Aliases for ZFP2 Gene

Aliases for ZFP2 Gene

  • ZFP2 Zinc Finger Protein 2 3 5
  • Zinc Finger Protein 2 Homolog 3 4
  • Zinc Finger Protein 751 3 4
  • ZNF751 3 4
  • Zfp-2 3 4
  • Zinc Finger Protein 2 Homolog (Mouse) 2

External Ids for ZFP2 Gene

Previous GeneCards Identifiers for ZFP2 Gene

  • GC05P178256
  • GC05P178257
  • GC05P178322
  • GC05P173049

Summaries for ZFP2 Gene

GeneCards Summary for ZFP2 Gene

ZFP2 (ZFP2 Zinc Finger Protein) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity. An important paralog of this gene is ZNF135.

UniProtKB/Swiss-Prot Summary for ZFP2 Gene

  • Probable transcription factor involved in neuronal differentiation and/or phenotypic maintenance.

Additional gene information for ZFP2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZFP2 Gene

Genomics for ZFP2 Gene

GeneHancer (GH) Regulatory Elements for ZFP2 Gene

Promoters and enhancers for ZFP2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J178895 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE CraniofacialAtlas 761.5 +0.2 187 1.8 RBPJ HCFC1 MAFK POLR2A KAT8 ZNF143 CHD2 ZFX ZBTB20 ELF1 ZFP2 ZNF354B HNRNPH1 MAML1 ZNF879 MRNIP ZNF354A ZNF354C RUFY1 LOC100422593
GH05J178921 Promoter 0.3 EPDnew 761.8 +26.1 26117 0.1 ZFP2 PIGFP1 lnc-ZNF454-2 ENSG00000254035 GRM6 ZNF879 CLK4 LOC100422593 lnc-ZFP2-1
GH05J179619 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 51.5 +726.2 726174 6.5 ZNF785 SIN3A ZBTB40 SP1 CTCF SREBF1 FOXA1 MLX RBPJ SMARCE1 HNRNPH1 lnc-C5orf60-3 ZNF879 MRNIP MAML1 CNOT6 ZFP2 GRM6 ENSG00000254035 ZNF354C
GH05J179696 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 25.2 +803.0 803047 4.9 ZBTB40 SP1 ZBTB6 RBPJ SMARCE1 POLR2A CEBPZ USF2 ATF1 FOS CANX lnc-CBY3-2 lnc-CBY3-4 MAML1 ZNF354B CNOT6 MRNIP HNRNPH1 ZNF879 ZNF354C
GH05J178229 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 28.3 -663.5 -663502 4.8 ZNF24 ZBTB40 ZBTB6 POLR2A MYC ELF1 HLF L3MBTL2 MAX ZNF121 PHYKPL piR-43839 ZFP2 ENSG00000254035 GRM6 ZNF454 ZNF879 GMCL2 ENSG00000249186 OR1X5P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZFP2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZFP2 gene promoter:
  • aMEF-2
  • C/EBPalpha
  • Cart-1
  • MEF-2A
  • POU6F1 (c2)
  • SRY

Genomic Locations for ZFP2 Gene

Genomic Locations for ZFP2 Gene
chr5:178,895,898-178,933,212
(GRCh38/hg38)
Size:
37,315 bases
Orientation:
Plus strand
chr5:178,322,895-178,360,213
(GRCh37/hg19)
Size:
37,319 bases
Orientation:
Plus strand

Genomic View for ZFP2 Gene

Genes around ZFP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZFP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZFP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFP2 Gene

Proteins for ZFP2 Gene

  • Protein details for ZFP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZN57-ZFP2_HUMAN
    Recommended name:
    Zinc finger protein 2 homolog
    Protein Accession:
    Q6ZN57
    Secondary Accessions:
    • A5PLN5
    • B7ZM23
    • Q9H6Z6

    Protein attributes for ZFP2 Gene

    Size:
    461 amino acids
    Molecular mass:
    52740 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB15104.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZFP2 Gene

Post-translational modifications for ZFP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZFP2 Gene

No data available for DME Specific Peptides for ZFP2 Gene

Domains & Families for ZFP2 Gene

Gene Families for ZFP2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZFP2 Gene

Suggested Antigen Peptide Sequences for ZFP2 Gene

GenScript: Design optimal peptide antigens:
  • ZFP2 protein (B7ZM21_HUMAN)
  • Zinc finger protein 751 (ZFP2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6ZN57

UniProtKB/Swiss-Prot:

ZFP2_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZFP2: view

Function for ZFP2 Gene

Molecular function for ZFP2 Gene

UniProtKB/Swiss-Prot Function:
Probable transcription factor involved in neuronal differentiation and/or phenotypic maintenance.

