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Aliases for ZFP14 Gene

Aliases for ZFP14 Gene

  • ZFP14 Zinc Finger Protein 2 3 5
  • Zinc Finger Protein 14 Homolog 3 4
  • Zinc Finger Protein 531 3 4
  • ZNF531 3 4
  • Zinc Finger Protein 14 Homolog (Mouse) 2
  • KIAA1559 4
  • Zfp-14 4

External Ids for ZFP14 Gene

Previous GeneCards Identifiers for ZFP14 Gene

  • GC19M041522
  • GC19M036828
  • GC19M033295
  • GC19M036829
  • GC19M037068
  • GC19M036387
  • GC19M036697
  • GC19M039001
  • GC19M036879
  • GC19M036900
  • GC19M037413
  • GC19M037742
  • GC19M038039
  • GC19M038335
  • GC19M038630
  • GC19M038871

Summaries for ZFP14 Gene

GeneCards Summary for ZFP14 Gene

ZFP14 (ZFP14 Zinc Finger Protein) is a Protein Coding gene. Among its related pathways are Herpes simplex virus 1 infection and Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity. An important paralog of this gene is ZFP82.

UniProtKB/Swiss-Prot for ZFP14 Gene

Additional gene information for ZFP14 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZFP14 Gene

Genomics for ZFP14 Gene

GeneHancer (GH) Regulatory Elements for ZFP14 Gene

Promoters and enhancers for ZFP14 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J036377 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 625 +0.5 503 2.6 ZNF652 SP1 CC2D1A ZFX ELF3 SIX5 POLR2A CEBPG RERE GTF2F1 ZFP14 ENSG00000266973 ZNF567 HAUS5 ZNF345 ZNF875 ZNF527 TMEM147-AS1 ZNF383 ZNF850
GH19J036916 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 81.2 -537.0 -536998 2.8 ZNF473 ZNF121 ZSCAN21 ZBTB7A YY1 ELF1 SP7 SP1 ZNF548 KLF14 ZNF568 ZNF829 GC19M040757 ZNF345 ZNF383 ZNF527 ZNF567 ZFP30 ZNF850 ZNF571
GH19J035897 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 63.1 +475.1 475145 13 ZNF473 ZNF652 SP1 ZFX CBFA2T2 ZNF148 NKRF POLR2A MLLT1 ZNF121 NFKBID TYROBP HCST ENSG00000280194 ZNF567 TMEM147-AS1 ZNF790 ZNF566 ZNF529 ZNF260
GH19J037369 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 77.3 -991.9 -991885 2.2 ZNF473 ZFX ELF3 MNT SIX5 ZNF148 NKRF ZNF121 POLR2A ZNF687 ZNF527 ZNF567 ZNF345 ZNF383 ZNF571 ZFP30 ZNF850 ZNF875 ZNF793 ZNF790
GH19J036526 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 59.1 -149.2 -149197 3.6 ZNF473 MTA3 SP1 ZFX SIX5 ZNF148 NKRF POLR2A MLLT1 ZNF121 ZNF260 ZNF566 ENSG00000228629 ZNF567 ZNF383 ZNF527 ZNF585B ZNF345 ZNF790 ZNF850
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZFP14 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZFP14 gene promoter:
  • Cart-1
  • GATA-1
  • HSF1 (long)
  • HSF1short
  • HSF2
  • STAT1

Genomic Locations for ZFP14 Gene

Genomic Locations for ZFP14 Gene
chr19:36,334,453-36,379,203
(GRCh38/hg38)
Size:
44,751 bases
Orientation:
Minus strand
chr19:36,825,355-36,870,105
(GRCh37/hg19)
Size:
44,751 bases
Orientation:
Minus strand

Genomic View for ZFP14 Gene

Genes around ZFP14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZFP14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZFP14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFP14 Gene

Proteins for ZFP14 Gene

  • Protein details for ZFP14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HCL3-ZFP14_HUMAN
    Recommended name:
    Zinc finger protein 14 homolog
    Protein Accession:
    Q9HCL3
    Secondary Accessions:
    • A7MD23

    Protein attributes for ZFP14 Gene

    Size:
    533 amino acids
    Molecular mass:
    63463 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB13385.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZFP14 Gene

Post-translational modifications for ZFP14 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZFP14 Gene

No data available for DME Specific Peptides for ZFP14 Gene

Domains & Families for ZFP14 Gene

Gene Families for ZFP14 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZFP14 Gene

Suggested Antigen Peptide Sequences for ZFP14 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 531 (ZFP14_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9HCL3

UniProtKB/Swiss-Prot:

ZFP14_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZFP14: view

Function for ZFP14 Gene

Molecular function for ZFP14 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZFP14 Gene

Gene Ontology (GO) - Molecular Function for ZFP14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZFP14: view
genes like me logo Genes that share phenotypes with ZFP14: view

Animal Models for ZFP14 Gene

MGI Knock Outs for ZFP14:
  • Zfp14 Zfp14<tm1b(KOMP)Wtsi>

Animal Model Products

CRISPR Products

miRNA for ZFP14 Gene

miRTarBase miRNAs that target ZFP14

Clone Products

  • Applied Biological Materials (abm): Clones for ZFP14 - Now 50% OFF >
  • * ZFP14 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * ZFP14 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZFP14 Gene

