Aliases for ZFAND2B Gene
External Ids for ZFAND2B Gene
Previous GeneCards Identifiers for ZFAND2B Gene
This gene encodes a protein containing AN1-type zinc-fingers and ubiquitin-interacting motifs. The encoded protein likely associates with the proteosome to stimulate the degradation of toxic or misfolded proteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]
GeneCards Summary for ZFAND2B Gene
ZFAND2B (Zinc Finger AN1-Type Containing 2B) is a Protein Coding gene. Diseases associated with ZFAND2B include Charcot-Marie-Tooth Disease, Axonal, Type 2E. An important paralog of this gene is ZFAND2A.
UniProtKB/Swiss-Prot Summary for ZFAND2B Gene
Plays a role in protein homeostasis by regulating both the translocation and the ubiquitin-mediated proteasomal degradation of nascent proteins at the endoplasmic reticulum. It is involved in the regulation of signal-mediated translocation of proteins into the endoplasmic reticulum. It also plays a role in the ubiquitin-mediated proteasomal degradation of proteins for which signal-mediated translocation to the endoplasmic reticulum has failed. May therefore function in the endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation (By similarity). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333).