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This gene encodes a zinc finger transcription factor. The encoded protein likely plays a role in transcriptional repression of interleukin 2. Mutations in this gene have been associated with posterior polymorphous corneal dystrophy-3 and late-onset Fuchs endothelial corneal dystrophy. Alternatively spliced transcript variants encoding different isoforms have been described.[pro... See more...
Aliases for ZEB1 Gene
Aliases for ZEB1 Gene
- Zinc Finger E-Box Binding Homeobox 1 2 3 5
- AREB6 2 3 4
- Transcription Factor 8 (Represses Interleukin 2 Expression) 2 3
- Posterior Polymorphous Corneal Dystrophy 3 2 3
- Zinc Finger E-Box-Binding Homeobox 1 3 4
- Negative Regulator Of IL2 3 4
- FECD6 2 3
- TCF8 3 4
- BZP 2 3
- Zinc Finger Homeodomain Enhancer-Binding Protein 3
- Delta-Crystallin Enhancer Binding Factor 1 3
- NIL-2-A Zinc Finger Protein 4
External Ids for ZEB1 Gene
- HGNC: 11642
- NCBI Entrez Gene: 6935
- Ensembl: ENSG00000148516
- OMIM®: 189909
- UniProtKB/Swiss-Prot: P37275
Previous HGNC Symbols for ZEB1 Gene
- TCF8
- PPCD3
Previous GeneCards Identifiers for ZEB1 Gene
- GC10P031648
- GC10P031330
Summaries for ZEB1 Gene
-
This gene encodes a zinc finger transcription factor. The encoded protein likely plays a role in transcriptional repression of interleukin 2. Mutations in this gene have been associated with posterior polymorphous corneal dystrophy-3 and late-onset Fuchs endothelial corneal dystrophy. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Mar 2010]
GeneCards Summary for ZEB1 Gene
ZEB1 (Zinc Finger E-Box Binding Homeobox 1) is a Protein Coding gene. Diseases associated with ZEB1 include Corneal Dystrophy, Posterior Polymorphous, 3 and Corneal Dystrophy, Fuchs Endothelial, 6. Among its related pathways are Transcriptional misregulation in cancer and Cytokine Signaling in Immune system. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and chromatin binding. An important paralog of this gene is ZEB2.
UniProtKB/Swiss-Prot Summary for ZEB1 Gene
-
Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3'). Promotes tumorigenicity by repressing stemness-inhibiting microRNAs.
Additional gene information for ZEB1 Gene
No data available for Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZEB1 Gene
Genomics for ZEB1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for ZEB1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around ZEB1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZEB1
- Top Transcription factor binding sites by QIAGEN in the ZEB1 gene promoter:
-
- AREB6
- MyoD
Genomic Locations for ZEB1 Gene
Latest Assembly
- chr10:31,318,417-31,529,814
- (GRCh38/hg38)
- Size:
- 211,398 bases
- Orientation:
- Plus strand
Previous Assembly
- chr10:31,607,346-31,818,732
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 211,387 bases
- Orientation:
- Plus strand
Genomic View for ZEB1 Gene
Genes around ZEB1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 10p11.22 by HGNC
- 10p11.22 by Entrez Gene
- 10p11.22 by Ensembl
ZEB1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ZEB1 Gene
Proteins for ZEB1 Gene
-
Protein details for ZEB1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P37275-ZEB1_HUMAN
- Recommended name:
- Zinc finger E-box-binding homeobox 1
- Protein Accession:
- P37275
- B4DJV0
- B4DUW9
- E9PCM7
- F5H4I8
- Q12924
- Q13800
- Q2KJ05
- Q5T968
- Q5VZ84
- Q8NB68
Protein attributes for ZEB1 Gene
- Size:
- 1124 amino acids
- Molecular mass:
- 124074 Da
- Quaternary structure:
-
- Interacts (via N-terminus) with SMARCA4/BRG1.
