This locus produces long non-coding RNA that is transcribed from a shared bi-directional promoter with zinc finger E-box binding homeobox 1 (ZEB1). This transcript binds lysine methyltransferase 2A and promotes histone modifications that are thought to promote expression of ZEB1. Expression of this gene is correlated with tumor progression. Alternative splicing results in multi... See more...

Aliases for ZEB1-AS1 Gene

Data sources for ZEB1-AS1 Gene:

RNA type for ZEB1-AS1 Gene

lncRNA

Aliases for ZEB1-AS1 Gene

External Ids for ZEB1-AS1 Gene

Previous GeneCards Identifiers for ZEB1-AS1 Gene

  • GC10M031606
  • GC10M031495
  • GC10M031206

Summaries for ZEB1-AS1 Gene

Entrez Gene Summary for ZEB1-AS1 Gene

  • This locus produces long non-coding RNA that is transcribed from a shared bi-directional promoter with zinc finger E-box binding homeobox 1 (ZEB1). This transcript binds lysine methyltransferase 2A and promotes histone modifications that are thought to promote expression of ZEB1. Expression of this gene is correlated with tumor progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2017]

GeneCards Summary for ZEB1-AS1 Gene

ZEB1-AS1 (ZEB1 Antisense RNA 1) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with ZEB1-AS1 include Squamous Cell Carcinoma and Osteogenic Sarcoma.

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZEB1-AS1 Gene

Genomics for ZEB1-AS1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZEB1-AS1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZEB1-AS1 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for ZEB1-AS1 Gene

Latest Assembly
chr10:31,166,834-31,320,774
(GRCh38/hg38)
Size:
153,941 bases
Orientation:
Minus strand

Previous Assembly
chr10:31,596,646-31,609,376
(GRCh37/hg19 by Entrez Gene)
Size:
12,731 bases
Orientation:
Minus strand

chr10:31,495,207-31,609,376
(GRCh37/hg19 by Ensembl)
Size:
114,170 bases
Orientation:
Minus strand

Genomic View for ZEB1-AS1 Gene

Genes around ZEB1-AS1 on UCSC Golden Path with GeneCards custom track
ZEB1-AS1 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
ZEB1-AS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZEB1-AS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZEB1-AS1 Gene

Proteins for ZEB1-AS1 Gene

Post-translational modifications for ZEB1-AS1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for ZEB1-AS1 Gene

Domains & Families for ZEB1-AS1 Gene

Gene Families for ZEB1-AS1 Gene

genes like me logo Genes that share domains with ZEB1-AS1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ZEB1-AS1 Gene

Function for ZEB1-AS1 Gene

Phenotypes From GWAS Catalog for ZEB1-AS1 Gene

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZEB1-AS1 Gene

Localization for ZEB1-AS1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZEB1-AS1 gene
Compartment Confidence
extracellular 1
cytoskeleton 1
nucleus 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for ZEB1-AS1 Gene

Pathways & Interactions for ZEB1-AS1 Gene

PathCards logo

SuperPathways for ZEB1-AS1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZEB1-AS1 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for ZEB1-AS1 Gene

Drugs & Compounds for ZEB1-AS1 Gene

No Compound Related Data Available

Transcripts for ZEB1-AS1 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for ZEB1-AS1 Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS00007DA334_9606 lncRNA 578 4