Localization for ZFP14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZFP14 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZFP14 gene
Compartment Confidence
nucleus 4
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZFP14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZFP14: view

Pathways & Interactions for ZFP14 Gene

genes like me logo Genes that share pathways with ZFP14: view

Pathways by source for ZFP14 Gene

2 Reactome pathways for ZFP14 Gene
1 KEGG pathway for ZFP14 Gene

Gene Ontology (GO) - Biological Process for ZFP14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001835 blastocyst hatching IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZFP14: view

No data available for SIGNOR curated interactions for ZFP14 Gene

Drugs & Compounds for ZFP14 Gene

No Compound Related Data Available

Transcripts for ZFP14 Gene

mRNA/cDNA for ZFP14 Gene

(2) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(38) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for ZFP14 Gene

ZFP14 zinc finger protein:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for ZFP14 - Now 50% OFF >
  • * ZFP14 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * ZFP14 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for ZFP14 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5
SP1: -
SP2: -
SP3:

Relevant External Links for ZFP14 Gene

GeneLoc Exon Structure for
ZFP14
ECgene alternative splicing isoforms for
ZFP14

Expression for ZFP14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZFP14 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZFP14 Gene:

ZFP14

SOURCE GeneReport for Unigene cluster for ZFP14 Gene:

Hs.35524

Evidence on tissue expression from TISSUES for ZFP14 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ZFP14: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZFP14 Gene

Orthologs for ZFP14 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZFP14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZFP14 35 34
  • 99.62 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ZFP14 35
  • 96 (a)
OneToOne
LOC100683244 34
  • 88.45 (n)
cow
(Bos Taurus)
Mammalia ZFP14 34
  • 92.12 (n)
ZNF404 35
  • 54 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Zfp14 17 35 34
  • 83.33 (n)
Species where no ortholog for ZFP14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZFP14 Gene

ENSEMBL:
Gene Tree for ZFP14 (if available)
TreeFam:
Gene Tree for ZFP14 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZFP14: view image

Paralogs for ZFP14 Gene

Paralogs for ZFP14 Gene

(478) SIMAP similar genes for ZFP14 Gene using alignment to 3 proteins:

  • ZFP14_HUMAN
  • K7EM99_HUMAN
  • L8EB30_HUMAN

Pseudogenes.org Pseudogenes for ZFP14 Gene

genes like me logo Genes that share paralogs with ZFP14: view

Variants for ZFP14 Gene

Sequence variations from dbSNP and Humsavar for ZFP14 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000003085 -- 36,357,783(-) C/T intron_variant
rs1000111521 -- 36,334,229(-) G/A downstream_transcript_variant
rs1000119981 -- 36,375,675(-) A/G genic_upstream_transcript_variant, intron_variant
rs1000227997 -- 36,334,003(-) A/T downstream_transcript_variant
rs1000285303 -- 36,363,484(-) C/G/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZFP14 Gene

Variant ID Type Subtype PubMed ID
dgv1041e212 CNV loss 25503493
dgv1777n106 CNV deletion 24896259
dgv3523n100 CNV loss 25217958
dgv3524n100 CNV loss 25217958
dgv638e199 CNV deletion 23128226
dgv6424n54 CNV loss 21841781
dgv6425n54 CNV loss 21841781
dgv6426n54 CNV loss 21841781
dgv6427n54 CNV gain 21841781
dgv6428n54 CNV loss 21841781
dgv6429n54 CNV loss 21841781
dgv6430n54 CNV loss 21841781
dgv6431n54 CNV loss 21841781
dgv83n73 CNV deletion 24416366
esv1010898 CNV gain 20482838
esv2421498 CNV deletion 20811451
esv26179 CNV gain 19812545
esv2718503 CNV deletion 23290073
esv2760511 CNV loss 21179565
esv2763143 CNV loss 21179565
esv3556338 CNV deletion 23714750
esv3644253 CNV gain 21293372
esv3644255 CNV loss 21293372
nsv1066190 CNV loss 25217958
nsv174 CNV deletion 15895083
nsv2474 CNV deletion 18451855
nsv436255 CNV deletion 17901297
nsv498900 CNV loss 21111241
nsv514898 CNV loss 21397061
nsv579431 CNV loss 21841781
nsv579432 CNV loss 21841781
nsv579440 CNV loss 21841781
nsv579459 CNV loss 21841781
nsv579460 CNV loss 21841781
nsv821399 CNV deletion 20802225
nsv833816 CNV gain 17160897
nsv9716 CNV gain+loss 18304495

Variation tolerance for ZFP14 Gene

Residual Variation Intolerance Score: 36% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.66; 56.94% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZFP14 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZFP14
Human Gene Mutation Database (HGMD)
ZFP14

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZFP14 Gene

Disorders for ZFP14 Gene

Additional Disease Information for ZFP14

No disorders were found for ZFP14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZFP14 Gene

Publications for ZFP14 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10997877) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4 58
  2. The protein interaction landscape of the human CMGC kinase group. (PMID: 23602568) Varjosalo M … Gstaiger M (Cell reports 2013) 3 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for ZFP14 Gene

Sources for ZFP14 Gene