- SequenceCaution:
-
- Sequence=BAG62481.1; Type=Frameshift; Evidence={ECO:0000305};
Protein Expression for ZEB1 Gene
Post-translational modifications for ZEB1 Gene
Other Protein References for ZEB1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
-
- XP_006717561.1
- XP_011517945.1
- XP_016872086.1
- NP_001121600.1
- NP_001167564.1
- NP_001167565.1
- NP_001167566.1
- NP_001167567.1
- NP_001310567.1
- NP_001310570.1
- NP_001310571.1
- NP_001310572.1
- NP_001310573.1
- NP_001310574.1
- NP_001310575.1
- NP_001310576.1
- NP_001310577.1
- NP_001310578.1
- NP_001310579.1
- NP_001310580.1
- NP_001310581.1
- NP_001310582.1
- NP_001310583.1
- NP_001310584.1
- NP_001310585.1
- NP_001310586.1
- NP_001310587.1
- NP_001310588.1
- NP_001310589.1
- NP_001310590.1
- NP_001310591.1
- NP_001310592.1
- NP_001310593.1
- NP_001310594.1
- NP_001310595.1
- NP_001310600.1
- NP_001310601.1
- NP_001310602.1
- NP_001310603.1
- NP_001310604.1
- NP_001310605.1
- NP_001310606.1
- NP_001310607.1
- NP_110378.3
Antibodies for research
- LifeSpan BioSciences ZEB1 / AREB6 Antibody
- G Biosciences Immunotag™ ZEB1 Antibody
- NSJ Bioreagents ZEB1 Antibody (Mouse Monoclonal)
- BioLegend TCF8 (ZEB1) Antibody
-
Custom Antibody ServicesOriGene Antibodies for ZEB1
- AP55676PU-N
- CF802295
- CF802298
- CF802302
- CF802309
- CF802311
- CF802313
- CF802321
- CF802336
- CF802338
- CF802351
- TA305688
- TA310041
- TA319713
- TA332404
- TA332781
- TA336943
- TA802295
- TA802295S
- TA802298
- TA802298S
- TA802302
- TA802302S
- TA802309
- TA802309S
- TA802311
- TA802311S
- TA802313
- TA802313S
- TA802321
- TA802321S
- TA802336
- TA802336S
- TA802338
- TA802338S
- TA802351
- TA802351S
- Novus Biologicals Antibodies for ZEB1
-
Abcam antibodies for ZEB1
- Invitrogen Antibodies for ZEB1 (AFLGC-Zeb1)
- antibodies-online: Show 38 available ZEB1 Antibodies ranked by validation data
- Compare Top ZEB1 Antibodies
-
Recommended
- 144 WB Antibodies (anti-human)
- 9 FACS Antibodies (anti-human)
- 9 IF (p) Antibodies (anti-human)
- 1 DB Antibody (anti-human)
- 1 ICC Antibody (anti-human)
- 1 IF Antibody (anti-human)
- 1 IHC (p) Antibody (anti-human)
- 35 WB Antibodies (anti-mouse)
- 9 IF (p) Antibodies (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 45 WB Antibodies (anti-rat)
- 9 IF (p) Antibodies (anti-rat)
- 2 FACS Antibodies (anti-rat)
-
Santa Cruz Biotechnology (SCBT) Antibodies for ZEB1
Protein products for research
-
OriGene Purified Proteins for ZEB1
- Search Origene for MassSpec and Protein Over-expression Lysates for ZEB1
- Origene Custom Protein Services for ZEB1
- antibodies-online: Search results for available ZEB1 related products ranked by validation data
-
Abcam proteins for ZEB1
Assay products for research
No data available for DME Specific Peptides for ZEB1 Gene
Domains & Families for ZEB1 Gene
Gene Families for ZEB1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Disease related genes
- Predicted intracellular proteins
- Transcription factors
Protein Domains for ZEB1 Gene
- InterPro:
- Blocks:
-
- C2H2-type zinc finger signature
Suggested Antigen Peptide Sequences for ZEB1 Gene
- GenScript: Design optimal peptide antigens:
-
- ZEB1 protein (A0JLS9_HUMAN)
- Zinc finger E-box binding homeobox 1 (Q2KJ05_HUMAN)
- ZEB1 protein (Q32Q63_HUMAN)
- Zinc finger E-box binding homeobox 1 (Q5T6B8_HUMAN)
- Zinc finger E-box binding homeobox 1 (Q5T967_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P37275- Family:
-
- Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family.
