This locus produces long non-coding RNA that is transcribed from a shared bi-directional promoter with zinc finger E-box binding homeobox 1 (ZEB1). This transcript binds lysine methyltransferase 2A and promotes histone modifications that are thought to promote expression of ZEB1. Expression of this gene is correlated with tumor progression. Alternative splicing results in multi... See more...

Aliases for ZEB1-AS1 Gene

Subcategory (RNA class) for ZEB1-AS1 Gene

lncRNA

Quality Score for this RNA gene is

15

Aliases for ZEB1-AS1 Gene

  • ZEB1 Antisense RNA 1 2 3 5
  • ZEB1 Antisense RNA 1 (Non-Protein Coding) 2 3
  • ZEB1-AS1 2 170
  • HSALNG0077083 169
  • NONHSAG005548 94

External Ids for ZEB1-AS1 Gene

Previous GeneCards Identifiers for ZEB1-AS1 Gene

  • GC10M031606
  • GC10M031495
  • GC10M031206

Summaries for ZEB1-AS1 Gene

Entrez Gene Summary for ZEB1-AS1 Gene

  • This locus produces long non-coding RNA that is transcribed from a shared bi-directional promoter with zinc finger E-box binding homeobox 1 (ZEB1). This transcript binds lysine methyltransferase 2A and promotes histone modifications that are thought to promote expression of ZEB1. Expression of this gene is correlated with tumor progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2017]

GeneCards Summary for ZEB1-AS1 Gene

ZEB1-AS1 (ZEB1 Antisense RNA 1) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with ZEB1-AS1 include Bladder Cancer and Squamous Cell Carcinoma.

Additional gene information for ZEB1-AS1 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZEB1-AS1 Gene

Genomics for ZEB1-AS1 Gene

GeneHancer (GH) Regulatory Elements for ZEB1-AS1 Gene

Promoters and enhancers for ZEB1-AS1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZEB1-AS1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ZEB1-AS1 Gene

Genomic Locations for ZEB1-AS1 Gene
chr10:31,166,835-31,320,774
(GRCh38/hg38)
Size:
153,940 bases
Orientation:
Minus strand
chr10:31,495,207-31,609,376
(GRCh37/hg19)
Size:
114,170 bases
Orientation:
Minus strand

Genomic View for ZEB1-AS1 Gene

Genes around ZEB1-AS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZEB1-AS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZEB1-AS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZEB1-AS1 Gene

Proteins for ZEB1-AS1 Gene

Post-translational modifications for ZEB1-AS1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for ZEB1-AS1 Gene

Domains & Families for ZEB1-AS1 Gene

Gene Families for ZEB1-AS1 Gene

genes like me logo Genes that share domains with ZEB1-AS1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ZEB1-AS1 Gene

Function for ZEB1-AS1 Gene

Phenotypes From GWAS Catalog for ZEB1-AS1 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZEB1-AS1 Gene

Localization for ZEB1-AS1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for ZEB1-AS1 Gene

Pathways & Interactions for ZEB1-AS1 Gene

PathCards logo

SuperPathways for ZEB1-AS1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZEB1-AS1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ZEB1-AS1 Gene

Drugs & Compounds for ZEB1-AS1 Gene

No Compound Related Data Available

Transcripts for ZEB1-AS1 Gene

mRNA/cDNA for ZEB1-AS1 Gene

(6) REFSEQ mRNAs :
(12) Additional mRNA sequences :
(11) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
(11) NONCODE transcripts :
(35) RNACentral transcripts :
(20) LncBook transcripts :
(29) LNCipedia transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZEB1-AS1 Gene

No ASD Table

Relevant External Links for ZEB1-AS1 Gene

GeneLoc Exon Structure for
ZEB1-AS1
ECgene alternative splicing isoforms for
ZEB1-AS1

Expression for ZEB1-AS1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZEB1-AS1 Gene

SOURCE GeneReport for Unigene cluster for ZEB1-AS1 Gene:

Hs.372654
genes like me logo Genes that share expression patterns with ZEB1-AS1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZEB1-AS1 Gene

Orthologs for ZEB1-AS1 Gene

Evolution for ZEB1-AS1 Gene

ENSEMBL:
Gene Tree for ZEB1-AS1 (if available)
TreeFam:
Gene Tree for ZEB1-AS1 (if available)

No data available for Orthologs for ZEB1-AS1 Gene

Paralogs for ZEB1-AS1 Gene

No data available for Paralogs for ZEB1-AS1 Gene

Variants for ZEB1-AS1 Gene

Sequence variations from dbSNP and Humsavar for ZEB1-AS1 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1554797626 pathogenic, not provided 31,319,237(-) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000010183 -- 31,311,088(-) C/T genic_downstream_transcript_variant, intron_variant
rs1000688715 -- 31,315,614(-) G/A genic_downstream_transcript_variant, intron_variant
rs1000835788 -- 31,318,383(-) G/A/T intron_variant, non_coding_transcript_variant
rs1000959355 -- 31,312,745(-) C/T genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZEB1-AS1 Gene

Variant ID Type Subtype PubMed ID
nsv831824 CNV loss 17160897

Additional Variant Information for ZEB1-AS1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZEB1-AS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for ZEB1-AS1 Gene

Disorders for ZEB1-AS1 Gene

MalaCards: The human disease database

(7) MalaCards diseases for ZEB1-AS1 Gene - From: LncRNADisease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
bladder cancer
  • bladder cancer, somatic
squamous cell carcinoma
  • epidermoid carcinoma
glioma
osteogenic sarcoma
  • osteosarcoma; osrc
gastric cancer
  • gastric cancer, somatic
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZEB1-AS1

genes like me logo Genes that share disorders with ZEB1-AS1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZEB1-AS1 Gene

Publications for ZEB1-AS1 Gene

  1. Interplay Between Long Noncoding RNA ZEB1-AS1 and miR-200s Regulates Osteosarcoma Cell Proliferation and Migration. (PMID: 28075045) Liu C … Wang H (Journal of cellular biochemistry 2017) 2 3 56
  2. Long noncoding RNA ZEB1-AS1 acts as an oncogene in osteosarcoma by epigenetically activating ZEB1. (PMID: 27829995) Liu C … Lin J (American journal of translational research 2016) 2 3 56
  3. Expression of long non-coding RNA ZEB1-AS1 in esophageal squamous cell carcinoma and its correlation with tumor progression and patient survival. (PMID: 26617942) Wang YL … Wang ZM (International journal of clinical and experimental pathology 2015) 2 3 56
  4. Long non-coding RNA ZEB1-AS1 regulates miR-200b/FSCN1 signaling and enhances migration and invasion induced by TGF-β1 in bladder cancer cells. (PMID: 30823924) Gao R … Bi J (Journal of experimental & clinical cancer research : CR 2019) 3 56
  5. LncRNA ZEB1-AS1 expression in cancer prognosis: Review and meta-analysis. (PMID: 29885321) Chen C … Wang X (Clinica chimica acta; international journal of clinical chemistry 2018) 3 56

Products for ZEB1-AS1 Gene

Sources for ZEB1-AS1 Gene