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Aliases for ZFAND4 Gene

Aliases for ZFAND4 Gene

  • Zinc Finger AN1-Type Containing 4 2 3 5
  • AN1-Type Zinc Finger And Ubiquitin Domain-Containing Protein-Like 1 3 4
  • Zinc Finger, AN1-Type Domain 4 2 3
  • ANUBL1 3 4
  • AN1-Type Zinc Finger And Ubiquitin Domain-Containing Protein 1 3
  • AN1, Ubiquitin-Like, Homolog (Xenopus Laevis) 2
  • AN1-Type Zinc Finger Protein 4 3
  • AN1, Ubiquitin-Like, Homolog 3

External Ids for ZFAND4 Gene

Previous HGNC Symbols for ZFAND4 Gene

  • ANUBL1

Previous GeneCards Identifiers for ZFAND4 Gene

  • GC10M046112

Summaries for ZFAND4 Gene

GeneCards Summary for ZFAND4 Gene

ZFAND4 (Zinc Finger AN1-Type Containing 4) is a Protein Coding gene. An important paralog of this gene is ZFAND5.

Additional gene information for ZFAND4 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZFAND4 Gene

Genomics for ZFAND4 Gene

GeneHancer (GH) Regulatory Elements for ZFAND4 Gene

Promoters and enhancers for ZFAND4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J045671 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 669.1 +0.2 183 2.4 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 ZNF2 ZBTB7B YY1 ZFAND4 MARCH8 WASHC2C
GH10J045726 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 19.3 -54.4 -54424 1.6 CLOCK MLX ARNT ARID4B SIN3A FEZF1 ZNF2 YY1 POLR2B ZNF213 WASHC2C ENSG00000228702 FAM21FP PARGP1 AGAP4 LOC105378289 ZFAND4 ENSG00000273363 AGAP10P DEPP1
GH10J045592 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 14 +78.9 78914 3 CLOCK FOXA2 MLX ARNT ARID4B SIN3A DMAP1 IRF4 YY1 SLC30A9 MARCH8 PARGP1 AGAP4 ZFAND4 WASHC2C ENSG00000273363 GC10P045511
GH10J044971 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.3 +693.1 693119 16.9 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC MEF2D SSRP1 DEPP1 PIR49011 C10orf25 WASHC2C ZNF22 TMEM72-AS1 RASSF4 FAM21FP ENSG00000223462 ENSG00000234504
GH10J046017 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.3 -348.9 -348874 8.4 MLX ZFP64 FEZF1 DMAP1 YY1 ZNF143 SP3 NFYC SSRP1 ZNF610 NCOA4 AGAP4 AGAP7P MSMB PARGP1 LOC105378289 ZFAND4 GC10M046012 PIR52076
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZFAND4 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ZFAND4 Gene

Genomic Locations for ZFAND4 Gene
chr10:45,614,567-45,672,962
(GRCh38/hg38)
Size:
58,396 bases
Orientation:
Minus strand
chr10:46,111,039-46,168,251
(GRCh37/hg19)

Genomic View for ZFAND4 Gene

Genes around ZFAND4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZFAND4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZFAND4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFAND4 Gene

Proteins for ZFAND4 Gene

  • Protein details for ZFAND4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86XD8-ZFAN4_HUMAN
    Recommended name:
    AN1-type zinc finger protein 4
    Protein Accession:
    Q86XD8
    Secondary Accessions:
    • A8K8V4
    • B2RAX2
    • Q5VVY5

    Protein attributes for ZFAND4 Gene

    Size:
    727 amino acids
    Molecular mass:
    80358 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZFAND4 Gene

Post-translational modifications for ZFAND4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZFAND4 Gene

Domains & Families for ZFAND4 Gene

Gene Families for ZFAND4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ZFAND4 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZFAND4: view

No data available for UniProtKB/Swiss-Prot for ZFAND4 Gene

Function for ZFAND4 Gene

Phenotypes From GWAS Catalog for ZFAND4 Gene

Gene Ontology (GO) - Molecular Function for ZFAND4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0031386 protein tag IBA --
GO:0031625 ubiquitin protein ligase binding IBA --
GO:0046872 metal ion binding IEA --
GO:0070628 proteasome binding IBA --
genes like me logo Genes that share ontologies with ZFAND4: view
genes like me logo Genes that share phenotypes with ZFAND4: view

Animal Model Products

CRISPR Products

miRNA for ZFAND4 Gene

miRTarBase miRNAs that target ZFAND4

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZFAND4

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZFAND4 Gene

Localization for ZFAND4 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZFAND4 gene
Compartment Confidence
nucleus 3
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZFAND4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with ZFAND4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ZFAND4 Gene

Pathways & Interactions for ZFAND4 Gene

SuperPathways for ZFAND4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZFAND4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IBA --
GO:0019941 modification-dependent protein catabolic process IBA --
genes like me logo Genes that share ontologies with ZFAND4: view

No data available for Pathways by source and SIGNOR curated interactions for ZFAND4 Gene

Drugs & Compounds for ZFAND4 Gene

No Compound Related Data Available

Transcripts for ZFAND4 Gene

Unigene Clusters for ZFAND4 Gene

Zinc finger, AN1-type domain 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZFAND4