Function for ZEB1 Gene
Molecular function for ZEB1 Gene
- UniProtKB/Swiss-Prot Function:
- Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3'). Promotes tumorigenicity by repressing stemness-inhibiting microRNAs.
Phenotypes From GWAS Catalog for ZEB1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IBA | 21873635 |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | ISA | -- |
| GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific | IDA | 23765923 |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003700 | DNA-binding transcription factor activity | TAS | 8138542 |
Phenotypes for ZEB1 Gene
- MGI mutant phenotypes for ZEB1:
-
inferred from 9 alleles
- normal phenotype
- nervous system phenotype
- muscle phenotype
- homeostasis/metabolism phenotype
- growth/size/body region phenotype
- cardiovascular system phenotype
- behavior/neurological phenotype
- immune system phenotype
- respiratory system phenotype
- mortality/aging
- hematopoietic system phenotype
- neoplasm
- digestive/alimentary phenotype
- endocrine/exocrine gland phenotype
- reproductive system phenotype
- vision/eye phenotype
- limbs/digits/tail phenotype
- hearing/vestibular/ear phenotype
- skeleton phenotype
- integument phenotype
- embryo phenotype
- pigmentation phenotype
- craniofacial phenotype
- adipose tissue phenotype
- taste/olfaction phenotype
- GenomeRNAi human phenotypes for ZEB1:
-
- Decreased NF-kappaB reporter expression
- shRNA abundance <= 50%
- no effect
- Increased S DNA content
- Decreased viability
- Decreased vaccinia virus (VACV) infection
- Decreased epidermal growth factor (EGF) endocytosis, decreased transferrin (TF) endocytosis
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection after direct virus infection
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection after viral supernatant infection
- Decreased viability in ovarian lineage
Animal Models for ZEB1 Gene
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for ZEB1 - Starting at $85 >
- * ZEB1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for ZEB1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ZEB1
-
Santa Cruz Biotechnology (SCBT) CRISPR for ZEB1
miRNA for ZEB1 Gene
- miRTarBase miRNAs that target ZEB1
-
- hsa-miR-141-3p (MIRT000317)
- mmu-miR-429-3p (MIRT001664)
- mmu-miR-200b-3p (MIRT001677)
- mmu-miR-200a-3p (MIRT001680)
- mmu-miR-141-3p (MIRT001694)
- hsa-miR-429 (MIRT001743)
- hsa-miR-200c-3p (MIRT002286)
- mmu-miR-200c-3p (MIRT002336)
- hsa-miR-205-5p (MIRT002478)
- hsa-miR-200a-3p (MIRT002480)
- hsa-miR-200b-3p (MIRT002483)
- rno-miR-200c-3p (MIRT003698)
- rno-miR-200b-3p (MIRT003701)
- rno-miR-200a-3p (MIRT003703)
- hsa-miR-150-5p (MIRT006984)
- hsa-miR-130b-3p (MIRT007059)
- rno-miR-429 (MIRT007415)
- mmu-miR-758-3p (MIRT007650)
- mmu-miR-324-3p (MIRT010992)
- hsa-miR-335-5p (MIRT018433)
- hsa-miR-101-3p (MIRT053160)
- hsa-miR-23b-3p (MIRT053244)
- hsa-miR-591 (MIRT053387)
- hsa-miR-629-5p (MIRT053407)
- hsa-miR-203a-3p (MIRT053444)
- hsa-miR-494-3p (MIRT053515)
- hsa-miR-539-5p (MIRT053516)
- hsa-miR-655-3p (MIRT054485)
- hsa-miR-1236-3p (MIRT054560)
- hsa-miR-183-5p (MIRT054653)
- hsa-miR-96-5p (MIRT054654)
- hsa-miR-142-5p (MIRT437940)
- mmu-miR-335-3p (MIRT594202)
- hsa-miR-574-5p (MIRT607020)
- hsa-miR-4455 (MIRT607021)
- hsa-miR-5010-3p (MIRT607022)
- hsa-miR-2113 (MIRT607023)
- hsa-miR-147a (MIRT607024)
- hsa-miR-6818-5p (MIRT607025)
- hsa-miR-6867-5p (MIRT607026)
- hsa-miR-133a-3p (MIRT731591)
- hsa-miR-144-3p (MIRT731796)
- hsa-miR-590-3p (MIRT732321)
