This gene encodes a four transmembrane protein that is a member of the zinc finger DHHC domain-containing protein family. The encoded protein may function as a palmitoyltransferase. Defects in this gene may be associated with a susceptibility to schizophrenia. Alternate splicing of this gene results in multiple transcript variants. A pseudogene of this gene is found on chromoso... See more...

Aliases for ZDHHC8 Gene

Aliases for ZDHHC8 Gene

  • Zinc Finger DHHC-Type Palmitoyltransferase 8 2 3
  • Zinc Finger DHHC-Type Containing 8 2 3 5
  • Probable Palmitoyltransferase ZDHHC8 3 4
  • Zinc Finger Protein 378 3 4
  • ZDHHCL1 3 4
  • ZNF378 3 4
  • Membrane-Associated DHHC8 Zinc Finger Protein 3
  • Zinc Finger DHHC Domain-Containing Protein 8 4
  • Zinc Finger, DHHC Domain Like Containing 1 3
  • EC 2.3.1.225 4
  • KIAA1292 4
  • EC 2.3.1 52
  • DHHC-8 4
  • DHHC8 3

External Ids for ZDHHC8 Gene

Previous GeneCards Identifiers for ZDHHC8 Gene

  • GC22P017059
  • GC22P018494
  • GC22P018493
  • GC22P018499
  • GC22P020116
  • GC22P003740

Summaries for ZDHHC8 Gene

Entrez Gene Summary for ZDHHC8 Gene

  • This gene encodes a four transmembrane protein that is a member of the zinc finger DHHC domain-containing protein family. The encoded protein may function as a palmitoyltransferase. Defects in this gene may be associated with a susceptibility to schizophrenia. Alternate splicing of this gene results in multiple transcript variants. A pseudogene of this gene is found on chromosome 22.[provided by RefSeq, May 2010]

GeneCards Summary for ZDHHC8 Gene

ZDHHC8 (Zinc Finger DHHC-Type Palmitoyltransferase 8) is a Protein Coding gene. Diseases associated with ZDHHC8 include Schizophrenia and Chromosome 6Q24-Q25 Deletion Syndrome. Among its related pathways are Lipoprotein metabolism and Metabolism. Gene Ontology (GO) annotations related to this gene include palmitoyltransferase activity. An important paralog of this gene is ZDHHC5.

UniProtKB/Swiss-Prot Summary for ZDHHC8 Gene

  • Palmitoyltransferase involved in glutamatergic transmission. Mediates palmitoylation of ABCA1.

Gene Wiki entry for ZDHHC8 Gene

Additional gene information for ZDHHC8 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZDHHC8 Gene

Genomics for ZDHHC8 Gene

GeneHancer (GH) Regulatory Elements for ZDHHC8 Gene

Promoters and enhancers for ZDHHC8 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZDHHC8 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZDHHC8

Top Transcription factor binding sites by QIAGEN in the ZDHHC8 gene promoter:
  • CREB
  • deltaCREB
  • HOXA5
  • Pax-5
  • SRF (504 AA)
  • YY1

Genomic Locations for ZDHHC8 Gene

Genomic Locations for ZDHHC8 Gene
chr22:20,129,456-20,148,007
(GRCh38/hg38)
Size:
18,552 bases
Orientation:
Plus strand
chr22:20,116,979-20,135,530
(GRCh37/hg19)
Size:
18,552 bases
Orientation:
Plus strand

Genomic View for ZDHHC8 Gene

Genes around ZDHHC8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZDHHC8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZDHHC8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZDHHC8 Gene

Proteins for ZDHHC8 Gene

  • Protein details for ZDHHC8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULC8-ZDHC8_HUMAN
    Recommended name:
    Probable palmitoyltransferase ZDHHC8
    Protein Accession:
    Q9ULC8
    Secondary Accessions:
    • Q2TGE9
    • Q6ICL1
    • Q6ZNF5
    • Q7Z6L9

    Protein attributes for ZDHHC8 Gene

    Size:
    765 amino acids
    Molecular mass:
    81443 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • According to PubMed:15489219 and PubMed:15184899, defects in ZDHHC8 may contribute to susceptibility to schizophrenia, but according to PubMed:15992527, PubMed:15631889 and PubMed:16150541, it is not the case.
    SequenceCaution:
    • Sequence=BAD18420.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAG30243.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZDHHC8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZDHHC8 Gene

