Aliases for ZFAT Gene
External Ids for ZFAT Gene
Previous HGNC Symbols for ZFAT Gene
Previous GeneCards Identifiers for ZFAT Gene
This gene encodes a protein that likely binds DNA and functions as a transcriptional regulator involved in apoptosis and cell survival. This gene resides in a susceptibility locus for autoimmune thyroid disease (AITD) on chromosome 8q24. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Nov 2009]
GeneCards Summary for ZFAT Gene
ZFAT (Zinc Finger And AT-Hook Domain Containing) is a Protein Coding gene. Diseases associated with ZFAT include Autoimmune Thyroid Disease 3 and Type 1 Diabetes Mellitus 11. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific. An important paralog of this gene is PRDM15.
UniProtKB/Swiss-Prot Summary for ZFAT Gene
May be involved in transcriptional regulation. Overexpression causes down-regulation of a number of genes involved in the immune response. Some genes are also up-regulated (By similarity).