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Aliases for ZFHX2 Gene

Aliases for ZFHX2 Gene

  • Zinc Finger Homeobox 2 2 3 5
  • Zinc Finger Homeodomain Protein 2 3 4
  • Zinc Finger Protein 409 2 3
  • ZNF409 3 4
  • ZFH-2 3 4
  • Zinc Finger Homeobox Protein 2 3
  • KIAA1056 4
  • KIAA1762 4
  • ZFH-5 3

External Ids for ZFHX2 Gene

Previous HGNC Symbols for ZFHX2 Gene

  • ZNF409

Previous GeneCards Identifiers for ZFHX2 Gene

  • GC14M017777
  • GC14M021981
  • GC14M021982
  • GC14M021983
  • GC14M023059
  • GC14M023990

Summaries for ZFHX2 Gene

GeneCards Summary for ZFHX2 Gene

ZFHX2 (Zinc Finger Homeobox 2) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and actin binding. An important paralog of this gene is ZFHX3.

UniProtKB/Swiss-Prot for ZFHX2 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZFHX2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZFHX2 Gene

Genomics for ZFHX2 Gene

Regulatory Elements for ZFHX2 Gene

Enhancers for ZFHX2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14H022976 1.9 FANTOM5 ENCODE dbSUPER 10.7 +576.3 576287 7 MLX ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF548 SP3 ACIN1 NGDN PRMT5 RBM23 C14orf93 HAUS4 MMP14 LOC102724814 PABPN1 SLC22A17
GH14H023588 1.3 Ensembl ENCODE 11.6 -33.0 -33017 1 PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 SP3 IPO4 PRMT5 ZFHX2 ZFHX2-AS1 RNF31 HOMEZ JPH4 ENSG00000274002
GH14H023608 1.3 ENCODE dbSUPER 10.8 -55.6 -55566 6 FOXA2 ATF1 MLX ZFP64 ARID4B DMAP1 YY1 SLC30A9 ATF7 RUNX3 IPO4 PRMT5 JPH4 RNF31 ZFHX2 ZFHX2-AS1 HOMEZ DHRS4-AS1 SDR39U1 HAUS4
GH14H023284 1.4 ENCODE dbSUPER 9.9 +270.4 270442 3 HDGF PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ACIN1 PRMT5 IPO4 HOMEZ RNF31 NGDN THTPA TSSK4 RABGGTA RNA5SP383
GH14H023279 1.2 ENCODE dbSUPER 9.3 +275.6 275606 2 HDGF PKNOX1 ATF1 ARNT TCF12 ZNF766 CBX5 GATA2 FOS ATF7 PABPN1 CMTM5 MIR208B ACIN1 ZFHX2-AS1 ZFHX2 HOMEZ PIR53909 HMGN2P1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZFHX2 on UCSC Golden Path with GeneCards custom track

Promoters for ZFHX2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000066758 92 1401 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF207 ZNF143

Genomic Location for ZFHX2 Gene

Chromosome:
14
Start:
23,520,855 bp from pter
End:
23,556,192 bp from pter
Size:
35,338 bases
Orientation:
Minus strand

Genomic View for ZFHX2 Gene

Genes around ZFHX2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZFHX2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZFHX2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFHX2 Gene

Proteins for ZFHX2 Gene

  • Protein details for ZFHX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9C0A1-ZFHX2_HUMAN
    Recommended name:
    Zinc finger homeobox protein 2
    Protein Accession:
    Q9C0A1
    Secondary Accessions:
    • Q9UPU6

    Protein attributes for ZFHX2 Gene

    Size:
    2572 amino acids
    Molecular mass:
    274176 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA83008.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZFHX2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZFHX2 Gene

Post-translational modifications for ZFHX2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZFHX2 Gene

Domains & Families for ZFHX2 Gene

Gene Families for ZFHX2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for ZFHX2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZFHX2: view

No data available for UniProtKB/Swiss-Prot for ZFHX2 Gene

Function for ZFHX2 Gene

Molecular function for ZFHX2 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZFHX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0008270 zinc ion binding IEA --
GO:0043565 sequence-specific DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZFHX2: view
genes like me logo Genes that share phenotypes with ZFHX2: view

Animal Models for ZFHX2 Gene

MGI Knock Outs for ZFHX2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZFHX2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZFHX2 Gene

Localization for ZFHX2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZFHX2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZFHX2 gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli fibrillar center (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZFHX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZFHX2: view

