Aliases for ZFP28 Gene

Aliases for ZFP28 Gene

  • ZFP28 Zinc Finger Protein 2 3 5
  • Krueppel-Like Zinc Finger Factor X6 3 4
  • Zinc Finger Protein 28 Homolog 3 4
  • Zfp-28 3 4
  • Zinc Finger Protein 28 Homolog (Mouse) 2
  • Zinc Finger Factor X6 3
  • KIAA1431 4
  • Mkr5 3

External Ids for ZFP28 Gene

Previous GeneCards Identifiers for ZFP28 Gene

  • GC19U990300
  • GC19P057504
  • GC19P061592
  • GC19P061618
  • GC19P061609
  • GC19P061742
  • GC19P057050
  • GC19P053360

Summaries for ZFP28 Gene

GeneCards Summary for ZFP28 Gene

ZFP28 (ZFP28 Zinc Finger Protein) is a Protein Coding gene. Diseases associated with ZFP28 include Alternating Hemiplegia Of Childhood. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity. An important paralog of this gene is ZNF33A.

UniProtKB/Swiss-Prot Summary for ZFP28 Gene

  • May be involved in transcriptional regulation. May have a role in embryonic development.

Additional gene information for ZFP28 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZFP28 Gene

Genomics for ZFP28 Gene

GeneHancer (GH) Regulatory Elements for ZFP28 Gene

Promoters and enhancers for ZFP28 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZFP28 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZFP28

Top Transcription factor binding sites by QIAGEN in the ZFP28 gene promoter:
  • aMEF-2
  • AREB6
  • FOXO4
  • HFH-1
  • MEF-2A
  • p53
  • Pax-5
  • TBP

Genomic Locations for ZFP28 Gene

Genomic Locations for ZFP28 Gene
chr19:56,537,716-56,556,810
(GRCh38/hg38)
Size:
19,095 bases
Orientation:
Plus strand
chr19:57,050,317-57,068,170
(GRCh37/hg19)
Size:
17,854 bases
Orientation:
Plus strand

Genomic View for ZFP28 Gene

Genes around ZFP28 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZFP28 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZFP28 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFP28 Gene

Proteins for ZFP28 Gene

  • Protein details for ZFP28 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NHY6-ZFP28_HUMAN
    Recommended name:
    Zinc finger protein 28 homolog
    Protein Accession:
    Q8NHY6
    Secondary Accessions:
    • A0JNV6
    • K7ES88
    • Q8NHU8
    • Q9BY30
    • Q9P2B6

    Protein attributes for ZFP28 Gene

    Size:
    868 amino acids
    Molecular mass:
    98705 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA92669.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ZFP28 Gene

    Alternative splice isoforms for ZFP28 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZFP28 Gene

Post-translational modifications for ZFP28 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZFP28 Gene

No data available for DME Specific Peptides for ZFP28 Gene

Domains & Families for ZFP28 Gene

Gene Families for ZFP28 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZFP28 Gene

Blocks:
  • KRAB box
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZFP28 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 28 homolog (Mouse) (A0JNV5_HUMAN)
  • ZFP28 protein (Q8NHU8_HUMAN)
  • Zinc finger protein 28 homolog (Mouse), isoform CRA_b (Q9UQD2_HUMAN)
  • Krueppel-like zinc finger factor X6 (ZFP28_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NHY6

UniProtKB/Swiss-Prot:

ZFP28_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZFP28: view

Function for ZFP28 Gene

Molecular function for ZFP28 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation. May have a role in embryonic development.

