Aliases for ZER1 Gene
External Ids for ZER1 Gene
Previous HGNC Symbols for ZER1 Gene
Previous GeneCards Identifiers for ZER1 Gene
This gene encodes a subunit of an E3 ubiquitin ligase complex that may be involved in meiosis. The encoded protein contains three leucine-rich repeat motifs. [provided by RefSeq, Nov 2012]
GeneCards Summary for ZER1 Gene
ZER1 (Zyg-11 Related Cell Cycle Regulator) is a Protein Coding gene. Diseases associated with ZER1 include De Quervain Disease and Photokeratitis. Gene Ontology (GO) annotations related to this gene include binding and ubiquitin-protein transferase activity. An important paralog of this gene is ZYG11B.
UniProtKB/Swiss-Prot Summary for ZER1 Gene
Serves as substrate adapter subunit in the E3 ubiquitin ligase complex ZYG11B-CUL2-Elongin BC (PubMed:17304241, PubMed:31273098). Acts redudantly with ZYG11B to target substrates bearing N-terminal glycine degrons for proteasomal degradation (PubMed:33093214). Involved in the clearance of proteolytic fragments generated by caspase cleavage during apoptosis since N-terminal glycine degrons are strongly enriched at caspase cleavage sites. Also important in the quality control of protein N-myristoylation in which N-terminal glycine degrons are conditionally exposed after a failure of N-myristoylation (PubMed:31273098).