Ensembl: ENST00000450834 (view in UCSC) ,

LncBook: HSALNT0160892,

LNCipedia: ZEB1-AS1:10,

NONCODE: NONHSAT012605.2,

URS00007CA92B_9606 lncRNA 573 4

Ensembl: ENST00000606250 (view in UCSC) ,

LncBook: HSALNT0160910,

LNCipedia: ZEB1-AS1:2,

NONCODE: NONHSAT156848.1,

URS00007D941F_9606 lncRNA 559 4

Ensembl: ENST00000607455 (view in UCSC) ,

LncBook: HSALNT0160908,

LNCipedia: ZEB1-AS1:7,

NONCODE: NONHSAT156847.1,

URS00007E11EC_9606 lncRNA 476 4

Ensembl: ENST00000606286 (view in UCSC) ,

LncBook: HSALNT0160906,

LNCipedia: ZEB1-AS1:1, ZEB1-AS1:19,

NONCODE: NONHSAT156846.1,

URS00007DE213_9606 lncRNA 458 4

Ensembl: ENST00000423714 (view in UCSC) ,

LncBook: HSALNT0160913,

LNCipedia: ZEB1-AS1:3,

NONCODE: NONHSAT012613.2,

ZEB1-AS1 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for ZEB1-AS1 Gene

12 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for ZEB1-AS1 Gene

No ASD Table

Relevant External Links for ZEB1-AS1 Gene

GeneLoc Exon Structure for
ZEB1-AS1

Expression for ZEB1-AS1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZEB1-AS1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZEB1-AS1

SOURCE GeneReport for Unigene cluster for ZEB1-AS1 Gene:

Hs.372654
genes like me logo Genes that share expression patterns with ZEB1-AS1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZEB1-AS1 Gene

Orthologs for ZEB1-AS1 Gene

Evolution for ZEB1-AS1 Gene

ENSEMBL:
Gene Tree for ZEB1-AS1 (if available)
TreeFam:
Gene Tree for ZEB1-AS1 (if available)
Alliance of Genome Resources:
Additional Orthologs for ZEB1-AS1

No data available for Orthologs for ZEB1-AS1 Gene

Paralogs for ZEB1-AS1 Gene

No data available for Paralogs for ZEB1-AS1 Gene

Variants for ZEB1-AS1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZEB1-AS1 Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
rs1554797626 Pathogenic: not provided 31,319,237(-) G/A
NM_030751.6(ZEB1):c.3G>A (p.Met1Ile)
INITIATIOR_CODON_VARIANT,MISSENSE_VARIANT,FIVE_PRIME_UTR_VARIANT,INTRON

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for ZEB1-AS1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for ZEB1-AS1 Gene

Variant ID Type Subtype PubMed ID
nsv831824 CNV loss 17160897

Additional Variant Information for ZEB1-AS1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZEB1-AS1
Leiden Open Variation Database (LOVD)
ZEB1-AS1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for ZEB1-AS1 Gene

Disorders for ZEB1-AS1 Gene

MalaCards: The human disease database

(8) MalaCards diseases for ZEB1-AS1 Gene - From: LNC, COP, and GCD

Disorder Aliases PubMed IDs
squamous cell carcinoma
  • epidermoid carcinoma
osteogenic sarcoma
  • osteosarcoma; osrc
bladder cancer
  • bladder cancer, somatic
hereditary hemorrhagic telangiectasia
  • osler hemorrhagic telangiectasia syndrome
glioma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZEB1-AS1

genes like me logo Genes that share disorders with ZEB1-AS1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZEB1-AS1 Gene

Publications for ZEB1-AS1 Gene

  1. Long noncoding RNA ZEB1-AS1 acts as an oncogene in osteosarcoma by epigenetically activating ZEB1. (PMID: 27829995) Liu C … Lin J (American journal of translational research 2016) 2 3 72
  2. Expression of long non-coding RNA ZEB1-AS1 in esophageal squamous cell carcinoma and its correlation with tumor progression and patient survival. (PMID: 26617942) Wang YL … Wang ZM (International journal of clinical and experimental pathology 2015) 2 3 72
  3. High expression of long non-coding RNA ZEB1-AS1 promotes colorectal cancer cell proliferation partially by suppressing p15 expression. (PMID: 28618933) Gong H … Zhu J (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017) 3 72
  4. Interplay Between Long Noncoding RNA ZEB1-AS1 and miR-200s Regulates Osteosarcoma Cell Proliferation and Migration. (PMID: 28075045) Liu C … Wang H (Journal of cellular biochemistry 2017) 2 3
  5. Increased expression of ZEB1-AS1 correlates with higher histopathological grade and promotes tumorigenesis in bladder cancer. (PMID: 28445936) Lin J … Huang W (Oncotarget 2017) 3 72

Products for ZEB1-AS1 Gene

Sources for ZEB1-AS1 Gene