This gene encodes a small antisense RNA that may be involved in regulating the sense strand locus, zinc finger and AT hook domain containing. This RNA may play a role in B cell function. A single nucleotide polymorphism in the promoter of this gene is associated with an increased risk of autoimmune thyroid disease.[provided by RefSeq, Jan 2010] See more...

Aliases for ZFAT-AS1 Gene

Subcategory (RNA class) for ZFAT-AS1 Gene

lncRNA

Number of RNA Genes sources:

3 / 14

Aliases for ZFAT-AS1 Gene

  • ZFAT Antisense RNA 1 2 3 5
  • ZFAT Antisense RNA 1 (Non-Protein Coding) 2 3
  • Zinc Finger Protein 406 Antisense Transcript 3
  • ZFAT Antisense RNA (Non-Protein Coding) 2
  • Non-Protein Coding RNA 70 2
  • HSALNG0068805 167
  • NONHSAG051351 92
  • NCRNA00070 3
  • SAS-ZFAT 3
  • ZFAT-AS1 2
  • ZFAT-AS 3
  • ZFATAS 3

External Ids for ZFAT-AS1 Gene

Previous HGNC Symbols for ZFAT-AS1 Gene

  • ZFATAS
  • ZFAT-AS

Previous GeneCards Identifiers for ZFAT-AS1 Gene

  • GC08P135610
  • GC08P134601
  • GC08P134603
  • GC08P134615
  • GC08P134616
  • GC08P134617
  • GC08P134604
  • GC08P134605
  • GC08P134608
  • GC08P134609
  • GC08P134610
  • GC08P134611
  • GC08P134612
  • GC08P134614

Summaries for ZFAT-AS1 Gene

Entrez Gene Summary for ZFAT-AS1 Gene

  • This gene encodes a small antisense RNA that may be involved in regulating the sense strand locus, zinc finger and AT hook domain containing. This RNA may play a role in B cell function. A single nucleotide polymorphism in the promoter of this gene is associated with an increased risk of autoimmune thyroid disease.[provided by RefSeq, Jan 2010]

GeneCards Summary for ZFAT-AS1 Gene

ZFAT-AS1 (ZFAT Antisense RNA 1) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with ZFAT-AS1 include Autoimmune Disease and Type 1 Diabetes Mellitus 11.

Rfam classification for ZFAT-AS1 Gene

  • ZFAT antisense RNA 1 conserved region 1
  • ZFAT antisense RNA 1 conserved region 2
  • ZFAT antisense RNA 1 conserved region 3

Additional gene information for ZFAT-AS1 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for ZFAT-AS1 Gene

Genomics for ZFAT-AS1 Gene

GeneHancer (GH) Regulatory Elements for ZFAT-AS1 Gene

Promoters and enhancers for ZFAT-AS1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J134597 Enhancer 0.8 Ensembl ENCODE 500.7 +0.7 716 2.7 ZBTB40 POLR2A TCF12 MEF2B CHD1 SPI1 WRNIP1 EBF1 STAT1 MITF ENSG00000276140 ENSG00000277732 ENSG00000278454 ZFAT-AS1 ZFAT
GH08J134600 Enhancer 1 Ensembl ENCODE 0.7 +3.6 3626 3 SP1 TCF7 CTCF RELA MEF2C RAD21 REST SKI TRIM22 POLR2A ENSG00000278454 ZFAT-AS1 lnc-ST3GAL1-7 ZFAT
GH08J134572 Enhancer 0.9 Ensembl ENCODE 0.4 -24.8 -24770 2.2 BCL11A TCF12 ZNF316 ZNF384 FOS CEBPB ZBTB33 NR2F2 NFE2 SMARCA5 ZFAT ENSG00000276140 ZFAT-AS1 lnc-ST3GAL1-5
GH08J134579 Enhancer 0.8 Ensembl ENCODE 0.4 -16.3 -16270 3.6 JUND FOS FOSL2 NFE2 FOXA1 FOXP2 RAD21 TAF1 RXRA HNF4A ZFAT ZFAT-AS1 ENSG00000276140 lnc-ST3GAL1-5
GH08J134564 Promoter/Enhancer 0.9 EPDnew ENCODE 0.3 -33.0 -32979 1.1 MEF2B EBF1 ATF2 NFIC MYC CREM ZNF687 POLR2A ZBED1 EED ZFAT ENSG00000276140 ZFAT-AS1 lnc-ST3GAL1-5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZFAT-AS1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ZFAT-AS1 Gene