Selected DME Specific Peptides for ZDHHC8 Gene

Q9ULC8:
  • FYRPPRCSHCSVCDNCVE
  • WVNNCIG
  • FAPHALPNRNGSLSYDSLLNPGSP
  • REPSPVRYDNLSR
  • PLKVKLSDNGLKAG
  • FLFVLANFSMATFMDPG
  • DSLFGDSGVYD
  • VTGKFRGGVNPFT
  • TMAVMCVAGLFFIPV
  • RGRTTNE
  • EDEDKEDDFRAPLYK
  • EQVPGPDSLTL
  • GIQVRMKWCATC
  • PPFLRPE

Post-translational modifications for ZDHHC8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZDHHC8 Gene

Domains & Families for ZDHHC8 Gene

Gene Families for ZDHHC8 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins

Protein Domains for ZDHHC8 Gene

Blocks:
  • Zn-finger, DHHC type
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZDHHC8 Gene

GenScript: Design optimal peptide antigens:
  • ZDHHC8 protein (Q96GI9_HUMAN)
  • Zinc finger protein 378 (ZDHC8_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9ULC8

UniProtKB/Swiss-Prot:

ZDHC8_HUMAN :
  • The DHHC domain is required for palmitoyltransferase activity.
  • Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.
Domain:
  • The DHHC domain is required for palmitoyltransferase activity.
Family:
  • Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.
genes like me logo Genes that share domains with ZDHHC8: view

Function for ZDHHC8 Gene

Molecular function for ZDHHC8 Gene

UniProtKB/Swiss-Prot Function:
Palmitoyltransferase involved in glutamatergic transmission. Mediates palmitoylation of ABCA1.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-hexadecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:36683, Rhea:RHEA-COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:29950, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74151; EC=2.3.1.225;.

Enzyme Numbers (IUBMB) for ZDHHC8 Gene

Phenotypes From GWAS Catalog for ZDHHC8 Gene

Gene Ontology (GO) - Molecular Function for ZDHHC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016409 palmitoyltransferase activity IDA 23034182
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IEA --
GO:0019706 protein-cysteine S-palmitoyltransferase activity TAS --
genes like me logo Genes that share ontologies with ZDHHC8: view
genes like me logo Genes that share phenotypes with ZDHHC8: view

Animal Models for ZDHHC8 Gene

MGI Knock Outs for ZDHHC8:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZDHHC8

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZDHHC8 Gene

Localization for ZDHHC8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZDHHC8 Gene

Cytoplasmic vesicle membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZDHHC8 gene
Compartment Confidence
golgi apparatus 5
cytosol 4
plasma membrane 3
mitochondrion 3
extracellular 2
endoplasmic reticulum 2
cytoskeleton 1
nucleus 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZDHHC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005794 Golgi apparatus IDA,IBA 16647879
GO:0005829 cytosol TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ZDHHC8: view

Pathways & Interactions for ZDHHC8 Gene

genes like me logo Genes that share pathways with ZDHHC8: view

Interacting Proteins for ZDHHC8 Gene

;

Gene Ontology (GO) - Biological Process for ZDHHC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007626 locomotory behavior IEA --
GO:0018345 protein palmitoylation IBA,IDA 23034182
GO:0034380 high-density lipoprotein particle assembly TAS --
genes like me logo Genes that share ontologies with ZDHHC8: view

No data available for SIGNOR curated interactions for ZDHHC8 Gene

Drugs & Compounds for ZDHHC8 Gene

(1) Drugs for ZDHHC8 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Coenzyme A Investigational Nutra 0

(1) Additional Compounds for ZDHHC8 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
hexadecanoyl-CoA
  • coenzyme A, S-Hexadecanoate
  • Palmitoyl coenzyme A
  • S-Palmitoylcoenzyme A
  • coenzyme A, S-Hexadecanoic acid
genes like me logo Genes that share compounds with ZDHHC8: view

Transcripts for ZDHHC8 Gene

mRNA/cDNA for ZDHHC8 Gene

2 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZDHHC8

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZDHHC8 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13
SP1: - - -
SP2: - - - -
SP3: - - - - -
SP4:
SP5: - - - - - - - -
SP6: -
SP7: - -

Relevant External Links for ZDHHC8 Gene

GeneLoc Exon Structure for
ZDHHC8

Expression for ZDHHC8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZDHHC8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZDHHC8 Gene

This gene is overexpressed in Plasma (52.4) and Heart (14.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZDHHC8 Gene



Protein tissue co-expression partners for ZDHHC8 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZDHHC8

SOURCE GeneReport for Unigene cluster for ZDHHC8 Gene:

Hs.63128

Evidence on tissue expression from TISSUES for ZDHHC8 Gene

  • Nervous system(4.6)
  • Blood(4.2)
genes like me logo Genes that share expression patterns with ZDHHC8: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZDHHC8 Gene

