (ZFP30 Zinc Finger Protein) is a Protein Coding gene. Diseases associated with ZFP30 include Cerebral Visual Impairment. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA binding transcription factor activity. An important paralog of this gene is ZFP82.

UniProtKB/Swiss-Prot for ZFP30 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZFP30 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZFP30 Gene

Genomics for ZFP30 Gene

GeneHancer (GH) Regulatory Elements for ZFP30 Gene

Promoters and enhancers for ZFP30 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I037653 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 724.3 +37.0 37037 3 MLX ZFP64 FEZF1 DMAP1 YY1 ZNF213 ZNF416 ZNF143 ZNF548 SP3 ZFP30 ZNF527 ZNF567 ZNF383 ZNF345 ZNF571 ZNF790 HKR1 ZNF850 ZNF585A
GH19I037691 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 564.8 +0.2 225 1.5 PKNOX1 ATF1 ARID4B SIN3A DMAP1 ZNF48 YY1 ZNF143 ATF7 NFYC ZFP30 GC19M038813 SELENOKP1 ZNF781 LINC01535 ZNF607 ENSG00000267552 PIR37882
GH19I037593 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 190.1 +97.6 97636 2.2 PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 IRF4 YY1 SLC30A9 ZNF213 ZNF571 ZNF540 ZNF567 ZNF527 ZFP30 ZNF383 HKR1 ZNF345 ZNF585A ZNF607
GH19I037370 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 176.8 +321.3 321297 1.9 HDGF PKNOX1 SMAD1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF213 ZNF527 ZNF567 ZNF383 ZNF345 ZFP30 ZNF571 HKR1 ZNF850 ZNF793 ZNF790
GH19I038647 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 130.7 -967.5 -967456 25.6 ZFP64 FEZF1 DMAP1 YY1 ZNF213 ZNF143 ZNF548 SP3 NFYC ZC3H11A ACTN4 HNRNPL ZFP30 ZNF607 ZNF781 ZNF573 SUPT5H ENSG00000267152 PAK4 RN7SL566P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZFP30 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZFP30 gene promoter:

Genomic Locations for ZFP30 Gene

Genomic Locations for ZFP30 Gene
chr19:37,613,749-37,692,337
(GRCh38/hg38)
Size:
78,589 bases
Orientation:
Minus strand
chr19:38,104,650-38,183,238
(GRCh37/hg19)

Genomic View for ZFP30 Gene

Genes around ZFP30 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZFP30 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZFP30 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFP30 Gene

Proteins for ZFP30 Gene

  • Protein details for ZFP30 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2G7-ZFP30_HUMAN
    Recommended name:
    Zinc finger protein 30 homolog
    Protein Accession:
    Q9Y2G7
    Secondary Accessions:
    • Q58EY8

    Protein attributes for ZFP30 Gene

    Size:
    519 amino acids
    Molecular mass:
    61558 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA76805.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZFP30 Gene

Post-translational modifications for ZFP30 Gene

No Post-translational modifications

No data available for DME Specific Peptides for ZFP30 Gene

Domains & Families for ZFP30 Gene

Gene Families for ZFP30 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZFP30 Gene

Suggested Antigen Peptide Sequences for ZFP30 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y2G7

UniProtKB/Swiss-Prot:

ZFP30_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZFP30: view

Function for ZFP30 Gene

Molecular function for ZFP30 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZFP30 Gene

Gene Ontology (GO) - Molecular Function for ZFP30 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZFP30: view

Phenotypes for ZFP30 Gene

genes like me logo Genes that share phenotypes with ZFP30: view

miRNA for ZFP30 Gene

miRTarBase miRNAs that target ZFP30

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZFP30 Gene

Localization for ZFP30 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZFP30 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZFP30 gene
Compartment Confidence
nucleus 5
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZFP30 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZFP30: view

Pathways & Interactions for ZFP30 Gene

SuperPathways for ZFP30 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZFP30: view

Pathways by source for ZFP30 Gene

2 Reactome pathways for ZFP30 Gene

Gene Ontology (GO) - Biological Process for ZFP30 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZFP30: view

No data available for SIGNOR curated interactions for ZFP30 Gene

Drugs & Compounds for ZFP30 Gene

No Compound Related Data Available

Transcripts for ZFP30 Gene

mRNA/cDNA for ZFP30 Gene

(7) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(12) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZFP30 Gene

ZFP30 zinc finger protein:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZFP30 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b
SP1: - - - - -
SP2: - -
SP3: -
SP4: - - - - -
SP5: - - - -
SP6: - - - -
SP7: -

Relevant External Links for ZFP30 Gene

GeneLoc Exon Structure for
ZFP30
ECgene alternative splicing isoforms for
ZFP30

Expression for ZFP30 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZFP30 Gene

Protein differential expression in normal tissues from HIPED for ZFP30 Gene

This gene is overexpressed in Plasma (56.3) and Serum (12.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZFP30 Gene



Protein tissue co-expression partners for ZFP30 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZFP30 Gene:

ZFP30

SOURCE GeneReport for Unigene cluster for ZFP30 Gene:

Hs.716719

Evidence on tissue expression from TISSUES for ZFP30 Gene

  • Nervous system(4.2)
  • Eye(4)
genes like me logo Genes that share expression patterns with ZFP30: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZFP30 Gene

Orthologs for ZFP30 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZFP30 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZFP30 33 34
  • 99.68 (n)
dog
(Canis familiaris)
Mammalia ZFP30 33 34
  • 91.1 (n)
cow
(Bos Taurus)
Mammalia ZFP30 33
  • 90.94 (n)
-- 34
  • 63 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Zfp30 33 16 34
  • 79.84 (n)
rat
(Rattus norvegicus)
Mammalia LOC100910007 33
  • 76.81 (n)
Species where no ortholog for ZFP30 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZFP30 Gene

ENSEMBL:
Gene Tree for ZFP30 (if available)
TreeFam:
Gene Tree for ZFP30 (if available)

Paralogs for ZFP30 Gene

(467) SIMAP similar genes for ZFP30 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for ZFP30 Gene

genes like me logo Genes that share paralogs with ZFP30: view

Variants for ZFP30 Gene

Sequence variations from dbSNP and Humsavar for ZFP30 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs869312869 likely-pathogenic, Cerebral visual impairment and intellectual disability 37,635,811(-) A/G coding_sequence_variant, missense_variant
rs1000010153 -- 37,644,127(-) C/A/T intron_variant
rs1000047376 -- 37,638,619(-) G/T intron_variant
rs1000052870 -- 37,656,454(-) T/C upstream_transcript_variant
rs1000081452 -- 37,645,433(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZFP30 Gene

Variant ID Type Subtype PubMed ID
nsv579468 CNV gain 21841781

Variation tolerance for ZFP30 Gene

Residual Variation Intolerance Score: 50.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.13; 38.77% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZFP30 Gene

Human Gene Mutation Database (HGMD)
ZFP30
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZFP30

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZFP30 Gene

Disorders for ZFP30 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZFP30 Gene - From: HGMD and GeneCards

Disorder Aliases PubMed IDs
cerebral visual impairment
  • cortical visual impairment
- elite association - COSMIC cancer census association via MalaCards
Search ZFP30 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ZFP30

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ZFP30: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZFP30 Gene

Publications for ZFP30 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10231032) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 2 3 4 58
  2. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PMID: 19851296) Oguri M … Yamada Y (American journal of hypertension 2010) 3 44 58
  3. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PMID: 20198315) Yoshida T … Yamada Y (International journal of molecular medicine 2010) 3 44 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 58

Products for ZFP30 Gene

Sources for ZFP30 Gene

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