Aliases for ZFP3 Gene

Aliases for ZFP3 Gene

  • ZFP3 Zinc Finger Protein 2 3 5
  • ZNF752 2 3 4
  • Zinc Finger Protein Homologous To Zfp-3 In Mouse 2 3
  • Zinc Finger Protein 3 Homolog 3 4
  • Zinc Finger Protein 752 3 4
  • Zfp-3 3 4
  • Zinc Finger Protein 3 Homolog (Mouse) 2
  • Zinc Finger Protein-3 3
  • FLJ30726 2
  • ZFP3 5

External Ids for ZFP3 Gene

Previous GeneCards Identifiers for ZFP3 Gene

  • GC17U990112
  • GC17P004923
  • GC17P004872
  • GC17P004981

Summaries for ZFP3 Gene

GeneCards Summary for ZFP3 Gene

ZFP3 (ZFP3 Zinc Finger Protein) is a Protein Coding gene. Diseases associated with ZFP3 include Sleeping Sickness. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity. An important paralog of this gene is ZNF268.

UniProtKB/Swiss-Prot Summary for ZFP3 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZFP3 Gene

Genomics for ZFP3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZFP3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J005077 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 600.7 +0.1 133 2 SP1 LARP7 GABPA ZNF143 RFX1 TCF12 REST TRIM22 POLR2A GTF2F1 ENSG00000262693 ZFP3 ZNF232-AS1 ZNF232 piR-54957 USP6
GH17J005041 Promoter/Enhancer 1.2 EPDnew Ensembl ENCODE 611.5 -35.7 -35656 2.1 IKZF1 HDAC1 SOX6 TCF12 CTBP1 ZBTB11 GABPA NCOR1 FOSL1 NFIC ZFP3 piR-32214-267 SPAG7 ENO3 ENSG00000234203 INCA1 KIF1C CAMTA2 PFN1 SLC52A1
GH17J005110 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 11.7 +33.5 33534 3.2 HNRNPL CREB1 GATAD2A ZNF629 PRDM10 REST TFE3 SIX5 IKZF1 ZNF692 ZNF232 lnc-SLC52A1-3 ANKFY1 ZNF232-AS1 ENSG00000261879 RPAIN DHX33 DERL2 ENSG00000263272 ZNF594
GH17J004856 Promoter/Enhancer 1.5 Ensembl ENCODE CraniofacialAtlas dbSUPER 15.8 -219.7 -219691 5.3 GATAD2A PRDM10 SOX13 IKZF1 RXRB IRF2 GABPA KMT2B TCF7 JUND ATP6V0CP1 CHRNE C17orf107 ZFP3 MINK1 PLD2 ARRB2 PELP1 RPS12P29 LOC101559451
GH17J005120 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE CraniofacialAtlas 12 +43.6 43561 3.1 CREB1 SCRT2 MNT CTCF EZH2 ZFHX2 POLR2A EGR2 ZNF232 ZFP3 SPAG7 SCIMP USP6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZFP3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZFP3

Top Transcription factor binding sites by QIAGEN in the ZFP3 gene promoter:
  • Bach2
  • CBF(2)
  • CBF-A
  • CBF-B
  • Chx10
  • CP1A
  • CUTL1
  • NF-Y
  • NF-YA
  • NF-YB

Genomic Locations for ZFP3 Gene

Genomic Locations for ZFP3 Gene
chr17:5,078,467-5,096,374
(GRCh38/hg38)
Size:
17,908 bases
Orientation:
Plus strand
chr17:4,981,543-4,999,669
(GRCh37/hg19)
Size:
18,127 bases
Orientation:
Plus strand

Genomic View for ZFP3 Gene

Genes around ZFP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZFP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZFP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFP3 Gene

Proteins for ZFP3 Gene

  • Protein details for ZFP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96NJ6-ZFP3_HUMAN
    Recommended name:
    Zinc finger protein 3 homolog
    Protein Accession:
    Q96NJ6
    Secondary Accessions:
    • A5PLL4