Phenotypes From GWAS Catalog for ZFP2 Gene

Gene Ontology (GO) - Molecular Function for ZFP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZFP2: view
genes like me logo Genes that share phenotypes with ZFP2: view

Animal Model Products

CRISPR Products

miRNA for ZFP2 Gene

miRTarBase miRNAs that target ZFP2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZFP2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZFP2 Gene

Localization for ZFP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZFP2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZFP2 gene
Compartment Confidence
nucleus 4

Gene Ontology (GO) - Cellular Components for ZFP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZFP2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZFP2 Gene

Pathways & Interactions for ZFP2 Gene

PathCards logo

SuperPathways for ZFP2 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZFP2: view

Pathways by source for ZFP2 Gene

2 Reactome pathways for ZFP2 Gene

Gene Ontology (GO) - Biological Process for ZFP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZFP2: view

No data available for SIGNOR curated interactions for ZFP2 Gene

Drugs & Compounds for ZFP2 Gene

No Compound Related Data Available

Transcripts for ZFP2 Gene

mRNA/cDNA for ZFP2 Gene

(1) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZFP2

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZFP2 Gene

No ASD Table

Relevant External Links for ZFP2 Gene

GeneLoc Exon Structure for
ZFP2
ECgene alternative splicing isoforms for
ZFP2

Expression for ZFP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZFP2 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZFP2 Gene



NURSA nuclear receptor signaling pathways regulating expression of ZFP2 Gene:

ZFP2

SOURCE GeneReport for Unigene cluster for ZFP2 Gene:

Hs.654533

Evidence on tissue expression from TISSUES for ZFP2 Gene

  • Nervous system(4.2)
  • Intestine(4.1)
genes like me logo Genes that share expression patterns with ZFP2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZFP2 Gene

Orthologs for ZFP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZFP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZFP2 33 32
  • 99.28 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ZFP2 33 32
  • 91.4 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ZFP2 33 32
  • 90.22 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp2 32
  • 85.76 (n)
mouse
(Mus musculus)
Mammalia Zfp2 17 33 32
  • 84.53 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 33
  • 60 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 33
  • 59 (a)
OneToMany
chicken
(Gallus gallus)
Aves ZFP3 32
  • 57.61 (n)
-- 33
  • 48 (a)
OneToMany
Species where no ortholog for ZFP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZFP2 Gene

ENSEMBL:
Gene Tree for ZFP2 (if available)
TreeFam:
Gene Tree for ZFP2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZFP2: view image

Paralogs for ZFP2 Gene

Paralogs for ZFP2 Gene

(528) SIMAP similar genes for ZFP2 Gene using alignment to 3 proteins:

  • ZFP2_HUMAN
  • B7ZM21_HUMAN
  • E5RJD3_HUMAN

Pseudogenes.org Pseudogenes for ZFP2 Gene

genes like me logo Genes that share paralogs with ZFP2: view

Variants for ZFP2 Gene

Sequence variations from dbSNP and Humsavar for ZFP2 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000199107 -- 178,896,028(+) C/A intron_variant
rs1000229326 -- 178,932,212(+) G/A/T coding_sequence_variant, missense_variant
rs1000232035 -- 178,899,642(+) C/T intron_variant
rs1000334680 -- 178,933,035(+) G/A 3_prime_UTR_variant
rs1000382886 -- 178,920,310(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZFP2 Gene

Variant ID Type Subtype PubMed ID
dgv10203n54 CNV loss 21841781
dgv10204n54 CNV loss 21841781
dgv10205n54 CNV loss 21841781
dgv10206n54 CNV loss 21841781
dgv10207n54 CNV loss 21841781
dgv1682e212 CNV loss 25503493
dgv987n67 CNV gain 20364138
esv2656988 CNV deletion 23128226
esv2659273 CNV deletion 23128226
esv27557 CNV gain 19812545
esv3567091 CNV deletion 23714750
esv3607729 CNV loss 21293372
esv3607730 CNV loss 21293372
esv3890769 CNV gain 25118596
nsv1120062 OTHER inversion 24896259
nsv471919 CNV novel sequence insertion 20440878
nsv5156 CNV deletion 18451855
nsv600469 CNV loss 21841781
nsv819936 CNV gain 19587683
nsv821324 CNV deletion 20802225
nsv964988 CNV duplication 23825009

Variation tolerance for ZFP2 Gene

Residual Variation Intolerance Score: 78.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.69; 57.24% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZFP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZFP2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZFP2 Gene

Disorders for ZFP2 Gene

Additional Disease Information for ZFP2

No disorders were found for ZFP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZFP2 Gene

Publications for ZFP2 Gene

  1. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 56
  2. HAUSP regulates c-MYC expression via de-ubiquitination of TRRAP. (PMID: 25925205) Bhattacharya S … Ghosh MK (Cellular oncology (Dordrecht) 2015) 3 56
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 56
  4. The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease. (PMID: 24705354) Butland SL … Hayden MR (Human molecular genetics 2014) 3 56
  5. An atlas of combinatorial transcriptional regulation in mouse and man. (PMID: 20211142) Ravasi T … Hayashizaki Y (Cell 2010) 3 56

Products for ZFP2 Gene

Sources for ZFP2 Gene