Orthologs for ZDHHC8 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZDHHC8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZDHHC8 31 30
  • 97.37 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ZDHHC8 31 30
  • 89.54 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZDHHC8 31
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zdhhc8 30
  • 86.09 (n)
mouse
(Mus musculus)
Mammalia Zdhhc8 17 31 30
  • 85.7 (n)
cow
(Bos Taurus)
Mammalia ZDHHC8 31
  • 74 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZDHHC8 31
  • 54 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZDHHC8 31 30
  • 67.19 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZDHHC8 31
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zdhhc8 30
  • 63.79 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.32325 30
zebrafish
(Danio rerio)
Actinopterygii zdhhc8b 31 30
  • 61.6 (n)
OneToOne
zdhhc5 30
fruit fly
(Drosophila melanogaster)
Insecta CG34449 31
  • 25 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea dhhc-8 31
  • 37 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 47 (a)
OneToMany
Species where no ortholog for ZDHHC8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZDHHC8 Gene

ENSEMBL:
Gene Tree for ZDHHC8 (if available)
TreeFam:
Gene Tree for ZDHHC8 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZDHHC8: view image

Paralogs for ZDHHC8 Gene

Paralogs for ZDHHC8 Gene

(6) SIMAP similar genes for ZDHHC8 Gene using alignment to 3 proteins:

  • ZDHC8_HUMAN
  • C9JVM2_HUMAN
  • Q96GI9_HUMAN

Pseudogenes.org Pseudogenes for ZDHHC8 Gene

genes like me logo Genes that share paralogs with ZDHHC8: view

Variants for ZDHHC8 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZDHHC8 Gene

SNP ID Clinical significance and condition Chr 22 pos Variation AA Info Type
rs193920775 Uncertain Significance: Malignant tumor of prostate 20,141,427(+) C/A MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for ZDHHC8 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZDHHC8 Gene

Variant ID Type Subtype PubMed ID
dgv4480n100 CNV gain 25217958
dgv4481n100 CNV gain 25217958
dgv726n67 CNV gain 20364138
dgv7983n54 CNV gain 21841781
esv2758825 CNV loss 17122850
esv3647284 CNV gain 21293372
esv3893434 CNV gain 25118596
nsv1112810 CNV deletion 24896259
nsv471183 CNV loss 18288195
nsv588248 CNV loss 21841781
nsv828938 CNV gain 20364138
nsv828939 CNV loss 20364138
nsv834133 CNV loss 17160897
nsv834134 CNV loss 17160897
nsv953027 CNV deletion 24416366

Variation tolerance for ZDHHC8 Gene

Residual Variation Intolerance Score: 21% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.98; 68.26% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZDHHC8 Gene

Human Gene Mutation Database (HGMD)
ZDHHC8
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZDHHC8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZDHHC8 Gene

Disorders for ZDHHC8 Gene

MalaCards: The human disease database

(6) MalaCards diseases for ZDHHC8 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
schizophrenia
  • sczd
chromosome 6q24-q25 deletion syndrome
  • chromosome 6q25-q25 deletion syndrome
velocardiofacial syndrome
  • digeorge syndrome
chromosomal deletion syndrome
chromosome 15q13.3 deletion syndrome
  • chromosome 15q13.3 microdeletion syndrome
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZDHHC8

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ZDHHC8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZDHHC8 Gene

Publications for ZDHHC8 Gene

  1. No association between the putative functional ZDHHC8 single nucleotide polymorphism rs175174 and schizophrenia in large European samples. (PMID: 15992527) Glaser B … Owen MJ (Biological psychiatry 2005) 3 4 23 41 54
  2. Case-control study and transmission disequilibrium test provide consistent evidence for association between schizophrenia and genetic variation in the 22q11 gene ZDHHC8. (PMID: 15489219) Chen WY … He L (Human molecular genetics 2004) 3 4 23 41 54
  3. Evidence that the gene encoding ZDHHC8 contributes to the risk of schizophrenia. (PMID: 15184899) Mukai J … Gogos JA (Nature genetics 2004) 2 3 4 41 54
  4. ZDHHC8 as a candidate gene for schizophrenia: analysis of a putative functional intronic marker in case-control and family-based association studies. (PMID: 16225675) Faul T … Stöber G (BMC psychiatry 2005) 3 23 41 54
  5. The ZDHHC8 gene did not associate with bipolar disorder or schizophrenia. (PMID: 16150541) Otani K … Kuroda S (Neuroscience letters 2005) 3 4 41 54

Products for ZDHHC8 Gene

Sources for ZDHHC8 Gene