This gene belongs to the zinc finger protein family. Some members of this family bind to DNA by zinc-mediated secondary structures called zinc fingers, and are involved in transcriptional regulation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016] See more...

Aliases for ZFP1 Gene

Aliases for ZFP1 Gene

  • ZFP1 Zinc Finger Protein 2 3 5
  • ZNF475 2 3 4
  • Zinc Finger Protein 1 Homolog 3 4
  • Zinc Finger Protein 475 3 4
  • Zinc Finger Protein 1 Homolog (Mouse) 2
  • Zinc Finger Protein 1 2
  • FLJ34243 2
  • Zfp-1 4
  • ZFP1 5

External Ids for ZFP1 Gene

Previous GeneCards Identifiers for ZFP1 Gene

  • GC16P074921
  • GC16P074961
  • GC16P073739
  • GC16P075182
  • GC16P060933

Summaries for ZFP1 Gene

Entrez Gene Summary for ZFP1 Gene

  • This gene belongs to the zinc finger protein family. Some members of this family bind to DNA by zinc-mediated secondary structures called zinc fingers, and are involved in transcriptional regulation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]

GeneCards Summary for ZFP1 Gene

ZFP1 (ZFP1 Zinc Finger Protein) is a Protein Coding gene. Diseases associated with ZFP1 include Zinc Finger Protein 1. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity. An important paralog of this gene is ZNF300.

UniProtKB/Swiss-Prot Summary for ZFP1 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZFP1 Gene

Genomics for ZFP1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZFP1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J075147 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 635.8 +22.7 22737 2.4 ZNF221 HNRNPL PRDM10 ZNF629 SIX5 NFKBIZ POLR2A ZNF692 BACH1 TARDBP ZFP1 lnc-LDHD-3 lnc-ZNRF1-1 ENSG00000239763 ENSG00000260884 ENSG00000259972 WDR59 ENSG00000214331 NPIPB15 RF00017-2157
GH16J075118 Promoter/Enhancer 1.2 EPDnew Ensembl ENCODE 606.3 -6.9 -6882 2.4 GATAD2A RCOR2 FOXA1 CEBPA SOX13 ZNF10 FOXA2 YY1 CREB1 CREM ZFP1 ENSG00000261058 ZNRF1 LDHD
GH16J075129 Enhancer 1.1 Ensembl ENCODE 20.1 +4.0 4031 1.8 GATAD2A CTCF NFKBIZ RCOR2 PKNOX1 RXRB REST IRF2 BRD9 HDAC1 RF00017-2156 ZFP1 lnc-ZFP1-3 ENSG00000261058 CTRB2
GH16J075140 Enhancer 0.7 Ensembl ENCODE 22 +14.4 14421 0.9 CEBPB MAX NFIC POLR3A TBP USF2 MAFK NFIA ZBTB33 HLF lnc-ZFP1-2 ZFP1 CHST5 lnc-ZNRF1-1 ENSG00000261058 CTRB2
GH16J075549 Enhancer 0.9 ENCODE dbSUPER 11.1 +424.3 424264 1.4 CTCF ZNF143 RELA ZIC2 RAD21 IKZF2 TRIM22 EED DPF2 RELB ADAT1 TMEM231 TERF2IP ZFP1 piR-35672-023 ENSG00000260092 ENSG00000259992
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZFP1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZFP1

Top Transcription factor binding sites by QIAGEN in the ZFP1 gene promoter:
  • Nkx5-1

Genomic Locations for ZFP1 Gene

Genomic Locations for ZFP1 Gene
chr16:75,126,285-75,172,236
(GRCh38/hg38)
Size:
45,952 bases
Orientation:
Plus strand
chr16:75,182,390-75,206,134
(GRCh37/hg19)
Size:
23,745 bases
Orientation:
Plus strand

Genomic View for ZFP1 Gene

Genes around ZFP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZFP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZFP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFP1 Gene

Proteins for ZFP1 Gene

  • Protein details for ZFP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P2D0-ZFP1_HUMAN
    Recommended name:
    Zinc finger protein 1 homolog
    Protein Accession:
    Q6P2D0
    Secondary Accessions:
    • A8K5Q7
    • B4DKG9
    • Q8N188
    • Q8N9F9

    Protein attributes for ZFP1 Gene

    Size:
    407 amino acids
    Molecular mass:
    47516 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH33774.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZFP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZFP1 Gene

Post-translational modifications for ZFP1 Gene

  • Ubiquitination at Lys74, Lys88, Lys105, Lys111, Lys114, Lys129, Lys145, and Lys196
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ZFP1 Gene

Domains & Families for ZFP1 Gene

Gene Families for ZFP1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZFP1 Gene

InterPro:
Blocks:
  • KRAB box
ProtoNet:

Suggested Antigen Peptide Sequences for ZFP1 Gene

GenScript: Design optimal peptide antigens:
  • ZFP1 protein (Q29RW8_HUMAN)
  • Zinc finger protein 475 (ZFP1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6P2D0

UniProtKB/Swiss-Prot:

ZFP1_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZFP1: view

Function for ZFP1 Gene

Molecular function for ZFP1 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZFP1 Gene

Gene Ontology (GO) - Molecular Function for ZFP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZFP1: view
genes like me logo Genes that share phenotypes with ZFP1: view

Animal Model Products

CRISPR Products

miRNA for ZFP1 Gene

miRTarBase miRNAs that target ZFP1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZFP1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZFP1 Gene

Localization for ZFP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZFP1 Gene