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZFAND4 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d · 4e · 4f ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13a ·
SP1: - - - - -
SP2: - - - - - - - - - - - -
SP3: - - - - - -
SP4: - - - - - -
SP5: - -
SP6:
SP7: - - - - - - -
SP8: - - - - - - - - - - -
SP9: - - - -
SP10: - - - - - - - - - -
SP11: - - - - - -
SP12: - - - - - - - - - - - - - -
SP13: - -
SP14: - - - - - - - - -
SP15: - - - - -
SP16:
SP17: - - -
SP18: - - - - - - - - - - -
SP19:

ExUns: 13b · 13c ^ 14a · 14b · 14c · 14d ^ 15 ^ 16 ^ 17a · 17b ^ 18a · 18b
SP1: - - - -
SP2: - - - -
SP3: - - - -
SP4: - - - - - - -
SP5: - - - -
SP6: - - -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15: -
SP16: - - - - -
SP17:
SP18:
SP19:

Relevant External Links for ZFAND4 Gene

GeneLoc Exon Structure for
ZFAND4
ECgene alternative splicing isoforms for
ZFAND4

Expression for ZFAND4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZFAND4 Gene

mRNA differential expression in normal tissues according to GTEx for ZFAND4 Gene

This gene is overexpressed in Testis (x10.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZFAND4 Gene



NURSA nuclear receptor signaling pathways regulating expression of ZFAND4 Gene:

ZFAND4

SOURCE GeneReport for Unigene cluster for ZFAND4 Gene:

Hs.89029
genes like me logo Genes that share expression patterns with ZFAND4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZFAND4 Gene

Orthologs for ZFAND4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZFAND4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANUBL1 33
  • 99.27 (n)
ZFAND4 34
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZFAND4 34 33
  • 87.45 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ZFAND4 33
  • 84.98 (n)
ANUBL1 34
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfand4 33
  • 81.25 (n)
mouse
(Mus musculus)
Mammalia Zfand4 16 34 33
  • 80.83 (n)
oppossum
(Monodelphis domestica)
Mammalia ZFAND4 34
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 67 (a)
OneToMany
-- 34
  • 50 (a)
OneToMany
chicken
(Gallus gallus)
Aves ZFAND4 34 33
  • 70 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZFAND4 34
  • 16 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100144290 33
  • 73.67 (n)
Str.20232 33
African clawed frog
(Xenopus laevis)
Amphibia LOC397781 33
zebrafish
(Danio rerio)
Actinopterygii zfand4 34 33
  • 56.45 (n)
OneToOne
Dr.15582 33
fruit fly
(Drosophila melanogaster)
Insecta RpL40 34
  • 40 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL40B 34
  • 36 (a)
ManyToMany
RPL40A 34
  • 36 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 53 (a)
OneToMany
-- 34
  • 22 (a)
OneToMany
Cin.488 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.488 33
Species where no ortholog for ZFAND4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZFAND4 Gene

ENSEMBL:
Gene Tree for ZFAND4 (if available)
TreeFam:
Gene Tree for ZFAND4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZFAND4: view image

Paralogs for ZFAND4 Gene

Paralogs for ZFAND4 Gene

(8) SIMAP similar genes for ZFAND4 Gene using alignment to 6 proteins:

  • ZFAN4_HUMAN
  • F2Z2H4_HUMAN
  • J3KPC0_HUMAN
  • Q5VVY2_HUMAN
  • Q5VVY4_HUMAN
  • Q5VVY6_HUMAN
genes like me logo Genes that share paralogs with ZFAND4: view

Variants for ZFAND4 Gene

Sequence variations from dbSNP and Humsavar for ZFAND4 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000057889 -- 45,652,022(-) C/G 5_prime_UTR_variant, coding_sequence_variant, genic_upstream_transcript_variant, intron_variant, missense_variant, non_coding_transcript_variant
rs1000074980 -- 45,671,999(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000151908 -- 45,655,675(-) A/T genic_upstream_transcript_variant, intron_variant
rs1000184064 -- 45,630,313(-) G/A/C genic_downstream_transcript_variant, intron_variant
rs1000220177 -- 45,645,448(-) T/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZFAND4 Gene

Variant ID Type Subtype PubMed ID
dgv2e24 CNV gain 17666407
esv3623100 CNV loss 21293372
esv3623101 CNV loss 21293372
esv3623102 CNV loss 21293372
esv3623103 CNV gain 21293372
esv3891797 CNV gain 25118596
nsv1137917 CNV deletion 24896259
nsv947910 CNV duplication 23825009

Variation tolerance for ZFAND4 Gene

Residual Variation Intolerance Score: 90.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.53; 82.33% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZFAND4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZFAND4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZFAND4 Gene

Disorders for ZFAND4 Gene

Additional Disease Information for ZFAND4

No disorders were found for ZFAND4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZFAND4 Gene

Publications for ZFAND4 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Zinc finger AN1-type containing 4 is a novel marker for predicting metastasis and poor prognosis in oral squamous cell carcinoma. (PMID: 29074611) Kurihara-Shimomura M … Kirita T (Journal of clinical pathology 2018) 3 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for ZFAND4 Gene

Sources for ZFAND4 Gene

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