Aliases for ZDHHC7 Gene

Aliases for ZDHHC7 Gene

  • Zinc Finger DHHC-Type Palmitoyltransferase 7 2 3 5
  • Zinc Finger DHHC Domain-Containing Protein 7 3 4
  • Zinc Finger DHHC-Type Containing 7 2 3
  • Palmitoyltransferase ZDHHC7 3 4
  • SERZ-B 2 3
  • ZNF370 2 3
  • DHHC-7 3 4
  • DHHC7 2 3
  • SERZ1 2 3
  • Sertoli Cell Gene With Zinc Finger Domain-I(2) 3
  • Sertoli Cell Gene With Zinc Finger Domain-Beta 3
  • Sertoli Cell Gene With Zinc Finger Domain-Β 2
  • Zinc Finger, DHHC Domain Containing 7 3
  • Zinc Finger Protein 370 3
  • EC 2.3.1.225 4
  • FLJ10792 2
  • FLJ20279 2
  • EC 2.3.1 51
  • ZDHHC7 5

External Ids for ZDHHC7 Gene

Previous GeneCards Identifiers for ZDHHC7 Gene

  • GC16M075554
  • GC16M085974
  • GC16M084746
  • GC16M084787
  • GC16M083565
  • GC16M085007
  • GC16M070760

Summaries for ZDHHC7 Gene

GeneCards Summary for ZDHHC7 Gene

ZDHHC7 (Zinc Finger DHHC-Type Palmitoyltransferase 7) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include protein-cysteine S-palmitoyltransferase activity and palmitoyltransferase activity. An important paralog of this gene is ZDHHC3.

UniProtKB/Swiss-Prot Summary for ZDHHC7 Gene

  • Golgi-localized palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and therefore functions in several unrelated biological processes (PubMed:22031296, PubMed:27380321, PubMed:28196865). Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane and their function in rapid intracellular signaling upon binding of sex hormones (PubMed:22031296). Palmitoylates GNAQ, a heterotrimeric G protein, regulating its dynamic localization at the plasma membrane and is thereby involved in GNAQ-dependent G protein-coupled receptor signaling pathways (PubMed:19001095). Functions also in ligand-induced cell death by regulating the FAS signaling pathway through the palmitoylation and stabilization of the receptor at the plasma membrane (PubMed:25301068). In epithelial cells, palmitoylates SCRIB and regulates its localization to the plasma membrane, regulating indirectly cell polarity and differentiation (PubMed:27380321). Also palmitoylates JAM3 and promotes its expression at tight junctions and regulates its function in cell migration (PubMed:28196865). Palmitoylates the glucose transporter GLUT4/SLC2A4 and controls the insulin-dependent translocation of GLUT4 to the plasma membrane (By similarity). In brain, could also palmitoylate SNAP25 and DLG4/PSD95 (By similarity). Could also palmitoylate DNAJC5 and regulate its localization to the Golgi membrane (By similarity). Could also palmitoylate NCDN (By similarity). May play a role in follicle stimulation hormone (FSH) activation of testicular Sertoli cells (By similarity).

Additional gene information for ZDHHC7 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZDHHC7 Gene

Genomics for ZDHHC7 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZDHHC7 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZDHHC7 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZDHHC7

Top Transcription factor binding sites by QIAGEN in the ZDHHC7 gene promoter:
  • Bach2
  • ER-alpha
  • HOXA5
  • JunB
  • JunD
  • Nkx6-1
  • Olf-1
  • Pax-2
  • Pax-2a
  • TGIF

Genomic Locations for ZDHHC7 Gene

Genomic Locations for ZDHHC7 Gene
chr16:84,974,175-85,011,535
(GRCh38/hg38)
Size:
37,361 bases
Orientation:
Minus strand
chr16:85,007,787-85,045,141
(GRCh37/hg19)
Size:
37,355 bases
Orientation:
Minus strand

Genomic View for ZDHHC7 Gene

Genes around ZDHHC7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZDHHC7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZDHHC7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZDHHC7 Gene

Proteins for ZDHHC7 Gene

  • Protein details for ZDHHC7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NXF8-ZDHC7_HUMAN
    Recommended name:
    Palmitoyltransferase ZDHHC7
    Protein Accession:
    Q9NXF8
    Secondary Accessions:
    • D3DUM1
    • Q8WV42
    • Q9NVD8

    Protein attributes for ZDHHC7 Gene

    Size:
    308 amino acids
    Molecular mass:
    35140 Da
    Quaternary structure:
    • Homooligomers. Heterooligomers with ZDHHC3.
    SequenceCaution:
    • Sequence=AAH17702.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAA91814.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZDHHC7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZDHHC7 Gene

Selected DME Specific Peptides for ZDHHC7 Gene

Q9NXF8:
  • MDHHCPW
  • WFIRDGCG
  • MLTDPGAVPKGNATKE
  • FVLFTMYIAL

Post-translational modifications for ZDHHC7 Gene

Other Protein References for ZDHHC7 Gene

Domains & Families for ZDHHC7 Gene

Gene Families for ZDHHC7 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins

Protein Domains for ZDHHC7 Gene

InterPro:
Blocks:
  • Zn-finger, DHHC type
ProtoNet:

Suggested Antigen Peptide Sequences for ZDHHC7 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 370 (ZDHC7_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NXF8

UniProtKB/Swiss-Prot:

ZDHC7_HUMAN :
  • The DHHC domain is required for palmitoyltransferase activity.
  • Belongs to the DHHC palmitoyltransferase family.
Domain:
  • The DHHC domain is required for palmitoyltransferase activity.
Family:
  • Belongs to the DHHC palmitoyltransferase family.
genes like me logo Genes that share domains with ZDHHC7: view

Function for ZDHHC7 Gene

Molecular function for ZDHHC7 Gene

UniProtKB/Swiss-Prot Function:
Golgi-localized palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and therefore functions in several unrelated biological processes (PubMed:22031296, PubMed:27380321, PubMed:28196865). Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane and their function in rapid intracellular signaling upon binding of sex hormones (PubMed:22031296). Palmitoylates GNAQ, a heterotrimeric G protein, regulating its dynamic localization at the plasma membrane and is thereby involved in GNAQ-dependent G protein-coupled receptor signaling pathways (PubMed:19001095). Functions also in ligand-induced cell death by regulating the FAS signaling pathway through the palmitoylation and stabilization of the receptor at the plasma membrane (PubMed:25301068). In epithelial cells, palmitoylates SCRIB and regulates its localization to the plasma membrane, regulating indirectly cell polarity and differentiation (PubMed:27380321). Also palmitoylates JAM3 and promotes its expression at tight junctions and regulates its function in cell migration (PubMed:28196865). Palmitoylates the glucose transporter GLUT4/SLC2A4 and controls the insulin-dependent translocation of GLUT4 to the plasma membrane (By similarity). In brain, could also palmitoylate SNAP25 and DLG4/PSD95 (By similarity). Could also palmitoylate DNAJC5 and regulate its localization to the Golgi membrane (By similarity). Could also palmitoylate NCDN (By similarity). May play a role in follicle stimulation hormone (FSH) activation of testicular Sertoli cells (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-hexadecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:36683, Rhea:RHEA-COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:29950, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74151; EC=2.3.1.225; Evidence={ECO:0000269|PubMed:22031296, ECO:0000269|PubMed:25301068, ECO:0000269|PubMed:27380321, ECO:0000269|PubMed:28196865};.

Enzyme Numbers (IUBMB) for ZDHHC7 Gene

Phenotypes From GWAS Catalog for ZDHHC7 Gene

Gene Ontology (GO) - Molecular Function for ZDHHC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016409 palmitoyltransferase activity IEA,IDA 23034182
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IEA --
GO:0019706 protein-cysteine S-palmitoyltransferase activity IEA,IMP 25301068
genes like me logo Genes that share ontologies with ZDHHC7: view

Phenotypes for ZDHHC7 Gene

genes like me logo Genes that share phenotypes with ZDHHC7: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZDHHC7

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZDHHC7 Gene

Localization for ZDHHC7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZDHHC7 Gene

Golgi apparatus membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZDHHC7 gene
Compartment Confidence
golgi apparatus 5
plasma membrane 4
nucleus 4
endoplasmic reticulum 4
extracellular 1
cytoskeleton 1
mitochondrion 1
endosome 1
cytosol 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (3)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZDHHC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005654 nucleoplasm IDA --
GO:0005783 endoplasmic reticulum IBA 21873635
GO:0005794 Golgi apparatus IDA 16647879
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with ZDHHC7: view

Pathways & Interactions for ZDHHC7 Gene

PathCards logo

SuperPathways for ZDHHC7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZDHHC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006612 protein targeting to membrane IBA 21873635
GO:0008277 regulation of G protein-coupled receptor signaling pathway IMP 19001095
GO:0009895 negative regulation of catabolic process IMP 25301068
GO:0018230 peptidyl-L-cysteine S-palmitoylation IEA,IMP 22031296
GO:0018345 protein palmitoylation IEA,IMP 19001095
genes like me logo Genes that share ontologies with ZDHHC7: view

No data available for Pathways by source and SIGNOR curated interactions for ZDHHC7 Gene

Drugs & Compounds for ZDHHC7 Gene

(2) Drugs for ZDHHC7 Gene - From: PharmGKB and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Methylphenidate Approved, Investigational Pharma 431
Coenzyme A Investigational Nutra 0

(1) Additional Compounds for ZDHHC7 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
hexadecanoyl-CoA
  • coenzyme A, S-Hexadecanoate
  • Palmitoyl coenzyme A
  • S-Palmitoylcoenzyme A
  • coenzyme A, S-Hexadecanoic acid
genes like me logo Genes that share compounds with ZDHHC7: view

