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Aliases for ZFP3 Gene

Aliases for ZFP3 Gene

  • ZFP3 Zinc Finger Protein 2 3 5
  • Zinc Finger Protein Homologous To Zfp-3 In Mouse 2 3
  • Zinc Finger Protein 752 3 4
  • ZNF752 3 4
  • Zfp-3 3 4
  • Zinc Finger Protein 3 Homolog (Mouse) 2
  • Zinc Finger Protein 3 Homolog 3
  • Zinc Finger Protein-3 3

External Ids for ZFP3 Gene

Previous GeneCards Identifiers for ZFP3 Gene

  • GC17U990112
  • GC17P004923
  • GC17P004872
  • GC17P004981

Summaries for ZFP3 Gene

GeneCards Summary for ZFP3 Gene

ZFP3 (ZFP3 Zinc Finger Protein) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity. An important paralog of this gene is ZNF16.

UniProtKB/Swiss-Prot for ZFP3 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZFP3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZFP3 Gene

Genomics for ZFP3 Gene

GeneHancer (GH) Regulatory Elements for ZFP3 Gene

Promoters and enhancers for ZFP3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I005077 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 550.8 +0.3 297 1.9 PKNOX1 SMAD1 RB1 SIN3A ZBTB7B ZBTB40 ETS1 ELK1 ZNF207 ZNF143 ENSG00000262693 ZFP3 GC17M005076 LOC101928000 ZNF232 LOC100130950 RPAIN ZNF594 ENSG00000263272 PELP1
GH17I004856 Enhancer 1.2 Ensembl ENCODE dbSUPER 15.8 -219.5 -219472 5.3 ELF3 FOXA2 RAD21 ZBTB40 ETS1 EGR1 FOS THAP11 MIXL1 EGR2 ATP6V0CP1 CHRNE C17orf107 ZFP3 MINK1 PLD2 ARRB2 LOC101559451 PELP1 RPS12P29
GH17I005110 Promoter/Enhancer 1.6 Ensembl ENCODE 11.7 +33.7 33726 2.1 HDGF MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 LOC101928000 ANKFY1 LOC100130950 RPAIN DHX33 ZNF232 DERL2 ENSG00000263272 ZNF594 ENSG00000263220
GH17I005122 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 11.9 +44.7 44707 0.9 CTCF POLR2A CREB1 EZH2 GC17P005122 ZNF232 ZFP3 SPAG7 SCIMP USP6 PIRC90 GC17P005090
GH17I004852 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 9.9 -224.6 -224613 3.3 NFIA NFIB CBFB ZIC2 ZFHX2 NFIC POLR2A KLF16 ZNF547 PRDM10 CHRNE MINK1 PLD2 ZMYND15 CXCL16 RNF167 SLC25A11 SPAG7 ENO3 PFN1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZFP3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZFP3 gene promoter:

Genomic Locations for ZFP3 Gene

Genomic Locations for ZFP3 Gene
chr17:5,078,248-5,096,374
(GRCh38/hg38)
Size:
18,127 bases
Orientation:
Plus strand
chr17:4,981,543-4,999,669
(GRCh37/hg19)

Genomic View for ZFP3 Gene

Genes around ZFP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZFP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZFP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFP3 Gene

Proteins for ZFP3 Gene

  • Protein details for ZFP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96NJ6-ZFP3_HUMAN
    Recommended name:
    Zinc finger protein 3 homolog
    Protein Accession:
    Q96NJ6
    Secondary Accessions:
    • A5PLL4

    Protein attributes for ZFP3 Gene

    Size:
    502 amino acids
    Molecular mass:
    57662 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZFP3 Gene

Post-translational modifications for ZFP3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZFP3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZFP3 Gene

Domains & Families for ZFP3 Gene

Gene Families for ZFP3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZFP3 Gene

Suggested Antigen Peptide Sequences for ZFP3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96NJ6

UniProtKB/Swiss-Prot:

ZFP3_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZFP3: view

Function for ZFP3 Gene

Molecular function for ZFP3 Gene

GENATLAS Biochemistry:
zinc finger protein 3
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZFP3 Gene

Gene Ontology (GO) - Molecular Function for ZFP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZFP3: view
genes like me logo Genes that share phenotypes with ZFP3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZFP3 Gene

Localization for ZFP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZFP3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZFP3 gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZFP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZFP3: view

Pathways & Interactions for ZFP3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZFP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with ZFP3: view

No data available for Pathways by source and SIGNOR curated interactions for ZFP3 Gene

Drugs & Compounds for ZFP3 Gene

No Compound Related Data Available

Transcripts for ZFP3 Gene

mRNA/cDNA for ZFP3 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(40) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZFP3 Gene

ZFP3 zinc finger protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZFP3 Gene

No ASD Table

Relevant External Links for ZFP3 Gene

GeneLoc Exon Structure for
ZFP3
ECgene alternative splicing isoforms for
ZFP3

Expression for ZFP3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZFP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZFP3 Gene

This gene is overexpressed in Retina (59.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZFP3 Gene



Protein tissue co-expression partners for ZFP3 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZFP3 Gene:

ZFP3

SOURCE GeneReport for Unigene cluster for ZFP3 Gene:

Hs.48832

Evidence on tissue expression from TISSUES for ZFP3 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with ZFP3: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZFP3 Gene

Orthologs for ZFP3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZFP3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZFP3 33 34
  • 99.8 (n)
cow
(Bos Taurus)
Mammalia ZFP3 33 34
  • 91.63 (n)
mouse
(Mus musculus)
Mammalia Zfp3 33 16 34
  • 84.1 (n)
rat
(Rattus norvegicus)
Mammalia Zfp3 33
  • 83.86 (n)
dog
(Canis familiaris)
Mammalia ZFP3 33 34
  • 75.7 (n)
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 49 (a)
ManyToMany
Species where no ortholog for ZFP3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZFP3 Gene

ENSEMBL:
Gene Tree for ZFP3 (if available)
TreeFam:
Gene Tree for ZFP3 (if available)

Paralogs for ZFP3 Gene

(479) SIMAP similar genes for ZFP3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZFP3: view

Variants for ZFP3 Gene

Sequence variations from dbSNP and Humsavar for ZFP3 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000217058 -- 5,079,633(+) T/C intron_variant
rs1000272444 -- 5,086,648(+) T/C intron_variant
rs1000726620 -- 5,079,267(+) A/G intron_variant
rs1000747607 -- 5,091,669(+) G/A coding_sequence_variant, missense_variant
rs1000952812 -- 5,091,295(+) T/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZFP3 Gene

Variant ID Type Subtype PubMed ID
nsv1134589 CNV deletion 24896259
nsv509648 CNV insertion 20534489
nsv574273 CNV gain 21841781
nsv827868 CNV gain 20364138

Variation tolerance for ZFP3 Gene

Residual Variation Intolerance Score: 45% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.28; 25.53% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZFP3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZFP3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZFP3 Gene

Disorders for ZFP3 Gene

Additional Disease Information for ZFP3

No disorders were found for ZFP3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZFP3 Gene

Publications for ZFP3 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 58
  3. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PMID: 15342556) Suzuki Y … Sugano S (Genome research 2004) 3 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for ZFP3 Gene

Sources for ZFP3 Gene

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