    Protein attributes for ZFP3 Gene

    Size:
    502 amino acids
    Molecular mass:
    57662 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZFP3 Gene

Post-translational modifications for ZFP3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZFP3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZFP3 Gene

Domains & Families for ZFP3 Gene

Gene Families for ZFP3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZFP3 Gene

InterPro:
Blocks:
  • C2H2-type zinc finger signature
ProtoNet:

Suggested Antigen Peptide Sequences for ZFP3 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 752 (ZFP3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96NJ6

UniProtKB/Swiss-Prot:

ZFP3_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZFP3: view

Function for ZFP3 Gene

Molecular function for ZFP3 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
GENATLAS Biochemistry:
zinc finger protein 3

Phenotypes From GWAS Catalog for ZFP3 Gene

Gene Ontology (GO) - Molecular Function for ZFP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IBA 21873635
GO:0043565 sequence-specific DNA binding IBA 21873635
genes like me logo Genes that share ontologies with ZFP3: view
genes like me logo Genes that share phenotypes with ZFP3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZFP3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZFP3 Gene

Localization for ZFP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZFP3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZFP3 gene
Compartment Confidence
nucleus 4
cytoskeleton 1
mitochondrion 1
peroxisome 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZFP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with ZFP3: view

Pathways & Interactions for ZFP3 Gene

PathCards logo

SuperPathways for ZFP3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZFP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with ZFP3: view

No data available for Pathways by source and SIGNOR curated interactions for ZFP3 Gene

Drugs & Compounds for ZFP3 Gene

No Compound Related Data Available

Transcripts for ZFP3 Gene

mRNA/cDNA for ZFP3 Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZFP3

Alternative Splicing Database (ASD) splice patterns (SP) for ZFP3 Gene

No ASD Table

Relevant External Links for ZFP3 Gene

GeneLoc Exon Structure for
ZFP3

Expression for ZFP3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZFP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZFP3 Gene

This gene is overexpressed in Retina (59.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZFP3 Gene



Protein tissue co-expression partners for ZFP3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZFP3

SOURCE GeneReport for Unigene cluster for ZFP3 Gene:

Hs.48832

Evidence on tissue expression from TISSUES for ZFP3 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with ZFP3: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZFP3 Gene

Orthologs for ZFP3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZFP3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZFP3 30 31
  • 99.8 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ZFP3 30 31
  • 91.63 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Zfp3 30 17 31
  • 84.1 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Zfp3 30
  • 83.86 (n)
Dog
(Canis familiaris)
Mammalia ZFP3 30 31
  • 75.7 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 49 (a)
ManyToMany
Species where no ortholog for ZFP3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZFP3 Gene

ENSEMBL:
Gene Tree for ZFP3 (if available)
TreeFam:
Gene Tree for ZFP3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZFP3: view image

Paralogs for ZFP3 Gene

Paralogs for ZFP3 Gene

(479) SIMAP similar genes for ZFP3 Gene using alignment to 1 proteins:

  • ZFP3_HUMAN
genes like me logo Genes that share paralogs with ZFP3: view

Variants for ZFP3 Gene

Additional dbSNP identifiers (rs#s) for ZFP3 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZFP3 Gene

Variant ID Type Subtype PubMed ID
nsv1134589 CNV deletion 24896259
nsv509648 CNV insertion 20534489
nsv574273 CNV gain 21841781
nsv827868 CNV gain 20364138

Variation tolerance for ZFP3 Gene

Residual Variation Intolerance Score: 45% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.28; 25.53% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZFP3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZFP3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZFP3 Gene

Disorders for ZFP3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZFP3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
sleeping sickness
  • african sleeping sickness
- elite association - COSMIC cancer census association via MalaCards
Search ZFP3 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with ZFP3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZFP3 Gene

Publications for ZFP3 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  3. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  5. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PMID: 15342556) Suzuki Y … Sugano S (Genome research 2004) 3

Products for ZFP3 Gene

Sources for ZFP3 Gene