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Aliases for ZFP1 Gene

Aliases for ZFP1 Gene

  • ZFP1 Zinc Finger Protein 2 3 5
  • Zinc Finger Protein 475 3 4
  • ZNF475 3 4
  • Zinc Finger Protein 1 Homolog (Mouse) 2
  • Zinc Finger Protein 1 Homolog 3
  • Zinc Finger Protein 1 2
  • Zfp-1 4

External Ids for ZFP1 Gene

Previous GeneCards Identifiers for ZFP1 Gene

  • GC16P074921
  • GC16P074961
  • GC16P073739
  • GC16P075182
  • GC16P060933

Summaries for ZFP1 Gene

Entrez Gene Summary for ZFP1 Gene

  • This gene belongs to the zinc finger protein family. Some members of this family bind to DNA by zinc-mediated secondary structures called zinc fingers, and are involved in transcriptional regulation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]

GeneCards Summary for ZFP1 Gene

ZFP1 (ZFP1 Zinc Finger Protein) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA binding transcription factor activity. An important paralog of this gene is ZNF586.

UniProtKB/Swiss-Prot for ZFP1 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZFP1 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZFP1 Gene

Genomics for ZFP1 Gene

GeneHancer (GH) Regulatory Elements for ZFP1 Gene

Promoters and enhancers for ZFP1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J075147 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 685.8 +16.3 16313 2 PKNOX1 CLOCK ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 SLC30A9 ZFP1 RPL21P118 ENSG00000260884 ENSG00000259972 WDR59 ENSG00000214331 ADAT1 NPIPB15 GC16P075140 RPS4Y1P1
GH16J075119 Promoter 0.9 EPDnew 650.4 -13.1 -13117 0.1 SOX5 GATAD2A HLF ELF1 ZNF384 PPARG ETV5 ETV4 NR2F6 HNF4A ENSG00000261058 ZFP1 LDHD
GH16J075130 Enhancer 0.8 ENCODE 658.2 -1.7 -1743 0.9 ELF3 CTCF ZNF792 SAP130 KAT7 ERF CEBPG DMAP1 E4F1 RBPJ ZFP1 ENSG00000261058
GH16J075129 Enhancer 0.7 ENCODE 19.6 -3.0 -2951 0.2 NCOA3 MEIS2 PKNOX1 ARID4B DMAP1 KMT2B SLC30A9 CREM SP5 NFIA ZFP1 ENSG00000261058
GH16J075549 Enhancer 1.2 Ensembl ENCODE dbSUPER 11.1 +418.0 418040 1.4 ELF3 CTCF USF1 SALL2 EBF1 ZIC2 IRF4 RAD21 RELA ETS1 ADAT1 TMEM231 TERF2IP ZFP1 ENSG00000260092 ENSG00000259992
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZFP1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZFP1 gene promoter:
  • Nkx5-1

Genomic Locations for ZFP1 Gene

Genomic Locations for ZFP1 Gene
39,728 bases
Plus strand
23,745 bases
Plus strand

Genomic View for ZFP1 Gene

Genes around ZFP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZFP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZFP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFP1 Gene

Proteins for ZFP1 Gene

  • Protein details for ZFP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 1 homolog
    Protein Accession:
    Secondary Accessions:
    • A8K5Q7
    • B4DKG9
    • Q8N188
    • Q8N9F9

    Protein attributes for ZFP1 Gene

    407 amino acids
    Molecular mass:
    47516 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH33774.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZFP1 Gene


neXtProt entry for ZFP1 Gene

Post-translational modifications for ZFP1 Gene

  • Ubiquitination at posLast=196196, isoforms=2145, posLast=129129, posLast=114114, posLast=111111, isoforms=2105, isoforms=288, and isoforms=274
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ZFP1 Gene

Domains & Families for ZFP1 Gene

Gene Families for ZFP1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZFP1 Gene

Suggested Antigen Peptide Sequences for ZFP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZFP1: view

Function for ZFP1 Gene

Molecular function for ZFP1 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZFP1 Gene

Gene Ontology (GO) - Molecular Function for ZFP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZFP1: view
genes like me logo Genes that share phenotypes with ZFP1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZFP1

Clone Products

  • Addgene plasmids for ZFP1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZFP1 Gene

Localization for ZFP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZFP1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZFP1 gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZFP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZFP1: view

Pathways & Interactions for ZFP1 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZFP1: view

Pathways by source for ZFP1 Gene

2 Reactome pathways for ZFP1 Gene

Gene Ontology (GO) - Biological Process for ZFP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA,IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZFP1: view