- gga-miR-23b-5p (MIRT733260)
- gga-miR-199-5p (MIRT733261)
- hsa-miR-409-3p (MIRT733559)
- hsa-miR-33b-5p (MIRT734065)
- hsa-miR-484 (MIRT734111)
- hsa-miR-652-3p (MIRT734659)
- hsa-miR-10b-5p (MIRT734679)
- hsa-miR-223-3p (MIRT734767)
- hsa-miR-455-3p (MIRT735387)
- hsa-miR-19a-5p (MIRT784095)
- hsa-miR-19b-1-5p (MIRT784108)
- hsa-miR-19b-2-5p (MIRT784121)
- hsa-miR-2052 (MIRT784149)
- hsa-miR-3149 (MIRT784671)
Transcription Factor Targets for ZEB1 Gene
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ZEB1
- Browse OriGene Inhibitory RNA Products For ZEB1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZEB1
Clone products for research
- Applied Biological Materials (abm): Clones for ZEB1 - Starting at $45 >
- * ZEB1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG223095
- MR223095
- MR223095L1
- MR223095L2
- MR223095L3
- MR223095L4
- RC217704
- RC217704L1
- RC217704L2
- RC217704L3
- RC217704L4
- RC226329
- RC226329L1
- RC226329L2
- RC226329L3
- RC226329L4
- RC230631
- RC230631L3
- RC230631L4
- RC230650
- RC230650L3
- RC230650L4
- RC230651
- RC230651L3
- RC230651L4
- RC230656
- RC230656L3
- RC230656L4
- RG217704
- RG226329
- RG230631
- RG230650
- RG230651
- RG230656
- RR203713
- RR203713L3
- RR203713L4
- MR223095L1V
- MR223095L2V
- MR223095L3V
- MR223095L4V
- RC217704L1V
- RC217704L2V
- RC217704L3V
- RC217704L4V
- RC226329L1V
- RC226329L2V
- RC226329L3V
- RC226329L4V
- RC230631L3V
- RC230631L4V
- RC230650L3V
- RC230650L4V
- RC230651L3V
- RC230651L4V
- RC230656L3V
- RC230656L4V
- RR203713L3V
- RR203713L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for ZEB1
- Addgene plasmids for ZEB1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ZEB1
No data available for Enzyme Numbers (IUBMB) and HOMER Transcription for ZEB1 Gene
Localization for ZEB1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ZEB1 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| plasma membrane | 3 |
| extracellular | 3 |
| cytoskeleton | 3 |
| mitochondrion | 2 |
| endoplasmic reticulum | 2 |
| endosome | 2 |
| lysosome | 2 |
| peroxisome | 1 |
| golgi apparatus | 1 |
- Nucleoli (3)
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000785 | chromatin | ISA | -- |
| GO:0005634 | nucleus | IEA,IDA | 20418909 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005829 | cytosol | IDA | -- |
Pathways & Interactions for ZEB1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Human Embryonic Stem Cell Pluripotency |
Factors Promoting Cardiogenesis in Vertebrates
.50
|
Human Embryonic Stem Cell Pluripotency
.50
|
| 2 | ERK Signaling |
MAPK Signaling
.58
|
ILK Signaling
.49
|
| 3 | Cytokine Signaling in Immune system | ||
| 4 | Wnt / Hedgehog / Notch | ||
| 5 | MicroRNAs in cancer | ||
Pathways by source for ZEB1 Gene
3 BioSystems pathways for ZEB1 Gene
4 Reactome pathways for ZEB1 Gene
1 PharmGKB pathway for ZEB1 Gene
3 KEGG pathways for ZEB1 Gene
7 Qiagen pathways for ZEB1 Gene
- Epithelial Adherens Junctions
- Factors Promoting Cardiogenesis in Vertebrates
- Human Embryonic Stem Cell Pluripotency
- ILK Signaling
- JNK Pathway
1 Cell Signaling Technology pathway for ZEB1 Gene
Interacting Proteins for ZEB1 Gene
GPS-Prot Interaction Network for ZEB1
SIGNOR curated interactions for ZEB1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | TAS,IDA | 23765923 |
| GO:0006357 | regulation of transcription by RNA polymerase II | TAS,IBA | 21873635 |
| GO:0007399 | nervous system development | IEA | -- |
| GO:0019221 | cytokine-mediated signaling pathway | TAS | -- |
