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Aliases for ZFHX2 Gene

Aliases for ZFHX2 Gene

  • Zinc Finger Homeobox 2 2 3 5
  • Zinc Finger Homeodomain Protein 2 3 4
  • Zinc Finger Protein 409 2 3
  • ZNF409 3 4
  • ZFH-2 3 4
  • Zinc Finger Homeobox Protein 2 3
  • KIAA1056 4
  • KIAA1762 4
  • MARSIS 3
  • ZFH-5 3
  • ZFH5 3

External Ids for ZFHX2 Gene

Previous HGNC Symbols for ZFHX2 Gene

  • ZNF409

Previous GeneCards Identifiers for ZFHX2 Gene

  • GC14M017777
  • GC14M021981
  • GC14M021982
  • GC14M021983
  • GC14M023059
  • GC14M023990

Summaries for ZFHX2 Gene

GeneCards Summary for ZFHX2 Gene

ZFHX2 (Zinc Finger Homeobox 2) is a Protein Coding gene. Diseases associated with ZFHX2 include Marsili Syndrome. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and actin binding. An important paralog of this gene is ZFHX3.

UniProtKB/Swiss-Prot for ZFHX2 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZFHX2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZFHX2 Gene

Genomics for ZFHX2 Gene

GeneHancer (GH) Regulatory Elements for ZFHX2 Gene

Promoters and enhancers for ZFHX2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J023555 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.7 -1.4 -1441 4.7 MLX ZFP64 ARID4B SIN3A YBX1 DMAP1 ZNF2 YY1 SLC30A9 POLR2B THTPA ZFHX2 ACIN1 RNF31 AP1G2 PRMT5 IPO4 KHNYN HAUS4 RNA5SP383
GH14J022976 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.7 +576.3 576286 7.6 MLX ZFP64 FEZF1 DMAP1 YBX1 IRF4 YY1 SLC30A9 E2F8 ZNF143 AJUBA ACIN1 NGDN HAUS4 PRMT5 C14orf93 RBM23 LOC102724814 PABPN1 MMP14
GH14J023284 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 9.9 +270.4 270441 3.4 HDGF PKNOX1 CLOCK FOXA2 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 HOMEZ PIR53909 ACIN1 PRMT5 IPO4 RNF31 NGDN THTPA TSSK4 RABGGTA
GH14J023588 Enhancer 1.2 Ensembl ENCODE 11.6 -33.0 -33016 1.2 PKNOX1 SMAD1 MLX ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 SLC30A9 IPO4 PRMT5 ZFHX2 ZFHX2-AS1 RNF31 HOMEZ JPH4 ENSG00000274002
GH14J023577 Promoter/Enhancer 1.2 EPDnew ENCODE 11.4 -22.6 -22594 2.2 BRD4 MXI1 ZFHX2 POLR2A ZFP91 ZNF189 NFIA ZNF398 GABPA SP1 JPH4 ZFHX2 ZFHX2-AS1 DHRS4-AS1 AP1G2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZFHX2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZFHX2 gene promoter:
  • AP-2alpha
  • HOXA5
  • YY1
  • AP-2alphaA
  • AP-2beta
  • AP-2gamma
  • GATA-1
  • GATA-2
  • Meis-1b
  • Meis-1

Genomic Locations for ZFHX2 Gene

Genomic Locations for ZFHX2 Gene
chr14:23,520,855-23,556,192
(GRCh38/hg38)
Size:
35,338 bases
Orientation:
Minus strand
chr14:23,990,064-24,025,401
(GRCh37/hg19)
Size:
35,338 bases
Orientation:
Minus strand

Genomic View for ZFHX2 Gene

Genes around ZFHX2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZFHX2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZFHX2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFHX2 Gene

Proteins for ZFHX2 Gene

  • Protein details for ZFHX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9C0A1-ZFHX2_HUMAN
    Recommended name:
    Zinc finger homeobox protein 2
    Protein Accession:
    Q9C0A1
    Secondary Accessions:
    • Q9UPU6

    Protein attributes for ZFHX2 Gene

    Size:
    2572 amino acids
    Molecular mass:
    274176 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA83008.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZFHX2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZFHX2 Gene

Post-translational modifications for ZFHX2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZFHX2 Gene

Domains & Families for ZFHX2 Gene

Gene Families for ZFHX2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for ZFHX2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZFHX2: view

No data available for UniProtKB/Swiss-Prot for ZFHX2 Gene

Function for ZFHX2 Gene

Molecular function for ZFHX2 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZFHX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISM 19274049
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0008270 zinc ion binding IEA --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with ZFHX2: view
genes like me logo Genes that share phenotypes with ZFHX2: view

Human Phenotype Ontology for ZFHX2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for ZFHX2 Gene

MGI Knock Outs for ZFHX2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZFHX2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Transcription Factor Targets and HOMER Transcription for ZFHX2 Gene

Localization for ZFHX2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZFHX2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZFHX2 gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli fibrillar center (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZFHX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZFHX2: view