No data available for SIGNOR curated interactions for ZFP1 Gene

Drugs & Compounds for ZFP1 Gene

No Compound Related Data Available

Transcripts for ZFP1 Gene

Unigene Clusters for ZFP1 Gene

ZFP1 zinc finger protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZFP1

Clone Products

  • Addgene plasmids for ZFP1

Alternative Splicing Database (ASD) splice patterns (SP) for ZFP1 Gene

ExUns: 1a · 1b ^ 2a · 2b
SP1: -

Relevant External Links for ZFP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZFP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZFP1 Gene

Protein differential expression in normal tissues from HIPED for ZFP1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (56.0) and Islet of Langerhans (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZFP1 Gene

Protein tissue co-expression partners for ZFP1 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZFP1 Gene:


SOURCE GeneReport for Unigene cluster for ZFP1 Gene:


Evidence on tissue expression from TISSUES for ZFP1 Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with ZFP1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZFP1 Gene

Orthologs for ZFP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZFP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZFP1 34 33
  • 99.67 (n)
(Canis familiaris)
Mammalia ZFP1 34 33
  • 90.86 (n)
(Bos Taurus)
Mammalia ZFP1 34 33
  • 89.84 (n)
(Mus musculus)
Mammalia Zfp1 16 34 33
  • 82.88 (n)
(Rattus norvegicus)
Mammalia Zfp1 33
  • 82.05 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 46 (a)
-- 34
  • 40 (a)
-- 34
  • 39 (a)
-- 34
  • 36 (a)
(Danio rerio)
Actinopterygii si:dkey-262g12.7 34
  • 41 (a)
CABZ01081748.1 34
  • 40 (a)
zgc:175008 34
  • 39 (a)
CABZ01015530.1 34
  • 39 (a)
CR788316.4 34
  • 38 (a)
si:dkey-77p23.2 34
  • 38 (a)
CABZ01071909.3 34
  • 37 (a)
si:ch73-266f23.3 34
  • 37 (a)
BX649328.1 34
  • 36 (a)
CABZ01081749.1 34
  • 35 (a)
si:ch211-161m3.4 34
  • 34 (a)
si:dkey-240n22.8 34
  • 34 (a)
si:dkey-77f5.14 34
  • 32 (a)
si:ch73-57f22.2 34
  • 29 (a)
si:dkey-77f5.15 34
  • 25 (a)
fruit fly
(Drosophila melanogaster)
Insecta Kr-h1 34
  • 13 (a)
(Caenorhabditis elegans)
Secernentea M03D4.4 34
  • 16 (a)
Species where no ortholog for ZFP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ZFP1 Gene

Gene Tree for ZFP1 (if available)
Gene Tree for ZFP1 (if available)
Evolutionary constrained regions (ECRs) for ZFP1: view image

Paralogs for ZFP1 Gene

Paralogs for ZFP1 Gene

(552) SIMAP similar genes for ZFP1 Gene using alignment to 5 proteins:

  • H3BM94_HUMAN
  • H3BV40_HUMAN
  • Q29RW8_HUMAN Pseudogenes for ZFP1 Gene

genes like me logo Genes that share paralogs with ZFP1: view

Variants for ZFP1 Gene

Sequence variations from dbSNP and Humsavar for ZFP1 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000068594 -- 75,154,179(+) G/A intron_variant
rs1000083076 -- 75,141,748(+) A/C genic_upstream_transcript_variant, intron_variant
rs1000148973 -- 75,148,470(+) C/A 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000179135 -- 75,127,065(+) T/C genic_upstream_transcript_variant, intron_variant
rs1000228112 -- 75,131,535(+) G/A genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZFP1 Gene

Variant ID Type Subtype PubMed ID
esv2714705 CNV deletion 23290073
esv2714706 CNV deletion 23290073
esv2761914 CNV gain 21179565
esv3639085 CNV gain 21293372
nsv7286 OTHER inversion 18451855
nsv833282 CNV gain+loss 17160897

Variation tolerance for ZFP1 Gene

Residual Variation Intolerance Score: 20% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.24; 24.84% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZFP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZFP1 Gene

Disorders for ZFP1 Gene

Additional Disease Information for ZFP1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ZFP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZFP1 Gene

Publications for ZFP1 Gene

  1. Fine mapping and association studies of a high-density lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian subjects. (PMID: 19844255) Dastani Z … Genest J (European journal of human genetics : EJHG 2010) 3 44 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Structure, expression and chromosomal localization of Zfp-1, a murine zinc finger protein gene. (PMID: 2574853) Chowdhury K … Gruss P (Nucleic acids research 1989) 2 3 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for ZFP1 Gene

  • Addgene plasmids for ZFP1

Sources for ZFP1 Gene

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