This gene represents a snoRNA host gene that produces a non-coding RNA. Increased expression or amplification of this locus is associated with cancer progression and metastasis. This transcript regulates expression of genes involved in differentiation. It may act a molecular sponge for microRNAs. Alternatively spliced transcript variants have been observed. [provided by RefSeq,... See more...

Aliases for ZFAS1 Gene

Subcategory (RNA class) for ZFAS1 Gene

lncRNA

Number of RNA Genes sources:

3 / 14

Aliases for ZFAS1 Gene

  • ZNFX1 Antisense RNA 1 2 3 5
  • ZNFX1 Antisense RNA 1 (Non-Protein Coding) 2 3
  • ZFAS1 2 168
  • Chromosome 20 Open Reading Frame 199 2
  • ZNFX1 Antisense Gene Protein 1 3
  • Non-Protein Coding RNA 275 2
  • NONHSAG031976 92
  • HSALNG0130661 167
  • NCRNA00275 3
  • C20orf199 3
  • ZNFX1-AS1 3
  • HSUP1 3
  • HSUP2 3

External Ids for ZFAS1 Gene

Previous HGNC Symbols for ZFAS1 Gene

  • C20orf199
  • NCRNA00275
  • ZNFX1-AS1

Previous GeneCards Identifiers for ZFAS1 Gene

  • GC20P047905
  • GC20P047910
  • GC20P047917
  • GC20P049281
  • GC20P049288
  • GC20P049328
  • GC20P049333
  • GC20P049292
  • GC20P049296
  • GC20P049300
  • GC20P049306
  • GC20P049310
  • GC20P049314
  • GC20P049318
  • GC20P049321

Summaries for ZFAS1 Gene

Entrez Gene Summary for ZFAS1 Gene

  • This gene represents a snoRNA host gene that produces a non-coding RNA. Increased expression or amplification of this locus is associated with cancer progression and metastasis. This transcript regulates expression of genes involved in differentiation. It may act a molecular sponge for microRNAs. Alternatively spliced transcript variants have been observed. [provided by RefSeq, Dec 2017]

GeneCards Summary for ZFAS1 Gene

ZFAS1 (ZNFX1 Antisense RNA 1) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with ZFAS1 include Breast Ductal Carcinoma and Rheumatoid Arthritis.

Rfam classification for ZFAS1 Gene

  • ZNFX1 antisense RNA 1 conserved region 1
  • ZNFX1 antisense RNA 1 conserved region 2
  • ZNFX1 antisense RNA 1 conserved region 3
  • Small nucleolar SNORD12/SNORD106

Additional gene information for ZFAS1 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for ZFAS1 Gene

Genomics for ZFAS1 Gene

GeneHancer (GH) Regulatory Elements for ZFAS1 Gene

Promoters and enhancers for ZFAS1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZFAS1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ZFAS1 Gene

Genomic Locations for ZFAS1 Gene
chr20:49,276,739-49,361,131
(GRCh38/hg38)
Size:
84,393 bases
Orientation:
Plus strand
chr20:47,894,715-47,905,797
(GRCh37/hg19)
Size:
11,083 bases
Orientation:
Plus strand

Genomic View for ZFAS1 Gene

Genes around ZFAS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZFAS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZFAS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFAS1 Gene

Proteins for ZFAS1 Gene

Post-translational modifications for ZFAS1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for ZFAS1 Gene

Domains & Families for ZFAS1 Gene

genes like me logo Genes that share domains with ZFAS1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ZFAS1 Gene

Function for ZFAS1 Gene

Phenotypes From GWAS Catalog for ZFAS1 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZFAS1 Gene

Localization for ZFAS1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZFAS1 gene
Compartment Confidence
nucleus 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endosome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for ZFAS1 Gene

Pathways & Interactions for ZFAS1 Gene

PathCards logo

SuperPathways for ZFAS1 Gene

No Data Available
;

Gene Ontology (GO) - Biological Process for ZFAS1 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for ZFAS1 Gene

Drugs & Compounds for ZFAS1 Gene

No Compound Related Data Available

Transcripts for ZFAS1 Gene

mRNA/cDNA for ZFAS1 Gene

36 RNACentral transcripts :
5 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
14 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
12 NONCODE transcripts :
11 LncBook transcripts :
30 LNCipedia transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZFAS1 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8
SP1: - - -
SP2: - - -
SP3: - - - - - -
SP4: - - - -
SP5: - - -
SP6: - - - - - -
SP7: - - - - -
SP8: -
SP9:

Relevant External Links for ZFAS1 Gene

GeneLoc Exon Structure for
ZFAS1

Expression for ZFAS1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZFAS1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZFAS1

SOURCE GeneReport for Unigene cluster for ZFAS1 Gene:

Hs.356766
genes like me logo Genes that share expression patterns with ZFAS1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZFAS1 Gene

Orthologs for ZFAS1 Gene

Evolution for ZFAS1 Gene

ENSEMBL:
Gene Tree for ZFAS1 (if available)
TreeFam:
Gene Tree for ZFAS1 (if available)

No data available for Orthologs for ZFAS1 Gene

Paralogs for ZFAS1 Gene

No data available for Paralogs for ZFAS1 Gene

Variants for ZFAS1 Gene

Additional dbSNP identifiers (rs#s) for ZFAS1 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZFAS1 Gene

Variant ID Type Subtype PubMed ID
dgv1248e212 CNV loss 25503493
nsv1064443 CNV gain 25217958
nsv1067146 CNV loss 25217958
nsv1072545 CNV deletion 25765185
nsv437839 CNV loss 16327808

Additional Variant Information for ZFAS1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZFAS1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for ZFAS1 Gene

Disorders for ZFAS1 Gene

MalaCards: The human disease database

(11) MalaCards diseases for ZFAS1 Gene - From: LncRNADisease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
breast ductal carcinoma
  • duct carcinoma
rheumatoid arthritis
  • ra
bladder cancer
  • bladder cancer, somatic
gastric cancer
  • gastric cancer, somatic
glioma
- elite association - COSMIC cancer census association via MalaCards
Search ZFAS1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ZFAS1

genes like me logo Genes that share disorders with ZFAS1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZFAS1 Gene

Publications for ZFAS1 Gene

  1. SNORD-host RNA Zfas1 is a regulator of mammary development and a potential marker for breast cancer. (PMID: 21460236) Askarian-Amiri ME … Mattick JS (RNA (New York, N.Y.) 2011) 2 3 54
  2. Long non-coding RNA ZFAS1 promotes proliferation and metastasis of clear cell renal cell carcinoma via targeting miR-10a/SKA1 pathway. (PMID: 30841471) Dong D … Zhao C (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019) 3 54
  3. Knockdown of ZFAS1 suppresses the progression of acute myeloid leukemia by regulating microRNA-150/Sp1 and microRNA-150/Myb pathways. (PMID: 30502345) Gan S … Sun H (European journal of pharmacology 2019) 3 54
  4. Long non-coding RNA ZFAS1 regulates the malignant progression of gastric cancer via the microRNA-200b-3p/Wnt1 axis. (PMID: 30999814) Zhang F … Xu H (Bioscience, biotechnology, and biochemistry 2019) 3 54
  5. Knockdown of lncRNA ZFAS1 inhibits progression of nasopharyngeal carcinoma by sponging miR-135a. (PMID: 31307201) Wang M … Li XS (Neoplasma 2019) 3 54

Products for ZFAS1 Gene

Sources for ZFAS1 Gene