Pathways & Interactions for ZFHX2 Gene

SuperPathways for ZFHX2 Gene

No Data Available

Interacting Proteins for ZFHX2 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 7)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000413418%0d%0a9606.ENSP00000320050%0d%0a9606.ENSP00000351530%0d%0a9606.ENSP00000396402%0d%0a9606.ENSP00000253159%0d%0a9606.ENSP00000374359%0d%0a
Selected Interacting proteins: Q9C0A1-ZFHX2_HUMAN ENSP00000413418 for ZFHX2 Gene via IID STRING

Gene Ontology (GO) - Biological Process for ZFHX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0030534 adult behavior IEA --
genes like me logo Genes that share ontologies with ZFHX2: view

No data available for Pathways by source and SIGNOR curated interactions for ZFHX2 Gene

Drugs & Compounds for ZFHX2 Gene

No Compound Related Data Available

Transcripts for ZFHX2 Gene

Unigene Clusters for ZFHX2 Gene

Zinc finger homeobox 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZFHX2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ZFHX2 Gene

No ASD Table

Relevant External Links for ZFHX2 Gene

GeneLoc Exon Structure for
ZFHX2
ECgene alternative splicing isoforms for
ZFHX2

Expression for ZFHX2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZFHX2 Gene

mRNA differential expression in normal tissues according to GTEx for ZFHX2 Gene

This gene is overexpressed in Testis (x6.5).

Protein differential expression in normal tissues from HIPED for ZFHX2 Gene

This gene is overexpressed in Adipocyte (62.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZFHX2 Gene



Protein tissue co-expression partners for ZFHX2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZFHX2 Gene:

ZFHX2

SOURCE GeneReport for Unigene cluster for ZFHX2 Gene:

Hs.508937

Evidence on tissue expression from TISSUES for ZFHX2 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ZFHX2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZFHX2 Gene

Orthologs for ZFHX2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZFHX2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZFHX2 33 34
  • 98.97 (n)
dog
(Canis familiaris)
Mammalia ZFHX2 33 34
  • 88.59 (n)
cow
(Bos Taurus)
Mammalia ZFHX2 33 34
  • 87.26 (n)
rat
(Rattus norvegicus)
Mammalia Zfhx2 33
  • 85.98 (n)
mouse
(Mus musculus)
Mammalia Zfhx2 33 16 34
  • 85.52 (n)
oppossum
(Monodelphis domestica)
Mammalia ZFHX2 34
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZFHX2 34
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zfhx2 33
  • 54.18 (n)
zebrafish
(Danio rerio)
Actinopterygii zfhx2 34
  • 17 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta zfh2 34
  • 15 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea zfh-2 34
  • 24 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 30 (a)
ManyToMany
-- 34
  • 24 (a)
ManyToMany
Species where no ortholog for ZFHX2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZFHX2 Gene

ENSEMBL:
Gene Tree for ZFHX2 (if available)
TreeFam:
Gene Tree for ZFHX2 (if available)

Paralogs for ZFHX2 Gene

Paralogs for ZFHX2 Gene

(2) SIMAP similar genes for ZFHX2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with ZFHX2: view

Variants for ZFHX2 Gene

Sequence variations from dbSNP and Humsavar for ZFHX2 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000070652 -- 23,521,059(+) CCTGG(A/G)GGCTG intron-variant, utr-variant-3-prime
rs1000308389 -- 23,526,376(+) AGGGC(C/T)GGGCA intron-variant, reference, missense
rs1000375875 -- 23,550,211(+) GCTTC(C/T)CTGGT intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000420254 -- 23,520,965(+) GCACG(C/T)ACTCT intron-variant, utr-variant-3-prime
rs1000476809 -- 23,550,969(+) CCTTC(C/T)CCCCG intron-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for ZFHX2 Gene

Variant ID Type Subtype PubMed ID
nsv477115 CNV novel sequence insertion 20440878
nsv524778 CNV loss 19592680
nsv564043 CNV loss 21841781
nsv564044 CNV loss 21841781
nsv952817 CNV deletion 24416366

Variation tolerance for ZFHX2 Gene

Gene Damage Index Score: 14.86; 96.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZFHX2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZFHX2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZFHX2 Gene

Disorders for ZFHX2 Gene

Relevant External Links for ZFHX2

Genetic Association Database (GAD)
ZFHX2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZFHX2

No disorders were found for ZFHX2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZFHX2 Gene

Publications for ZFHX2 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4 60
  2. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10470851) Kikuno R … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 2 3 60
  3. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L … Andersson-Svahn H (Molecular & cellular proteomics : MCP 2008) 3 60
  4. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R … Weissenbach J (Nature 2003) 4 60
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 60

Products for ZFHX2 Gene

Sources for ZFHX2 Gene

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