| GO:0030154 | cell differentiation | IEA | -- |
Drugs & Compounds for ZEB1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Zinc | Approved, Investigational | Pharma | 1706 |
Transcripts for ZEB1 Gene
mRNA/cDNA for ZEB1 Gene
- 41 REFSEQ mRNAs :
- 36 NCBI additional mRNA sequence :
- 24 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000320985 5423 nts (view in UCSC)
- ENST00000361642 5990 nts (view in UCSC)
- ENST00000424869 5937 nts (view in UCSC)
- ENST00000437844 6246 nts (view in UCSC)
- ENST00000446923 6250 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for ZEB1 - Starting at $85 >
- * ZEB1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for ZEB1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ZEB1
-
Santa Cruz Biotechnology (SCBT) CRISPR for ZEB1
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ZEB1
- Browse OriGene Inhibitory RNA Products For ZEB1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZEB1
Clone products for research
- Applied Biological Materials (abm): Clones for ZEB1 - Starting at $45 >
- * ZEB1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG223095
- MR223095
- MR223095L1
- MR223095L2
- MR223095L3
- MR223095L4
- RC217704
- RC217704L1
- RC217704L2
- RC217704L3
- RC217704L4
- RC226329
- RC226329L1
- RC226329L2
- RC226329L3
- RC226329L4
- RC230631
- RC230631L3
- RC230631L4
- RC230650
- RC230650L3
- RC230650L4
- RC230651
- RC230651L3
- RC230651L4
- RC230656
- RC230656L3
- RC230656L4
- RG217704
- RG226329
- RG230631
- RG230650
- RG230651
- RG230656
- RR203713
- RR203713L3
- RR203713L4
- MR223095L1V
- MR223095L2V
- MR223095L3V
- MR223095L4V
- RC217704L1V
- RC217704L2V
- RC217704L3V
- RC217704L4V
- RC226329L1V
- RC226329L2V
- RC226329L3V
- RC226329L4V
- RC230631L3V
- RC230631L4V
- RC230650L3V
- RC230650L4V
- RC230651L3V
- RC230651L4V
- RC230656L3V
- RC230656L4V
- RR203713L3V
- RR203713L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for ZEB1
- Addgene plasmids for ZEB1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ZEB1
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | ||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | |||||||||||||||||||||||||||
| SP5: | - | - | - | ||||||||||||||||||||||||||||||
| SP6: |
Relevant External Links for ZEB1 Gene
- GeneLoc Exon Structure for
- ZEB1
Expression for ZEB1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Cardiovascular System)
- Definitive Hematopoietic Stem Cells Definitive Yolk Sac
- pre Conventional Dendritic Cells Peripheral Blood
-
Kidney (Urinary System)
- Metanephric Mesenchyme Cells Metanephric Mesenchyme
- S-shaped Body
-
Eye (Sensory Organs)
- Keratoblasts Corneal Stroma
- Mature Endothelial Cells Corneal Endothelium
- Brain (Nervous System)
- Neural Tube (Nervous System)
-
Yolk Sac (Extraembryonic Tissues)
- Definitive Hematopoietic Stem Cells Definitive Yolk Sac
-
Ovary (Reproductive System)
- Ovarian Mesenchymal Stroma Cells Ovary Interstitium
-
Head Mesenchyme (Muscoskeletal System)
- Dental Mesenchymal Cells Branchial Arch 1
-
Tooth
- Dental Mesenchymal Cells Branchial Arch 1
-
Endothelium (Cardiovascular System)
- Mature Endothelial Cells Corneal Endothelium
- Dermis (Integumentary System)
- Fibroblasts
-
Uterus (Reproductive System)
This gene is overexpressed in Rectum (32.4), Fetal gut (10.1), Fetal Brain (9.1), Liver (8.9), and Uterus (6.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZEB1 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZEB1
SOURCE GeneReport for Unigene cluster for ZEB1 Gene:
Hs.124503mRNA Expression by UniProt/SwissProt for ZEB1 Gene:
P37275-ZEB1_HUMAN
Tissue specificity:
Colocalizes with SMARCA4/BRG1 in E-cadherin-negative cells from established lines, and stroma of normal colon as well as in de-differentiated epithelial cells at the invasion front of colorectal carcinomas (at protein level). Expressed in heart and skeletal muscle, but not in liver, spleen, or pancreas.
Evidence on tissue expression from TISSUES for ZEB1 Gene
- Gall bladder(5)
- Nervous system(4.9)
- Muscle(3.2)
- Heart(3.2)
- Lung(3.2)
- Kidney(3.1)
- Intestine(3)
- Lymph node(2.9)
- Liver(2.9)
- Skin(2.7)
- Spleen(2.6)
- Blood(2.6)
- Thyroid gland(2.4)
- Pancreas(2.4)
- Stomach(2.3)
- Bone marrow(2.3)
Phenotype-based relationships between genes and organs from Gene ORGANizer for ZEB1 Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- digestive
- immune
- nervous
- skeletal muscle
- skeleton
Regions:
Head and neck:
- eye
- head
- jaw
- mandible
- maxilla
- mouth
- skull
- tooth
Abdomen:
- abdominal wall
- intestine
General:
- blood vessel
Primer products for research
-
OriGene qPCR primer pairs for ZEB1
Gene Expression Assays for research
No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for ZEB1 Gene
Orthologs for ZEB1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | ZEB1 29 30 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | ZEB1 29 30 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | ZEB1 29 30 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Zeb1 29 16 30 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | ZEB1 30 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Zeb1 29 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | ZEB1 30 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | ZEB1 29 30 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | ZEB1 30 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | zeb1 29 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | zeb1b 29 30 |
|
OneToMany | |
| zeb1a 30 |
|
OneToMany | |||
| zfhx1 29 |
|
||||
| Worm (Caenorhabditis elegans) |
Secernentea | F58G1.2 30 |
|
ManyToMany | |
| tra-4 30 |
|
ManyToMany |
- Species where no ortholog for ZEB1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for ZEB1 Gene
- ENSEMBL:
- Gene Tree for ZEB1 (if available)
- TreeFam:
- Gene Tree for ZEB1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ZEB1: view image
- Alliance of Genome Resources:
- Additional Orthologs for ZEB1
Paralogs for ZEB1 Gene
(29) SIMAP similar genes for ZEB1 Gene using alignment to 11 proteins:
- ZEB1_HUMAN
- A0JLS9_HUMAN
- F6TDF5_HUMAN
- F6U0D0_HUMAN
- H0YMD3_HUMAN
- H0YMN2_HUMAN
- H0YN12_HUMAN
- H0YND9_HUMAN
- L0R5E9_HUMAN
- L8EAF3_HUMAN
- Q32Q63_HUMAN
Variants for ZEB1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZEB1 Gene
| SNP ID | Clinical significance and condition | Chr 10 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 1032236 | Likely Pathogenic: Corneal dystrophy, Fuchs endothelial, 6 | 31,510,691(+) |
CA/C NM_001174096.2(ZEB1):c.504del (p.Gln169fs) |
FRAMESHIFT_VARIANT,FIVE_PRIME_UTR | |
| 12632 | Pathogenic: Posterior polymorphous corneal dystrophy 3 | 31,520,683(+) |
C/T NM_001174096.2(ZEB1):c.1351C>T (p.Gln451Ter) |
NONSENSE | |
| rs1057518956 | Pathogenic: Glaucoma; Visual loss; Polymorphous corneal dystrophy; not provided | 31,520,308(+) |
C/T NM_030751.6(ZEB1):c.973C>T (p.Arg325Ter) |
NONSENSE | |
| rs117885608 | Benign: not provided | 31,510,885(+) |
A/G NM_030751.6(ZEB1):c.684+10A>G |
INTRON | |