Pathways & Interactions for ZFHX2 Gene

SuperPathways for ZFHX2 Gene

No Data Available

Interacting Proteins for ZFHX2 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 7)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000413418%0d%0a9606.ENSP00000324441%0d%0a9606.ENSP00000320050%0d%0a9606.ENSP00000396402%0d%0a9606.ENSP00000382513%0d%0a9606.ENSP00000253159%0d%0a
Selected Interacting proteins: Q9C0A1-ZFHX2_HUMAN ENSP00000413418 for ZFHX2 Gene via IID STRING

Gene Ontology (GO) - Biological Process for ZFHX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
GO:0030534 adult behavior IEA --
genes like me logo Genes that share ontologies with ZFHX2: view

No data available for Pathways by source and SIGNOR curated interactions for ZFHX2 Gene

Drugs & Compounds for ZFHX2 Gene

No Compound Related Data Available

Transcripts for ZFHX2 Gene

Unigene Clusters for ZFHX2 Gene

Zinc finger homeobox 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZFHX2

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZFHX2 Gene

No ASD Table

Relevant External Links for ZFHX2 Gene

GeneLoc Exon Structure for
ZFHX2
ECgene alternative splicing isoforms for
ZFHX2

Expression for ZFHX2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZFHX2 Gene

mRNA differential expression in normal tissues according to GTEx for ZFHX2 Gene

This gene is overexpressed in Testis (x6.5).

Protein differential expression in normal tissues from HIPED for ZFHX2 Gene

This gene is overexpressed in Adipocyte (62.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZFHX2 Gene



Protein tissue co-expression partners for ZFHX2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZFHX2 Gene:

ZFHX2

SOURCE GeneReport for Unigene cluster for ZFHX2 Gene:

Hs.508937

Evidence on tissue expression from TISSUES for ZFHX2 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with ZFHX2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZFHX2 Gene

Orthologs for ZFHX2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZFHX2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZFHX2 34 33
  • 98.97 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ZFHX2 34 33
  • 88.59 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ZFHX2 34 33
  • 87.26 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfhx2 33
  • 85.98 (n)
mouse
(Mus musculus)
Mammalia Zfhx2 16 34 33
  • 85.52 (n)
oppossum
(Monodelphis domestica)
Mammalia ZFHX2 34
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZFHX2 34
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zfhx2 33
  • 54.18 (n)
zebrafish
(Danio rerio)
Actinopterygii zfhx2 34
  • 17 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta zfh2 34
  • 15 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea zfh-2 34
  • 24 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 30 (a)
ManyToMany
-- 34
  • 24 (a)
ManyToMany
Species where no ortholog for ZFHX2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZFHX2 Gene

ENSEMBL:
Gene Tree for ZFHX2 (if available)
TreeFam:
Gene Tree for ZFHX2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZFHX2: view image

Paralogs for ZFHX2 Gene

Paralogs for ZFHX2 Gene

(2) SIMAP similar genes for ZFHX2 Gene using alignment to 6 proteins:

  • ZFHX2_HUMAN
  • A2RRC6_HUMAN
  • B7ZM83_HUMAN
  • B9EK48_HUMAN
  • C9JSX6_HUMAN
  • G3V3N5_HUMAN
genes like me logo Genes that share paralogs with ZFHX2: view

Variants for ZFHX2 Gene

Sequence variations from dbSNP and Humsavar for ZFHX2 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000070652 -- 23,521,059(-) A/G 3_prime_UTR_variant
rs1000308389 -- 23,526,376(-) C/T coding_sequence_variant, missense_variant
rs1000375875 -- 23,550,211(-) T/C 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000420254 -- 23,520,965(-) T/C 3_prime_UTR_variant
rs1000476809 -- 23,550,969(-) C/T 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZFHX2 Gene

Variant ID Type Subtype PubMed ID
nsv952817 CNV deletion 24416366
nsv564044 CNV loss 21841781
nsv564043 CNV loss 21841781
nsv524778 CNV loss 19592680
nsv477115 CNV novel sequence insertion 20440878

Variation tolerance for ZFHX2 Gene

Gene Damage Index Score: 14.86; 96.73% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZFHX2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZFHX2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZFHX2 Gene

Disorders for ZFHX2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZFHX2 Gene - From: OMIM and ClinVar

Disorder Aliases PubMed IDs
marsili syndrome
  • marsis
- elite association - COSMIC cancer census association via MalaCards
Search ZFHX2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ZFHX2

genes like me logo Genes that share disorders with ZFHX2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZFHX2 Gene

Publications for ZFHX2 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4 58
  2. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10470851) Kikuno R … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 2 3 58
  3. A novel human pain insensitivity disorder caused by a point mutation in ZFHX2. (PMID: 29253101) Habib AM … Cox JJ (Brain : a journal of neurology 2018) 3 58
  4. A census of human transcription factors: function, expression and evolution. (PMID: 19274049) Vaquerizas JM … Luscombe NM (Nature reviews. Genetics 2009) 3 58
  5. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L … Andersson-Svahn H (Molecular & cellular proteomics : MCP 2008) 3 58

Products for ZFHX2 Gene

Sources for ZFHX2 Gene

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