Aliases for ZFAND2A Gene

Aliases for ZFAND2A Gene

  • Zinc Finger AN1-Type Containing 2A 2 3 5
  • Arsenite Inducible RNA Associated Protein 2 3
  • Zinc Finger, AN1-Type Domain 2A 2 3
  • AN1-Type Zinc Finger Protein 2A 3 4
  • AIRAP 2 3
  • ZFAND2A 5

External Ids for ZFAND2A Gene

Previous GeneCards Identifiers for ZFAND2A Gene

  • GC07M000966
  • GC07M001159
  • GC07M001103
  • GC07M001191
  • GC07M001164
  • GC07M001186

Summaries for ZFAND2A Gene

GeneCards Summary for ZFAND2A Gene

ZFAND2A (Zinc Finger AN1-Type Containing 2A) is a Protein Coding gene. An important paralog of this gene is ZFAND2B.

Additional gene information for ZFAND2A Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZFAND2A Gene

Genomics for ZFAND2A Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZFAND2A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZFAND2A on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZFAND2A

Top Transcription factor binding sites by QIAGEN in the ZFAND2A gene promoter:
  • AML1a
  • c-Rel
  • C/EBPalpha
  • CHOP-10
  • CREB
  • FOXO1
  • FOXO1a
  • GATA-3
  • Pax-4a

Genomic Locations for ZFAND2A Gene

Genomic Locations for ZFAND2A Gene
chr7:1,148,850-1,160,759
(GRCh38/hg38)
Size:
11,910 bases
Orientation:
Minus strand
chr7:1,191,707-1,200,395
(GRCh37/hg19)
Size:
8,689 bases
Orientation:
Minus strand

Genomic View for ZFAND2A Gene

Genes around ZFAND2A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZFAND2A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZFAND2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFAND2A Gene

Proteins for ZFAND2A Gene

  • Protein details for ZFAND2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N6M9-ZFN2A_HUMAN
    Recommended name:
    AN1-type zinc finger protein 2A
    Protein Accession:
    Q8N6M9
    Secondary Accessions:
    • A4D220

    Protein attributes for ZFAND2A Gene

    Size:
    145 amino acids
    Molecular mass:
    16477 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZFAND2A Gene

Post-translational modifications for ZFAND2A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZFAND2A Gene

No data available for DME Specific Peptides for ZFAND2A Gene

Domains & Families for ZFAND2A Gene

Gene Families for ZFAND2A Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ZFAND2A Gene

InterPro:
Blocks:
  • Zn-finger, AN1-like
  • HNH nuclease
ProtoNet:

Suggested Antigen Peptide Sequences for ZFAND2A Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger, AN1-type domain 2A, isoform CRA_b (A8MYA3_HUMAN)
  • AN1-type zinc finger protein 2A (ZFN2A_HUMAN)
genes like me logo Genes that share domains with ZFAND2A: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ZFAND2A Gene

Function for ZFAND2A Gene

Phenotypes From GWAS Catalog for ZFAND2A Gene

Gene Ontology (GO) - Molecular Function for ZFAND2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZFAND2A: view
genes like me logo Genes that share phenotypes with ZFAND2A: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZFAND2A

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZFAND2A Gene

Localization for ZFAND2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZFAND2A Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZFAND2A gene
Compartment Confidence
nucleus 4
extracellular 2
cytosol 2
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for ZFAND2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 proteasome complex IEA --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with ZFAND2A: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZFAND2A Gene

Pathways & Interactions for ZFAND2A Gene

PathCards logo

SuperPathways for ZFAND2A Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZFAND2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IEA --
GO:0071243 cellular response to arsenic-containing substance IEA --
genes like me logo Genes that share ontologies with ZFAND2A: view

No data available for Pathways by source and SIGNOR curated interactions for ZFAND2A Gene

Drugs & Compounds for ZFAND2A Gene

No Compound Related Data Available

Transcripts for ZFAND2A Gene

mRNA/cDNA for ZFAND2A Gene

3 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZFAND2A

Alternative Splicing Database (ASD) splice patterns (SP) for ZFAND2A Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6
SP1: - - - -
SP2: - - -
SP3: - -
SP4: -
SP5:

Relevant External Links for ZFAND2A Gene

GeneLoc Exon Structure for
ZFAND2A

Expression for ZFAND2A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZFAND2A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZFAND2A

SOURCE GeneReport for Unigene cluster for ZFAND2A Gene:

Hs.648111

Evidence on tissue expression from TISSUES for ZFAND2A Gene

  • Nervous system(4.4)
  • Liver(2.3)
genes like me logo Genes that share expression patterns with ZFAND2A: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZFAND2A Gene

Orthologs for ZFAND2A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ZFAND2A Gene

Organism Taxonomy Gene Similarity Type Details
Dog
(Canis familiaris)
Mammalia ZFAND2A 30 31
  • 86.57 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Zfand2a 30
  • 79.17 (n)
Cow
(Bos Taurus)
Mammalia ZFAND2A 30 31
  • 79.08 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Zfand2a 30 17 31
  • 78.7 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 67 (a)
OneToMany
-- 31
  • 61 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia ZFAND2A 31
  • 52 (a)
OneToOne
Chicken
(Gallus gallus)
Aves ZFAND2A 30 31
  • 66.2 (n)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii zfand2a 31
  • 33 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta CG12795 31
  • 30 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea aip-1 31
  • 30 (a)
OneToMany
Thale Cress
(Arabidopsis thaliana)
eudicotyledons AT3G57480 30
  • 46.17 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.5587 31
  • 27 (a)
OneToMany
Species where no ortholog for ZFAND2A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for ZFAND2A Gene

ENSEMBL:
Gene Tree for ZFAND2A (if available)
TreeFam:
Gene Tree for ZFAND2A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZFAND2A: view image

Paralogs for ZFAND2A Gene

Paralogs for ZFAND2A Gene

(1) SIMAP similar genes for ZFAND2A Gene using alignment to 4 proteins:

  • ZFN2A_HUMAN
  • A8MYA3_HUMAN
  • I3L1X3_HUMAN
  • J3KQ25_HUMAN

Pseudogenes.org Pseudogenes for ZFAND2A Gene

genes like me logo Genes that share paralogs with ZFAND2A: view

Variants for ZFAND2A Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZFAND2A Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
rs17855544 - p.His53Leu

Additional dbSNP identifiers (rs#s) for ZFAND2A Gene

Structural Variations from Database of Genomic Variants (DGV) for ZFAND2A Gene

Variant ID Type Subtype PubMed ID
dgv1062e201 CNV deletion 23290073
dgv11119n54 CNV loss 21841781
esv1295388 CNV deletion 17803354
esv1724460 CNV deletion 17803354
esv2110851 CNV deletion 18987734
esv2499925 CNV deletion 19546169
esv2733727 CNV deletion 23290073
esv2733730 CNV deletion 23290073
esv2759499 CNV loss 17122850
esv3541017 CNV deletion 23714750
esv3541018 CNV deletion 23714750
nsv1028941 CNV gain 25217958
nsv1032992 CNV gain 25217958
nsv1125423 OTHER inversion 24896259
nsv471182 CNV loss 18288195
nsv508441 CNV deletion 20534489
nsv605705 CNV loss 21841781
nsv605735 CNV gain 21841781
nsv830876 CNV loss 17160897

Variation tolerance for ZFAND2A Gene

Residual Variation Intolerance Score: 52.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.64; 13.63% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZFAND2A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZFAND2A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZFAND2A Gene

Disorders for ZFAND2A Gene

Additional Disease Information for ZFAND2A

No disorders were found for ZFAND2A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZFAND2A Gene

Publications for ZFAND2A Gene

  1. AIRAP, a new human heat shock gene regulated by heat shock factor 1. (PMID: 20185824) Rossi A … Santoro MG (The Journal of biological chemistry 2010) 2 3
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  4. Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism. (PMID: 28986522) Antoniali G … Tell G (Nature communications 2017) 3
  5. TNIP2 is a Hub Protein in the NF-κB Network with Both Protein and RNA Mediated Interactions. (PMID: 27609421) Banks CA … Washburn MP (Molecular & cellular proteomics : MCP 2016) 3

Products for ZFAND2A Gene

Sources for ZFAND2A Gene