Aliases for ZFAND3 Gene

Aliases for ZFAND3 Gene

  • Zinc Finger AN1-Type Containing 3 2 3 5
  • Zinc Finger, AN1-Type Domain 3 2 3
  • AN1-Type Zinc Finger Protein 3 3 4
  • Testis Expressed Sequence 27 2 3
  • Testis-Expressed Protein 27 3 4
  • TEX27 3 4
  • FLJ13222 2
  • ZFAND3 5

External Ids for ZFAND3 Gene

Previous HGNC Symbols for ZFAND3 Gene

  • TEX27

Previous GeneCards Identifiers for ZFAND3 Gene

  • GC06P037896
  • GC06P037787
  • GC06P037507
  • GC06P037940
  • GC06P042850
  • GC06P043195
  • GC06P043384
  • GC06P046073
  • GC06P037950
  • GC06P038436
  • GC06P039027
  • GC06P039613
  • GC06P040174
  • GC06P041258
  • GC06P041931
  • GC06P042574

Summaries for ZFAND3 Gene

GeneCards Summary for ZFAND3 Gene

ZFAND3 (Zinc Finger AN1-Type Containing 3) is a Protein Coding gene. Diseases associated with ZFAND3 include Maturity-Onset Diabetes Of The Young. An important paralog of this gene is ZFAND6.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZFAND3 Gene

Genomics for ZFAND3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZFAND3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZFAND3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZFAND3

Top Transcription factor binding sites by QIAGEN in the ZFAND3 gene promoter:
  • AP-1
  • c-Fos
  • c-Jun
  • GR
  • GR-alpha
  • GR-beta
  • HNF-4alpha1
  • HOXA3
  • LCR-F1
  • NF-kappaB

Genomic Locations for ZFAND3 Gene

Genomic Locations for ZFAND3 Gene
334,898 bases
Plus strand
335,126 bases
Plus strand

Genomic View for ZFAND3 Gene

Genes around ZFAND3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZFAND3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZFAND3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFAND3 Gene

Proteins for ZFAND3 Gene

  • Protein details for ZFAND3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    AN1-type zinc finger protein 3
    Protein Accession:
    Secondary Accessions:
    • Q5SZZ0
    • Q5SZZ1

    Protein attributes for ZFAND3 Gene

    227 amino acids
    Molecular mass:
    25184 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ZFAND3 Gene

neXtProt entry for ZFAND3 Gene

Post-translational modifications for ZFAND3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZFAND3 Gene

No data available for DME Specific Peptides for ZFAND3 Gene

Domains & Families for ZFAND3 Gene

Gene Families for ZFAND3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ZFAND3 Gene

  • Zn-finger, AN1-like
  • Zn-finger, A20-like

Suggested Antigen Peptide Sequences for ZFAND3 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger, AN1-type domain 3 (Q5JVV6_HUMAN)
  • Testis-expressed sequence 27 (ZFAN3_HUMAN)
genes like me logo Genes that share domains with ZFAND3: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ZFAND3 Gene

Function for ZFAND3 Gene

Phenotypes From GWAS Catalog for ZFAND3 Gene

Gene Ontology (GO) - Molecular Function for ZFAND3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZFAND3: view
genes like me logo Genes that share phenotypes with ZFAND3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZFAND3

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZFAND3 Gene

Localization for ZFAND3 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZFAND3 gene
Compartment Confidence
nucleus 4
extracellular 2
plasma membrane 1
mitochondrion 1
cytosol 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ZFAND3 Gene

Pathways & Interactions for ZFAND3 Gene

PathCards logo

SuperPathways for ZFAND3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZFAND3 Gene


No data available for Pathways by source and SIGNOR curated interactions for ZFAND3 Gene

Drugs & Compounds for ZFAND3 Gene

No Compound Related Data Available

Transcripts for ZFAND3 Gene

mRNA/cDNA for ZFAND3 Gene

7 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZFAND3

Alternative Splicing Database (ASD) splice patterns (SP) for ZFAND3 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c · 10d · 10e
SP1: - - - - - -
SP2: -
SP3: - - - - - -
SP4: -
SP5: - - - -
SP6: - -
SP7: - -

Relevant External Links for ZFAND3 Gene

GeneLoc Exon Structure for

Expression for ZFAND3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZFAND3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZFAND3 Gene

This gene is overexpressed in Fetal ovary (51.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZFAND3 Gene

Protein tissue co-expression partners for ZFAND3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZFAND3

SOURCE GeneReport for Unigene cluster for ZFAND3 Gene:


Evidence on tissue expression from TISSUES for ZFAND3 Gene

  • Kidney(4.4)
  • Nervous system(3.9)
  • Pancreas(2.4)
  • Skin(2.3)
  • Muscle(2.2)
  • Intestine(2.2)
  • Liver(2.2)
  • Thyroid gland(2.1)
genes like me logo Genes that share expression patterns with ZFAND3: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZFAND3 Gene

Orthologs for ZFAND3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZFAND3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZFAND3 30 31
  • 99.84 (n)
(Canis familiaris)
Mammalia ZFAND3 30 31
  • 95.45 (n)
(Bos Taurus)
Mammalia ZFAND3 30 31
  • 94.57 (n)
(Mus musculus)
Mammalia Zfand3 30 17 31
  • 91.71 (n)
(Rattus norvegicus)
Mammalia Zfand3 30
  • 91.48 (n)
(Monodelphis domestica)
Mammalia ZFAND3 31
  • 90 (a)
(Ornithorhynchus anatinus)
Mammalia ZFAND3 31
  • 76 (a)
(Gallus gallus)
Aves ZFAND3 30 31
  • 82.85 (n)
(Anolis carolinensis)
Reptilia ZFAND3 31
  • 82 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia zfand3 30
  • 80.59 (n)
Str.10054 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.24200 30
(Danio rerio)
Actinopterygii zfand3 30 31
  • 67.74 (n)
wufj17a09 30
Species where no ortholog for ZFAND3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ZFAND3 Gene

Gene Tree for ZFAND3 (if available)
Gene Tree for ZFAND3 (if available)
Evolutionary constrained regions (ECRs) for ZFAND3: view image

Paralogs for ZFAND3 Gene

Paralogs for ZFAND3 Gene

genes like me logo Genes that share paralogs with ZFAND3: view

Variants for ZFAND3 Gene

Additional dbSNP identifiers (rs#s) for ZFAND3 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZFAND3 Gene

Variant ID Type Subtype PubMed ID
esv1320553 CNV deletion 17803354
esv23277 CNV loss 19812545
esv2668461 CNV deletion 23128226
esv2731938 CNV deletion 23290073
esv2731939 CNV deletion 23290073
esv2731941 CNV deletion 23290073
esv2731942 CNV deletion 23290073
esv2731943 CNV deletion 23290073
esv2731944 CNV deletion 23290073
esv2731945 CNV deletion 23290073
esv2731946 CNV deletion 23290073
esv2761037 CNV loss 21179565
esv2763549 CNV loss 21179565
esv3083578 CNV deletion 24192839
esv3286606 CNV deletion 24192839
esv3303092 CNV tandem duplication 20981092
esv34450 CNV gain 17911159
esv3567660 CNV deletion 23714750
esv3571019 CNV loss 25503493
esv3571021 CNV loss 25503493
esv3576142 CNV gain 25503493
esv3608721 CNV gain 21293372
esv3608722 CNV gain 21293372
esv3608723 CNV gain 21293372
esv3608724 CNV loss 21293372
esv3608726 CNV gain 21293372
esv3608727 CNV loss 21293372
esv989910 CNV deletion 20482838
esv990874 CNV deletion 20482838
esv991004 CNV loss 20482838
nsv1015689 CNV gain 25217958
nsv1020625 CNV gain 25217958
nsv1073550 CNV deletion 25765185
nsv1114798 CNV deletion 24896259
nsv1145099 CNV deletion 24896259
nsv348662 CNV deletion 16902084
nsv478390 CNV novel sequence insertion 20440878
nsv507324 OTHER sequence alteration 20534489
nsv524213 CNV loss 19592680
nsv602956 CNV loss 21841781
nsv823674 CNV loss 20364138
nsv950164 CNV duplication 24416366
nsv950165 CNV duplication 24416366
nsv950166 CNV deletion 24416366

Variation tolerance for ZFAND3 Gene

Residual Variation Intolerance Score: 47% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.58; 12.50% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZFAND3 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZFAND3 Gene

Disorders for ZFAND3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZFAND3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
maturity-onset diabetes of the young
  • mody
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZFAND3

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with ZFAND3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZFAND3 Gene

Publications for ZFAND3 Gene

  1. Genome-wide detection of allele specific copy number variation associated with insulin resistance in African Americans from the HyperGEN study. (PMID: 21901158) Irvin MR … Arnett DK (PloS one 2011) 3 41
  2. Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians. (PMID: 22158537) Cho YS … Seielstad M (Nature genetics 2011) 3 41
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for ZFAND3 Gene

Sources for ZFAND3 Gene