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This gene represents a snoRNA host gene that produces a non-coding RNA. Increased expression or amplification of this locus is associated with cancer progression and metastasis. This transcript regulates expression of genes involved in differentiation. It may act a molecular sponge for microRNAs. Alternatively spliced transcript variants have been observed. [provided by RefSeq,... See more...
Aliases for ZFAS1 Gene
Subcategory (RNA class) for ZFAS1 Gene
lncRNA
Number of RNA Genes sources:
3 / 17
Aliases for ZFAS1 Gene
External Ids for ZFAS1 Gene
- HGNC: 33101
- Entrez Gene: 441951
- Ensembl: ENSG00000177410
Previous HGNC Symbols for ZFAS1 Gene
- C20orf199
- NCRNA00275
- ZNFX1-AS1
Previous GeneCards Identifiers for ZFAS1 Gene
- GC20P047905
- GC20P047910
- GC20P047917
- GC20P049281
- GC20P049288
- GC20P049328
- GC20P049333
- GC20P049292
- GC20P049296
- GC20P049300
- GC20P049306
- GC20P049310
- GC20P049314
- GC20P049318
- GC20P049321
Summaries for ZFAS1 Gene
-
This gene represents a snoRNA host gene that produces a non-coding RNA. Increased expression or amplification of this locus is associated with cancer progression and metastasis. This transcript regulates expression of genes involved in differentiation. It may act a molecular sponge for microRNAs. Alternatively spliced transcript variants have been observed. [provided by RefSeq, Dec 2017]
GeneCards Summary for ZFAS1 Gene
ZFAS1 (ZNFX1 Antisense RNA 1) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with ZFAS1 include Breast Ductal Carcinoma and Rheumatoid Arthritis.
Rfam classification for ZFAS1 Gene
No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for ZFAS1 Gene
Genomics for ZFAS1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for ZFAS1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around ZFAS1 on the GeneHancer Hub at the UCSC Golden Path
Genomic Locations for ZFAS1 Gene
Genomic Locations for ZFAS1 Gene
- chr20:49,276,739-49,361,131
- (GRCh38/hg38)
- Size:
- 84,393 bases
- Orientation:
- Plus strand
- chr20:47,894,715-47,905,797
- (GRCh37/hg19)
- Size:
- 11,083 bases
- Orientation:
- Plus strand
Genomic View for ZFAS1 Gene
Genes around ZFAS1 on UCSC Golden Path with GeneCards custom track
ZFAS1 in the GeneCards ncRNA compendium hub on the UCSC Golden Path
- Cytogenetic band:
-
- 20q13.13 by HGNC
- 20q13.13 by Entrez Gene
- 20q13.13 by Ensembl
ZFAS1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ZFAS1 Gene
Proteins for ZFAS1 Gene
Post-translational modifications for ZFAS1 Gene
No Post-translational modifications
Antibody Products
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for ZFAS1
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No data available for DME Specific Peptides for ZFAS1 Gene
Domains & Families for ZFAS1 Gene
Gene Families for ZFAS1 Gene
No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ZFAS1 Gene
Function for ZFAS1 Gene
Phenotypes From GWAS Catalog for ZFAS1 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ZFAS1 - Select products 50% OFF >
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-
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miRNA Products
Inhibitory RNA Products
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Clone Products
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No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZFAS1 Gene
Localization for ZFAS1 Gene
| Compartment | Confidence |
|---|---|
| extracellular | 2 |
| nucleus | 2 |
| plasma membrane | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| cytosol | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for ZFAS1 Gene
Transcripts for ZFAS1 Gene
Non-coding RNA (ncRNA) Transcripts from RNAcentral for ZFAS1 Gene
| RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
|---|---|---|---|---|
| URS00001AEC9F_9606 | lncRNA | 504 | 5 |
RefSeq: NR_036659, Ensembl: ENST00000326677 (view in UCSC) , LncBook: HSALNT0268350, LNCipedia: ZFAS1:12, ZFAS1:24, NONCODE: NONHSAT080210.2, |
| URS000045E7E2_9606 | lncRNA | 1008 | 4 |
HGNC: 33101, RefSeq: NR_003604, LNCipedia: ZFAS1:4, NONCODE: NONHSAT080206.2, |
| URS00004B003D_9606 | lncRNA | 946 | 4 |
RefSeq: NR_036658, Ensembl: ENST00000441722 (view in UCSC) , LNCipedia: ZFAS1:1, NONCODE: NONHSAT080209.2, |
| URS00000C1202_9606 | lncRNA | 860 | 4 |
RefSeq: NR_003606, Ensembl: ENST00000417721 (view in UCSC) , LNCipedia: ZFAS1:3, NONCODE: NONHSAT080205.2, |
| URS00007CF26E_9606 | lncRNA | 732 | 4 |
Ensembl: ENST00000623640 (view in UCSC) , LncBook: HSALNT0268354, LNCipedia: ZFAS1:17, NONCODE: NONHSAT188881.1, |