Genomic Locations for ZFAT-AS1 Gene
chr8:134,598,071-134,600,690
(GRCh38/hg38)
Size:
2,620 bases
Orientation:
Plus strand
chr8:135,610,314-135,612,932
(GRCh37/hg19)
Size:
2,619 bases
Orientation:
Plus strand

Genomic View for ZFAT-AS1 Gene

Genes around ZFAT-AS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZFAT-AS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZFAT-AS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFAT-AS1 Gene

Proteins for ZFAT-AS1 Gene

Post-translational modifications for ZFAT-AS1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for ZFAT-AS1 Gene

Domains & Families for ZFAT-AS1 Gene

No data available for Gene Families , Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ZFAT-AS1 Gene

Function for ZFAT-AS1 Gene

Phenotypes From GWAS Catalog for ZFAT-AS1 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZFAT-AS1 Gene

Localization for ZFAT-AS1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for ZFAT-AS1 Gene

Pathways & Interactions for ZFAT-AS1 Gene

PathCards logo

SuperPathways for ZFAT-AS1 Gene

No Data Available
;

Gene Ontology (GO) - Biological Process for ZFAT-AS1 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for ZFAT-AS1 Gene

Drugs & Compounds for ZFAT-AS1 Gene

No Compound Related Data Available

Transcripts for ZFAT-AS1 Gene

mRNA/cDNA for ZFAT-AS1 Gene

2 RNACentral transcripts :
1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
2 NONCODE transcripts :
1 ENA transcripts :
2 LncBook transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZFAT-AS1 Gene

No ASD Table

Relevant External Links for ZFAT-AS1 Gene

GeneLoc Exon Structure for
ZFAT-AS1

Expression for ZFAT-AS1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZFAT-AS1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZFAT-AS1

SOURCE GeneReport for Unigene cluster for ZFAT-AS1 Gene:

Hs.626298
genes like me logo Genes that share expression patterns with ZFAT-AS1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZFAT-AS1 Gene

Orthologs for ZFAT-AS1 Gene

Evolution for ZFAT-AS1 Gene

ENSEMBL:
Gene Tree for ZFAT-AS1 (if available)
TreeFam:
Gene Tree for ZFAT-AS1 (if available)

No data available for Orthologs for ZFAT-AS1 Gene

Paralogs for ZFAT-AS1 Gene

No data available for Paralogs for ZFAT-AS1 Gene

Variants for ZFAT-AS1 Gene

Additional dbSNP identifiers (rs#s) for ZFAT-AS1 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZFAT-AS1 Gene

Variant ID Type Subtype PubMed ID
esv2660261 CNV deletion 23128226
nsv612335 CNV loss 21841781

Additional Variant Information for ZFAT-AS1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZFAT-AS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for ZFAT-AS1 Gene

Disorders for ZFAT-AS1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for ZFAT-AS1 Gene - From: LncRNADisease and DISEASES

Disorder Aliases PubMed IDs
autoimmune disease
  • autoimmune hypersensitivity disease
type 1 diabetes mellitus 11
  • diabetes mellitus, insulin-dependent, 11
type 1 diabetes mellitus 15
  • diabetes mellitus, insulin-dependent, 15
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZFAT-AS1

genes like me logo Genes that share disorders with ZFAT-AS1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZFAT-AS1 Gene

Publications for ZFAT-AS1 Gene

  1. A genome-wide approach reveals novel imprinted genes expressed in the human placenta. (PMID: 22894909) Barbaux S … Vaiman D (Epigenetics 2012) 2 3 54
  2. SNPs in the promoter of a B cell-specific antisense transcript, SAS-ZFAT, determine susceptibility to autoimmune thyroid disease. (PMID: 15294872) Shirasawa S … Sasazuki T (Human molecular genetics 2004) 2 3 54

Products for ZFAT-AS1 Gene

Sources for ZFAT-AS1 Gene