Transcripts for ZDHHC7 Gene

mRNA/cDNA for ZDHHC7 Gene

2 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZDHHC7

Alternative Splicing Database (ASD) splice patterns (SP) for ZDHHC7 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b · 10c · 10d
SP1: - - - -
SP2: - - - - -
SP3: - -
SP4: - - - - -
SP5: -
SP6:
SP7:

Relevant External Links for ZDHHC7 Gene

GeneLoc Exon Structure for
ZDHHC7

Expression for ZDHHC7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZDHHC7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZDHHC7 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZDHHC7 Gene



Protein tissue co-expression partners for ZDHHC7 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZDHHC7

SOURCE GeneReport for Unigene cluster for ZDHHC7 Gene:

Hs.461610

Evidence on tissue expression from TISSUES for ZDHHC7 Gene

  • Skin(4.4)
  • Intestine(4.4)
  • Nervous system(2.8)
  • Kidney(2.3)
  • Heart(2.1)
genes like me logo Genes that share expression patterns with ZDHHC7: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZDHHC7 Gene

Orthologs for ZDHHC7 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZDHHC7 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZDHHC7 30 31
  • 99.57 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia ZDHHC7 31
  • 94 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia ZDHHC7 31
  • 92 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia ZDHHC7 30 31
  • 89.83 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Zdhhc7 30
  • 86.8 (n)
Mouse
(Mus musculus)
Mammalia Zdhhc7 30 17 31
  • 85.93 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ZDHHC7 30 31
  • 85.5 (n)
OneToOne
Chicken
(Gallus gallus)
Aves ZDHHC7 30 31
  • 81.75 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia ZDHHC7 31
  • 91 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100485887 30
  • 77.19 (n)
Zebrafish
(Danio rerio)
Actinopterygii zdhhc7 30 31
  • 74.5 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta CG8314 31 32
  • 50 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea F33D11.12 32
  • 55 (a)
dhhc-3 31
  • 54 (a)
OneToMany
C17D12.1a 32
  • 35 (a)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 54 (a)
OneToMany
Species where no ortholog for ZDHHC7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for ZDHHC7 Gene

ENSEMBL:
Gene Tree for ZDHHC7 (if available)
TreeFam:
Gene Tree for ZDHHC7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZDHHC7: view image

Paralogs for ZDHHC7 Gene

(5) SIMAP similar genes for ZDHHC7 Gene using alignment to 3 proteins:

  • ZDHC7_HUMAN
  • H3BMI0_HUMAN
  • H3BNQ9_HUMAN

Pseudogenes.org Pseudogenes for ZDHHC7 Gene

genes like me logo Genes that share paralogs with ZDHHC7: view

Variants for ZDHHC7 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZDHHC7 Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
VAR_036261 A colorectal cancer sample p.Asp44Asn
rs13334011 - p.Val201Ile

Additional dbSNP identifiers (rs#s) for ZDHHC7 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZDHHC7 Gene

Variant ID Type Subtype PubMed ID
esv2660467 CNV deletion 23128226
esv29431 CNV loss 19812545
esv3639449 CNV loss 21293372
nsv1066260 CNV gain 25217958
nsv1111144 CNV tandem duplication 24896259
nsv1132874 CNV insertion 24896259
nsv1134573 CNV deletion 24896259
nsv483044 CNV gain 15286789

Variation tolerance for ZDHHC7 Gene

Residual Variation Intolerance Score: 40.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.14; 51.44% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZDHHC7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZDHHC7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZDHHC7 Gene

Disorders for ZDHHC7 Gene

Additional Disease Information for ZDHHC7

No disorders were found for ZDHHC7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZDHHC7 Gene

Publications for ZDHHC7 Gene

  1. S-Palmitoylation of Junctional Adhesion Molecule C Regulates Its Tight Junction Localization and Cell Migration. (PMID: 28196865) Aramsangtienchai P … Lin H (The Journal of biological chemistry 2017) 2 3 4
  2. ZDHHC7-mediated S-palmitoylation of Scribble regulates cell polarity. (PMID: 27380321) Chen B … Wu X (Nature chemical biology 2016) 2 3 4
  3. Palmitoylation of caveolin-1 is regulated by the same DHHC acyltransferases that modify steroid hormone receptors. (PMID: 30158247) Tonn Eisinger KR … Mermelstein PG (The Journal of biological chemistry 2018) 2 3
  4. Fas palmitoylation by the palmitoyl acyltransferase DHHC7 regulates Fas stability. (PMID: 25301068) Rossin A … Hueber AO (Cell death and differentiation 2015) 3 4
  5. DHHC-7 and -21 are palmitoylacyltransferases for sex steroid receptors. (PMID: 22031296) Pedram A … Levin ER (Molecular biology of the cell 2012) 3 4

Products for ZDHHC7 Gene

Sources for ZDHHC7 Gene