Phenotypes From GWAS Catalog for ZFP28 Gene

Gene Ontology (GO) - Molecular Function for ZFP28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZFP28: view
genes like me logo Genes that share phenotypes with ZFP28: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZFP28

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZFP28 Gene

Localization for ZFP28 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZFP28 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZFP28 gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZFP28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZFP28: view

Pathways & Interactions for ZFP28 Gene

genes like me logo Genes that share pathways with ZFP28: view

Pathways by source for ZFP28 Gene

2 Reactome pathways for ZFP28 Gene
1 KEGG pathway for ZFP28 Gene

Gene Ontology (GO) - Biological Process for ZFP28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZFP28: view

No data available for SIGNOR curated interactions for ZFP28 Gene

Drugs & Compounds for ZFP28 Gene

No Compound Related Data Available

Transcripts for ZFP28 Gene

mRNA/cDNA for ZFP28 Gene

2 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZFP28

Alternative Splicing Database (ASD) splice patterns (SP) for ZFP28 Gene

No ASD Table

Relevant External Links for ZFP28 Gene

GeneLoc Exon Structure for
ZFP28

Expression for ZFP28 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZFP28 Gene

Protein differential expression in normal tissues from HIPED for ZFP28 Gene

This gene is overexpressed in Plasma (31.9), Pancreatic juice (26.5), and Heart (10.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZFP28 Gene



Protein tissue co-expression partners for ZFP28 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZFP28

SOURCE GeneReport for Unigene cluster for ZFP28 Gene:

Hs.14794

Evidence on tissue expression from TISSUES for ZFP28 Gene

  • Heart(4.2)
  • Nervous system(4.2)
  • Muscle(4.1)
genes like me logo Genes that share expression patterns with ZFP28: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZFP28 Gene

Orthologs for ZFP28 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZFP28 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZFP28 31 30
  • 99.46 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ZFP28 31 30
  • 87.14 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp28 17 31 30
  • 79.29 (n)
rat
(Rattus norvegicus)
Mammalia LOC102548693 30
  • 78.47 (n)
cow
(Bos Taurus)
Mammalia LOC100301148 30
  • 71.49 (n)
ZFP28 31
  • 71 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZFP28 31
  • 44 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 48 (a)
OneToMany
-- 31
  • 35 (a)
OneToMany
Species where no ortholog for ZFP28 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZFP28 Gene

ENSEMBL:
Gene Tree for ZFP28 (if available)
TreeFam:
Gene Tree for ZFP28 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZFP28: view image

Paralogs for ZFP28 Gene

Paralogs for ZFP28 Gene

(517) SIMAP similar genes for ZFP28 Gene using alignment to 6 proteins:

  • ZFP28_HUMAN
  • A0JNV5_HUMAN
  • K7EL00_HUMAN
  • K7ES88_HUMAN
  • Q8NHU8_HUMAN
  • Q9UQD2_HUMAN

Pseudogenes.org Pseudogenes for ZFP28 Gene

genes like me logo Genes that share paralogs with ZFP28: view

Variants for ZFP28 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZFP28 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs10409531 - p.Ala620Val
rs34136271 - p.Ser141Trp

Additional dbSNP identifiers (rs#s) for ZFP28 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZFP28 Gene

Variant ID Type Subtype PubMed ID
dgv6591n54 CNV loss 21841781
nsv1055357 CNV gain 25217958
nsv524734 CNV loss 19592680
nsv828651 CNV gain 20364138

Variation tolerance for ZFP28 Gene

Residual Variation Intolerance Score: 27.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.83; 97.39% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZFP28 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZFP28

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZFP28 Gene

Disorders for ZFP28 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZFP28 Gene - From: DISEASES

Disorder Aliases PubMed IDs
alternating hemiplegia of childhood
  • ahc
- elite association - COSMIC cancer census association via MalaCards
Search ZFP28 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ZFP28

genes like me logo Genes that share disorders with ZFP28: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZFP28 Gene

Publications for ZFP28 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  2. Identification and characterization of two novel zinc finger genes, ZNF359 and ZFP28, in human development. (PMID: 12127974) Zhou L … Wu X (Biochemical and biophysical research communications 2002) 3 4 54
  3. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 3 4 54
  4. A Y2H-seq approach defines the human protein methyltransferase interactome. (PMID: 23455924) Weimann M … Stelzl U (Nature methods 2013) 3 54
  5. A directed protein interaction network for investigating intracellular signal transduction. (PMID: 21900206) Vinayagam A … Wanker EE (Science signaling 2011) 3 54

Products for ZFP28 Gene

Sources for ZFP28 Gene