ZFAS1 in the GeneCards ncRNA compendium hub on the UCSC Golden Path
Additional transcripts not in RNAcentral for ZFAS1 Gene
- 15 NCBI additional mRNA sequence :
- 1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000663883 640 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ZFAS1 - Select products 50% OFF >
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-
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miRNA Products
Inhibitory RNA Products
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Clone Products
- Applied Biological Materials (abm): Clones for ZFAS1 - Select products 50% OFF >
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| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||
| SP3: | - | - | - | - | - | - | |||||||||||||||
| SP4: | - | - | - | - | |||||||||||||||||
| SP5: | - | - | - | ||||||||||||||||||
| SP6: | - | - | - | - | - | - | |||||||||||||||
| SP7: | - | - | - | - | - | ||||||||||||||||
| SP8: | - | ||||||||||||||||||||
| SP9: |
Relevant External Links for ZFAS1 Gene
- GeneLoc Exon Structure for
- ZFAS1
Expression for ZFAS1 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZFAS1
SOURCE GeneReport for Unigene cluster for ZFAS1 Gene:
Hs.356766Primer Products
-
OriGene qPCR primer pairs for ZFAS1
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZFAS1 Gene
Orthologs for ZFAS1 Gene
No data available for Orthologs for ZFAS1 Gene
Paralogs for ZFAS1 Gene
No data available for Paralogs for ZFAS1 Gene
Variants for ZFAS1 Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1248e212 | CNV | loss | 25503493 |
| nsv1064443 | CNV | gain | 25217958 |
| nsv1067146 | CNV | loss | 25217958 |
| nsv1072545 | CNV | deletion | 25765185 |
| nsv437839 | CNV | loss | 16327808 |
Additional Variant Information for ZFAS1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ZFAS1
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for ZFAS1 Gene
Disorders for ZFAS1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| breast ductal carcinoma |
|
|
| rheumatoid arthritis |
|
|
| bladder cancer |
|
|
| gastric cancer |
|
|
| glioma |
|
Search ZFAS1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for ZFAS1
No data available for UniProtKB/Swiss-Prot and Genatlas for ZFAS1 Gene
Publications for ZFAS1 Gene
- SNORD-host RNA Zfas1 is a regulator of mammary development and a potential marker for breast cancer. (PMID: 21460236) Askarian-Amiri ME … Mattick JS (RNA (New York, N.Y.) 2011) 2 3
- Knockdown of ZFAS1 suppresses the progression of acute myeloid leukemia by regulating microRNA-150/Sp1 and microRNA-150/Myb pathways. (PMID: 30502345) Gan S … Sun H (European journal of pharmacology 2019) 3
- Long non-coding RNA ZFAS1 promotes proliferation and metastasis of clear cell renal cell carcinoma via targeting miR-10a/SKA1 pathway. (PMID: 30841471) Dong D … Zhao C (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019) 3
- Exosomal lncRNA ZFAS1 regulates esophageal squamous cell carcinoma cell proliferation, invasion, migration and apoptosis via microRNA-124/STAT3 axis. (PMID: 31775815) Li Z … Li S (Journal of experimental & clinical cancer research : CR 2019) 3
- ZFAS1 knockdown inhibits viability and enhances cisplatin cytotoxicity by up-regulating miR-432-5p in glioma cells. (PMID: 31246330) Yang G … Feng T (Basic & clinical pharmacology & toxicology 2019) 3
ExternalLinks
Products for ZFAS1 Gene
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Sources for ZFAS1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
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- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
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- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
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- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
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- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
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- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
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- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
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- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
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- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
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- (169) SILVA
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- (177) snoDB
- (178) MirGeneDB