| rs118020901 | Uncertain Significance: Corneal dystrophy, Fuchs endothelial, 6. Corneal dystrophy, Fuchs endothelial, 6 (FECD6) [MIM:613270] | 31,521,854(+) |
A/Cp.Gln840Pro NM_030751.6(ZEB1):c.2519A>C (p.Gln840Pro) |
MISSENSE |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
Residual Variation Intolerance Score:
38.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.08;
60.96% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ZEB1 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZEB1 Gene
Disorders for ZEB1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| corneal dystrophy, posterior polymorphous, 3 |
|
|
| corneal dystrophy, fuchs endothelial, 6 |
|
|
| corneal dystrophy |
|
|
| corneal dystrophy, posterior polymorphous, 1 |
|
|
| intraocular pressure quantitative trait locus |
|
|
Search ZEB1 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
ZEB1_HUMAN- Corneal dystrophy, posterior polymorphous, 3 (PPCD3) [MIM:609141]: A subtype of posterior corneal dystrophy, a disease characterized by alterations of Descemet membrane presenting as vesicles, opacities or band-like lesions on slit-lamp examination and specular microscopy. Affected patient typically are asymptomatic. {ECO:0000269 PubMed:16252232, ECO:0000269 PubMed:23599324}. Note=The disease is caused by variants affecting the gene represented in this entry.
- Corneal dystrophy, Fuchs endothelial, 6 (FECD6) [MIM:613270]: A corneal disease caused by loss of endothelium of the central cornea. It is characterized by focal wart-like guttata that arise from Descemet membrane and develop in the central cornea, epithelial blisters, reduced vision and pain. Descemet membrane is thickened by abnormal collagenous deposition. {ECO:0000269 PubMed:20036349, ECO:0000269 PubMed:23599324, ECO:0000269 PubMed:25190660}. Note=The disease is caused by variants affecting the gene represented in this entry.
Additional Disease Information for ZEB1
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for Genatlas for ZEB1 Gene
Publications for ZEB1 Gene
- Mutations in TCF8 cause posterior polymorphous corneal dystrophy and ectopic expression of COL4A3 by corneal endothelial cells. (PMID: 16252232) Krafchak CM … Richards JE (American journal of human genetics 2005) 2 3 4 22 72
- Missense mutations in TCF8 cause late-onset Fuchs corneal dystrophy and interact with FCD4 on chromosome 9p. (PMID: 20036349) Riazuddin SA … Katsanis N (American journal of human genetics 2010) 3 4 22 72
- Analysis of the posterior polymorphous corneal dystrophy 3 gene, TCF8, in late-onset Fuchs endothelial corneal dystrophy. (PMID: 18172091) Mehta JS … Aung T (Investigative ophthalmology & visual science 2008) 3 22 40
- Posterior polymorphous corneal dystrophy is associated with TCF8 gene mutations and abdominal hernia. (PMID: 17935237) Aldave AJ … Richards JE (American journal of medical genetics. Part A 2007) 3 22 40
- The TCF8 gene encoding a zinc finger protein (Nil-2-a) resides on human chromosome 10p11.2. (PMID: 1427828) Williams TM … Shows TB (Genomics 1992) 2 3 22
ExternalLinks
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- 45 WB Antibodies (anti-rat)
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Sources for ZEB1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Apr-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
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- (29) HomoloGene
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- (35) Pseudogene
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