Nucleus. Note=Shows widespread expression throughout the nucleus, but appears to be excluded from nucleoli. {ECO:0000250 UniProtKB:P08042}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZFP1 gene
Compartment Confidence
nucleus 4
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
cytosol 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZFP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZFP1: view

Pathways & Interactions for ZFP1 Gene

genes like me logo Genes that share pathways with ZFP1: view

Pathways by source for ZFP1 Gene

2 Reactome pathways for ZFP1 Gene
1 KEGG pathway for ZFP1 Gene

Gene Ontology (GO) - Biological Process for ZFP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZFP1: view

No data available for SIGNOR curated interactions for ZFP1 Gene

Drugs & Compounds for ZFP1 Gene

No Compound Related Data Available

Transcripts for ZFP1 Gene

mRNA/cDNA for ZFP1 Gene

8 REFSEQ mRNAs :
20 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZFP1

Alternative Splicing Database (ASD) splice patterns (SP) for ZFP1 Gene

ExUns: 1a · 1b ^ 2a · 2b
SP1: -
SP2:

Relevant External Links for ZFP1 Gene

GeneLoc Exon Structure for
ZFP1

Expression for ZFP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZFP1 Gene

Protein differential expression in normal tissues from HIPED for ZFP1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (56.0) and Islet of Langerhans (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZFP1 Gene



Protein tissue co-expression partners for ZFP1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZFP1

SOURCE GeneReport for Unigene cluster for ZFP1 Gene:

Hs.388813

Evidence on tissue expression from TISSUES for ZFP1 Gene

  • Nervous system(4.7)
  • Liver(2)
genes like me logo Genes that share expression patterns with ZFP1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZFP1 Gene

Orthologs for ZFP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZFP1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZFP1 30 31
  • 99.67 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ZFP1 30 31
  • 90.86 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ZFP1 30 31
  • 89.84 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Zfp1 30 17 31
  • 82.88 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Zfp1 30
  • 82.05 (n)
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 46 (a)
OneToMany
-- 31
  • 40 (a)
OneToMany
-- 31
  • 39 (a)
OneToMany
-- 31
  • 36 (a)
OneToMany
Zebrafish
(Danio rerio)
Actinopterygii si:dkey-262g12.7 31
  • 41 (a)
ManyToMany
CABZ01081748.1 31
  • 40 (a)
ManyToMany
zgc:175008 31
  • 39 (a)
ManyToMany
CABZ01015530.1 31
  • 39 (a)
ManyToMany
CR788316.4 31
  • 38 (a)
ManyToMany
si:dkey-77p23.2 31
  • 38 (a)
ManyToMany
CABZ01071909.3 31
  • 37 (a)
ManyToMany
si:ch73-266f23.3 31
  • 37 (a)
ManyToMany
BX649328.1 31
  • 36 (a)
ManyToMany
CABZ01081749.1 31
  • 35 (a)
ManyToMany
si:ch211-161m3.4 31
  • 34 (a)
ManyToMany
si:dkey-240n22.8 31
  • 34 (a)
ManyToMany
si:dkey-77f5.14 31
  • 32 (a)
ManyToMany
si:ch73-57f22.2 31
  • 29 (a)
ManyToMany
si:dkey-77f5.15 31
  • 25 (a)
ManyToMany
Fruit Fly
(Drosophila melanogaster)
Insecta Kr-h1 31
  • 13 (a)
ManyToMany
Worm
(Caenorhabditis elegans)
Secernentea M03D4.4 31
  • 16 (a)
OneToMany
Species where no ortholog for ZFP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for ZFP1 Gene

ENSEMBL:
Gene Tree for ZFP1 (if available)
TreeFam:
Gene Tree for ZFP1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZFP1: view image

Paralogs for ZFP1 Gene

Paralogs for ZFP1 Gene

(552) SIMAP similar genes for ZFP1 Gene using alignment to 5 proteins:

  • ZFP1_HUMAN
  • H3BM94_HUMAN
  • H3BV40_HUMAN
  • J3KNQ1_HUMAN
  • Q29RW8_HUMAN

Pseudogenes.org Pseudogenes for ZFP1 Gene

genes like me logo Genes that share paralogs with ZFP1: view

Variants for ZFP1 Gene

Additional dbSNP identifiers (rs#s) for ZFP1 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZFP1 Gene

Variant ID Type Subtype PubMed ID
esv2714705 CNV deletion 23290073
esv2714706 CNV deletion 23290073
esv2761914 CNV gain 21179565
esv3639085 CNV gain 21293372
nsv7286 OTHER inversion 18451855
nsv833282 CNV gain+loss 17160897

Variation tolerance for ZFP1 Gene

Residual Variation Intolerance Score: 20% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.24; 24.84% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZFP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZFP1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZFP1 Gene

Disorders for ZFP1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZFP1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
zinc finger protein 1
  • znf1
- elite association - COSMIC cancer census association via MalaCards
Search ZFP1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ZFP1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with ZFP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZFP1 Gene

Publications for ZFP1 Gene

  1. Fine mapping and association studies of a high-density lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian subjects. (PMID: 19844255) Dastani Z … Genest J (European journal of human genetics : EJHG 2010) 3 41
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. Structure, expression and chromosomal localization of Zfp-1, a murine zinc finger protein gene. (PMID: 2574853) Chowdhury K … Gruss P (Nucleic acids research 1989) 2 3
  5. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3

Products for ZFP1 Gene

Sources for ZFP1 Gene